NOVONUTRIENTS. Food from CO 2. Microbial Factories. Food. Industrial CO 2. Feed

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1 NOVONUTRIENTS Food from CO 2 Microbial Factories Food Industrial CO 2 Feed 1

2 Our Approach Biological CO 2 capture and conversion using hydrogenpowered bacteria 2

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7 NovoNutrients Microbial Factories CO 2 Available from many sources. Process validated using raw emissions from cement manufacture, Oil refinery waste gas, gasified waste, fermentation gases. Gas Fermentation Products Chemoautotrophic Bacteria Hydrogen Produced as a waste gas in mixed gas streams. SMR or electrolysis of water using renewable power 142 MJ per Kg highest energy density 7

8 Why CCU with Aerobic Bacteria? Bacteria Chemoautotropic: produce complex molecules from elemental inputs: CO 2 + H 2 + O 2 24/7 operation in the dark Tolerant to O 2 in flue gas or atmosphere Higher value products: higher prices and larger markets High metabolic rate Able to derive more energy from H 2 Chemical Produces simple molecules from CO 2 capture 8

9 Aerobic Hydrogen Bacteria 9

10 Energy and Mass Balance 3.3 to 5 Mol H 2 per Mol CO 2 captured 18 kg H 2 & 100 kg CO 2 yields 50 kg of product 50% energy efficient Great net efficiency from renewable power to H 2 to product. 10

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12 Novomeal: Microbial Consortium of food grade bacteria 12

13 Novomeal vs. Fishmeal Defined consortia; cheaper to produce, better nutrition, less toxins > 65% protein 10 essential amino acids Fatty acids including PUFAs Carotenoids Vitamins B2, B6, B12 Coenzymes Probiotics Prebiotics 13

14 Potential for hundreds of plants I There are possible hydrogen sites on every inhabited continent. In each, 1.5 million liters of aerobic bioreactor modules feed one drier and processing line. 14

15 Plant Inputs and Outputs Industrial CO tonnes per day Hydrogen 108 tonnes per day Capital $340 million from strategic partner Novomeal / yr. 100,000 tonnes ~$150 million Water, oxygen, spent media $ CO H 2 NM 2 O H 2 O 2 15

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17 Hydrogen CO 2 is a low energy form of carbon. It requires (reducing) energy to be captured and converted: H 2 CO2 is feasible to transport, H2 is not. Our plants must be near H2 production or pipeline. SMR Electrolysis By-product Gasification Biohydrogen Constraints Difficulty in transporting hydrogen Price of H 2 Availability CapEx of H 2 production 17

18 Steam Methane Reformation ( SMR ) Largest form of hydrogen production today Releases CO 2 major GHG producer Lowest cost H 2 today Produces CO 2 and H 2 Benefits Can use existing SMR infrastructure Can use biogas as feedstock 18

19 Electrolysis Green when renewable power is used Modular Clean Produces O 2 Enablers Low cost renewable power of less than $0.04/Kwh Increased scale of electrolyzers Decreased CapEx of electrolyzer plants Increased efficiency 19

20 Byproduct Hydrogen Green? (GHG reducing) Stranded gases in oil refineries Flared gas Byproduct (propylene manufacture) Can produce CO 2 and H 2 Benefits Large source Low cost 20

21 Gasification Early stage industrially On track for widespread adoption Green from renewable feedstocks Remediating/Green with waste feedstocks Can Produce H2 and CO2 Enablers Post processing of gas to reduce CO and increase H2 Wider practice as waste processing tool 21

22 Different Sources of CO 2 Seek lowest cost. Very flexible on contaminants. Emitter must have incentives. Best sources come with H2 Cement Manufacture Fermentation Oil Refining / Stranded SMR Gasification 22

23 Cement Plant Flue Gas Proof-of-concept Direct feed from flue stack Adapted Strain Original strain (wild type) NovoNutrients Field Lab Conversion of CO 2 and O 2 in raw cement flue gas to biomass Adapted Strain Microbes selected in actual industrial environment conditions Biomass High level of CO2 capture and high efficiency conversion into products 23

24 A620 Proof-of-Concept with Oil Refinery Demonstrated direct conversion of CO 2 waste gas to single cell protein and bioplastic Gasified Asphaltines, Flare Gases Refinery waste gas contains both H 2 and CO 2, greatly reducing cost. 74% H 2 17% CO 2 7% CH 4 2% CO Industrial Refinery Gas Biomass Growth at 250ml Scale Time 24

25 Novomeal Readiness and Milestones PRODUCTION Ready to Advance LAB Put 30 L on gas, produce kg quantities Novomeal prototype Validated proof of concept 2019 PILOT Novoceutical sales (toll fermentation) 1000 L Reliable production Support trials Regulatory approval DEMO 20,000 L Trial sales of Novomeal First module online 250,000 L 25

26 Public Sector Support Grants Research assistance / collaboration Tax incentives Loan guarantees Economic development aid Carbon credits, trading systems Regulatory caps Mandates: reduction, CCU/CCS 26

27 Research Assistance Collaboration Collaborations Federal laboratories and agencies National laboratories DOE, NREL, USDA, NOAA Analytics and testing Analytic services Metabolomics, genomics, etc. Synthetic biology Feed trials Design and Development Aid in design and simulation of bioreactors Access to facilities with H2 production (i.e. gasifiers, electrolyzers) Access to scale-up/pilot/demo facilities 27

28 Bioreactor Systems Bioreactor design is a critical aspect of viable gas fermentation systems. Lack of scaled test facilities for gas fermentation (GF) Lack of toll manufacturers for GF Optimization of GF bioreactor design Low Solubility of Hydrogen Safety Concerns Explosion Toxicity Cost/Time of building GF systems Lack of large scale existing systems 28

29 Boundary Conditions Must be Profitable : ROI within 5 Years Cost of hydrogen < 3$ Kg Proximity of hydrogen and CO 2 Market Market size > $1B Market growth > 4% Competition: unable to meet market growth Strategic partners 29

30 Potential Scale: Bioconversion of CO2 Widely practicable method to produce chemicals and food products Potential to manufacture: Fuels Foods Commodity Chemicals Polymers/Plastics Fine and specialty chemicals Pharmaceuticals Potential to decouple industrial production from petrochemicals Potential to revolutionize agriculture 30

31 Potential Scale: Our Approach Production of alternative proteins for aquaculture / feed 1 5 million tons of CO 2 captured Production of proteins and nutrition products for broader markets 10 s of millions of tons of CO 2 captured Impact within time frame of 2 C target: Kilotons in 6 years Megatons in 8 12 years 31

32 Environmental Benefits / Concerns Land Footprint acres: much smaller than equivalent agriculture Water Usage Lower water use than traditional agriculture, less runoff Water re-use possible Extremely efficient at removal of N and S LCA of H 2 Production 32

33 Experienced Team BRIAN SEFTON CTO, FOUNDER Serial entrepreneur. biochemist, MBA Berkeley, Santa Clara University HEYWARD ROBINSON PhD VP CORPORATE DEVELOPMENT SRI, Ex-Mayor Menlo Park Stanford University Duke University DAVID TZE CEO Aquaculture micro-vc GP Aquacopia, 12 yrs, startups raised $250M, Princeton BILL COLEMAN PhD VP BIOLOGY Intrexon, Kairos, Protelica University of Pensylvania University of Illinois RUSSELL HOWARD PhD CHAIRMAN, FOUNDER Founder Maxygen, President Affymax, NIH 33

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35 NOVONUTRIENTS Food from CO Sobrante Way, Suite M Sunnyvale CA Brian Sefton x801 bsefton@novonutrients.com 35