: Pyridine-Barbituric Acid Reagent

Transcription

1 SECTION 1: Identification 1.1. Identification Product form Product name Product code Pyridine-Barbituric Acid Reagent Date of issue: 03/28/2014 Revision date: 02/14/2018 Supersedes: 04/02/2014 Version: 1.2 : Mixtures : Pyridine-Barbituric Acid Reagent : LC Recommended use and restrictions on use Use of the substance/mixture Recommended use Restrictions on use 1.3. Supplier : For laboratory and manufacturing use only. : Laboratory chemicals : Not for food, drug or household use LabChem Inc Jackson's Pointe Commerce Park Building 1000, 1010 Jackson's Pointe Court Zelienople, PA USA T F info@labchem.com Emergency telephone number Emergency number : CHEMTREC: or SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mixture GHS-US classification Acute toxicity (oral) Category 4 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2A Hazardous to the aquatic environment - Acute Hazard Category 2 H302 H315 H319 H401 Full text of H statements : see section 16 Harmful if swallowed Causes skin irritation Causes serious eye irritation Toxic to aquatic life 2.2. GHS Label elements, including precautionary statements GHS-US labeling Hazard pictograms (GHS-US) : Signal word (GHS-US) Hazard statements (GHS-US) Precautionary statements (GHS-US) GHS07 : Warning : H302 - Harmful if swallowed H315 - Causes skin irritation H319 - Causes serious eye irritation H401 - Toxic to aquatic life : P264 - Wash exposed skin thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P280 - Wear protective gloves, eye protection. P301+P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352 - IF ON SKIN: Wash with plenty of soap and water. P305+P351+P338 - If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P330 - If swallowed, rinse mouth P332+P313 - If skin irritation occurs: Get medical advice/attention. P337+P313 - If eye irritation persists: Get medical advice/attention. P362+P364 - Take off contaminated clothing and wash it before reuse. P501 - Dispose of contents/container to comply with local, state and federal regulations 02/14/2018 EN (English US) Page 1

2 2.3. Other hazards which do not result in classification Other hazards not contributing to the classification 2.4. Unknown acute toxicity (GHS US) : None under normal conditions. SECTION 3: Composition/Information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % GHS-US classification Water (CAS-No.) Not classified Pyridine (CAS-No.) Flam. Liq. 2, H225 Acute Tox. 4 (Oral), H302 Acute Tox. 4 (Dermal), H312 Aquatic Acute 2, H401 Barbituric Acid (CAS-No.) Skin Irrit. 2, H315 Eye Irrit. 2A, H319 STOT SE 3, H335 Comb. Dust Hydrochloric Acid, 37% w/w (CAS-No.) Acute Tox. 4 (Oral), H302 Skin Corr. 1B, H314 Eye Dam. 1, H318 STOT SE 3, H335 Aquatic Acute 3, H402 Full text of hazard classes and H-statements : see section 16 SECTION 4: First-aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Never give anything by mouth to an unconscious person. If you feel unwell, seek medical advice (show the label where possible). : Allow victim to breathe fresh air. Allow the victim to rest. : Wash with plenty of soap and water. Wash contaminated clothing before reuse. If skin irritation occurs: Get medical advice/attention. : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. : Rinse mouth. Do NOT induce vomiting. Obtain emergency medical attention. Call a POISON CENTER or doctor/physician if you feel unwell Most important symptoms and effects (acute and delayed) Symptoms/effects after skin contact Symptoms/effects after eye contact Symptoms/effects after ingestion : Causes skin irritation. : Causes serious eye irritation Immediate medical attention and special treatment, if necessary Obtain medical assistance. SECTION 5: Fire-fighting measures 5.1. Suitable (and unsuitable) extinguishing media Suitable extinguishing media Unsuitable extinguishing media 5.2. Specific hazards arising from the chemical No additional information available : Swallowing a small quantity of this material will result in serious health hazard. : Foam. Dry powder. Carbon dioxide. Water spray. Sand. : Do not use a heavy water stream Special protective equipment and precautions for fire-fighters Firefighting instructions Protection during firefighting : Use water spray or fog for cooling exposed containers. Exercise caution when fighting any chemical fire. Prevent fire-fighting water from entering environment. : Do not enter fire area without proper protective equipment, including respiratory protection. 02/14/2018 EN (English US) 2/9

3 SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Protective equipment Emergency procedures For emergency responders Protective equipment Emergency procedures : Safety glasses. Gloves. Combined gas/dust mask with filter type A/P2. : Evacuate unnecessary personnel. : Equip cleanup crew with proper protection. : Ventilate area Environmental precautions Prevent entry to sewers and public waters. Notify authorities if liquid enters sewers or public waters. Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up 6.4. Reference to other sections See Heading 8. Exposure controls and personal protection. : Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible. Collect spillage. Store away from other materials. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work. Provide good ventilation in process area to prevent formation of vapor. : Do not eat, drink or smoke when using this product. Wash exposed skin thoroughly after handling Conditions for safe storage, including any incompatibilities Storage conditions Incompatible products Incompatible materials : Keep only in the original container in a cool, well ventilated place away from : Ignition sources, Heat sources, incompatible materials. Keep container closed when not in use. Refrigerate. : Strong oxidizers. : Sources of ignition. Direct sunlight. SECTION 8: Exposure controls/personal protection 8.1. Control parameters ACGIH ACGIH TWA (mg/m³) 3.1 mg/m³ ACGIH ACGIH TWA (ppm) 1 ppm (Pyridine; USA; Time-weighted average exposure limit 8 h; TLV - Adopted Value) OSHA OSHA PEL (TWA) (mg/m³) 15 mg/m³ OSHA OSHA PEL (TWA) (ppm) 5 ppm IDLH US IDLH (ppm) 1000 ppm NIOSH NIOSH REL (TWA) (mg/m³) 15 mg/m³ NIOSH NIOSH REL (TWA) (ppm) 5 ppm ACGIH ACGIH Ceiling (mg/m³) 2.98 mg/m³ ACGIH ACGIH Ceiling (ppm) 2 ppm OSHA OSHA PEL (Ceiling) (mg/m³) 7 mg/m³ OSHA OSHA PEL (Ceiling) (ppm) 5 ppm IDLH US IDLH (ppm) 50 ppm NIOSH NIOSH REL (ceiling) (mg/m³) 7 mg/m³ NIOSH NIOSH REL (ceiling) (ppm) 5 ppm Water ( ) 02/14/2018 EN (English US) 3/9

4 8.2. Appropriate engineering controls Appropriate engineering controls : Emergency eye wash fountains should be available in the immediate vicinity of any potential exposure Individual protection measures/personal protective equipment Personal protective equipment: Gloves. Safety glasses. Hand protection: Wear protective gloves. Eye protection: Chemical goggles or safety glasses Skin and body protection: Wear suitable protective clothing Respiratory protection: Respiratory protection not required in normal conditions Other information: Do not eat, drink or smoke during use. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Color : Colorless Odor : characteristic Odor threshold ph Melting point Freezing point Boiling point Flash point Relative evaporation rate (butyl acetate=1) Flammability (solid, gas) : Non flammable. Vapor pressure Relative vapor density at 20 C Relative density Solubility : Soluble in water. Log Pow Auto-ignition temperature Decomposition temperature Viscosity, kinematic Viscosity, dynamic Explosion limits 02/14/2018 EN (English US) 4/9

5 Explosive properties Oxidizing properties 9.2. Other information No additional information available SECTION 10: Stability and reactivity Reactivity No additional information available Chemical stability Unstable on exposure to heat Possibility of hazardous reactions Conditions to avoid Direct sunlight. Extremely high or low temperatures Incompatible materials Strong oxidizers Hazardous decomposition products Nitrogen oxides. Carbon monoxide. Carbon dioxide. Hydrogen chloride. SECTION 11: Toxicological information Information on toxicological effects Likely routes of exposure Acute toxicity Pyridine-Barbituric Acid Reagent ATE US (oral) LD50 oral rat LD50 dermal rabbit LC50 inhalation rat (mg/l) ATE US (oral) ATE US (dermal) ATE US (vapors) ATE US (dust, mist) LD50 oral rat LD50 dermal rabbit ATE US (oral) ATE US (dermal) Water ( ) LD50 oral rat ATE US (oral) LD50 oral rat Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity IARC group : Inhalation; Skin and eye contact : Oral: Harmful if swallowed mg/kg body weight > 891 mg/kg (Rat) 1120 mg/kg (Rabbit) mg/l/4h 500 mg/kg body weight 1120 mg/kg body weight mg/l/4h mg/l/4h 700 mg/kg 5010 mg/kg 700 mg/kg body weight 5010 mg/kg body weight mg/kg mg/kg body weight > 5000 mg/kg (Rat) : Causes skin irritation. : Causes serious eye irritation. 3 - Not classifiable 02/14/2018 EN (English US) 5/9

6 IARC group Reproductive toxicity Specific target organ toxicity single exposure 3 - Not classifiable Specific target organ toxicity repeated exposure Aspiration hazard Potential Adverse human health effects and symptoms Symptoms/effects after skin contact Symptoms/effects after eye contact Symptoms/effects after ingestion SECTION 12: Ecological information Toxicity Ecology - water : Based on available data, the classification criteria are not met. Harmful if swallowed. : Causes skin irritation. : Causes serious eye irritation. : Swallowing a small quantity of this material will result in serious health hazard. : Toxic to aquatic life. LC50 fish mg/l (LC50; 96 h) EC50 Daphnia mg/l (EC50; 48 h) LC50 fish mg/l (LC50; 96 h) EC50 Daphnia 1 < 56 mg/l (EC50; 72 h) Pyridine-Barbituric Acid Reagent Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD Readily biodegradable in water. Non degradable in the soil. Biodegradable in the soil under anaerobic conditions g O₂/g substance 0.05 g O₂/g substance 2.23 g O₂/g substance BOD (% of ThOD) 0.52 Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD Water ( ) Biodegradability: not applicable. No test data on mobility of the components available. Biodegradability in water: no data available Bioaccumulative potential Pyridine-Barbituric Acid Reagent Bioaccumulative potential Log Pow (Experimental value) Bioaccumulative potential Low potential for bioaccumulation (Log Kow < 4). 02/14/2018 EN (English US) 6/9

7 Log Pow 0.25 (QSAR) Bioaccumulative potential Low potential for bioaccumulation (Log Kow < 4). Water ( ) Bioaccumulative potential Bioaccumulative potential No bioaccumulation data available Mobility in soil Surface tension Ecology - soil N/m (20 C) May be harmful to plant growth, blooming and fruit formation Other adverse effects Other information : Avoid release to the environment. SECTION 13: Disposal considerations Disposal methods Waste disposal recommendations Ecology - waste materials SECTION 14: Transport information Department of Transportation (DOT) In accordance with DOT Not regulated : Dispose in a safe manner in accordance with local/national regulations. Dispose of contents/container to comply with local, state and federal regulations. : Avoid release to the environment. SECTION 15: Regulatory information US Federal regulations All components of this product are listed, or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory Chemical(s) subject to the reporting requirements of Section 313 or Title III of the Superfund Amendments and Reauthorization Act (SARA) of 1986 and 40 CFR Part 372. Pyridine CAS-No % Hydrochloric Acid, 37% w/w CAS-No % RQ (Reportable quantity, section 304 of EPA's List of Lists) SARA Section 311/312 Hazard Classes EPA TSCA Regulatory Flag RQ (Reportable quantity, section 304 of EPA's List of Lists) SARA Section 302 Threshold Planning Quantity (TPQ) SARA Section 311/312 Hazard Classes 1000 lb Fire hazard Immediate (acute) health hazard T - T - indicates a substance that is the subject of a Section 4 test rule under TSCA lb 500 lb Health hazard - Acute toxicity (any route of exposure) Health hazard - Skin corrosion or Irritation Health hazard - Serious eye damage or eye irritation Health hazard - Specific target organ toxicity (single or repeated exposure) 02/14/2018 EN (English US) 7/9

8 15.2. International regulations CANADA Listed on the Canadian DSL (Domestic Substances List) Listed on the Canadian DSL (Domestic Substances List) EU-Regulations No additional information available National regulations Listed on the Canadian IDL (Ingredient Disclosure List) Not listed on the Canadian IDL (Ingredient Disclosure List) US State regulations This product can expose you to Pyridine, which is known to the State of California to cause cancer. For more information go to U.S. - California - Proposition 65 - Carcinogens List U.S. - California - Proposition 65 - Developmental Toxicity U.S. - California - Proposition 65 - Reproductive Toxicity - Female Yes No No No U.S. - California - Proposition 65 - Reproductive Toxicity - Male No significant risk level (NSRL) SECTION 16: Other information Revision date : 02/14/2018 Other information Full text of H-phrases: see section 16: H225 H302 H312 H314 H315 H318 H319 H335 H401 H402 NFPA health hazard NFPA fire hazard NFPA reactivity : None. Highly flammable liquid and vapour Harmful if swallowed Harmful in contact with skin Causes severe skin burns and eye damage Causes skin irritation Causes serious eye damage Causes serious eye irritation May cause respiratory irritation Toxic to aquatic life Harmful to aquatic life : 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. : 1 - Materials that must be preheated before ignition can occur. : 0 - Material that in themselves are normally stable, even under fire conditions. 02/14/2018 EN (English US) 8/9

9 Hazard Rating Health Flammability Physical Personal protection : 2 Moderate Hazard - Temporary or minor injury may occur : 1 Slight Hazard - Materials that must be preheated before ignition will occur. Includes liquids, solids and semi solids having a flash point above 200 F. (Class IIIB) : 0 Minimal Hazard - Materials that are normally stable, even under fire conditions, and will NOT react with water, polymerize, decompose, condense, or self-react. Non-Explosives. : G G - Safety glasses, Gloves, Vapor respirator SDS US LabChem Information in this SDS is from available published sources and is believed to be accurate. No warranty, express or implied, is made and LabChem Inc assumes no liability resulting from the use of this SDS. The user must determine suitability of this information for his application. 02/14/2018 EN (English US) 9/9