Second Generation Biofuels & Biochemicals

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1 Second Generation Biofuels & Biochemicals

2 Beta Renewables Vision For both Bio-Fuels and Bio-based Chemicals to be viable in the long term, they must be: 1.Competitive pricing compared to petroleum based products (at oil prices in the USD $60-$70/Bbl range); 2.Environmentally sustainable with respect to Green House Gases: overall GHG sequestration balance (including biomass feedstock farming, transportation, chemicals or biofuels production processes); 3.Agronomically sustainable on the long term (i.e. no competition with food) 4.Profitable for farmers to grow biomass feedstock

3 Center for Renewable Resources Rivalta, Italy Fully equipped analytical and fermentation laboratories Pilot Plant 3000 m 2 dedicated to fuel chemistry and technology from renewable resources 85 staff dedicated to R&D activities

4 Center for Renewable Chemistries Fundamental and applied cellulosic sugar chemistry and engineering research from glassware to pilot scale. Sharon Center,Ohio Catalytic Conversion of Sugar Bio-chemicals other than fuels Lignin conversion Intermediate and final product separation technologies US based agronomic studies 49,000 ft sq. of space

5 Break-through Technology Lower capital investment as a result of minimum handling of biomass, simplified flow schemes and no special materials of construction. Cash cost of fermentable sugars at ~10 /lb. Cash cost of ethanol of <$1.5/USG ($0.4/L). Pure lignin by-product. Feedstock flexibility energy crops, agricultural wastes woody biomass (e.g. eucalyptus & poplar) and/or SC bagasse. Commercial flexibility: no long-term enzyme supply commitments ability to provide power, based on thermovalorization of lignin, with positive supply to the electrical grid. Competitive and attractive economics without subsidies

6 PROESA - A Total Project Solution Biomass Enzymes CO 2 Water Feed Handling Pre-Treatment and Viscosity Reduction Hydrolysis + Fermentation Recovery Ethanol Steam Water Boiler + Generator Steam Power A Total Project Solution based on: 1. Agronomy: Field experimentation and best energy crops identified and characterized. 2. Biomass Pre-Treatment and Viscosity Reduction: Continuous process developed and piloted to produce costeffective and clean fermentable sugars. 3. Hydrolysis and Fermentation: Unique hybrid SSCF process scheme yielding high ethanol concentrations.

7 Agronomy & Sustainability Our Philosophy: Respect for the environment No debate between food vs. fuel Easy fit into the traditional agronomic system Our Approach to Sustainability High yielding species and agricultural residuals High conversion of biomass to sugars/ethanol Biomass requiring low inputs (chemicals & utilities) Optimization of agronomic systems (cultivation-logisticstransportation) Chemtex Agro created to support supply chain development

8 Pre-Treatment & Viscosity Reduction Break-Through Technology to produce cost-effective cellulosic sugar Feedstock flexibility without hardware changes. Minimal feedstock size reduction requirements. High recovery yield for cellulose and hemi-cellulose. Only steam used - No chemicals. Low capex (no special metallurgy, standard equipment, simplified process scheme) and opex. Easy to scale-up. Low sugar degradation and low level of contaminants (furfural, HMF) and ability to reduce acetic acid concentration via state of the art technology. Material is liquefied after few hours (less than 8 h) even at low enzyme load in patent-pending viscosity reduction step. High quality low cost sugar released as a feedstock for ethanol and/or bio-based chemical production.

9 Amyris and M&G Finanziaria Enter Into Off-Take Agreement EMERYVILLE, CA and TORTONA, ITALY (June 24, 2010) Amyris, Inc. and M&G Finanziaria S.R.L announced today that they have entered into a two-part collaboration agreement. The first part of the agreement contemplates the incorporation of Amyris farnesene as an ingredient into M&G PET processing. This would culminate in an off-take agreement that would commence upon successful completion of product integration. In the second part of the agreement, the parties will work together to combine access to low cost sugars by integrating M&G's ProEsa lignocellulosic process with Amyris s synthetic biology platform to produce renewable fuels and chemicals. M&G is a leader in the supply of plastics to bottlers worldwide. By providing a renewable ingredient for a portion of their PET products, we are collaborating to improve the environmental profile of their business, said John Melo, chief executive officer of Amyris.In April 2010, Amyris entered into a joint venture with São Martinho, a leading producer of sugar and ethanol, to construct the first commercial scale plant dedicated to the production of Amyris products. Amyris expects production from this plant may be used to provide farnesene for M&G. About Amyris Amyris is building an integrated renewable products company applying industrial synthetic biology to genetically modify microorganisms to serve as living factories. Amyris designs these microorganisms to produce defined molecules for use as renewable chemicals and transportation fuels. Amyris Brasil S.A., a subsidiary of Amyris, oversees the establishment and expansion of Amyris s production in Brazil, including SMA Indústria Química S.A., its joint venture with Usina São Martinho, one of the largest sugar and ethanol producers in Brazil. In addition, Amyris is building fuels distribution capabilities in the United States through its subsidiary, Amyris Fuels LLC. More information about Amyris and its subsidiaries is available at or About M&G M&G is a chemical engineering company headquartered in Tortona, Italy. It develops PET resins for container packaging. The group is presently the world s largest producer of PET for packaging applications with production capacity of 1.7 million tons annually. Group sales proceeds in 2008 were almost $2.6B. The group has manufacturing assets in Brazil, Italy, Mexico and USA and supports three R&D facilities in Rivalta, Italy; Sharon Center, Ohio; and in Poços de Caldas, Brazil. Forward-Looking Statements This press release contains forward-looking statements, including quotations from Amyris management and statements relating to Amyris s expectations regarding a strategic partnership arrangement You should not place undue reliance on these forward-looking statements because they involve many risks and uncertainties that are, in some cases, beyond our control and that could materially affect actual results. Factors that could materially affect actual results can be found in Amyris s Registration Statement on Form S-1 dated June 22, 2010, as amended, particularly under the caption "Risk Factors." Amyris expressly disclaims any intent or obligation to update these forward-looking statements except as required by law.

10 PRESS RELEASE 18 April 2011 Tortona, Italy Chemtex and Genomatica Enter Into A Strategic Partnership for Sustainable Chemicals from Biomass For Immediate Release: Chemtex is pleased to announce that it has entered into a strategic partnership with Genomatica for sustainable chemicals from biomass. The partnership includes the combination of best-in-class technologies, demonstration-scale production and commercial plant engineering by Chemtex. Genomatica, an emerging leader in sustainable chemicals, and Chemtex will develop a complete, proprietary process for the second generation production of Bio-BDO by combining Chemtex s break-through PROESA Process to produce cost-effective and clean fermentable sugars derived from cellulosic biomass with Genomatica s Bio-BDO process. Production of Bio-BDO is targeted to start at demonstration scale at Chemtex s Research and Development Center in Rivalta, Italy starting in Genomatica will have exclusive rights to the use of PROESA for the production of Bio-BDO. Chemtex has also been selected as Genomatica s preferred process engineering partner for the design and construction of Genomatica s commercial bio-based chemical plants, for both first and second generation feedstocks. Genomatica s proven, direct, one-step production processes combined with our PROESA biomass technology will drive further improvements in bio-product competitiveness and faster worldwide adoption, said Guido Ghisolfi, President and CEO of Chemtex. The European market is particularly keen to move to bio-based products, and Genomatica s strategy of greening the industry at its source offers today s industry a painless and economically beneficial way to make it happen. Our agreement with M&G further expands the feedstock flexibility we intend to deliver for the chemical industry, said Christophe Schilling, CEO of Genomatica. Depending on the geography they serve, our chemical industry partners will be able to sell sustainably produced chemicals from their choice of conventional sugars and starches, cellulosic biomass or syngas all while delivering superior profitability compared to petrochemical processes, the ability to deploy economical smaller-scale plants, and a smaller environmental footprint.

11 Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market Redwood City, CA and Tortona, Italy, July 28, 2011 Codexis, Inc. (Nasdaq: CDXS) and Chemtex, a global technology and engineering Company wholly-owned by Italy s Gruppo Mossi & Ghisolfi ( M&G Group ), today announced a broad collaboration to develop and produce sustainable detergent alcohols for use in the household products market. The collaboration includes development of second generation detergent alcohols from cellulosic (non-food) biomass. Detergent alcohols - a $6 billion worldwide market are surfactants which stabilize mixtures of oil and water. They are widely used in laundry detergents, shampoos and other consumer products. Detergent alcohols today are made from non-sustainable palm kernel and petroleum sources. The collaboration with Chemtex includes the following: Development of a world-class process for the conversion of cellulosic biomass to sustainable detergent alcohols Scale up of second generation detergent alcohols Engineering services for Codexis commercial facilities With this collaboration, Codexis has a fully integrated production process for converting cellulosic biomass to marketable, sustainable detergent alcohols, said Alan Shaw, Ph.D., Codexis President and Chief Executive Officer. By combining Codexis proven enzyme technology with Chemtex s leading technology and engineering design expertise, we are making significant progress towards production of commercial products from renewable feedstocks. We are very pleased to be working with Codexis in this important collaboration. said Mr. Guido Ghisolfi President and CEO of Chemtex. PROESA is break-through technology that produces high quality cellulosic sugar from biomass with best in class opex and capex. Coupling PROESA with the unique features of Codexis technology platform has the potential to make the production of detergent alcohols from biomass a reality. Codexis joins the list of leading biotech companies that has selected Chemtex s PROESA Process as their technology platform of choice to expedite the production of green chemicals from biomass. This is further evidence that PROESA is the break-through technology that the marketplace has been seeking in its drive for sustainability.

12 Paving the Way to Sustainability 1 Ethanol for Fuel From Energy Crops Agricultural Residuals SC Bagasse/Trash Hardwoods 2 Bio-chemicals Farnasene Detergent Alcohols BDO Others 3 Bio-ethylene For Bio-PE Other Packaging 4 Drop-In Fuels Bio-diesel Marine Diesel Bio-jet

13 Hydrolysis and Fermentation Advantages: Possibility to work at dry matter contents up to 40% (potential to yield 12% ethanol in fermentation). A unique hybrid SSCF process. Efficient use of enzyme cocktails; flexible to multiple biotech solutions. Low energy consumption for agitation. Easy ph and temperature control.

14 PRESS RELEASE 12 April 2011 Tortona, Italy Chemtex Breaks Ground on a 40 ktpa Cellulosic Ethanol Plant in Italy For Immediate Release: Chemtex is pleased to announce that it has broken ground on a 40ktpa cellulosic ethanol plant to be constructed in Crescentino, Vercelli, Italy for its parent, Gruppo Mossi and Ghisolfi ( M&G ). The plant will utilize Chemtex s own proprietary break-through technology, the PROESA Process, to produce costeffective sugars from cellulosic biomass that will be subsequently fermented into second generation bioethanol. The plant will include features from the Biolyfe Project that was supported by the European Community DG Energy within the 7th Framework Program. Chemtex s Italian operation, Chemtex Italia S.R.L., based in Tortona will provide a complete project solution on a lump-sum EPC basis. The construction of the Crescentino plant represents a significant achievement as well as a new beginning. Not only do we materialize a project that we strongly believe in but we position our Group and Italy as technological leader in bio-chemistry and in the production of 2nd generation bioethanol. Nevertheless, our commitment to R&D does not stop here. The next challenge is to find new applications for the PROESA Technology in the green chemistry field. - stated Vittorio Ghisolfi, President of M&G Group. By moving forward with this project, Chemtex will be the first commercial second generation ethanol producer in the world. We strongly believe that PROESATM is the break-through that the industry has been looking for and needs. We look forward to deploying this technology on a broad scale to produce cellulosic ethanol and green chemicals a reality throughout the world, said Guido Ghisolfi, President & CEO of Chemtex. The Crescentino Biorefinery will produce bioethanol from Arundo Donax and wheat straw, ligno cellulosic biomass locally sourced. Start-up is expected in H1, 2012.

15 Crescentino Demonstration Plant In April 2011 Chemtex broke ground for a 40 ktpa/13.4 mmgpy nameplate (60ktpa/ 20mmgpy design) cellulosic ethanol plant based on Arundo Donax & wheat straw. Plant will generate 15MW of green power from lignin to the grid and will sell ethanol to major oil companies. Design incorporates state-of-the-art wastewater treatment facility for the maximum recycle of water. Start-up: end H1, 2012 (target).

16 Enabling the Future... Today! PROESA is a Total Project Solution: From Field to Product Viable & Practical - developed by an organization with a heritage in plant design, construction and operation. For advanced biofuels and/or green chemicals. PROESA offers the best-in-class capex and opex No added acids or bases. Simplified flow scheme, standard equipment & simple metallurgy. Premium by-product. PROESA is unique multiple patent filings to protect IP. PROESA provides confidence the technology is backed by BETA RENEWABLES and Chemtex who are committed to continuous development and improvement of the offering.

17 What We Offer The opportunity to increase profitability by: Adding value to existing by-products and or waste/residual materials Producing higher margin/in-demand advanced biofuels and/or green chemicals Feedstock support through Chemtex Agro Feedstock Evaluation testing and trialing Project Development capabilities Feasibility Studies and EPC Services for: New Builds Co-Locations Integration into existing facilities Global Reach

18 PROESA We Are Ready! Second Generation Technology Up and Running Now!

19 Copyright and Disclaimer Copyright Copyright of all published material including photographs, drawings and images in this document remains vested in BETA RENEWABLES, Chemtex and third party contributors as appropriate. Accordingly, neither the whole nor any part of this document shall be reproduced in any form nor used in any manner without express prior permission and applicable acknowledgements. No trademark, copyright or other notice shall be altered or removed from any reproduction. Disclaimer This Presentation includes and is based, inter alia, on forward-looking information and statements that are subject to risks and uncertainties that could cause actual results to differ. These statements and this Presentation are based on current expectations, estimates and projections about global economic conditions, the economic conditions of the regions and industries that are major markets for BETA RENEWABLES, Chemtex and their (including subsidiaries and affiliates) lines of business. These expectations, estimates and projections are generally identifiable by statements containing words such as expects, believes, estimates or similar expressions. Important factors that could cause actual results to differ materially from those expectations include, among others, economic and market conditions in the geographic areas and industries that are or will be major markets for BETA RENEWABLES and Chemtex s businesses, oil prices, market acceptance of new products and services, changes in governmental regulations, interest rates, fluctuations in currency exchange rates and such other factors as may be discussed from time to time in the Presentation. Although BETA RENEWABLES and Chemtex believe that its expectations and the Presentation are based upon reasonable assumptions, it can give no assurance that those expectations will be achieved or that the actual results will be as set out in the Presentation. Neither BETA RENEWABLES nor Chemtex is making no representation or warranty, expressed or implied, as to the accuracy, reliability or completeness of the Presentation, and neither BETA RENEWABLES, Chemtex nor any of its directors, officers or employees will have any liability to you or any other persons resulting from your use. The Chemtex group consists of legally independent entities, constituting their own separate identities. Chemtex is used as the common brand or trade mark for most of these entities. In this presentation we may sometimes use Chemtex Global, Chemtex Group, we or us when we refer to Chemtex companies in general or where no useful purpose is served by identifying any particular Chemtex company.