SmartPrep. Automated Cartridge Extractor. Horizon Technology, Inc. Salem, NH USA

Transcription

1 Automated Cartridge Extractor Horizon Technology, Inc. Salem, NH USA

2 Trace Organics Contaminants Sample Matrices Drinking Waters Municipal Water Bottled Water Reservoirs Waste Waters Storm Water Waste Effluents Surface Waters Lakes Rivers Steams Seawater Solid Waste Groundwater Landfills Beverages Beer Wine Juices Ground Waters

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4 Liquid-Liquid Extractions Separatory Funnel Strengths Simple process Relatively inexpensive Easy & well understood Weaknesses Labor intensive Best case 4 man hours to extract 20 samples Solvent intensive Cost to buy Cost to dispose of Environmental impact Incomplete extraction in some cases Emulsions; low recoveries Safety - exposure to solvent, repetitive movements, and glassware Quality - subject to human error

5 Strengths Rapid Can be automated Little solvent used Limited exposure to solvent, glassware, repetitive movement Automation will remove much of the human error Elution Weaknesses Perceived higher costs Training is required Different some labs fear change

6 SPE Process Conditioning Loading Sample Washing Eluting Conditioning Cleans sorbent bed or any manufacturing residues Activates particular sorbent chemistry and assures more reproducible flow rates Loading Sample Load sample at a flow rate so no breakthrough or channeling occurs Washing If needed used to get rid of interferences Use a washing solvent that will selectively remove the interfering compounds. Eluting Compounds of interest are eluted off cartridge and collected for further processing

7 Where Do Your Samples Fall In Line?

8 Automated Cartridge-Based Extraction System Unique Features: Prewritten with EPA Methods Modular & scalable : 1-8 Extractors Processes 1-12 samples per Extractor Individual method selection per sample Compatible with most 1, 3 or 6 ml cartridges Rinses the sample container automatically Accommodates (8) different reagents Solvent mixing station Collects up to 4 fractions per sample Reagent Management Assistant Small footprint Separates solvent and sample waste System status updated dynamically

9 SPE Cartridges Uses most kinds of commercially available cartridges (columns) Compatible with 1, 3 and 6 ml cartridges Proven methods, ideal for small clean sample Gives Horizon the ability to scale methods From method development to production

10 Loading Collection Rack Standard racks for 20 ml & 40 ml VOA vials, 13x100, 16x100 test tubes Custom racks are available per customer request

11 Graphical User Interface

12 Multi-Modules: Up to 8

13 Graphic Icons for Visual Feedback Green icons indicate that a reagent is being moved

14 Graphic Icons for Visual Feedback Additional Icons: Blue icons indicate that sample is being moved Yellow icons indicate that gas is being moved

15 Setup Module

16 Compose Method Upti-Clean C18-S

17 Typical SPE Method PolyClean HAX

18 Conclusion Scalable You can process one sample to as many as 96 Samples Flexible Can run 12 different methods per module, and up to 8 modules Method development a snap with 4 fractions per sample 8 different solvents and solvent mixing Small Foot Print Does not take up lab space, easily fits in hood Easy to use Intuitive software, designed for a chemists by chemists Easy setup Segregated waste lines for aqueous and organics SmartPrep Technology Reagent Management Assistant (RMA) Dynamic status and error messages Post run reports for QA Pre and post run routines Common SPE Cartridge Format Many methods already developed for 1,3,6 ml SPE cartridges

19 Popular SPE Applications Total Extractable Hydrocarbons : C10 to C40 Drugs of abuse : BZE (benzoylecgnonine = metabolite of cocaine), amphetamines, morphine's and cocaine in urine, blood, plasma and oral fluids prior to GCMS Acid, basic and neutral drugs in animal urine : horses greyhounds, bulls, camels SPE Sudan I and IV additive screening : prohibited dyes (red) in food, solvents, oils, waxes, shoes, floor polishes

20 Popular SPE Applications Organic compounds from marine sediments, soil and dust samples : alkenones (2-nonadecanone), tetra ethers, n-alkanes, sterols and fatty acids to chart temp. changes Vitamin D or its metabolite 24,25 dihydroxyvitamin-d3 from plasma, blood and urine Antibiotics in animal feed : corn, rice, grains Organic acid profiles in wines Cyclosporine in Blood = immunosuppressant used in organ transplants

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