Direct fermentation to bio-based isobutene, a platform to fuels and chemicals. October 2017

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1 Direct fermentation to bio-based isobutene, a platform to fuels and chemicals October 2017

2 2 Mission Develop processes converting 1 st, 2 nd, and 3 rd generation feedstocks into renewable fuels and materials to secure supply and limit global warming First target: isobutene, a key platform molecule today massively derived from oil

3 Synthetic biology at the heart of new value chains Sugar beet and cane Agro-industries Breakthrough innovation: - First artificial metabolic pathway created by way of synthetic biology Intellectual property: - Exclusive rights on 32 patent families - 38 patents already granted Petrochemistry Drop-in gasoline, LPG and jet fuel Cereals Industrial sugars 1 Fermentation 2 Breakthrough technology: direct fermentation to a gas Purification Combination of proven petrochemical modules Isobutene Materials, specialty chemicals, cosmetics Illustrations are not representative of current Global Bioenergies installations 3

4 Direct fermentation to isobutene: Technology and upscaling

5 5 Isobutene: a platform molecule with large existing markets Gasoline Chemicals and cosmetics Existing market $0.6bn Existing additives market $15bn Potential as drop-in fuel $1000bn Organic glass Existing market $0.8bn Jet fuel Existing $0bn Materials 2.5 million tons/yr as of today Plastics and lubricants Existing market $1.6bn Butyl rubber Existing market $2.0bn Domestic gas Potential market $15bn Potential $120bn Fuels 12 million tons/yr as of today

6 6 How can it be produced renewably? Synthetic biology has enabled Global Bioenergies to create Microbial factories Genetically engineered microorganism Renewable resources Isobutene This breakthrough innovation: Opens up a new domain: the direct production of gaseous hydrocarbons Is protected by 32 patent families

7 A simple and robust industrial process Renewable resources 1 Fermentation 2 Purification Isobutene Breakthrough technology: direct fermentation to a gas Combination of proven petrochemical modules Illustrations are not representative of current Global Bioenergies installations 7

8 8 Approaching commercial maturity using 1 st generation resources R&D Phase I Pre-industrialization Phase II Industrial pilot Phase III Demo plant Full-scale plants Proof of concept and prototype Laboratory pilot First industrial scale up Final scale up before commercial operations Joint Venture with IBN-Two Samples production Creation of the commercial technology package IBN-Three IBN-Four IBN-n

9 9 Headquarters, R&D, lab piloting Evry, France Evry 55 employees Unique technology platforms oriented toward gaseous fermentation

10 10 Industrial pilot Pomacle, France Pomacle 10 tons/yr capacity 10.5m program 5.2m public financing Consortium with and Up and running since Nov Operated by, a affiliate Purified isobutene shipped to numerous industrialists Conversion into e-gasoline for

11 11 Demonstration plant - Leuna, Germany The demo plant a glance Capacity: 100 tons/yr CAPEX: 10m 5.7m public financing 4.4m bank loan Operated by Startup sequence started December 2016 Objectives Demonstrate process on 1 st generation industrial sugars Deliver ton scale batches for market development Provide data for engineering of 1 st commercial plant Start testing 2 nd generation sugars

12 12 A Joint Venture with First commercial plant project France 50/50 JV between Global Bioenergies and Cristal Union Estimated CAPEX 115 million euros First commercial agreements with to supply specialty fuels market to supply domestic gas sector Collaboration with to evaluate opportunities in cosmetic sector 3.3 million from ADEME and Investissements d Avenir program to support engineering, environmental studies and commercial development activities Target schedule Engineering and construction to be completed in 2019 Commissioning and start of commercial operations in

13 13 Collaborations on isobutene derivatives Since 2012 Since 2013 Since 2016 Leading German car manufacturer Collaboration on e-gasoline development France s #1 chemicals company Collaboration on methacrylic acid World s #1 cosmetics company Collaboration on cosmetic applications of Isobutene Since 2017 Leading French gas provider Commercial agreement on domestic gas applications Since 2016 Leader in specialty fuels Commercial agreement on isooctane for small engines Applications tests underway at numerous industrialists including World s #1 Butyl rubber manufacturer European leader in specialty chemicals

14 Feedstock diversification: 2 nd and 3 rd generation

15 15 Various resources 1G 2G 3G Cereals, sugar beet and sugar cane Wood chips, straw, bagasse CO 2, CO and syngas Traditional feedstock In some cases, competition with other uses Advanced feedstock Waste or on-purpose production Emerging feedstocks Currently treated as wastes Increasing potential Cost of resource Environmental impact Diverse prospects major agricultural players Forest operators Present: Steel mills (syngas). Future: all CO 2 -emitting industries Process maturity Demo plant Pilot plant Lab scale Main partners

16 16 Second Generation: agricultural & forestry wastes Numerous trials since 2015 using 2G sugar batches: - Collaboration with 9 companies specialized in 2G sugars derived from various types of agricultural wastes - Lab-scale testings First success in scale-up - 2G sugars provided by Clariant (formerly Süd Chemie, Germany) a leader in the field - Production of «Second generation Isobutene» on Global Bioenergies pilot plant located in Pomacle (France) Project in Sweden to explore forestry waste valorization into drop-in biofuels, with Sveaskog, Preem and Sekab, supported by the Swedish Energy Agency.

17 2 nd Generation: Optisochem project Straw Hydrolysate European consortium to validate a new value chain (from straw to isobutene-derived products) at Demo scale European Union grant: 9.8m (including 4.4m to Global Bioenergies) Isobutene Partners: Global Bioenergies, Clariant, Ineos, TechnipFMC, IPSB and JKU Cosmetics, Plastics, solvents 17

18 18 3 rd Generation: waste gases and CO 2 Technology integrator and developer Drivers Syngas and CO 2 from steel mills, concrete plants, power stations are major green house gases Specific microorganisms grow on such feedstock Value creation + carbon capture Possible partnerships with heavy industries in non agricultural regions Technological challenge to develop isobutene-producing microbe and process Global Bioenergies positions itself as a technology integrator and developer Collaboration with, global leader in the field Recent acquisition of Dutch 3 years old start-up Specific microbe + genetic tools + know-how 6 employees Network of connections with pioneering academic labs

19 19 Contact Ronan Rocle Business Development Manager