Eisai Environmental Report 2017

Transcription

1 Eisai Environmental Report 217 Ongoing Efforts to Ensure Coexistence with the Global Environment The Eisai Group conducts business operations emphasizing protection of the global environment based on the Eisai Network Companies (ENW) Environmental Protection Policy. By quantitatively assessing resource input and environmental impact, we strive to reduce our burden on the environment and promote environmental protection activities worldwide. Reduction of Environmental Impact Today we face many environmental issues, such as climate change and water shortages, which have substantial impact on a global scale. In terms of environmental protection, there are significant issues as well, including air pollution caused by fine particulate matters (PM 2.5), waste problems and destruction of the natural environment. To create a sustainable society while resolving these environmental issues, leaders of more than 15 UN member states, including Japan, adopted the new 23 Agenda for Sustainable Development, which encompasses 17 Sustainable Development Goals (SDGs), at a summit held at the UN Headquarters in September 215. In addition to observing environmental laws and regulations, ordinances and agreements with local governments, the Eisai Group implements more stringent voluntary standards and accordingly undertakes activities to protect the environment. By doing so, we will continue to seek coexistence with the global environment through its business operations. In promoting business expansion into countries across the world, we will work to reduce environmental impact at each stage of business, while also committing ourselves to contributing to the achievement of the SDGs. Based on the Eisai Network Companies (ENW) Environmental Protection Policy, all employees recognize the importance of environmental protection and incorporate an environmental perspective in working to execute our social responsibilities. Eisai Network Companies (ENW) Environmental Protection Policy Fundamental Environmental Protection Policy Eisai and its Group companies (hereafter ENW) place global environmental protection as an important component of business operations and strive to maintain the environment. Environmental Protection Guidelines 1. ENW is aware of the dignity and importance of nature and adopts measures to maintain the global environment in all business operations. 2. ENW places environmental protection as a top priority at all stages of corporate activities from research and development, production, distribution and sales to product usage and disposal. 3. ENW constructs and operates an environmental management system and promotes environmentally protective operations. 4. ENW complies with all applicable laws, regulations and agreements concerning environmental protection, and each company implements voluntary standards that exceed the minimum standards set forth in the applicable laws, regulations and agreements. 5. ENW actively introduces advanced environmental technology to be at the forefront of reducing environmental impacts. 6. ENW reduces usage of resources and energy as well as reduces or recycles waste products in all business operations. 7. ENW reduces usage and promotes the removal of chemical substances that cause environmental pollutant emission and prevents environmental pollution. 8. ENW shares the fundamental policy on environmental protection and implements educational training to strengthen specialties at each workplace progressively and continuously. 9. ENW actively discloses information on policies, objectives, programs and results concerning environmental protection. 1

2 Manufacturing and Drug Discovery Research Sites Worldwide European Knowledge Centre (United Kingdom) Benxi Plant (China) Suzhou Plant (China) Eisai Knowledge Centre, India (India) Bogor Plant (Indonesia) Kawashima Plant (Gifu) Kashima Plant (Ibaraki) Morphotek Inc. (United States) Tsukuba Research Laboratories (Ibaraki) KAN Research Institute (Hyogo) EA Pharma Co., Ltd., Fukushima Plant (Fukushima) EA Pharma Co., Ltd., Drug Discovery Research Institute (Kanagawa) Andover Research Institute (United States) H3 Biomedicine Inc. (United States) Baltimore Plant (United States) Editorial Policy This report describes the Eisai Group s approach toward environmental protection and provides details of environmental activities undertaken during fiscal 216. The report has been developed in reference to the Environmental Reporting Guidelines (212 Version) issued by Japan s Ministry of the Environment and includes Eisai s efforts both in and outside Japan. Scope of Reporting The scope of data aggregation in this report primarily covers and its Group companies in Japan as well as its production sites and research centers outside Japan. The scope of individual data is specified as needed. Period Covered The data has been aggregated based on the results achieved from April 1, 216 to March 31, 217. Inquiries For inquiries regarding this report, please contact: General Affairs and Environmental & Safety Affairs Department Tel: Fax:

3 Glossary and CO2 Emissions Coefficient Glossary Term ISO 141 EA21 PRTR SOx NOx BOD Scope 1 Scope 2 Scope 3 VOCs Zero emissions Description An international standard for environmental management issued by the International Organization for Standardization EcoAction 21: an environmental management system certification for small- and medium-sized enterprises issued by Japan s Ministry of the Environment Pollutant Release and Transfer Register: A system for understanding, collecting and publicly disclosing information on the extent to which chemical substances involving environmental risk are either released into the environment or are contained in waste matter and transferred from operational sites Sulfur oxides Nitrogen oxides Biochemical oxygen demand: A measure used to evaluate the quality of river water and factory wastewater Energy-derived direct greenhouse gas (GHG) emissions. GHG emissions released directly into the atmosphere through the use of fuels Energy-derived indirect GHG emissions. GHG emissions associated with the use of purchased energy (electricity and heat) Other indirect GHG emissions. GHG emissions associated with business activities in a supply chain, other than Scope 1 and Scope 2 emissions Volatile organic compounds: Organic compounds that are volatile at ordinary temperatures and cause air pollution through the generation of photochemical oxidants The Eisai Group uses this term as a target of emission management. It indicates a ratio of waste sent to landfill to total waste of less than 1.% Energy Consumption and CO2 Emissions Coefficient Used in Emissions Calculations Energy type Calorific value per unit CO 2 emissions coefficient FY216 In and before FY212 In and after FY213 Electric power 9.97 (GJ/MWh) *1 LPG 5.1 (GJ/tons) 3. (tons/tons) 3.1 (tons/tons) LNG 55. (GJ/tons) 2.7 (tons/tons) 2.76 (tons/tons) Natural gas 4.2 (GJ/1, Nm 3 ) 2.22 (tons/1, Nm 3 ) 2.6 (tons/1, Nm 3 ) Processed natural gas 4.1 (GJ/1, Nm 3 ) 2.23 (tons/1, Nm 3 ) 2.3 (tons/1, Nm 3 ) Kerosene 36.5 (GJ/kl) 2.49 (tons/kl) 2.5 (tons/kl) Light oil 38.1 (GJ/kl) 2.59 (tons/kl) 2.62 (tons/kl) Fuel oil A 38.9 (GJ/kl) 2.71 (tons/kl) 2.76 (tons/kl) Gasoline 33.1 (GJ/kl) 2.32 (tons/kl) 2.28 (tons/kl) Industrial steam 1.2 (GJ/GJ) *2 Hot water and cold water 1.36 (GJ/GJ).57 (tons/gj) *1 Emissions in Japan up until fiscal 214 are calculated using the emissions coefficient announced by the Federation of Electric Power Companies of Japan (FEPC). Calculations for fiscal 215 and 216 use the emissions coefficient reported by the Electric Power Council for a Low Carbon Society for fiscal 215. In calculating emissions outside Japan, the emissions coefficient is taken from the following source. However, the coefficient for fiscal 214 is used to calculate emissions for fiscal 215 and 216, since corresponding figures are not available from the source. IEA: CO2 EMISSIONS FROM FUEL COMBUSTION (216) *2 Calculations use the emissions coefficient provided by respective suppliers every fiscal year. 3

4 1 Environmental Protection Initiatives and Results Fiscal 216 Environmental Protection Initiatives and Results of the Eisai Group in Japan Theme Targets Results Evaluation Pages Enhancement of environmental management Energy conservation and combating climate change Enhancement and smooth operation of management systems Planning and implementation of environmental education Implementation of environmental communication Reduction of CO2 emissions by 23% from fiscal 25 level by fiscal 22 Promotion of the replacement of commercial vehicles with hybrid vehicles () Purchase of wind-generated green power Reduction of waste generated Increase in recycled waste Reduction of waste sent to landfill Waste reduction Ratio of waste sent to landfill to total waste < 1% Implementation of onsite inspections based on the Waste Management and Public Cleansing Law Legend used in Evaluation section: Achieved; Partially achieved; Not achieved Proper application of the PDCA cycle Periodic and renewal inspections of ISO 141 certification (Kawashima Plant, Kashima Plant, EA Pharma Co., Ltd. Head Office, Drug Discovery Research Institute, Fukushima Plant) Interim and renewal inspections of EA21 certification (Eisai Distribution Co., Ltd.) Internal training sessions: 6; external training sessions: 24 P7 Publication of the Environmental Report 216 Local community meetings (Kawashima Plant) and administrative committee meetings (Kashima Plant) Information exchange meetings (EA Pharma Co., Ltd., Fukushima Plant) CO2 emissions: 73,946 tons *1 (4.1% increase from fiscal 215) 61,217 tons *2 (33.1% decrease from fiscal 25) Adoption rate for commercial vehicles: 62.3% (2.5% increase from fiscal 215) (Adoption rate for company-owned vehicles: 75% Adoption rate for employee-owned vehicles: 58.5%) Purchase of 1,, kwh from Japan Natural Energy Co., Ltd. Amount of waste generated: 2,935 tons (decrease of 546 tons from fiscal 215) Amount of recycled waste: 13 tons (increase of 3 tons from fiscal 215) Amount of waste sent to landfill: 1,238 tons (increase of 227 tons from fiscal 215) :.22% Eisai Group companies in Japan: 1.4% Eisai Group in Japan:.43% Implemented onsite inspections based on the Waste Management and Public Cleansing Law at 65 sites nationwide; confirmed that waste is being disposed of legally and in a proper manner P7 P8 P9 P1 P12 P12 P12 Theme Targets Results Evaluation Pages Resource conservation Management of chemical substances Air pollution and water pollution prevention measures Conservation of the local environment Promotion of awareness-raising activities and education to encourage green purchasing Response to PRTR system and proper management of designated substances Proper management of fluorocarbons Compliance with Air Pollution Control Act, Water Pollution Control Act and pollution control agreements Compliance with environment-related laws (noise, vibrations, offensive odors, soil contamination) Involvement with local community Zero complaints made by neighboring residents Awareness-raising activities and education were provided on a timely basis. The green purchasing rate: 32.6% (1.3 % increase from fiscal 215). Proper management based on an understanding of amounts of substances subject to the PRTR system that were handled, emitted and transferred Implement legally required inspections based on the Act on Rational Use and Proper Management of Fluorocarbons and systematically change to hydrofluorocarbons and nonfluorocarbons Regular measurements showed that the amounts of pollutant emissions into the atmosphere and water systems were below standard values Regularly measured levels of noise, vibrations and offensive odors to confirm compliance Held regular cleanup activities of areas around each operation site and affiliated company as well as within industrial parks Kawashima Plant received a complaint from neighboring residents about fallen leaves. Strong winds caused trees on the plant premises to shed leaves on gardens of adjacent residents and nearby roads. Increased perimeter patrols when windy and on a regular basis. P14 P13 P14 P8, 15 P8 *1 The carbon emissions coefficient based on power usage utilized was.531 t-co2/mwh, the same coefficient used in fiscal 215. *2 The carbon emissions coefficient based on power usage utilized was.43 t-co2/mwh, which is used in evaluating targets of the Eisai Group in Japan. For details, please refer to page 44 of the Environmental and Social Report

5 2 Resource Input and Environmental Impact Resource Input and Environmental Impact Resource Input and Environmental Impact Data of the Eisai Group in Japan Electric power (MWh) LPG (tons) Processed natural gas (1, Nm 3 ) Kerosene (kl) Light oil (kl) Gasoline (kl) Fuel oil A (kl) Industrial steam (GJ) Hot water (GJ) Cold water (GJ) amount handled (including unreported amount) (tons) Energy 72, , , ,698 6 PRTR substances Group companies in Japan 27,12 1, Group companies in Japan 99,573 1,588 6, , , Resource Input INPUT 6 Water consumption (1,m 3 ) Clean water (1,m 3 ) Industrial water (1,m 3 ) Groundwater (1,m 3 ) Desalinated water (1,m 3 ) Recycled water (1,m 3 ) Copy paper consumption (1, sheets) Water 2, , Other Group companies in Japan Group companies in Japan Note: Due to rounding, the sum of and Group companies in Japan may not correspond to for some items. 2,155 1,297 2, , ,453 Atmospheric Emissions (from operational sites) CO2 (Scope 1, 2) (tons) SOx (tons) NOx (tons) Soot and dust (tons) PRTR substances (release into the atmosphere) (tons) Amount generated (tons) Amount recycled (tons) Amount sent to landfill (tons) Wastewater discharge (1,m 3 ) BOD (tons) Nitrogen (tons) Phosphorous (tons) PRTR substances (off-site transfer as waste) (tons) PRTR substances (release into water bodies) (tons) 53, Waste 2, , Group companies in Japan 2, Group companies in Japan Environmental Impact OUTPUT 73, ,935 1, , CO2 emissions from commercial vehicles (tons) CO2 emissions from business-use vehicles other than commercial vehicles (tons) Purchased goods and services (tons) Capital goods (tons) Fuel- and energy related activities not included in Scope 1 or 2 (tons) Transportation and delivery (upstream) (tons) Waste generated in operations (tons) Business travel (tons) Employee commuting (tons) Transportation and delivery (downstream) (tons) End of life treatment of sold products (tons) Exhaust Gas from Vehicles 3,786 9 Group companies in Japan 1, Indirect CO 2 Emissions (Scope 3 * ) 28,194 11,42 3, , ,1 758 Group companies in Japan 123,45 3, ,11 1, , ,643 14,533 4,14 1,35 3, ,699 3,126 1,192 Containers and Packaging Recycling Recycling of containers and packaging materials (oblitory recycling amount) (tons) Group companies in Japan 1, ,88 * Calculations based on the Basic Guidelines on Accounting for Greenhouse Gas Emissions Throughout the Supply Chain, Version 2.2 (released by the Ministry of the Environment and the Ministry of Economy, Trade and Industry) 5

6 Environmental Accounting 3The Eisai Group in Japan has used a standardized form for assessing environmental costs to tabulate any discernible investments and expenses relating to environmental protection and has been effectively promoting environmental protection activities. We will seek to identify the economic effects of environmental protection measures and make improvements to increase the form s usefulness as a management index. Environmental Protection Costs in Fiscal 216 (In major implementation items, indicates investment and indicates expense.) (million yen) Main category Subcategory Major implementation items Investment Expense Major results / outcomes Pages A. Costs to achieve objectives B. Costs to comply with environmental regulations C. Environmental administration costs * Includes depreciation costs 1. Environmental management systems ISO 141 regular and recertification inspections 6 Promotion of environmental protection activities P7 2. Energy conservation and measures to address climate change 3. Resource conservation activities 4. Air pollution prevention measures Renewal of air conditioners Renewal of humidifiers Introduction of LED lighting Maintenance and administration of energy monitoring equipment Introduction of hybrid cars for commercial vehicles Purchase of green power Maintenance of wastewater treatment system Green purchasing Boiler repair and inspection Atmospheric analysis Disposal of fluorocarbons ,33 Reduced CO2 emissions from commercial vehicles by 942 tons (down 2% year on year) Purchased 1,, kwh of wind-generated green power (corresponding to 531 tons of CO2 emissions) Recycled water: 64, m 3 Promotion of purchasing environmentally friendly products P9-1 4 Prevention of air pollution P8 5. Management of chemical substances Database usage expenses 2 Appropriate management of chemicals 6. Waste reduction activities Entrustment of waste disposal 162 Amount of waste generated decreased by 546 tons Recycled amount increased by 227 tons P12 Amount sent to landfill increased by 3 tons 7. Product design 1. Waste disposal 2. Pollution prevention measures Management of waste treatment facilities * Disposal of polychlorinated biphenyl (PCB) waste Renewal of TOC analyzers for wastewater resulting from manufacturing processes Installation of mixers for wastewater treatment Installation of ph meters for wastewater resulting from manufacturing processes Wastewater treatment facilities management expenses Cleaning of various drainage tanks Wastewater, noise, vibration and odor measurements 3. Soil contamination Inspection costs for fuel oil A leakage 4. Recycling of containers and packaging 1. Environment-related costs excluding A and B Subcontracting of container and packaging recycling 2 Greenery maintenance and management costs Publication of the Environmental Report 216 Verification of CO2 emissions 53 Compliance with related laws and regulations P Prevention of contaminant discharge P ,948 Prevention of soil and groundwater contamination Compliance with the Containers and Packaging Recycling Act Promotion of business activities that coexist with nature Improved communication P14 P8 P5 Eco-Efficiency For the Eisai Group in Japan, we calculated eco-efficiency indicators using various environmental impact categories, such as CO2 emissions, amount of waste generated, amount of PRTR designated substances handled, water consumption, biological oxygen demand (BOD) and sulfur oxides (SOx) and nitrogen oxides (NOx) emissions. For each fiscal year under evaluation, eco-efficiency was calculated by dividing environmental impact by net domestic sales volume. The table below shows a comparison of the resulting figures, using fiscal 28 as the base year. Declines mean improved environmental performance. The trend for some primary indicators is also shown in the graph below. Eco-Efficiency Indicator FY28 FY29 FY21 FY211 FY212 FY213 FY214 FY215 FY216 CO2 emissions Waste generation PRTR substances Water consumption SOx NOx BOD Eco-efficiency Primary Indicators CO2 Waste PRTR Water Eco-efficiency Economic Effect of Environmental Protection Measures Item Details Amount Scope of calculations: Eisai Group in Japan Period of data collection: April 1, 216 through March 31, 217 Notes: 1) Figures are rounded to the nearest hundred thousand yen. 2) Since fiscal 24, personnel costs have included only the subcontractors commissions. (million yen) Sales of by-products Proceeds from selling recyclable items 1 Reduction in synthetic solvent expenses through recycling Reduction in synthetic solvent expenses through distillation of waste solvent in the production process

7 4 Environmental Management Promotion Structure The Eisai Group established the Company- Wide Environment and Safety Committee as a decision-making body for deliberation of important environmental issues. To the present, the committee mainly carried out discussions focused on Japan. However, the committee is now promoting global activities encompassing topics from overseas. We are also strengthening activities for ascertaining environment-related risks and for establishing measures to reduce them. Moreover, as a consultative body promoting the environmental activities of Group companies in Japan, the Eisai Group also established the Environment and Safety Conference of Group Companies in Japan to share information and Structure to Promote Environmental Management Corporate Officer Responsible for General Affairs, Environmental & Safety Affairs General Affairs and Environmental & Safety Affairs Department Company-Wide Environment and Safety Committee discuss relevant activities. Each operational site of the Eisai Group has established its own unique management system to promote environmental activities. Eisai s main production sites in Japan as well as the Suzhou Plant in China and Vizag Plant in India have all acquired ISO 141 certification and are conducting activities based on the ISO standard while striving to raise awareness through environmental education and environmental risk management training. Besides complying with environmental laws, ordinances and agreements, we periodically conduct internal environmental audits by a department specializing in internal auditing to identify and solve issues. Operational sites / Headquarters office complex * Communication offices Group Companies outside Japan Specific Projects Energy Conservation Study Meeting Waste Processing Study Meeting Environment and Safety Group Companies in Japan Conference of Group Companies in Japan * The office complex that serves as the corporate headquarters for the Eisai Group Environment-related meetings Environment-related meetings Environmental Education In order to promote environmental protection activities ensuring coexistence with the global environment, it is important that all employees have a proper understanding of the relationship between their daily work and environmental problems, and that they make efforts to enhance their own individual awareness for problemsolving. At the Eisai Group, operational sites and Group companies voluntarily formulate education programs in accordance with their respective Internal Audits The Eisai Group has environmental internal audits conducted by a department specializing in internal auditing. This department makes efforts to undertake objective audits from an independent standpoint, and the audits cover all Group companies in and outside Japan. The audits for fiscal 216 indicated that there were no urgent or serious issues. External inspections are also carried out once a year at those operational sites and Group companies that have acquired ISO 141 certification to confirm the validity of their environmental management systems. During fiscal 216, no business characteristics and local issues. In addition to education targeted at all workers, education is also provided for various levels of employees, along with further efforts to improve the learning content. Furthermore, for the purpose of developing environmental educators and officially qualified employees and improving the level of environmental awareness of individual employees, we also actively promote participation in both internal and external professional training courses. serious material issues were identified by external auditing organizations. Furthermore, these certified operational sites and companies also educate their own internal auditors and seek to raise the level of their audits through training. The results of each annual independent internal audit are reflected in the ongoing improvement of the Group s environmental management system and translate into the enhanced quality of our environmental protection activities. Operational Sites Certified under ISO 141, Kawashima Plant and Kashima Plant EA Pharma Co., Ltd., Fukushima Plant, Drug Discovery Research Institute and Head Office Eisai China Inc., Suzhou Plant Eisai Pharmaceuticals India Pvt. Ltd., Vizag Plant 7

8 Environmental Risk Management The Eisai Group in Japan has compiled its procedures for responding to environmental incidents in its Disaster and Accident Response Manual and the Industrial Accident Reporting and Compilation Standards. We aim to minimize damage by collecting accurate information and taking swift and appropriate action and at the same time make every possible effort to prevent recurrence. At production plants and research facilities, in particular, we have been preparing for an emergency by regularly conducting emergency Compliance with Laws and Regulations The Eisai Group in Japan is committed to observing environmental laws and regulations, ordinances and agreements with local governments. In particular, at production plants and research facilities, we regularly measure the environmental burden of causative agents in air pollution and water pollution to check that there are no problems. Also, from the perspective of protecting the neighboring environment, we conducted regular measurements of noise, vibrations and offensive odors at production plants and research facilities and confirmed that these all were below the regulatory values. During fiscal 216, we made steady progress in our response to the Act on Rational Use and Proper Management of Fluorocarbons and also submitted each type of environmental notification to the relevant authorities without any delay. From November 216 to April 217, as a preparation for constructing a parking lot within the Kawashima Plant, we conducted a soil survey in accordance with the Soil Contamination drills assuming, for instance, the leak of hazardous chemical substances from wastewater, exhaust gas or effluents as situations that significantly affect the environment. Along with these efforts, we issued our own independent guidelines, working to identify sources of risks, and enhancing our risk management structure with a view to further ensuring appropriate environmental risk management Group-wide, including Group companies outside Japan. Countermeasures Act. We found arsenic and arsenic compounds exceeding standard values in some of the soil taken from the former site of the No. 1 Drug Formulation Building and reported the results to the Gifu prefectural government. Groundwater quality measurements at observation wells located at the contaminated area and in the downstream areas of the subsoil flow showed that the two substances were both below the lower detection limit. We believe that effects on the health of local community members are unlikely, since the subject area is paved and does not cause the surface soil to disperse into the atmosphere. Also, there is no impairing impact on the safety of products manufactured at the Kawashima Plant. We will implement appropriate measures under the guidance of the Gifu prefectural government (Details are available at: others/ pdf). During fiscal 216, there were no administrative dispositions or lawsuits related to the environment. Environmental Communication In promoting our business activities, mutual understanding and cooperation with the local community is extremely important. As such, the Kawashima Plant has been holding local community meetings every year since 28 as a platform for sharing information and enhancing communication with the local community. The plant invites neighborhood representatives and government officials to these meetings to introduce its production activities and environmental protection initiatives and also listen directly to participants comments and requests to the plant. Similar initiatives are also undertaken by the Fukushima Plant of EA Pharma Co., Ltd. to share information on the plant s environmental and local community contribution activities and cultivate a deeper mutual understanding. Environmental Incident Report Environmental Incidents and Countermeasures in Fiscal 216 Environmental incident Operational site/company Details Response Leakage Head office Fluorocarbon refrigerants leaked from a crack in an capillary tube equipped with an executive room air conditioner s outdoor unit installed on the roof of Koishikawa Daini-Building After replacing the relevant parts and restoring the unit quickly, an incident report was filed with the Tokyo Metropolitan Government. 8

9 5 Formation of a Low-Carbon Society Efforts toward the SDGs Toward the Formation of a Low-Carbon Society The Eisai Group in Japan is promoting initiatives for the formation of a low-carbon society to help solve the problem of climate change. is participating in the Commitment to a Low Carbon Society initiated by the Federation of Pharmaceutical Manufacturers Associations of Japan (FPMAJ), and the Eisai Group in Japan is implementing relevant initiatives based on its own medium-term plan for the reduction of CO2 emissions. During fiscal 216, EA Pharma Co., Ltd., which was established through a merger of Eisai s corresponding business with AJINOMOTO PHARMACEUTICALS CO., LTD., initiated business operations as an Eisai Group company in Japan. In China, the Benxi Plant also went into full-scale operation. Our production and research operations are becoming more active both in and outside Japan. These factors led to an increase in the amount of energy consumption, causing more CO2 emissions. As energy-saving initiatives, we adopted two measures at the Kawashima Plant. Firstly, we renewed the plant s co-generation system. Secondly, we installed an inverter-equipped air conditioning system for production processes and successfully set up an energy-saving mode of operation. Moreover, Kawashima plant s Synthesis Facility ended operation following the termination of in-house production of vitamin E. Consequently, we reduced CO2 emissions by more than 3, tons. The transfer of the North Carolina Plant in the U.S. to another company in fiscal 215 has greatly contributed to lower CO2 emissions overseas. As a result of this and the above, the Eisai Group s CO2 emissions for the Eisai Group in Japan and production plants and research facilities outside Japan showed a 4.1% increase and 1.3% decrease, respectively, from fiscal 215. *2, *3 Eisai Group CO 2 Emissions (CO2/t) 18, 16, 14, 12, 1, 8, 6, 4, 2, 123, , ,25 153,952 16,736 Eisai Group in Japan 163, ,15 Overseas operational sites 12, , *2 Emissions from vehicles are not included. *3 Emissions from business activities at offices outside Japan are not included. *1, *2 Eisai Group in Japan CO 2 Emissions *4, *5 CO 2 Emissions by Region (tons) (t) 12, Group companies in Japan Region Scope 1 Scope 2 1, 91,558 91,742 92,641 1,53 Japan 24,374 54,749 79,123 Asia 4,376 21,322 25,698 8, 81,96 79,41 82,26 75,942 71,6 73,946 U.S. 7,882 15,559 23,441 6, EMEA 4,522 3,576 8,98 *4 Including emissions from vehicles for commercial use in and outside Japan *5 Including emissions from business activities at offices in and outside Japan 4, 2, *1 Revisions were made to the fiscal 215 data provided in the previous year s report by using the finalized coefficient shown below. FY215 carbon emissions coefficient based on power usage =.531 t- CO2/MWh 9

10 Efforts Undertaken at Offices Efforts concerning Commercial Vehicles Based on the Seven Power-Saving Rules, (see Figure A) the Eisai Group in Japan strives to save electricity throughout the year, not only during the power-saving campaigns held in summer and winter. Offices, including administration and sales offices, are trying to save power through such means as controlling the temperature of air-conditioning systems, turning off lights when not in use and shutting down computers when employees leave their seats for a while. At the head office buildings, we have installed demand controllers to control peak power. We are also focusing on raising employee awareness of reducing power by implementing regular energy-saving patrols and visualizing actual power savings achieved. CO2 emissions originating from office activities of the Eisai Group in Japan in fiscal 216 totaled 3,918 tons, a 12.6% increase from fiscal 215. The increase is attributable to the addition of the head and sales offices of EA Pharma Co., Ltd.. Office Activitiess CO 2 Emissions (Eisai Group in Japan) (t) 5, 4, 3, 2, 1, 3,999 4,25 4,547 4,139 3,481 3, also undertakes efforts to reduce CO2 emissions from sales operations. In Japan, the replacement of commercial vehicles with hybrid vehicles (HV) has been proceeding, whereby as a general rule, we have required to choose HVs when purchasing new vehicles since 21. However, from the viewpoint of preventing traffic accidents by Commercial Vehicles CO 2 Emissions (CO2/t) 7, 6, 5, 4, 3, 6, CO2 emissions 5, new employees, we allowed them to use vehicles other than HVs in fiscal 216. The adoption rate of HVs rose 2.5% to 62.3% in fiscal 216, and CO2 emissions originating from commercial vehicles decreased 2% from fiscal 215 to 3,786 tons. We will continue shifting to more fuel-efficient vehicles as part of our efforts to further reduce emissions. Hybrid vehicle adoption rate 5, , ,786 (%) Fig A: Seven Power-Saving Rules 2, 2 1, Note: The hybrid vehicle adoption rate now uses the annual average, instead of the year-end figure used up until fiscal 215. CO 2 Emissions Breakdown by Scope (Scopes 1 and 2, Eisai Group) (tons) Scope 1 Scope 2 Production plants and research facilities 29,665 82, ,58 Offices 667 1,14 1,681 Ware house 168 2,799 2,967 Vehicles for commercial and other business use 1,654 1,654 41,154 95,26 136,36 1

11 Breakdown of Energy Consumption Electric power (MWh) Gasoline (kl) Kerosene (kl) Light oil (kl) Fuel oil A (kl) LPG (tons) Natural gas (1, m 3 ) LNG (m 3 ) Processed natural gas (1, m 3 ) CWS * (tons) Industrial steam (GJ) Cold water (GJ) Amount used 99, , , , , In Japan Calorific value (GJ) 992, ,86.1 2, , , , , Ratio (%) Amount used 65, , , , , ,258. Outside Japan Calorific value (GJ) 656, , , , , , ,53.2 Ratio (%) Amount used 165, , , , , , , , Calorific value (GJ) 1,649, , , ,17.9 1, , , , , , , Ratio (%) * Abbreviation for COAL WATER SLURRY Group Companies in Japan CO 2 Emissions (tons) CO 2 Emissions (tons) Company name Office name Sunplanet Co., Ltd Sannova Co., Ltd. *1 8,214 8,964 8,811 8,67 Elmed Bracco Eisai Distribution Co., Ltd. 2,53 2,633 2,699 2,861 2,967 KAN Research Institute, Inc ,687 2,591 2,67 EIDIA Co., Ltd. * Eisai Food & Chemical Co., Ltd. * EA Pharma Co., Ltd. 14,294 Others Eisai Group in Japan 12,793 14,276 15,979 15,665 2,754 *1 These companies were transferred to other companies and were accordingly excluded from the Group during fiscal 215. Kawashima Plant 26,386 29,141 26,999 25,655 22,397 Misato Plant *2 2,288 2,597 Honjo Facility 1,63 1,223 1,124 1,17 94 Kashima Plant 7,84 8,71 8,142 8,3 8,196 Tsukuba Research Laboratories 2,659 22,466 2,71 18,146 18,927 Headquarters office complex 1,914 2,15 2,8 1,763 1,67 Communication offices (sales offices in Japan) 1,699 1,977 1, ,294 1,97 79,847 86,254 59,963 55,96 53,192 Eisai Group in Japan 92,641 1,53 75,942 71,6 73,946 *2 The Misato Plant was transferred to another company and was accordingly excluded from the Group as of March 31,

12 6 Establishment of a Recycling-Oriented Society Efforts toward the SDGs Waste Reduction Results in Fiscal 216 The Eisai Group in Japan is working to achieve zero emissions and conducting waste disposal with three goals in mind, specifically, reduce the amount of waste generated, increase the amount of recycled waste and decrease the amount of waste sent to landfill. In fiscal 216, we attained zero emissions for the ninth consecutive fiscal year, and the total amount of waste generated by the Eisai Group in Japan successfully declined 15.7% from fiscal 215. The amounts of waste acids, waste alkalis and waste oil decreased considerably at the Kawashima Plant, where the operation of the Synthesis Facility was terminated, and at the Kashima Plant, in which activities were shifted to those generating less waste liquid. At the Tsukuba Research Laboratories, we Waste and the Ratio of Waste Sent to Landfill to Waste Note waste (t) 9, 6, 3, 6,28 Ratio of waste sent to landfill to total waste 4, ,481 4,1 2, (%) Note: Corrected data from past by recount 1..5 were able to eliminate the use of a coagulant in the wastewater treatment process and drastically reduced the amount of mixed sludge waste. At the same time, we promoted the thorough sorting of waste for recycling and the sale of wastepaper and valuable metals and glass, which also contributed to a reduction in the amount of waste generated by the Eisai Group in Japan. Despite an increase in the amount of waste sent to landfill by 3 tons over fiscal 215, we recorded the ratio of waste sent to landfill to total waste of.43%, achieving the target of reducing the ratio to less than 1%. The recycling rate (including valuables) reached 62.8%, an increase of 5.1% compared with fiscal 215. Recycled Waste and recycling rate Amount recycled (including valuables) Recycling rate (including valuables) (t) 6, 5, 4, 3, 2, 1, ,255 4, ,575 3, ,94 2,973 Amount recycled Recycling rate ,11 3, ,238 2,86 (%) Waste for the Past Five Fiscal Years Note FY212 FY213 FY214 FY215 FY216 Sludge 3,143 2,523 1,636 1, Waste oil Waste acids and alkali Waste plastic Scrap metal Glass and ceramic waste Industrial waste and other General waste Amount of waste generated 6,28 4,917 4,1 3,481 2,935 Amount sold 1,82 1,546 1,879 2,36 1,622 Amount of waste generated and sold 8,11 6,463 5,88 5,841 4,557 Initiative for Recycling Resources In order to promote the establishment of a recyclingoriented society, it is essential to reduce the amount of waste generated in addition to reusing and recycling resources such as metal, glass, waste oil and paper products from waste. Based on this perspective, we actively promote the sale of equipment and devices for reuse as well as the recycling of scrap metal, glass bottles and waste oil. Also, to reduce the total amount of wastepaper, we are promoting the sale of wastepaper while avoiding Onsite Inspections of Waste-Processing Companies The Eisai Group in Japan has been conducting regular onsite inspections of its waste disposal contractors. For the purpose of checking that waste is being disposed of properly, periodic inspections are carried out for contractors engaged in the collection, transport, intermediate processing and final disposal of waste. During fiscal 216, a total of 65 onsite inspections were conducted by the Eisai Group in Japan at sites around the country, and it was confirmed that waste is being disposed of in an (tons) generation of unnecessary waste by devising better ways to proceed with meetings and to copy documents. We have expanded the scope of our efforts to promote the sale of wastepaper in Japan from operational sites and the head office to include sales offices. We also continue to reuse organic solvents, such as those used in the manufacture of active pharmaceutical ingredients, and sell these as auxiliary fuel. appropriate manner. For potential new contractors, we conduct careful screening that includes onsite inspections. At, in particular, new contracts are only signed after deliberation and approval by the Company-Wide Environment and Safety Committee, with priority given to government-certified excellent industrial waste management contractors. 12

13 7 Management of Chemical Substances Proper Management of PRTR Substances Chemical substances that are used in the research and development and production of pharmaceutical products include some substances subject to the PRTR system that could have an impact on the environment. The amounts of these substances handled, released into the environment and transferred as waste need to be understood and properly managed. Therefore, in addition to using our unique reagent management system to monitor the usage of reagents by the Eisai Group in Japan, we are also striving to reduce our usage of PRTR substances and to control their release into the environment. With regard to the usage of these substances exceeding the amount of the designated limit, we surely report this matter to the relevant prefectural governments without delay. The amount of chemical substances used in the manufacturing processes depends largely on the volume of pharmaceutical products produced. To maintain the quality of active pharmaceutical Actual Use of Substances Subject to the PRTR System (t) 1, ingredients, it is not easy to change manufacturing conditions after entering the commercial production phase. Therefore, we try to reduce the amount of chemical substances used by utilizing alternative solvents from the research and development stage and by developing synthesis processes that reduce the usage. At the same time, we actively promote the reuse of organic solvents and incorporate various means into the manufacturing processes to minimize their release into the atmosphere. The total amount of PRTR substances handled by the Eisai Group in Japan during fiscal 216 decreased 54.2% from fiscal 215 to 258 tons. Notifications were made to authorities for seven substances, three less substances than in fiscal 215. Because the inhouse production of vitamin E at the Kawashima Plant was terminated, water-soluble zinc compounds and isophytol no longer require reporting to the authorities. Additionally, there was a sharp decline in the amount of toluene handled. 499 Amount handled Amount released Transfers Fiscal 216 PRTR Data * for Eisai Group in Japan (Reported to Authorities) Chemical name Substance no. * Data on the usage of chemical substances subject to the PRTR system Volatile Organic Compounds (VOCs) Release Control VOCs, such as ethyl acetate, acetone and methanol, are highly volatile and turn into gas in the atmosphere, and as is the case with NOx discharged from production plants, cause the generation of photochemical oxidants. In view of preventing air pollution, these substances need to be controlled to reduce their release into the atmosphere. In response, main production plants and research facilities of the Eisai Group in Japan implement the same level of efforts as for PRTR substances to reduce the usage of VOCs and stipulate equipment operating procedures to minimize their release from production or research processes. The graph on the right shows the amount handled and released into the atmosphere of 55 substances (taken from the Ministry of the Environment s list of major 1 VOCs, excluding PRTR substances) for the past five fiscal years. Management of Fluorocarbons Number of operational sites We are making efforts to prevent leakage of fluorocarbons from the standpoint of curbing depletion of the ozone layer and global warming. The Eisai Group in Japan carries out a survey on the amount of fluorocarbons used every other year at its production plants and research facilities and is systematically renewing equipment. Additionally, as a response to the Act on Rational Use and Proper Management of Amount handled Into the atmosphere Release Into water bodies As waste Transfer (tons) To sewage Acetonitrile Ethylbenzene Dichloromethane (also known as methylene chloride) N, N-dimethylformamide Toluene Hexane Formaldehyde The total amount of VOCs handled during fiscal 216 declined 21.3% from fiscal 215, due mainly to the change of activities at the Kashima Plant, which resulted in a decrease of the VOC amount handled by the plant. The amount released into the atmosphere was held to just 4.1% of the total amount handled. Amount of VOCs Released from Production Plants and Research Facilities in Japan (t) 2,5 2, 1,5 1, 5 1, Amount handled Amount released into the atmosphere Fluorocarbons, we conduct regular inspections that also included offices for leakage of fluorocarbons from Class 1 Specified Products (commercial air conditioners and refrigeration and freezer equipment) that are subject to the Act. We also calculate the volume of leakage in each fiscal year and will make sure to report to the relevant authorities if the volume exceeds the reporting threshold ,

14 8 Saving Resources Efforts toward the SDGs Proper Management of Polychlorinated Biphenyl (PCB) Waste We have made early application to Japan Environmental Storage & Safety Corporation (JESCO) and have been proceeding with the disposal of waste containing or contaminated with high-concentration PCB. Currently, we store PCB waste at two sites, the Honjo Facility and Kawashima Plant, and the table on the right lists PCB waste by item. As the disposal site for the fluorescent ballasts stored in Tokyo and Saitama Prefecture was changed to the JESCO Hokkaido operational site, we have completed re-registration for disposal of 661 fluorescent ballasts stored at the Honjo Facility and are now on a waiting list for detoxification treatment. During fiscal 216, we have completed the disposal of low-concentration PCB waste that had been stored at the Honjo Facility. We are reporting the storage status without delay to the relevant prefecture as required under the Law Concerning Special Measures Against PCB Waste and are properly storing PCB waste in enclosures with locks and warning signs and with measures to prevent vaporization, dispersion and leakage. PCB waste still held by Eisai Quantity Low-concentration PCB waste (oil-extraction processing completed, casing only) 15 High-voltage capacitor 6 Low-voltage capacitor 3 Fluorescent ballast 665 Oil containing PCB 3 bags (37.5g) Non-metallic contaminants (chemical resistant gloves, plastic containers) 3 Effective Use of Water Resources As the sufficient acquisition of water resources is absolutely essential for the production of high-quality pharmaceuticals, the Eisai Group is working to ensure the quality of water discharged from its production plants and research facilities and is also implementing initiatives to reduce water consumption. We have an acute awareness of the need to conserve water and are taking such steps as minimizing consumption of water for production plants and reusing wastewater. In addition, we have established a framework for preventing the contamination of groundwater at Eisai production plants and research facilities in Japan in response to the Water Pollution Control Law. Eisai Group Water Consumption and Amount of Wastewater (1,m 3 ) 4, 3, 2, 3,562 2,948 3,82 3,125 In a survey carried out at the Eisai Group outside Japan, we confirmed that none of our production plants or research facilities are situated in areas with a high risk of having to stop operations due to water shortages in the near future. Over the medium to long term, however, there is an undeniable risk of water shortages due to the quickening pace of climate change and the resulting changes in the natural environment. We will endeavor to ensure a stable supply of high-quality products while effectively utilizing water resources and monitoring the information on water supply. 3,323 3,453 2,693 Water Consumption 2,77 Amount of Wastewater 3,147 2,446 1, Green Purchasing As one environmental effort undertaken by employees on a daily basis, the Eisai Group in Japan is promoting green purchasing, an initiative to purchase what is needed in the quantity needed, and if there are two products equivalent in both quality and price, to give preference to the one that is more environmentfriendly. By this initiative, we are gearing our efforts toward shifting away from a society of mass- production, mass-consumption and mass-waste. Eisai Co., Ltd., in particular, has been actively committed to this initiative through participation in the Green Purchasing Network * and in accordance with its own Green Purchasing Guidelines. * A network of companies, local governments and consumer groups (private organizations) supporting the concept of green purchasing 14

15 9 Air Pollutant Emissions and Pollutant Load in Wastewater Air Pollutant Emissions Eisai Group in Japan Group Companies outside Japan (tons) SOx Pollutant Load in Wastewater Eisai Group in Japan Group Companies outside Japan (tons) BOD Air Pollutant Emissions in Fiscal 216 by Site Category Operational site/company SOx (kg) NOx (kg) Soot and dust (kg) Kawashima Plant 48 6, Eisai Group in Japan Group Companies outside Japan Tsukuba Research Laboratories 2, EA Pharma Fukushima Plant Subtotal 48 9, Andover Research Institute 2 3,2 6 Vizag Plant 7,388 1,944 2,919 Morphotek Inc. 3 3,57 26 Subtotal 7,438 17,534 3,239 7,918 26,733 3, NOx Soot and dust Magnified scale Nitrogen Phosphorus Magnified scale Pollutant Load in Wastewater in Fiscal 216 by Site Category Eisai Group in Japan Group Companies outside Japan Operational site/company BOD (kg) COD (kg) Nitrogen (kg) Phosphorus (kg) Kawashima Plant 2,151 1, Tsukuba Research Laboratories 3,291 Kashima Plant Honjo Facility EA Pharma Fukushima Plant Subtotal 6, , Morphotek Inc. 84 Suzhou Plant 2 Vizag Plant 15,255 Subtotal 15, ,433 15,688 2, Note: indicates that no measurement was taken. 15

16 1 Principal Resource Input and Environmental Impact (Eisai Group in Japan) Kawashima Plant Kashima Plant KAN Research Institute, Inc. PRTR Substances Handled Kawashima Plant Electricity (MWh) 34,233 31,996 26,597 Processed natural gas (tons) 3,923 4,228 4,72 Liquefied petroleum gas (LPG) (tons) Amount generated (tons) Recycled amount (tons) Amount sent to landfill (tons) Air pollutant emissions and pollutant load in wastewater SOx (kg) 1, NOx (kg) 6,14 3,661 6,172 Soot and dust (kg) Water consumption (1, m 3 ) 2,471 2,635 2,317 Wastewater discharge (1, m 3 ) 2,142 2,211 1,938 BOD (kg) 3,941 3,46 2,151 Nitrogen (kg) 2,698 2,77 1,971 Phosphorus (kg) Electricity (MWh) 11,329 11,591 11,86 Industrial steam (GJ) 39,56 4,181 41,698 Liquefied petroleum gas (LPG) (tons) Amount generated (tons) 1,11 1,45 1,21 Recycled amount (tons) Amount sent to landfill (tons)... Air pollutant emissions and pollutant load in wastewater SOx (kg) NOx (kg) Soot and dust (kg) Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) BOD (kg) Nitrogen (kg) 76 Phosphorus (kg) 24 Electricity (MWh) 3,2 3,274 3,289 Processed natural gas (tons) Amount generated (tons) Recycled amount (tons) Amount sent to landfill (tons) Air pollutant emissions and pollutant load in wastewater SOx (kg) NOx (kg) Soot and dust (kg) Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) BOD (kg) Nitrogen (kg) Phosphorus (kg) indicates that no measurement was taken. Water-soluble zinc compounds (tons) Toluene (tons) 6 15 Isophytol (tons) Tsukuba Research Laboratories Acetonitrile (tons) Dichloromethane (tons) Hexane (tons) Kashima Plant Acetonitrile (tons) Ethylbenzene (tons) Dichloromethane (tons) N, N-dimethylformamide (tons) 2 7 Toluene (tons) Formaldehyde (tons) Hexane (tons) EA Pharma Co., Ltd., Fukushima Plant Acetonitrile (tons).7 Tsukuba Research Laboratories Electricity (MWh) 27,692 26,465 27,357 Processed natural gas (tons) 2,262 1,94 2,116 EA Pharma Co., Ltd., Fukushima Plant Electricity (MWh) 12,26 Liquefied petroleum gas (LPG) (tons) 1,569 Dichloromethane (tons) 27.7 KAN Research Institute, Inc. Xylene (kg) Chloroform (kg) Formaldehyde (kg) Fuel oil A (kl) Amount generated (tons) 464 Amount generated (tons) Recycled amount (tons) 119 Recycled amount (tons) Amount sent to landfill (tons).3 Amount sent to landfill (tons) Air pollutant emissions and pollutant load in wastewater Air pollutant emissions and pollutant load in wastewater SOx (kg) SOx (kg) 258 NOx (kg) 694 NOx (kg) 2,723 2,14 2,334 Soot and dust (kg) 12.6 Soot and dust (kg) Water consumption (1, m 3 ) 75 Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) 51 Recycled water (1, m 3 ) BOD (kg) 117 Wastewater discharge (1, m 3 ) Nitrogen (kg) 65 BOD (kg) 3,278 3,757 3,291 Phosphorus (kg) 24 Nitrogen (kg) Phosphorus (kg) 16

17 11 Principal Resource Input and Environmental Impact (Group Companies outside Japan) Eisai China Inc., Suzhou Plant (Jiangsu, China) Electricity (MWh) 1,22 1,52 11,9 Liquefied natural gas (LNG) (m 3 ) 1,31 1,8 631 Industrial steam (tons) 1,29 11,293 12,258 Amount generated (tons) Recycled amount (tons) Amount incinerated (tons) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) Phosphorus (kg) 29 2 Eisai (Liaoning) Pharmaceutical Co., Ltd., Benxi Plant (Liaoning, China) Electricity (MWh) 2,173 2,98 CWS (tons) 1,432 2,166 Light oil (kl) 9 12 Amount generated (tons) Recycled amount (tons) 6 12 Amount sent to landfill (tons) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) Phosphorus (kg) PT Eisai Indonesia, Bogor Plant (West Java, Indonesia) Electricity (MWh) 1,55 1,45 1,33 Light oil (kl) Liquefied petroleum gas (LPG) (tons) Amount generated (tons) Recycled amount (tons) Amount sent to landfill (tons) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) BOD (kg) Phosphorus (kg) Eisai Knowledge Centre, India (Andhra Pradesh, India) Electricity (MWh) 1,395 1,35 11,482 Light oil (kl) Liquefied petroleum gas (LPG) (tons) Amount generated (tons) Recycled amount (m 3 ) Amount incinerated (tons) Air pollutant emissions SOx (kg) 7,35 7,279 7,388 NOx (kg) 11,95 11,233 1,944 Soot and dust (kg) 3,26 3,13 2,919 Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) COD (kg) 19,39 22,511 15,255 Eisai Inc., Andover Research Institute (Massachusetts, U.S.) Electricity (MWh) 1,68 9,254 8,965 Natural gas (1,m 3 ) 1,893 1,124 1,588 Light oil (kl) Amount generated (U.S. tons) * Recycled amount (U.S. tons) Amount sent to landfill (U.S. tons) Air pollutant emissions SOx (kg) NOx (kg) 3,21 2,98 3,2 Soot and dust (kg) Pollutant load in Wastewater Water consumption (1, m 3 ) European Knowledge Centre (Hertfordshire, U.K) Electricity (MWh) 6,685 5,856 6,223 Natural gas (1,m 3 ) Light oil (kl) 4 3 Amount generated (tons) Recycled amount (tons) Amount sent to landfill (tons) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) Morphotek Inc., (Pennsylvania U.S.) Note Electricity (MWh) 9,45 9,151 8,675 Natural gas (decatherms) *2 55,16 42,93 48,883 Light oil (kl) Amount generated (U.S. tons) Recycled amount (U.S. tons) Amount sent to landfill (U.S. tons) Air pollutant emissions SOx (kg) NOx (kg) 3,47 3,39 3,57 Soot and dust (kg) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) BOD (kg) 1, Nitrogen (kg) Phosphorus (kg) 7 H3 Biomedicine Inc. (Massachusetts, U.S. ) Electricity (MWh) 3,618 4,82 4,75 Natural gas (decatherms) 1,547 4,92 4,19 Amount generated (tons) Recycled amount (tons) Amount sent to landfill (tons) Pollutant load in Wastewater Water consumption (1, m 3 ) Wastewater discharge (1, m 3 ) *1 One U.S. ton = metric tons *2 One decatherm = 1,55 MJ indicates that no measurement was taken. Note: Corrected data from past by recount Chemical Substances Used Suzhou Plant Ethanol (tons) Methanol (tons) Acetonitrile (tons) Ethyl acetate (tons) Benxi Plant Ethanol (tons) Methanol (tons).6.5 Ether (tons).4.3 Xylene (tons) Toluene (tons).3.2 Bogor Plant Methanol (l) Acetonitrile (l) Anhydrous ethanol (l) Andover Research Institute Methanol (U.S. tons) Ethyl acetate (U.S. tons) Acetonitrile (U.S. tons) Heptane (U.S. tons) Dichloromethane (U.S. tons) Methyl-t-butyl ether (U.S. tons) European Knowledge Centre Acetonitrile (tons) Methanol (tons) Ethanol (tons).1.1. Eisai Knowledge Centre, India (Note) Ethyl acetate (tons) Acetone (tons) Isopropyl acetate (tons) Methanol (tons) Ethanol (tons) Methyl-t-butyl ether (tons) n-heptane (tons) Dichloromethane (tons) Tetrahydrofuran (tons) N, N-dimethylformamide (tons) Morphotek Inc. Note Decon Quat 1 (quaternary ammonium solution) (kl) Decon Spore (kl) Decon Clean (residual remover) (kl) Ethanol (kl) H3 Biomedicine Inc. Acetonitrile (tons) Dichloromethane (tons) Ethyl acetate (tons) Hexane (tons)

18 12 Third-Party Verification of Greenhouse Gas Emissions Volume undergoes third-party verifications to improve the accuracy of measurement, aggregation, calculation and reporting methods for the amounts of greenhouse gasses emitted by the Group. In fiscal 217, seven business operational sites in Japan and eight business operational sites outside Japan, centering on production plants and research facilities, underwent verifications for Scope 1 emissions and Scope 2 emissions. 18