Industrialization of Green Chemistry: Opportunities & Barriers

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1 Industrialization of Green Chemistry: Opportunities & Barriers Awareness of Green Chemistry & Engg. for Plant & Production Managers 16 th October 14 Ankleshwar Nitesh H. Mehta Green ChemisTree Foundation

2 Flow Source of our inspiration to focus on industrialization of GC Why industrialization of Green Chemistry? E-Factor & its impact Impact on our Water Resources & on our Businesses Approaches & Strategies for industrialization of Green Chemistry Opportunities in Green Chemistry Barriers Solution Providers perspective Conclusions

3 Industrialization of GC: Our Source of Inspiration Patented Technology Customer s Feedback : Recycled mother liquor for over 2.5 years. Over 800 batches (at times on campaign basis) Just make-up for Water loss (saved millions of lit of water) Amine Quality 99%+ on HPLC, 10% Yield improvement

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5 Industrialization of Green Chemistry: Potential Impact Impact of TM Solutions that are ready with Newreka: No. Product Total Production in (TPM) E-Factor * (kgs waste/kg product) Effluent Quality Minimum No. of Recycles Effluent quantity before & after implementing NRS (litres per month) before after 1 Nevirapine 20 4 Mixture of solvents , Sildenafil Citrate Neutral effluent 25 3,50,000 14,000 3 Omeprazole 50 8 Highly alkaline effluent 10 4,00,000 40,000 4 Albendazole Highly alkaline effluent 25 8,00,000 32,000 5 Quietiapine 20 6 Neutral effluent 10 1,20,000 12,000 6 H-Acid Acidic effluent 15 5,20,00,000 35,00,000 7 OAPSA Acidic effluent 15 9,75,000 65,000 8 FC Acid Acidic effluent 15 5,00,000 33, ADAPSA Acidic effluent 15 4,00,000 26, m-phenylene Diamine Sulphonic Acid (MPDSA) Acidic effluent 15 5,00,000 33,000 Total Impact on environment : effluent discharge to environment & fresh water consumption of industry reduced by over 50,000 MT per month.

6 Why Industrialization of Green Chemistry? E-Factor = Environmental Impact Factor = kgs waste generated / kg product Sector E - Factor Product Tonnage Oil Refining Bulk Chemicals Fine Chemicals Pharmaceuticals Nature of Pharma, Specialty & Fine Chemicals manufacturing: Complex molecules & multi-step synthesis Chemistry Intensive processes Stringent quality & regulatory requirements Low process yields (low conversion, low selectivity & low separation efficiency) The above leads to High E - Factor or Environmental Impact Factor. Source: R A Sheldon

7 Impact on our Health & our Business Impact: huge threat to water bodies & human health Quantity Practice Issue Degradation : Billions of kgs of liquid effluents from Chemical Industries include solid & gaseous effluents include all wastes from all other sectors (mining, steel, power,..) : End-of-pipe-treatment (converting one kind of effluent in to other) : Toxicity not fully known (Ecotoxicity data available for less than 1% of human pharmaceuticals Ref: journal Regulatory Toxicology Pharmacology, April 2004) : very slow, impact unknown after degradation Impact on Economics Direct Cost : loss of solvent, raw material & finished product, loss of utilities, treatment cost, higher overheads, loss of business Indirect Cost : unreliable supplies, loss of credibility in market, anxiety, etc.

8 Impact on our Water Resources Just 3% of all water on planet is Fresh Water Only 1% of all this Fresh Water is ready available for human use In 20 th Century, population tripled. Water consumption up 6 times 1 in 5 people don t have access to safe drinking water 1 in 3 people lack access to adequate sanitation As per UN, a child dies of water related disease every 15 seconds By 2050, another 3 billion people on planet. Water for them? India: 1 bn people need fresh water daily, limited water resources, increasing outsourcing business & expanding chemical industry

9 Why Industrialization of GC?: A Possible Solution Regulatory Bodies Common Man/NGO Chemical Industry Customers/End Users Competition/Economics Principles of Green Chemistry & Green Engineering provides a powerful toolbox for innovations which offers both Economic & Environmental Competitiveness. These solutions have the potential to offer Triple Bottomline of: People Planet Profit

10 Reality of our processes Step 1 Step 2 Step 3 Step different chemicals 4-5 different chemicals 4-5 different chemicals 4-5 different chemicals Cocktail of different chemicals No option except Effluent Treatment Plant or Incineration

11 Reality of our plants Mfg. Block for Dedicated Products Manufacturing Site Mfg. Block for Campaign Products Dedicated Product Product 1 Product 2 Product 3 Step 1 Step 2 Step 3 Step 1 Step 2 Step 1 Step 2 Step 3 Step 1 Step 2 Step 3 Step 4

12 Reality of our effluent streams Each effluent stream has its own: Physical properties colour, ph, temperature Chemical composition organics, inorganics Volume Characteristics COD, BOD, TDS, ammonical nitrogen, etc. Toxicity & hazard What we have is: multiple effluent streams with widely differing quantities & characteristics

13 Reality of our effluent streams Effluent stream from dedicated products Effluent stream from product 1 Effluent stream from product 2 Effluent stream from product 2 Cocktail of different chemicals End-of-the-pipe Treatment (primary & secondary treatment, triple effect evaporator, incineration, solid waste disposal sites, land fill, etc.) Impossible to separate, recover or recycle Our Environment

14 Approaches to deal with environmental challenges Central Effluent Treatment Plant (CETP) - Capital intensive - Cost centric approach - Ineffective same treatment to wide variety of effluents End-of-the-pipe Treatment (ETP) - Capital intensive - Cost centric approach - Converts one type of effluent in to another Economics & Environmental Footprint Industrial Ecology - Low value creation - Logistics & capacity mismatch issues - Doesn t address problem at source level Green Chemistry - Address problem at source level - Profit centric approach, high value creation - Less capital intensive

15 Strategies for industrialization of Green Chemistry Where to start from? Basis of selection? Green Chemistry Metrices: may start with effluent stream with highest E-Factor, PMI, or any other matrices Toxicity Internal Competency Cost pressures Regulatory pressures Demand from customer Resources available Management s priority Ready availability of a particular technology in market place

16 Identification of project: E-Factor Calculations Reality of E-Factor & Effluents Load in current process Stage I Sulphonat ion Stage II Nitration Stage III Neutralizatio n Stage IV Reduction Stage V Caustic Fusion Stage VI Isolatio n E-Factor (per kg H-Acid) Effluent 264 TPM 308 TPM 1040 TPM 1766 TPM 1532 TPM 4930 TPM (for 200TPM plant) E-Factor for Overall Process = 50 (i.e. 50 kgs waste per kg H-Acid manufactured) Final Isolation Stage contributes around 50% of the overall waste generated. All isomers being carried forwarded through all stages to the final isolation step.

17 Identification of project: Mass Balance/Yield Calculations Reality of Yield in current process 1 kg of Naphthalene 2.4 kgs of H-Acid (Theoretically) 1 kg of Naphthalene 1.28 kgs of H-Acid (Current average yield of manufacturers) 53% of Theoretical Stage I Sulphonat ion Stage II & III Nitration & Neutralization Stage IV Reducti on Stage V Caustic Fusion Stage V Isolation Overall Yield 16% 12% 2% 7% 10% 47% Loss

18 Strategies for industrialization of Green Chemistry Medium term e.g. Process Intensification of Unit Processes & Unit Operations (Greener catalyst, etc) Short term e.g. Immediate, workable solution (reduce COD or reduce effluent load by recycling) Long term e.g. Paradigm shift in Engineering like micro reactors Very Long term e.g. designing new route of synthesis starting from renewable feedstock, using Biomimicry

19 Strategies for industrialization of Green Chemistry Medium term Time: 2 to 4 years Resources : low to medium Risk: low to medium Short term Time : 1 to 2 years Resources: very low Risk: very low Long term Time: 4 to 8 years Resources: high Risk: high Very Long term Time : 8 to 16 years Resources: very high Risk: very high

20 Opportunities in Green Chemistry: Benefits to Industry Tangible Benefits: Improvement in Yield Lower effluent treatment cost Higher productivity, freedom from shutdown due to closure Overall lower cost of production Saving of huge capital investments required to build effluent treatment facilities Intangible Benefits: Brand & credibility in local community as well as international customers Freedom from treatment of huge quantities of effluents Freedom from pressure of regulatory bodies & closure notices Reliable production & supplies to customers Saving of time & energy which otherwise goes in dealing with regulatory bodies

21 Barriers Solution Provider s perspective Inertia to New Paradigm against the gravity of existing paradigm Technical Barriers: no ecosystem for knowledge-based entrepreneurship Seed capital & funding barriers IP Barriers: protecting IP Market Barriers: awareness, business model Human Barriers: Inertia to change, culture, language Scale-up Barriers: same result in lab as in plant, availability of plant, risk Barriers created by Old Nexus Regulatory Barriers: changes in DMF, FDA & Customer approvals Financial Barriers: working capital for growth

22 Barriers Solution Provider s perspective Human Barriers inertia to change from old paradigm to New Paradigm decades of shop-floor experience becomes barrier instead of resource Scale-up Barriers want to see same result in lab as that expected in plant availability of plant to take trials with new technology risk of scale-up who will bear? Market Barriers Lack of awareness about potential of Green Chemistry tool box Some myths like it s expensive, it will increase cost, etc IP Barriers challenge to protect IP little respect for IP in the industry no hesitation in copying idea

23 Green Chemistry: Future Green Chemical Industry to Soar to $98.5 Billion by 2020 June 20, 2011 Copyright 2011 Pike Research Those who move early would have tremendous advantage.

24 Conclusions We have all it takes to develop & commercialize Green Chemistry solutions. What s needed is: Connect, Collaborate, Create & Commercialize Environmental challenges are opportunities to make PROFITS. Calculate E-Factor. Start wherever you want to or can. But START. Create short term & long term strategy to implement Green Chemistry & Green Engineering in to operations. GC Solutions are affordable & viable for SMEs as well. Need to be open, adventurous, willing to take some risk, stretch Patience & Perseverance, no ready-made solutions customization Barriers : 10% Technological. 90% Human Mind Set. For a solution provider, its all worth it when customers acknowledge & we see tangible difference made to the quality of our Environment.

25 Thank you For resources on Green Chemistry & Green Engineering: Please visit

26 TM applied to H-Acid effluent Amine Methanol Caustic Dilute Sulphuric Acid Fusion & Evaporation Isolation Vessel CENTRIFUGE H-Acid Representative diagram of Conventional Process Acidic Mother Liquor Characteristics Colour Deep Red ph COD 150,000 TDS 15-20% Toxicity Not Known

27 TM applied to H-Acid effluent Amine Methanol Caustic Mother Liquor Recycle Storage Vessel Recycle Cat TM Fusion & Evaporation Isolation Vessel RCat Treatment Patented Technology More than 15 recycles E-Factor = 90% Yield = 10% CENTRIFUGE H-Acid Acidic Mother Liquor Filter Spent RCat Representative diagram to explain the concept of Recycle@Source TM solution as applied to H-Acid

28 TM applied to H-Acid effluent Product Characterization & Impact on Yield (Basis: 500 gms batch size) Batch No. Product Colour Product Appearance Product Obtained (gm) Product Purity Fresh Offwhite Powder % Recycle 2 Offwhite Powder % Recycle 6 Offwhite Powder % Recycle 8 Offwhite Powder % Recycle 10 Offwhite Powder % Recycle 14 Offwhite Powder % Similar, Recycle Solutions developed for MPDSA, FC Acid, OAPSA, etc.