New Roc LC Columns The Reliable Cornerstone for Your LC Lab

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1 Product Launch Training New Roc LC Columns The Reliable Cornerstone for Your LC Lab Paul Connolly Business Manager Liquid Chromatography

2 Objectives What is Roc The competition Where to position Roc Product Offering Collateral

3 What is Roc Roc is a Conventional HPLC Column Line Roc is a quality, rugged, reproducible HPLC column. Roc is designed and built for everyday analytical needs. Roc provides solid performance and exceptional value.

4 Product Offering 100, 150, and 250 mm Lengths 3.0 and 4.6 mm IDs

5 Product Offering High Purity Type B Silica 3 and 5µm Low surface activity Low metals content

6 Product Offering 5 Phases C18 C8 Phenyl-Hexyl Cyano Silica New for Restek

7 Product Offering

8 Product Offering 10 x 4 mm, 5µm guard cartridge New Roc Guard Holder matches Roc columns

9 Roc Pricing Structure US List Pricing $ Roc Ultra Pinnacle II $ $ $ $ $ $0.00 3µm, 100 x 3.0 mm 5µm, 250 x 4.6 mm 3 pack Guards

10 Roc Competitively Priced Major Column Competitors LC Columns US List Price* Complementary Guard Cartridges LC Guard Cartridges US List Price (per cartridge)** Restek Roc $325 Restek Roc $40 Agilent Zorbax $569 Agilent Zorbax $52 Thermo Hypersil $586 Thermo Hypersil $144 Phenomenex Luna $705 Phenomenex Security Guard $40 Waters Symmetry $720 Synnetry C18 Sentry Guard $118 $0 $100 $200 $300 $400 $500 $600 $700 $800 *US List for a 150 x 4.6 mm 5um C18 Column $0 $20 $40 $60 $80 $100 $120 $140 $160 **US List for the recommended C18 Guard. Part List Price/quantity per pack shown

11 Roc Rugged for Long Life % Efficiency vs # of Injections Roc TM C bar 104 % Efficiency x4.6mm 150x4.6mm 250x4.6mm 100x3.0mm 150x3.0mm 250x3.0mm Number of Injections

12 Roc Exceptional Reproducibility Roc C18 5um, 150 x 4.6 mm columns from multiple lots Reverse Phase Test Roc Cyano 3um, 100 x 3.0mm columns from multiple lots Normal Phase Test

13 Roc Guard Cartridge Column Protection Roc Guard Column Cartridge and Holder Little To No change in Chromatography with Guard Change in Retention = 0 Change in Asymmetry = Change in Efficiency = + 6,072 N/m

14 Roc Packaging More of what you need, and less of what you don t.

15 Roc Packaging Remarkable reduction in packaging means less shipping cost and less storage space needed 250mm column Traditional packaging x 5 x 1.75 = cubic inches Roc packaging 12 x x = cubic inches 86.4% reduced volume! 15 / 9

16 Roc Packaging Remarkable reduction in packaging means less shipping cost and less storage space needed 100mm column Traditional packaging 9.5 x x 1.75 = 60.3 cubic inches Roc packaging 6 x x = 7.6 cubic inches 87.4% reduced volume! 16 / 9

17 Roc Packaging Secure, rugged packaging means confidence. Columns returned in intact package after rigorous shipping studies: Cross country ground (United States) and international air shipping Tested in both an envelope and an outer box 17 / 9

18 Roc Packaging Secure, rugged packaging means confidence. Columns safely and firmly suspended in tube with locking tabs. 18 / 9

19 Roc Packaging Secure, rugged packaging means confidence. Shrink-band seal: Tightly secures cap Allows obvious tamper evidence Perforated for hassle-free removal 19 / 9

20 Roc Packaging Online Certificates of Analysis means less waste. Lost copy? Need duplicate copies? Need it now? Problems solved! For your LC certificate of analysis go to: clearly printed on every column package insert. Packaging process is streamlined, less printing. Save customer time and worry certs always immediately available. Less is more! 20 / 9

21 Roc Packaging Online Certificates of Analysis means less waste. Visit Enter catalog and serial numbers Click pdf link in Certifications column View, save, or print certificate 21 / 9

22 Roc Packaging Online Certificates of Analysis means less waste. 22 / 9

23 Roc Guard Column Cartridge Packaging Roc Guard Holder Packaging 23 / 9

24 Conventional HPLC Instruments Intermediate HPLC UHPLC 400 bar Highest system volume $ 600 bar Moderate system volume $$ 1000 bar Lowest system volume $$$ The main differences are cost, operating pressures, and system volumes

25 Roc Target Customers HPLC users who are running standardized and/or Compendia methodology Environmentally or Economically conscious Looking for a rugged reproducible HPLC column for routine testing

26 Roc Target Customers USP Monographs, Breakdown by Phase L1 C % L7 C % L3 Silica 303 5% L11 Phenyl 300 5% L10 Cyano 237 4% L8 Amino 119 2% % of USP Methods

27 Example USP Monograph for Caffeine: Roc Target Customers Recommendation: Roc C18, 5µm, 150 x 4.6 mm, Part #

28 Roc Target Customers Nutritional Manufacturers and Labs Generic Pharmaceutical Manufacturers CMC Testing: Chemistry, Manufacturing and Controls. From early characterization, raw material and compendia testing; formulation and method development through commercial release and stability. Environmental Labs Food Labs

29 Business/Customer Opportunity Raptor [Premium] Clinical Diagnostics Innovation/Technology Conscious Reliability Speed & Throughput LC-MS/MS Roc [HPLC] Pharma/CMC Environmental Emerging Markets Price Conscious Reliability HPLC

30 Product Offering/Rationale 2.7µm SPP 5µm LC-MS/MS Market mm x 2.1mm Raptor Premium Phases Biphenyl, C18, FluoroPhenyl, Polar Amplified 3µm 5µm HPLC Market mm x mm Roc Standard Phases C18, C8, P-H, CN, Si FPP

31 Roc Complete Product Offering Roc C18 HPLC Columns (USP L1) Roc C8 HPLC Columns (USP L7) Roc Phenyl-Hexyl HPLC Columns (USP L11) Roc Cyano HPLC Columns (USP L10) Roc Silica HPLC Columns (USP L3) Roc LC Guard Column Cartridges Roc LC Guard Column Holder Replacement PEEK Ferrules

32 Buy in Bulk and Save Roc C18 5µm, 150 x 4.6 mm US List: $325 Improve your Margin by taking stock of Roc Columns List 30% Discount $325 $ column 5µm x 150 x 4.6 mm Brazil China Germany India Economy Shipping $53.56 $47.74 $42.28 $53.41 Duty Rate 14% 0% 0% 7.5% Landed Cost $ $ $ $ columns 5µm x 150 x 4.6 mm Brazil China Germany India Economy Shipping $53.56 $47.74 $42.28 $53.41 Duty Rate 14% 0% 0% 7.5% Landed Cost $1, $1, $1, $1, Landed cost/column $ $ $ $ Savings/column $42.85 $38.19 $33.82 $ columns 5µm x 150 x 4.6 mm Brazil China Germany India Economy Shipping $53.56 $47.74 $42.28 $53.41 Duty Rate 14% 0% 0% 7.5% Landed Cost $2, $2, $2, $2, Landed cost/column $ $ $ $ Savings/column $48.20 $42.97 $38.05 $48.07

33 Collateral Roc Landing Page ( Roc Sales Sheet (POD) : GNSS2332-UNV Press Release : GNPR2330-UNV E-Blast : GNEB2331-UNV On Web Ad What s New Social Media Product Pages

34 The Reliable Cornerstone For your LC Lab

35 Roc Sales Sheet : GNSS2332-UNV The Reliable Cornerstone For your LC Lab

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37 Questions can be directed to your Restek Sales Manager or to Paul Connolly, Business Manager, Liquid Chromatography Thank you