Finding Innovation Success in Biofuels and Forest Bioproducts. Jeff Lindsay Director of Solution Dev. Innovationedge Neenah, WI 54956

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1 Finding Innovation Success in Biofuels and Forest Bioproducts Jeff Lindsay Director of Solution Dev. Innovationedge Neenah, WI 54956

2 Forest Bioproducts: A Heritage of Innovation Green Innovation: cellulose to ethanol, biorefineries, biodiesel, energy recovery, and innovation in renewable bioproducts Nanotechnology Advanced process control & informatics Composite materials Advanced fluid mechanics, heat transfer, manufacturing technology, etc. Microencapsulation Supply chain management Forestry, genetics, land management

3 Innovation Fatigue? Market cap decline Innovation spending down Discouragement, brain drain Few recognize the technical and economic contributions of the pulp and paper industries Numerous regulatory pressures Is the industry innovative? How can we find innovation success in emerging areas?

4 Threats to Innovation Internal: Strategy and decision making Failure to nurture relationships with innovation communities External: partners, sources of innovation Internal: employees External innovation fatigue factors Regulatory burdens Intellectual property barriers

5 From Conquering Innovation Fatigue, J. Lindsay, C. Perkins, and M. Karanjikar (John Wiley & Sons, 2009).

Expedito José da Sá Parente, PI8007957-1, filed

COMBUSTÍVEL A PARTIR DE FRUTOS OU SEMENTES

6 The 1 st Biofuel Patent(?) The first bus fueled with biodiesel. Expedito José da Sá Parente, PI , filed 05/12/1980, issued 1983, PROCESSO DE PRODUÇÃO DE COMBUSTÍVEL A PARTIR DE FRUTOS OU SEMENTES OLEAGINOSAS. (BR A) And PROCESSO DE PRODUÇÃO DE UM COMBUSTIVEL SUCEDANEO DE OLEO TIPO DIESEL filed 7/14/1980.

7 Patents Matter But often not enough to exuberant startups Lesson from Vonage and VOIP fever Verizon sues Vonage for patent infringement Vonage ordered to pay $120 million

8 The Rise of Biofuels in IP

9 Key Trends Explosion in biofuels technologies, from gasification to fermentation (intl. class C10, C12) Very large recent boom in biological conversion of biofuels (e.g., intl. class C12) Synthetic biology New microbial strains New uses of microbes New enzymes Fermentation methods

10 Forest Biofuels: A New Face in Forest Bioproducts Young, small, rapidly evolving Many startups Significant university influence Patents are key to survival Finding the business model is an essential part of the innovation journey

11 Example: Coskata Flexible three-step conversion process: Incoming material converted to synthesis gas (gasification) Fermentation of synthesis gas into ethanol Separation and recovery of ethanol Coskata's proprietary microorganisms can simultaneously convert both CO and H2. Bioreactor design said to mitigate problems with phage infections. Anaerobic microorganisms licensed from Oklahoma State & Univ. of Oklahoma (Dr. Ralph Tanner et al.): US Pat. No. 7,704,723; US Novel species of bacteria found in a swamp in O2-free mud. History: see &

12 Interesting Inventors: Rathin Datta Chief Scientific Officer/Founder of Coskata 28 patent families assigned to: Coskata Argonne / Univ. of Chicago Michigan Biotech Institute Vertec Biosolvents Methods for producing ethanol, butanol, lactic acid, acetic acid, citric acid, etc., including anaerobic microbes that can convert syngas into other molecules

13 The Rise in IP: Most Still Pending Published applications versus issued patents for 100 companies focused on biofuels.

14 Focused Corporations: 1019 docs

15 Warning Signs on the Horizon Much of the IP that will govern the future of the forest biofuels industry is in the form of pending applications Which ones will be granted and prevail? Very hard to predict. Much uncertainty.

16 Facing IP Uncertainty: Tips Prepare for future IP challenges today Create your own IP bargaining chips Protect your future patent clearance position with defensive publications, other assets Build bridges, not walls, with IP Build relationships now with future winners Maintain a culture of open innovation so you can bring in the IP you will need.

Identify/Grow/ Collect Feedstock Harvest Pretreat React Products Distribute Issues: raw material selection,

17 IP Across the Supply Chain Supply Chain Business models, partnerships? Reactants, Microbes, Water, Energy Reactants, Microbes, Water, Energy Business models, partnerships? Identify/Grow/ Collect Feedstock Harvest Pretreat React Products Distribute Issues: raw material selection, growth, harvesting, seasons, transportation, storage, variability, competing uses, etc. Byproducts Reclaim Added Value Products Distribute Manage regulatory and tax issues

18 Reviving Old Technologies Gasification Biomass, black liquor (Chemrec), municipal waste (Enerkem), etc. Mixed Alcohol Synthesis (Range Fuels), packed bed, catalytic reactors (Fulcrum), or fermentation (INEOS and Coskata). Fischer Tropsch upgrades, catalytic processes to deliver many chemical products (Syntroleum, Greatpoint, etc.) Pyrolysis (e.g., UOP Honeywell, Dynamotive) updating uses of bio-oil (conversion to useful fuels) Acid and enzymatic hydrolysis many players Fermentation very hot Discovery of new microbes (e.g., thermophilic strains) Improved enzymes (Novozymes, Codexis, Novo Nordisk, Genencor/Danisco, Dyadic, etc.) Upgraded with genetic engineering /synthetic biology

19 Where Are Filings Occurring? ((TAC=(biofuel or biodiesel)) and (IC=(C10))) 1600 patent families, top 25 entities shown

20 Validated Paper Ind. Biofuels IP Only 55 active patent families from paper & lumber companies and major suppliers dealing with biofuels, biomass power. The push for biofuels IP is very recent.

21 Validated Paper Ind. Biofuels Diverse group of technologies, including microbes for treating biomass. This includes some recovery boiler innovations but excludes the microbial PHA polymers of P&G, pulping technology not directed to biofuel production, & biodegradeable polymers not made from cellulosic biomass. Only shown are those with > 1 pat. family. Metso has more dealing with pyrolysis.

22 360 IA Review Low-cost intellectual assets include publications of many varieties, domain names and other digital assets, trademarks, etc. 360 IA also requires taking advantage of broad patent approaches, including business method-based patents and early patents in potentially disruptive areas. Proactive, cost-effective strategies can help you maintain competitive advantage and overcome some of the innovation fatigue factors in your business. 6/2/2010 BioPro Expo & Marketplace / Atlanta, Innovationedge GA / March 14-16, Copyright

23 Two-Pronged Disruptive IA Strategy Proactive IA can be used to: Shield from disruptive threats. Open doors for future disruptive innovation. Detailed article available in JPIM available on request. 6/2/2010 Innovationedge Copyright 2010

24 Conclusions Emerging innovation opportunities in biofuels and forest bioproducts require careful attention to: Intellectual property strategy (offense + defense) Healthy relationships (ecosystem thinking) Flexible business models (iterations) Innovation across the supply chain

The Next Generation of Ethanol. Wes Bolsen CMO & VP The Coskata Process The Best of Both Worlds. Biofuels Journal Workshop October 30th, 2008

The Next Generation of Ethanol Wes Bolsen CMO & VP The Coskata Process The Best of Both Worlds Biofuels Journal Workshop October 30th, 2008 Biofuels are a large and growing industry in the U.S. U.S. biofuel