[ PURIFICATION SOLUTIONS ] Pure at Heart

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1 [ PURIFICATION SOLUTIONS ] Pure at Heart

2 Purification is at the heart of laboratory analysis. It s the foundation of every lab analysis, whether focused on pharmaceutical/ life science, chemical materials, food/fragrances, or environmental applications. Whether it s dedicated to commercial, academic, or government research. It can be easy to take a process that s so common for granted. But we don t. Waters and your workflow It s true that Waters has long led the way in expanding the boundaries of what laboratory technology can achieve and laboratory professionals can expect. We bring that same commitment to our purification solutions. That commitment extends to each step of every analysis. For Waters, excellence in sample purification and preparation should be part of every lab. Sound science and good business demand that. We brought mass-directed purification to the commercial market. Our experience in knowing the requirements of different types of laboratories and nearly every industry allows us to offer distinctly appropriate purification solutions refinements to a foundational process that fit easily and seamlessly into your operations. Further, our purification solutions are easily and fully integrated with Waters industry-leading analytical instruments, including ACQUITY UPLC, ACQUITY UPC 2, Alliance HPLC systems, and our full range of chemistries. This creates exceptional analytical capabilities within your lab with the added operational advantage of Waters support throughout your workflow. With Waters, Purification isn t an obligation. It s an asset.

3 Chemical Pharmaceutical and Life Sciences Because impurity identification is an essential part of the manufacture of fine chemicals, I have to rely on instruments that can process samples with the highest purity and highest yield. An uncharacterized impurity can affect the properties of my final product, so I need solutions that can be counted on throughout my process. The shorter my development cycle, the faster my products go to market, and many times doctors and patients are waiting for our discoveries. That s why we re always looking for ways to improve efficiencies that maintain our standards of quality. We need our samples to have the highest purity possible, and losing my compounds during the process is not an option. We need to have the highest confidence in our instruments. That is why we chose Waters AutoPurification HPLC system. Waters provides the chemical industry with the full spectrum of solutions: SFE, LC, and SFC in the course of several stages of purifying the same sample. Fine and Specialty Chemicals Cosmetics Fuel and Energy Production and Manufacturing Polymers Research and Development Waters provides pharmaceutical and life sciences labs with flexibility to use both LC and SFC. Our high-end mass-directed systems let researchers easily move from small sample analyses to larger scale production operations. Pharmaceutical Discovery Proteomics Biopharmaceutical Discovery Biomarker Identification Metabolomics and Lipidomics Research and Development Metabolic Identification Medicinal and Therapeutic Natural Products Pharmaceutical Commercialization Open up the possibilities Food We re increasingly relying on Waters SFE instruments to extract food oils from solid matrices such as olives and sunflower seeds. Using CO2 means our compounds emerge cleaner with no residual toxic solvents resulting in higher purity and yield with lower overall operating costs. Plus, the remaining product is physiologically safe, which allows us to re-sell the solid waste to local farms for cattle feed. So we save time, get a higher quality extracted sample, and have a strong secondary market. Total resource utilization is certainly better for the environment as well. Waters is demonstrating that SFE is not only more green, but that it s nearly as easy to use as basic LC. Environmental Food QC Food Research Food Safety We need to seek out the most effective methods in detection, identification, and characterization of chemical contaminants in our environment. Our biggest reason for choosing Waters is their full suite of purification technology. The complementary nature of LC, SFC, and SFE means that I have the selectivity and sensitivity required, no matter the challenge. And these methodologies can easily scale to meet EPA and other environmental standards worldwide. Waters understands the workflow demands of environmental analysts. Our easy-to-use instruments can readily translate their methodology to EPA or other strict governmental requirements. Air Biosolids Drinking Water Soil Surface Water Waste Water

4 Waters Purification Solutions The heart of the matter Waters robust purification solutions are flexible, scalable, and easily integrated. From high-throughput fraction collection of hundreds of samples, to purifying just a handful of samples a day, Waters enhances the speed and reliability of your lab s workflow. LC There are significant benefits of having multiple Waters instruments in your lab. Each of the three techniques for purifying samples can complement the others, and this orthogonal perspective gained by purifying with more than one technique allows for greater ability to discover and identify compounds in a sample. Analytical to Semi-Preparative to Preparative-Scale Purification Proven Performance Waters market-leading LC technologies make purification more accessible. Analytical to Semi-Preparative solutions enable quick response to occasional or on-demand purification requirements and are well-suited for situations where you only have a limited number of samples to purify. Semi-preparative to preparative-scale solutions offer more advanced features and are designed for labs where purification is a dedicated function. They offer fully automated UV- or mass-directed purification with an operating ease of use that satisfies situations with diverse staffing needs. AutoPurification System High throughput parallel runs Scalable prep configurations Purify microgram to kilogram quantities SFC Semi-Preparative to Preparative-Scale Purification The green alternative SFE Environmentally Friendly Sample Extraction The cleanest step in your workflow Supercritical fluid extraction (SFE) is a highly selective extraction technique, often used as a pre-purification sample preparation method, capable of extracting compounds from solid matrices to isolate compounds of interest. Waters supercritical fluid extraction (SFE) systems use supercritical C0 2 in place of toxic organic solvents. It has become the technique of choice for decaffeinating coffee, extracting natural oils, extraction of fat from food products, fractionating polymeric materials, and photo-resist and precision part cleaning. Waters SFE offers better selectivity, increased speed, and lower operating costs compared to traditional extraction systems. MV-10 ASFE System Accelerated, multi-vessel extraction Extract samples from up to 10 vessels Quality purification meets quality of life. Supercritical fluid chromatography (SFC) is a beneficial alternative that replaces toxic solvents expensive to purchase and dispose of with naturally occurring CO 2. The principles of SFC are similar to those of liquid chromatography. SFC is essentially a normal phase chromatographic technique with inherent high speed and efficiency that uses environmentally friendly liquid CO 2 as the main mobile phase component. Considered a leading green purification technology, SFC is a beneficial alternative that also delivers faster and more cost-efficient lab operations. Prep 100q SFC System Fully automated UV- or mass-directed Reduce fraction drydown time High speed and efficiency for improved workflow To see our entire Purification and SFE offering go to Lower operating costs

5 SALES OFFICES: Austria Australia Belgium and Luxembourg Brazil Canada China Czech Republic Denmark Finland France Germany Hong Kong Hungary India Ireland Italy Japan Korea Mexico The Netherlands Norway Poland Puerto Rico Russia/CIS / Singapore Spain Sweden Switzerland Taiwan UK US Waters Corporation 34 Maple Street Milford, MA U.S.A. T: F: Waters, ACQUITY UPLC, and Alliance are registered tademarks of Waters Corporation. ACQUITY UPC,2 AutoPurification, MV10-ASFE, and T he Science of W hat s Possible are trademarks of Waters Corporation. All other trademarks are the property of their respective owners Waters Corporation. Printed in the U.S.A. September EN LL-IGS

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