Material Safety Data Sheet Avicel RC-591 Suspension

Transcription

1 Material Safety Data Sheet Avicel RC-591 Suspension SDS # : B FMC BioPolymer This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR andcanada sworkplacehazardousmaterialsinformationsystem (WHMIS)requirements. 1. PRODUCT AND COMPANY IDENTIFICATION Product name Synyms Avicel RC-591 Suspension Microcrystalline cellulose (INCI Name): MCC, cellulose gel Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethyl ether, Sodium CMC, Sodium salt, Cellulose gum Chemical Family Recommended use Manufacturer Marcophil FMC BioPolymer Mandaue City Cebu, Republic of the Phillippines (General Information - Manila) msdsinfo@fmc.com ( - General Information) Carbohydrate, Cellulose Derivative Investigational pharmaceutical suspending agent. Emergency telephone number (FMC Plant - Cebu, Philippines) (CHEMTREC - PRC) 2. Hazards identification Emergency Overview May cause skin irritation and/or dermatitis. Appearance Physical state Odor suspension liquid, suspension solid odorless Eyes May cause slight irritation. Skin May cause irritation. Inhalation None kwn. Ingestion May cause gastrointestinal discomfort if consumed in large amounts. Chronic effects No kwn effect based on information supplied. Page 1 / 7

2 3. Composition/information on ingredients Hazardous Non-Hazardous Propylparaben Water Sodium carboxymethylcellulose Microcrystalline cellulose Methylparaben CAS-No CAS-No First aid measures Eye contact Skin contact Inhalation Ingestion Notes to physician Protection of first-aiders In case of contact, immediately flush eyes with plenty of water. Get medical attention immediately if symptoms occur. Wash with water and soap as a precaution. Move to fresh air. If breathing is irregular or stopped, administer artificial respiration. Consult a physician. Never give anything by mouth to an unconscious person. Drink plenty of water. Get medical attention immediately if symptoms occur. Treat symptomatically. Use personal protective equipment. 5. Fire-fighting measures Flash Point Suitable extinguishing media Specific hazards arising from the chemical Protective equipment and precautions for firefighters Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. None in particular. As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. NFPA Health Hazard 0 Flammability 0 Stability 0 Special Hazards - 6. Accidental release measures Personal precautions For personal protection see section 8. Methods for containment Methods for cleaning up Dike far ahead of liquid spill for later disposal. Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Pick up and transfer to properly labeled containers. Page 2 / 7

3 7. Handling and storage Handling Storage Wear personal protective equipment. Refer to Section 8. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat. 8. Exposure controls/personal protection Exposure guidelines ACGIH TLV OSHA PEL NIOSH Mexico Microcrystalline cellulose TWA: 10 mg/m 3 TWA: 15 mg/m 3 TWA: 5 TWA: 10 mg/m 3 TWA: 5 Mexico: TWA 10 mg/m 3 mg/m 3 mg/m 3 Mexico: STEL 20 mg/m 3 British Columbia Quebec Ontario TWAEV Alberta Microcrystalline cellulose TWA: 10 mg/m 3 TWA: 3 TWA: 10 mg/m 3 TWA: 10 mg/m 3 TWA: 10 mg/m 3 mg/m 3 Occupational exposure controls Engineering measures Apply technical measures to comply with the occupational exposure limits. Personal Protective Equipment General Information Respiratory protection Eye/face protection Skin and body protection Hand protection If the product is used in mixtures, it is recommended that you contact the appropriate protective equipment suppliers. These recommendations apply to the product as supplied. None under rmal use conditions. Safety glasses. No special precautions required. No special precautions required. Hygiene measures When using, do t eat, drink or smoke. Wear suitable gloves and eye/face protection. Wash hands before breaks and at the end of workday. Page 3 / 7

4 9. Physical and chemical properties Appearance Color Physical state Odor Odor Threshold ph Melting Point/Range Freezing point Boiling Point/Range Flash Point Evaporation rate Autoignition Temperature Vapor pressure Vapor density Density Specific Gravity Bulk density Water solubility Percent volatile Partition coefficient: Viscosity Oxidizing properties suspension off-white liquid, suspension solid odorless.. t determined ~100 C / ~212 F. 10. Stability and reactivity Stability Conditions to avoid Hazardous decomposition products Hazardous polymerization Stable. Excessive heat. None under rmal use. Hazardous polymerization does t occur. Page 4 / 7

5 11. Toxicological information Acute Toxicity This product is expected to have low oral, dermal and inhalation toxicity. Skin contact Eye contact Inhalation Ingestion There are data available for this product. Expected to be n-irritating based on ingredients. There are data available for this product. Expected to be n-irritating based on ingredients. There are data available for this product. There are data available for this product. Low order of toxicity based on components. Component Information LD50 Oral LD50 Dermal Water 90 ml/kg ( Rat ) Sodium carboxymethylcellulose mg/kg ( Rat ) >2 g/kg ( Rabbit ) Microcrystalline cellulose 5 g/kg ( Rat ) 2 g/kg ( Rabbit ) Methylparaben 2100 mg/kg ( Rat ) LC50 Inhalation >5800 mg/m 3 ( Rat ) 4 h >5800 mg/m 3 ( Rat ) 4 h Chronic Toxicity Chronic Toxicity No kwn effect based on information supplied. Sensitization Target Organ Effects Not expected to be sensitizing based on the components. None kwn. 12. Ecological information Ecotoxicity The environmental impact of this product has t been fully investigated. Toxicity to algae Toxicity to fish Toxicity to microorganisms Toxicity to daphnia and other aquatic invertebrates Microcrystalline cellulose 96-hour EC50 > 100%, 96-hour LC50 > 100%, 48-hour LC50 > 100%, saturated solution, NOEC = saturated solution, NOEC saturated solution, NOEC = 12.5% (algae) =100% (rainbow trout) 100% (daphnia) Persistence and degradability Bioaccumulation Mobility Other adverse effects No product level data available. Microcrystalline cellulose is inherently biodegradable in soil. Microcrystalline cellulose biodegrades in soil at a rate comparable to corn starch. Bioaccumulation is unlikely.. None kwn 13. Disposal considerations Waste disposal methods This material, as supplied, is t a hazardous waste according to Federal regulations (40 CFR 261). This material could become a hazardous waste if it is mixed with or otherwise comes in contact with a hazardous waste, if chemical additions are made to this material, or if the material is processed or otherwise altered. Consult 40 CFR 261 to determine whether the altered material is a hazardous waste. Consult the appropriate state, regional, or local regulations for additional requirements. Contaminated packaging Dispose of in accordance with local regulations. Page 5 / 7

6 14. Transport information DOT TDG ICAO/IATA IMDG/IMO t regulated t regulated t regulated t regulated 15. Regulatory information International Inventories Water Sodium carboxymethylcellulose Microcrystalline cellulose Methylparaben Propylparaben Legend: TSCA Inventory (United States of America) DSL (Canada) - Listed EINECS/E LINCS (Europe) ENCS (Japan) IECSC (China) - - KECL (Korea) PICCS (Philippines ) AICS (Australia) NZIoC (New Zealand) U.S. Federal Regulations SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does t contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute Health Hazard Chronic Health Hazard Fire Hazard Sudden Release of Pressure Hazard Reactive Hazard CERCLA This material, as supplied, does t contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material. International Regulations Mexico - Grade Slight risk, Grade 1 Carcigen Status Mexico Microcrystalline cellulose Mexico: TWA 10 mg/m 3 Mexico: STEL 20 mg/m 3 Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. Page 6 / 7

7 WHMIS Hazard Class Non-controlled 16. Other information HMIS Health Hazard 0 Flammability 0 Stability 0 Special precautions - NFPA/HMIS Ratings Legend Severe = 4; Serious = 3; Moderate = 2; Slight = 1; Minimal = 0 Reason for revision: Initial Release. Disclaimer FMC Corporation believes that the information and recommendations contained herein (including data and statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided herein relates only to the specified product designated and may t be applicable where such product is used in combination with any other materials or in any process. Further, since the conditions and methods of use are beyond the control of FMC Corporation, FMC corporation expressly disclaims any and all liability as to any results obtained or arising from any use of the products or reliance on such information. Prepared By Avicel and FMC BioPolymer Logo - Trademarks of FMC Corporation 2012 FMC Corporation. All Rights Reserved. End of Material Safety Data Sheet Page 7 / 7