smarter solutions better adherence improved results

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1 smarter solutions better adherence improved results

2 Medication non-adherence is a big problem Costs the healthcare system roughly $300 billion Prescription Adherence Rates Significant drop in adherence across chronic disease states in the first 3 months Adherence Rate 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Diabetes Cardiovascular Oncology Respiratory Months on therapy Source: SDI Patient Adherence is the Holy Grail 1) Complexity of Solutions 2) Spotty data to prove returns 3) Based on Behavioral Science Healthcare market is changing 1) Shift from treating to preventing 2) Regulations limit access to patients and physicians 3) Cost of new scripts is escalating

3 One size does not fit all To improve adherence the package must drive patient engagement Design Excellence + Tailored Solution = Improved Results Award Winning Designs More than just graphic art Balancing of Aesthetics, Functionality and Cost Adherence by Design Patient adherence program Solutions targeted to specific therapeutic challenges Increased Adherence Packaging can improve patient persistency Data to support that claim Adherence packaging starts with the fundamentals & adds adherencespec features Addressing multiple drivers is key to enhancing patient engagement Quantitative data isolating the persistency to a medication of 200K+ patients based on packaging format. Fundamentals Contain Protect Transport Preserve Customer Communication Reminder Prompting Personal Intervention Specialty packaging +17 Point Increase in patient persistency comparing 30-count Adherence Package versus 30-count Bottle Safety Prompting Engagement Communication Cost Burden

4 Designing a patient adherence solution Starts with addressing the functionality of the package Certain requirements are at the core of all packaging designs: Contain Dosage Form Protect Physical & Barrier Preserve Shelf Life, Efficacy Transport Distribution Channel Inform Regulatory Label Requirements Sell Brand Promise

5 To drive improved patient adherence Packaging must also meet Catalent s adherencespec Safety: Level of Child-Resistance* Prompting: The right dose at the right time Reminder Features & Dose Tracking: Time, Date, Dosage Amount Engagement: Adopt package to fit the lifestyle Connect with the patient or caregiver and provide helpful information in the right form. Communication: Provide confidence and comfort Educate and inform Deliver the brand promise * In the US, The PPPA requires the use of special packaging of harmful household substances including most Rx and OTC drug products

6 Tailoring solutions by customizing features Minimize adherence barriers and drive patient engagement Patient centric features Ease of use Creating positive opening experience for the user Right dose and the right time Simplify the dosing process for the patient Reminder prompting through the layout as well as the printing of dates/numbering/icons Titration packs are prime examples Discrete and Portable Package must be adaptable to fit the user s lifestyle Decrease the cost burden Attaching/integrating assistance programs directly to the package, i.e. Co Cards and Coupons

7 Transform packaging into a communication vehicle An intimate opportunity at the point of use Leveraging billboard space for patient communication Provide confidence and comfort through education Disease state Patient instructions Patient guidance Patient support Deliver the brand promise Convey the benefits and encourage persistence

8 Catalent s Media Enhanced Packaging technology Turns the package into an Internet portal A digital watermark is embedded into the graphics of the pharmaceutical packaging Through a smartphone app allows the patient to connect to internet This provides additional opportunities to - Communicate your brand message - Increase consumer reach - Real time content management - Provide additional information i.e., instructions, coupons or multiple languages Watermark is invisible to the human eye Takes up no package real estate

9 Applying the design principles of adherencespec Patient adherence packaging beyond a pill DelPouch Starter Kit Award Winning Design HCPC 2010 Innovative Design of the Year Safety Unit dose delivery system of topical treatment Prompting Night/day configuration, Printed days of the week Engagement Physician notes, Copay/Savings card, Convenient, Portable Communication MEP technology in 3 location, clear instructions with illustration, Brand messaging

10 Catalent: The partner of choice Strength in design, customization, and commercializing Expert Design Capabilities In-house package design team Prototyping & tooling expertise Ability to conceive, test and pilot Customized Solutions To meet your specific challenges Tailored adherence packaging Commercial Scale Extensive expertise and specialized capabilities Global footprint with a proven track record of success Unmatched expertise in biotech and cold chain solutions

11 discover more. CATALENT PHARMA SOLUTIONS 3001 RED LION ROAD PHILADELPHIA, PA adherence@catalent.com