Industrial Biosciences. Jim Collins - President

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1 Industrial Biosciences Jim Collins - President

2 Industrial Biosciences Mission Focused growth through bioprocessing technologies Build on Genencor s expertise in designing and operating cell factories Leverage Pioneer s relationship with growers Apply DuPont s capabilities in engineering and advanced materials Agriculture and Nutrition Industrial Biosciences Advanced Materials Intersection for innovation across DuPont s competencies 2

3 Key Segments in Our Business Agriculture and Nutrition Industrial Biosciences Advanced Materials Bio-based products End use markets Bioactives Enzymes, proteins, peptides Bioactives Biomaterials Biomaterials Biochemicals Biomaterials Biorefineries Food, feed, cleaning, paper, personal care Carpet, textiles Biorefineries: Biofuels Ethanol Biobutanol Fuels 3

4 Focused on Three Bio-based Segments Serving a diverse set of customers Carbon Sources Conversion Bio-based Products End use markets Bioactives Our Competitive Advantage Enzymes, proteins, peptides Starch Food, feed, cleaning, paper, personal care Biomaterials Bio/chemical transformation Sugars Bio/chemical transformation Biochemicals Biomaterials Carpet, textiles Biomass Biorefineries: Biofuels Ethanol Biobutanol Fuels 4

5 Based on Common Core Elements Agriculture and Nutrition Industrial Biosciences Bioactives Advanced Materials Biomaterials Core Core Elements Renewable, bio-based inputs Design and operation of cell factories Deliver enhanced process and product sustainability Biorefineries 5

6 Industrial Biosciences Our Business Developing customer-driven solutions that enhance value creation, reduce environmental footprints, and improve health & wellness for end users Our Markets $50B addressable market consisting of: Animal nutrition, food, cleaning/ detergents, textiles, carpet, personal care, feedstock processing, biofuels Our Business Segments Bioactives = enzymes, peptides and performance proteins for markets such as food, animal nutrition, detergents, textiles Biomaterials= advanced materials and intermediates manufactured with renewable feedstocks Biorefineries= products and technology for converting agricultural feedstocks into carbohydrates and fuels Long-term growth targets: sales % CAGR with 15-17% margins 6

7 Who We Are And Where We Work DuPont Industrial Biosciences Industrial Biosciences is comprised of more than 2500 dedicated colleagues worldwide We discover and develop market-based biotechnology solutions at 8 global R&D sites We produce a broad portfolio of products and manage 19 operations sites Production, Operations and Pilot Sites Research & Development Centers 7

8 Industrial Biosciences Sales Serving Customers in Multiple Markets Around the World Region Business Unit End Market Latin America 2011E Sales: $0.7B* Other Apparel Food Enzymes Asia Pacific Biorefineries Carpet Animal nutrition US & Canada Biomaterials Bioactives EMEA Detergent Feedstock enzymes processing * Segment sales include transfers. 8

9 Industrial Biosciences Markets Key Market Trends & Opportunities Market Addressable Market: $50 Billion Market Growth Drivers E CAGR $1.5 B Growing demand for protein in human diets More efficient and sustainable animal production 8 10% Detergent Enzymes $1 B Rising affluence and demand for convenience Water and energy conservation 5 7% Food Enzymes $1 B Natural and clean label Improved processing and product shelf life 7 9% Renewable Materials $20 B Desire for performance and renewability claims Supply diversification and stability in feedstocks 2 7% $25+ B Energy supply diversification and environmental concerns Rural and green economy development 7 12% Animal Nutrition Biofuels 9

10 Industry Capabilities Landscape DuPont Feedstock / Aggregator Conversion Enzyme Supplier Catalysts / Biocatalysts Engineering DSM Novozymes Amyris Gevo Solazyme Abengoa Poet BP 2 Shell DuPont strongly positioned across key steps in value chain DuPont provides unique integrated offerings 1. Enzymes limited to cellulosic ethanol 2. Participation primarily through partnerships 1 Application Development Other participants range in breadth of offering Narrow / specialist players must partner to access market 10

11 Customer Benefits/ Opportunities R&D Phase Industrial Biosciences Key R&D Programs Sustainability Productivity Health & wellness Feedstock diversification Safety and Regulatory Petroleum/ chemical replacement Launch Bioactives Feed enzyme system: Axtra XAP Omega-3 Cold water washing Next generation feed enzyme Biosurfaces Biomaterials Flame retardant fiber for carpet Bio-THF BioIsoprene Biorefineries Grain processing: Spezyme RSL Cellulosic ethanol Biobutanol R&D Phases: 1-Discovery; 2-Concept validation; 3-Prototype; 4-Scale up; 5-Launch preparation 11

12 Bioactives New Feed Enzyme System Specifically designed to help US broiler producers meet the challenge of rising feed costs Lower feed costs Improved calorie conversion More uniform birds Proven value in antibiotic growth promoter free nutrition Demonstrated net feed costs savings of at least $7 per ton (5%) DuPont science delivers radical feed cost savings 12

13 Biomaterials BioIsoprene monomer Provide significant raw material cost savings vs. synthetic and natural rubbers Enable cost-competitive replacement of natural rubber Build platform to access multi-billion dollar C5 chemical opportunity Partner to produce isoprene monomer for Goodyear s polyisoprene process Pilot plant construction target:

14 Global Biofuels Market Biofuel Demand by Type Large and Growing Addressable Market (Source: IEA ) Production surpassed 28 B gallons in 2010 (3% of total road transport fuel) B gals 150 More than 50 countries have enacted biofuel targets/mandates -- expected to reach >45 B gallons by 2020, or >$100B market Ethanol conventional (corn) Ethanol cane Ethanol cellulosic Biodiesel conventional Biodiesel advanced Biojet Biomethane Key drivers: energy independence; tech advancement ( green jobs); rural development; reduction of greenhouse gases Industry Challenges for Meeting Demand 100 Economies of scale and existing infrastructure still favor fossil fuels 50 Acceptance of technology risk and capital intensity required for capacity build-out Policy stabilization and consistency are critical. Change or uncertainty discourages investment 14

15 Cellulosic Ethanol Commercialize lower-cost, lower-capital production technology for biofuels from non-food feedstocks Market/Customers Biofuel producers Refinery operators Operating demonstration scale facility in Vonore, TN. Generating data for scale up 2011 field stover harvest confirmed economics for biomass delivery Engineering and front-end loading underway for Iowa site Deployment strategy includes commercial operations, licensing model and merchant enzymes 15

16 Major Biorefinery Program Updates Grain Processing Commercial business serving grain ethanol, sweeteners, and biochemicals industries Today Continuous productivity increases for cost and efficiency improvements Cellulosic Ethanol Biobutanol Demo facility in TN proving out commercial economics JV demo facility in UK complete 2011 field stover harvest confirmed economics for biomass delivery Process units being commissioned for integrated operation Commercial stover biorefinery site purchased in Iowa Negotiations in progress for first commercial partnerships Commercial production Multiple licensees for process technology First ethanol plant conversion Commercial production of biobutanol Expanded enzyme offerings and processing technology Expanded value offerings Multiple licensees of biobutanol technology Development of integrated bioprocessing refinery Additional offerings and technology extensions Additional offerings and technology extensions 16

17 Driving Profitable Growth Continuous Improvement Trichoderma grows in long filaments resulting in a highly viscous broth Cell mass limited to a fragmented, lower viscosity form Changing the way the host strain grows, lowers broth viscosity Frees up fermenter capacity Avoids additional capital investment Productivity Cost discipline Integration synergies Capacity Release - Optimization of cell factories 17

18 Industrial Biosciences 2012 and Long-term Priorities Sales and Margin Performance Deliver on Key Growth Opportunities $0.7 Broaden portfolio through innovation and application development Strong growth in developing markets Penetrate new market segments Launch new technologies for feedstock processing Commercialize biofuels 10% PTOI Margin Capture integration synergies Scale up biofuel technology licensing Drive cost and capital productivity 2011E Sales ($B)* Pre Tax Margins (%)** Long-term growth targets: sales % CAGR with 15-17% margins * Segment sales include transfers. * * Excludes significant items. Refer to company website for detailed reconciliations of non-gaap measures. 18

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