Personal Organic Purification

Transcription

1 Personal Organic Purification Optimize gradient at any time during run Purify 5 mg - 33 gm without additional hardware Separate compounds using normal or reversed phase chromatography Monitor and control from your PDA, desk or laptop PC Performance With Peace of Mind

2 Isco is... a designer, manufacturer and worldwide marketer of instruments used in the laboratory and the field. Our reputation for delivering robust reliability has been built up over 40 years of serving our customers. Just about everything we provide is made at our factory. We are a bricks-and-mortar manufacturing company employing more than 500 people in the pursuit of offering outstanding quality products and services. Our customers are involved in pharmaceutical research, chemical research and quality control. They use our innovative, technology based instruments to improve the quality of life on our planet. We love to talk to our customers. We find that, like us, they are looking for ways to move technology forward. Everyone wants the best possible tool for their job. Magic happens when there is a connection between a customer's need and our company s capabilities. One such moment happened 6 years ago when Isco introduced our CombiFlash line of organic purification systems. We are the pioneers in automated flash chromatography and the first with multi-sample parallel and sequential systems. These systems serve the diverse needs of organic synthetic chemists who are working on the creation of new compounds, and are particularly popular with those involved in drug discovery and chemical research. 1961, our founder and CEO, Dr. Bob Allington soon after his MIT days with an early fraction collector. Today nearly 2000 of Isco's automated flash systems have been embraced by our customers. We have taken what we have learned from you over the years and are bringing you the CombiFlash Companion personal purification system. The CombiFlash Companion is the most advanced, yet simplest to use, organic purification system available.

3 Performance with peace of mind All new with Isco's latest advances in real-time control, convenience and capability, CombiFlash Companion can be relied on to perform all types of purification including normal and reversed phase flash separations. Precious compounds stay in the lab at the bench for purification. Quick changes for pure compounds in less time Any size RediSep column can be installed on the CombiFlash Companion. The CombiFlash Companion senses the column size and will program itself to run optimal conditions for that column. Default parameters are established at the factory, and can be adjusted for customized method development. Get pure compounds quickly - the first time! Changes to the method are accomplished during the separation. Precision packed RediSep columns consistently provide more pure compound in less time than any glass column or other disposable columns. Move on to the next step The CombiFlash Companion's advanced automation and powerful internet communication capabilities allow system control and monitoring from either a hand-held computer or remotely, from your desktop PC. It will even send you an to let you know that it's all done. Remote access lets you choose where to monitor and control your CombiFlash Companion. A new standard of ease for walk-away automation.

4 Method parameters may be changed during the run. Companion provides real-time method control including click-and-drag gradients. Automatic column size recognition for optimum method conditions. Errors are eliminated with auto-method configuration when column sizes are changed. Companion uses all sizes of RediSep columns without additional hardware. Pure compounds for synthesis. Companion provides industry leading, peak cutting software providing only the purest compounds for synthesis. Automatic run extension collects all of the peaks. Selectable UV wavelength. Diode array spectrophotometer detects a wide array of compounds. Change solvents quickly. Convert from normal to reversed phase operation in minutes. Uses PC, laptop or hand-held computer. Control or monitor Companion from anywhere using any internet connection with Windows Explorer. Modern ergonomic design. Companion also integrates space-saving solvent storage for efficient use of lab space. Isco s reliable, versatile Foxy fraction collection. Companion is capable of high capacity collection - up to 1440 tubes! Auto rack-sensing eliminates spilled compounds. Automatic data archive. Data is stored and ed automatically at the end of the run. Safety exceeds regulatory requirements. The Companion is equipped with a vapor sensor, over-pressure sensor and has a fully grounded solvent path. Shut-down at the end of the run is automatic. Click on the graph to make changes. Color-coded peaks and test tubes. Change gradient slope. Install any RediSep column without hardware changes. Companion calls up the default method for that column. Just press. Click and drag the gradient any time during the run. Make changes as you go. Final results with tubes highlighted. Take your compound to the next step.

5 CombiFlash Companion Specifications Samples per run: 1 Solvent delivery: Two maintenance-free, valveless metering pumps Safety certification: CE Programmable gradients: 2-solvent isocratic, linear and/or step gradient Flow rate: ml/min Rated pressure: 50 psi Liquid sample loading: Injection valve to load column directly Solid sample loading: Solid load cartridge for low-solubility samples On-line UV detection: Photo diode array absorbance detector ( nm) Fraction collection: Foxy fraction collector with 1440 tube capacity Optional tube sizes: Racks available for 12, 13, 16, 18, & 25 mm tubes and other containers Power options: 100/117 VAC, 50/60 Hz; 234 VAC, 50/60 Hz System dimensions (H x W x D): 49 x 49 x 54cm Weight: 26.4 kg CombiFlash Companion Selection Guide CombiFlash Companion. Compact, one-channel gradient system with 100 ml/min max flow rate. Includes 1 collection rack for 18 mm tubes, PeakTrak TM control and data storage software, one package each of 12-gram (20/pkg) and 40-gram (15/pkg) RediSep TM Disposable Flash Columns, and one package empty, 5-gram sample load cartridges RediSep Normal Phase Columns 4-gram RediSep disposable Flash columns, pkg. of gram RediSep disposable Flash columns, pkg. of gram RediSep disposable Flash columns, pkg. of gram RediSep disposable Flash columns, pkg. of gram RediSep disposable Flash columns, pkg. of gram RediSep disposable Flash columns, 12 pkgs. of 20, (240 columns) gram RediSep disposable Flash columns, 12 pkgs. of 20, (240 columns) gram RediSep disposable Flash columns, 12 pkgs. of 15, (180 columns) gram RediSep disposable Flash columns, 12 pkgs. of 10, (120 columns) gram RediSep disposable Flash columns, 12 pkgs. of 4, (48 columns) RediSep Reusable Reversed Phase (C18) columns 4.3-gram reusable Reversed Phase RediSep columns, two columns per pkg gram reusable Reversed Phase RediSep column, one column per pkg gram reusable Reversed Phase RediSep column, one column per pkg gram reusable Reversed Phase RediSep column, one column per pkg Disposable solid sample load cartridges (Bulk packages also available please inquire) Sample load prepacked silica gel cartridges, 5 gram, pkg. of Sample load prepacked silica gel cartridges, 25 gram, pkg. of Sample load, empty cartridges, (holds up to 5 grams of media) pkg. of Sample load, empty cartridges, (holds up to 25 grams of media) pkg. of Isco, Inc Superior Street Lincoln, NE USA Toll free: (800) (USA & Canada) Phone: (402) Fax: (402) info@isco.com Brochure L-5118 Printed in the U.S.A. All rights reserved. 1/03