个人简介 境科学与工程国际顶级期刊. 引用 400 余次 浙江省新苗计划 浙江省挑战杯课外科技竞赛指导教师 联系方式 研究方向 潜在环境内分泌干扰物的甄别及风险评价 新型烟碱类农药的整合暴露评估与人群健康风险

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1 个人简介 张全, 男, 博士, 副教授, 浙江省 151 第三层次人才 主要研究方向为环境毒理学和环境健康, 着重以 污染物暴露 - 效应评价 - 生态与健康风险 为主线, 围绕人们频繁暴露新型污染物 ( 新型阻燃剂和新型烟碱类农药 ) 的生态健康风险及机制开展一系列相关工作 已发表 SCI 论文 40 余篇,6 篇发表在环 境科学与工程国际顶级期刊 Environmental Science & Technology 上,1 篇研究论文曾入选环境与生态领域 ESI 高被引论文, 另参编美国化学会 (ACS) 专著一部, 授权国家发明专利 2 项 目前, 已主持或参与国家自然科学基金等多项国家级项目 2012 年获浙江省自然科学学术奖三等奖 SCI 引用 400 余次 浙江省新苗计划 浙江省挑战杯课外科技竞赛指导教师 联系方式 :quanzhang@zjut.edu.cn 研究方向 潜在环境内分泌干扰物的甄别及风险评价 新型烟碱类农药的整合暴露评估与人群健康风险 研究经历 2016/ /10 美国哈佛大学公共卫生学院 Visiting Scientist. 2012/ /04 浙江大学环境与资源学院博士后

2 2010/ /07 美国休斯敦大学化学系 Exchange Scholar. 学术兼职 美国毒理学会会员 (SETAC) 中国毒理学会会员 浙江省生态学会会员 生态和环境毒理学的国际主流期刊 Environ. Sci.: Nano, Sci. of Total Environ., Pest Manga. Sci., Environ. Toxicol. Chem.,Chemosphere, Aquatic Toxicol. 等学术审稿人 主持和参加的科研项目 国家自然科学基金面上项目, 高效氯氰菊酯对幼鼠糖代谢紊乱的对映体选择性及其机制研究 万元 在研 主持 国家自然科学基金青年项目, 环境浓度下拟除虫菊酯类农药对斑马鱼多代慢性毒性研究 万元 结题 主持 ; 中国博士后科学基金第六批特别资助,2013T60599 斑马鱼体内氟虫腈生物转化对映体选择性机制研究 万元 结题 主持 ; 中国博士后科学基金第 52 批面上资助,2012M 基于代谢组学的氟虫腈斑马鱼发育毒性对映体差异研究 万元 结题 主持 ; 国家自然科学基金面上项目, 线粒体损伤介导的亚致死剂量烟碱类农药暴露蜜蜂隔代毒性机制研究 万元 在研 参与 (2/8); 国家自然科学基金面上项目, 斑马鱼体内拟除虫菊酯类农药对映体选择性生物转化机制 万元 在研 参与 (2/9); 国家自然科学基金青年基金, 非职业暴露浓度下二甲基甲酰胺与肝损伤相关性及肝细胞凋亡机制研究 万元 在研 参与 (3/8);

3 本人所发表论文受到媒体关注 报道, 或者同行引用较高, 举例如下 : 2018 年发表在 Environmental Science & Technology 期刊上的论文 Neonicotinoids Residues in Fruits and Vegetables: An Integrated Dietary Exposure Assessment Approac 受美国鸟类学会报道 2017 年发表在 Environmental Science & Technology 期刊上的论文 Potential glucocorticoid and mineralocorticoid effects of nine Organophosphate flame retardants 受 ACS 网站新闻摘要报道 2016 年发表在 Environmental Pollution 期刊上的论文 Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches 入选该期 Invited Paper, 并受到该杂志编辑推荐 ; 2014 年发表在 Environmental Science & Technology 期刊上的论文 Potential estrogenic effects of phosphorus-containing flame retardants 被美国环境工作组 (EWG)REACH 栏目作为研究范例引用报道 ; 2014 年发表在 Environmental Pollution 期刊上的论文 Risk assessment of polychlorinated biphenyls and heavy metals in soils of an abandoned e-waste site in China 曾入选 ESI 高被引论文 (Highly Cited Papers), 研究成果被国际巴塞尔公约组织等广泛报道 ; 2014 年在 Environmental Pollution, Chemosphere 发表的有关农药与新型工业污染物潜在内分泌干扰效应的论文同时入选 2015 年 POPs and Pesticides 领域最有影响力 Top20 论文 (Domain ), 其中 Characterization of estrogen receptor alpha activities in polychlorinated biphenyls by in vitro dual-luciferase reporter gene assay 在发表后三个月内被下载 ~1000 余次 ; 2012 年有关手性农药水生毒性论文 Enantioselective aquatic toxicity of current chiral pesticides 入选 Journal of Environmental Monitoring 杂志年度下载量最高的文章 ; 2011 年申请人参编美国化学会 American Chemical Society 出版的 Chiral Pesticides: Stereoselectivity and Its Consequences 专著一部( 第八章节 )

4 发表的主要论文 (* 为通讯作者 ) 1. Lu CS, Chang CH, Palmer C, Zhao MR, Zhang Q* Neonicotinoids Residues in Fruits and Vegetables: An Integrated Dietary Exposure Assessment Approach. Environmental Science & Technology. 52, Zhang Q, Wang JH, Zhu JQ, Liu J, Zhao MR* Potential glucocorticoid and mineralocorticoid effects of nine organophosphate flame retardants. Environmental Science & Technology, 51, Zhang Q, Lu MY, Dong XW, Hu YZ, Wang C, Zhao MR* Potential estrogenic effects of phosphorus-containing flame retardants. Environmental Science & Technology, 48, Zhang Q, Wang JH, Zhu JQ, Liu J, Zhang JY, Zhao MR* Assessment of the endocrinedisrupting effects of short-chain chlorinated paraffins in in vitro models. Environment International, 94, Zhang Q, Y JJ, Chen JY, Xu HJ, Wang C*, Zhao MR* Risk assessment of polychlorinated biphenyls and heavy metals in soils of an abandoned e-waste site in China. Environmental Pollution, 185, Zhang Q, Li Z, Chang CH, Lou JL, Zhao MR, Lu CS* Potential human exposures to neonicotinoid insecticides: A review. Environmental pollution, 236, Zhang Q, Ji CY, Yin XH, Yan L, Lu MY, Zhao MR* Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches. Environmental pollution, 210, Zhang Q, Ji CY, Yan L, Lu MY, Lu CS, Zhao MR* The identification of the metabolites of chlorothalonil in zebrafish (Danio rerio) and their embryo toxicity and endocrine effects at environmentally relevant levels. Environmental Pollution, 218: Song Q, Zhang Y, Yan L, Wang JH, Lu CS, Zhang Q*, Zhao MR Risk assessment of the endocrine-disrupting effects of nine chiral pesticides. Journal of Hazardous Materials, 338: Zhang Q#, Yan L#, Wu Y, Ji L, Chen YC, Zhao MR*, Dong XW* A ternary classification using machine learning methods of distinct estrogen receptor activities within a large collection of environmental chemicals. Science of the Total Environment, 580: 1268-

5 Zhang Q, Song Q, Wang C, Zhou C, Lu CS, Zhao MR* Effects of glufosinate on the growth of and microcystin production by Microcystis aeruginosa at environmentally relevant concentrations. Science of the Total Environment, 575: Zhang Q, Zhang Y, Du J, Zhao MR* Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo. Chemosphere, 185: Qian Y, Zhou PX, Zhang Q* Development of environment-friendly insecticides based on enantioselectivity: bifenthrin as a case. Current Protein Peptide Science, 18(1): Zhang Q*, Zhu JQ, Ye JJ. Chen F, Zhao MR Temporal trends and risk assessment of polychlorinated biphenyls and heavy metals in a solid waste site in Taizhou, China. Environmental Science Pollution Research, 23(1): Zhang Q, Zhou H, Li Z, Zhu JQ, Zhou C, Zhao MR* Effects of glyphosate at environmentally relevant concentrations on the growth of and microcystin production by Microcystis aeruginosa. Environmental Monitoring and Assessment, 188(11): Chen H, Zhu JQ, Li Z,Chen A, Zhang Q* The occurrence and risk assessment of five organophosphorus pesticides in river water from Shangyu, China. Environmental Monitoring and Assessment, 188(11): Zhang Q, Song Q, Li JL, Zou ML, Zhang CX, Zhang Q* Alteration of the enantioselective toxicity of diclofop acid by nonylphenol: effect on ascorbate-glutathione cycle in Microcystis aeruginosa. Chirality, 28(6): Zhang YJ, Zhang Y, Chen A, Zhang W, Zhang Q* Enantioselectivity in developmental toxicity of rac-metalaxyl and R-metalaxyl in zebrafish (Danio rerio) Embryo. Chirality, 28(6): Lu MY, Du J, Zhou PX, Chen H, Lu CS, Zhang Q* Endocrine disrupting potential of fipronil and its metabolite in reporter gene assays. Chemosphere, 120: Zhang Q, Ji CY, Yin XH, Yan L, Lu MY, Zhao MR* Characterization of estrogen receptor alpha activities in polychlorinated biphenyls by in vitro dual-luciferase reporter gene assay. Environmental pollution, 189, 他引 12 次. 21. Zhang Q, Liu WP, Geng SW, Qu JP, Liu M, Zhang YM, Zhao MR* Degradation of the

6 potential rodent contraceptive quinestrol and elimination of its estrogenic activity in soil and water. Environmental Science and Pollution Research, 21, Wang C#, Zhang Q#, Qian Y, Zhao MR* p,p DDE induces apoptosis through the modulation of tumor necrosis factor α in PC12 cells. Chemical Research in Toxicology, 27, Zhang Q, Wang C* Toxicity of binary mixtures of enantiomers in chiral organophosphorus insecticides: the significance of joint effects between enantiomers. Chirality, 25, Zhang Q, Wang C, Zhang XF, Jin DQ, Huang CJ*, Zhao MR* Enantioselective aquatic toxicity of current chiral pesticides. Journal of Environmental Monitoring, 14(2): Zhang Q, Wang C, Liu WP, Zhang XF, Zhuang SL* Evidence for DNA-diquat interaction and cytotoxicity in in vitro rat cells. Environmental Chemistry Letters, 10, Zhang Q, Wang C, Li L, Zhao MR* Cytotoxicity of lambda-cyhalothrin on the macrophage cell Line RAW Journal of Environmental Sciences, 22, Wang C#, Zhang Q#, Zhang XF, Liu J, Liu WP* Understanding the endocrine disruption of chiral pesticides: The enantioselectivity in estrogenic activity of synthetic pyrethroids. Science China, 53, He XM, Dong XW, Zou XW, Yu DH, Fang Y, Zhang QY, Zhang Q, Zhao MR.* Enantioselective Effects of o,p - DDT on Cell Invasion and Adhesion of Breast Cancer Cells: Chirality in Cancer Development. Environmental Science & Technology, 49(16): Zhang Y, Lu MY, Zhou PX, Wang C, Zhang Q, Zhao MR* Multilevel evaluations of potential liver injury of bifenthrin. Pesticide Biochemistry and Physiology, 122, Zhao MR, Zhang Y, Zhuang SL, Zhang Q, Liu WP* Disruption of the Hormonal Network and the Enantioselectivity of Bifenthrin in Trophoblast: Maternal-Fetal Health Risk of Chiral Pesticides. Environmental Science & Technology, 48, Wang C, Li ZY, Zhang Q, Zhao MR*, Liu WP* Chirality in risk assessment of POPs metabolite: enantioselective induction of cytotoxicity by o,p -DDD in PC12 cells. Environmental Science & Technology, 47, Chen F, Zhang Q, Wang C, Lu YC, Zhao MR* Enantioselectivity in estrogenicity of

7 organochlorine insecticide acetofenate in human trophoblast and MCF-7. Reproductive Toxicology, 33, Zhang Q, Zhao M R*, Qian H F, Lu T, Zhang Q, Liu WP* Enantioselective Damage of Diclofop Acid Mediated by Oxidative Stress and Acetyl-CoA Carboxylase in Nontarget Plant Arabidopsis thaliana. Environmental Science & Technology, 46, Zhang Q, Zhou C, Zhang Q, Qian H F, Liu WP*, Zhao MR* StereoselectivePhytotoxicity of HCH Mediated by Photosynthetic and Antioxidant Defense Systems in Arabidopsis thaliana. PLoS ONE, 8(1): e Wang C, Zhang Q, Zhao MR*, Liu WP Chiral Pesticides: Stereoselectivity and its Consequences, In: Enantioselectivity in Estrogenic Potential of Chiral Pesticides, American Chemical Society. 36. Hu F, Li L, Wang C, Zhang Q, Xu C, Zhao MR* Enantioselective induction of oxidative stress by permethrin in rat PC12 cells. Environmental Toxicological Chemistry, 29, Zhao MR, Chen F, Wang C, Zhang Q, Gan J, Liu WP* Integrative assessment of enantioselectivity in endocrine disruption and immunotoxicity of synthetic pyrethroids. Environmental Pollution, 158, Tong CL*,Ye RM,Zhang Q,Liu WP Interaction of S-Metolachlor with calf thymus DNA.Chemical Journal of Chinese University, 31, Wang C, Zhang N, Li L, Zhang Q, Zhao MR*, Liu WP* Enantioselective Interaction with Acetylcholinesterase of an Organophosphate Insecticide Fenamiphos. Chirality, 22, Wang C, Chen F*, Zhang Q, Fang Z Chronic Toxicity and Cytotoxicity of the Synthetic Pyrethroid Insecticide cis-bifenthrin. Journal of Environmental Sciences, 21, 张全, 王萃, 赵美蓉, 刘维屏 * 手性持久性有机污染物的环境界面过程及生态安全研究进展. 中国科学,43, 授权和受理专利 张全, 赵美蓉, 刘维屏, 王萃 一种毛细管电泳拆分 2,4,5 滴丙酸对映体 的新方法 ZL

8 赵美蓉, 张全, 刘维屏, 王萃 一种毛细管电泳拆分 2,4 滴丙酸对映体的新 方法 ZL ; 指导学生项目与获奖 2015 年浙江省第十四届挑战杯课外学术科技竞赛二等奖 : 潜在内分泌干扰物的环境行为及其健康风险效应研究 2016 年浙江省 新苗计划 资助 : 手性农药甲霜灵对斑马鱼对的发育毒性及生物转化机制研究 2014 年浙江省新苗计划资助 : 典型有机磷阻燃剂的潜在内分泌干扰效应研究