PROPYLENE OXIDE. 1. Product Identification. 2. Composition/Information on Ingredients. 3. Hazards Identification

Transcription

1 MSDS Number: P6961 * * * * * Effective Date: 04/08/11 * * * * * Supersedes: 11/17/99 1. Product Identification PROPYLENE OXIDE Synonyms: Oxirane, methyl; propene oxide; epoxy propane; 1,2-propylene oxide; 1,2-Epoxypropane; Methyl Ethylene Oxide CAS No.: Molecular Weight: Chemical Formula: C3H6O Product Codes: Composition/Information on Ingredients Ingredient CAS No Percent Hazardous Propylene Oxide % Yes 3. Hazards Identification Emergency Overview DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. HARMFUL IF SWALLOWED OR INHALED. CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. VAPOR IS IRRITATING TO EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM. POSSIBLE CANCER HAZARD. MAY CAUSE CANCER BASED ON ANIMAL DATA. Risk of cancer depends on duration and level of exposure. Potential Health Effects Inhalation: Vapor is irritating to the mucous membranes and upper respiratory tract. May cause depression of the central nervous system. Symptoms may parallel those from ingestion exposure. Ingestion: Corrosive. Swallowing can cause severe burns of the mouth, throat, and stomach. Can cause sore throat, vomiting, diarrhea. May cause depression of central nervous system. Symptoms may include headache, nausea,

2 vomiting, drunkenness. incoordination, dizziness, and general depression. May cause abnormal liver function as detected by laboratory tests. Skin Contact: Corrosive. Symptoms of redness, pain, and severe burn can occur. Diluted solutions are more irritating than undiluted materials. May be absorbed through the skin with possible systemic effects. Eye Contact: Corrosive! Vapors are irritating and may cause damage to the eyes. Contact may cause severe burns and permanent eye damage. Chronic Exposure: Suspected carcinogen. Positive animal studies showed local tumors after oral gavage in rats in a dose-dependent manner. Aggravation of Pre-existing Conditions: Persons with pre-existing skin disorders or impaired liver, kidney, or pulmonary function may be more susceptible to the effects of this agent. 4. First Aid Measures Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician immediately. Ingestion: DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Call a physician immediately. Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physician, immediately. Wash clothing before reuse. Eye Contact: Immediately flush eyes with gentle but large stream of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Call a physician immediately. 5. Fire Fighting Measures Fire: Flash point: -37C (-35F) CC Autoignition temperature: 449C (840F) Flammable limits in air % by volume: lel: 2.3; uel: 36 Extremely Flammable. Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along surfaces to distant ignition source and flash back. Material is highly volatile and readily gives off vapors which may travel along the ground or be moved by ventilation and ignited by pilot lights, other flames sparks, heaters, smoking, electric motors, static discharge or other ignition sources at locations distant from material handling point. Sensitive to static discharge. Fire Extinguishing Media: Water spray, dry chemical, alcohol foam, or carbon dioxide. Water spray may be used to keep fire exposed containers cool, dilute spills to nonflammable mixtures, protect personnel attempting to stop leak and disperse vapors. Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

3 6. Accidental Release Measures Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., dry sand, earth), and place in a chemical waste container. Do not use clay-based absorbents, as this material reacts with clay. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) Handling and Storage Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Wear special protective equipment (Sec. 8) for maintenance break-in or where exposures may exceed established exposure levels. Wash hands, face, forearms and neck when exiting restricted areas. Shower, dispose of outer clothing, change to clean garments at the end of the day. Avoid cross-contamination of street clothes. Wash hands before eating and do not eat, drink, or smoke in workplace. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product. 8. Exposure Controls/Personal Protection Airborne Exposure Limits: -OSHA Permissible Exposure Limit (PEL): 100 ppm (TWA) -ACGIH Threshold Limit Value (TLV): 20 ppm (TWA) -Immediately dangerous to life or health (IDLH): 400 ppm (NIOSH) Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details. Use explosion-proof equipment. Personal Respirators (NIOSH Approved): If the exposure limit is exceeded, wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece self-contained breathing apparatus. This substance has poor warning properties. The cartridges recommended for this material have a predicted service of less than 30 minutes at concentrations of ten times (10x) the exposure limits. Actual service life will vary considerbly, depending on concentration levels, temperature, humidity, and work rate. Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.

4 9. Physical and Chemical Properties Appearance: Clear, colorless liquid. Odor: Ethereal odor. Solubility: C in water Specific Gravity: 20C (68F) ph: No information found. % Volatiles by 21C (70F): 100 Boiling Point: 34C (93F) Melting Point: -112C (-170F) Vapor Density (Air=1): 2.0 Vapor Pressure (mm Hg): 20C (68F) Evaporation Rate (BuAc=1): No information found. 10. Stability and Reactivity Stability: Stable under ordinary conditions of use and storage. Hazardous Decomposition Products: Carbon dioxide and carbon monoxide may form when heated to decomposition. Hazardous Polymerization: If polymerization takes place in container, there may be heat and a violent rupture of container. Hazardous polymerization can occur when in contact with highly active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminum; alkali metal hydroxides; and peroxides of iron and aluminum. Incompatibilities: Acids, bases, oxidizing agents, high temperatures, polymerization catalysts, and epoxy resins. Violently reacts with acetylide-forming metals such as copper or copper alloys. Conditions to Avoid: Heat, flames, ignition sources and incompatibles. 11. Toxicological Information Toxicological Data: Oral rat LD50: 380 mg/kg; inhalation rat LC50: 4000 ppm/4h; skin rabbit LD50: 1500 ul/kg; investigated as a mutagen, tumorigen, reproductive effector. Reproductive Toxicity: This material has been linked to mutagenic effects in humans \Cancer Lists\ NTP Carcinogen--- Ingredient Known Anticipated IARC Category Propylene Oxide ( ) No Yes 2B

5 12. Ecological Information Environmental Fate: When released to moist soil or water, this material is expected to hydrolyze. When released into the soil, this material may leach into groundwater. When released into the soil, this material may evaporate to a moderate extent. When released into water, this material is expected to have a half-life between 10 and 30 days. When released into water, this material may evaporate to a moderate extent. This material has an estimated bioconcentration factor (BCF) of less than 100. This material is not expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into air, this material is expected to have a half-life between 10 and 30 days. Environmental Toxicity: The LC50/96-hour values for fish are over 100 mg/l. This material is not expected to be toxic to aquatic life. 13. Disposal Considerations Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements. 14. Transport Information Domestic (Land, D.O.T.) Proper Shipping Name: PROPYLENE OXIDE Hazard Class: 3 UN/NA: UN1280 Packing Group: I Information reported for product/size: 2KG International (Water, I.M.O.) Proper Shipping Name: PROPYLENE OXIDE Hazard Class: 3.1 UN/NA: UN1280 Packing Group: I Information reported for product/size: 2KG 15. Regulatory Information \Chemical Inventory Status - Part 1\ Ingredient TSCA EC Japan Australia Propylene Oxide ( ) Yes Yes Yes Yes \Chemical Inventory Status - Part 2\ Canada-- Ingredient Korea DSL NDSL Phil Propylene Oxide ( ) Yes Yes No Yes

6 \Federal, State & International Regulations - Part 1\ SARA SARA Ingredient RQ TPQ List Chemical Catg Propylene Oxide ( ) Yes No \Federal, State & International Regulations - Part 2\ RCRA- -TSCA- Ingredient CERCLA (d) Propylene Oxide ( ) 100 No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: Yes SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No Reactivity: Yes (Pure / Liquid) WARNING: THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER. Australian Hazchem Code: 2PE Poison Schedule: S7 WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR. 16. Other Information NFPA Ratings: Health: 3 Flammability: 4 Reactivity: 2 Label Hazard Warning: DANGER! EXTREMELY FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. HARMFUL IF SWALLOWED OR INHALED. CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. VAPOR IS IRRITATING TO EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM. POSSIBLE CANCER HAZARD. MAY CAUSE CANCER BASED ON ANIMAL DATA. Risk of cancer depends on duration and level of exposure. Label Precautions: Do not breathe vapor. Do not get in eyes, on skin, or on clothing. Wash thoroughly after handling. Keep away from heat, sparks and flame. Keep container closed. Use only with adequate ventilation. Label First Aid: In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. In all cases call a physician immediately. Product Use: Laboratory Reagent. Revision Information: No changes.

7 Disclaimer: ********************************************************************************************** THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS) WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE IN THEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDED HEREIN IS PROVIDED AS IS, AND AVANTOR PERFORMANCE MATERIALS MAKES AND GIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLY DISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TO WHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDING WITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS, MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY, STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISING FROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THIS MSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARY HANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT, AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONS OF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALS RECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENT JUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY, AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THE USE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE ARE INTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATION TO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, OR FOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOUR LEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUR EMPLOYEES. ********************************************************************************************** Prepared by: Environmental Health & Safety