Material Safety Data Sheet

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1 Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 1 Health Hazard Fire Hazard 2 1 See Section 15. Section 1. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Calcium Hydroxyapatite SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA 9248 Calcium Hydroxyapatite 4 mesh powder Calcium Hydroxyapatite Catalog Number(s). CAS# RTECS TSCA CI# C1264 IN CASE OF EMERGENCY CHEMTREC (24hr) Page Number: 1 TSCA 8(b) inventory: No products were found. Chemical Family Chemical Formula Supplier SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA 9248 CALL (31) Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight 1) Calcium Hydroxyapatite 1 Toxicological Data on Ingredients Calcium Hydroxyapatite LD5: LC5: Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Hazardous in case of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact (irritant), of ingestion. CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: Classified None. for human. TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male, Development toxin [None.]. Repeated or prolonged exposure is not known to aggravate medical condition.

2 Calcium Hydroxyapatite Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks, of oxidizing materials. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Slightly explosive in presence of open flames and sparks. Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion hazard. Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

3 Calcium Hydroxyapatite Page Number: 3 Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 24 C (75.2 F). Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.) Odor Molecular Weight ph (1% soln/water) Taste Color Beige. Boiling Point Melting Point Critical Temperature Specific Gravity Vapor Pressure Not applicable. Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility Section 1. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat, dust generation

4 Calcium Hydroxyapatite Page Number: 4 Corrosivity Polymerization Will not occur. Section 11. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. LD5: LC5: MUTAGENIC EFFECTS: Classified None. for human. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male, Development toxin [None.]. Hazardous in case of inhalation. Slightly hazardous in case of skin contact (irritant), of ingestion. Acute Potential Health Effects: Skin: It is unlikely to cause skin irritation or injury. Eyes: May cause eye irritation. Inhalation: This materials is a dust or may produce dust. It may cause respiratory tract irritation. Breathing small amounts of this material during normal industrial handling is not likely to be harmful. Ingestion. Swallowing small amounts of this material during normal industrial handling is not not likely to be harmful. The toxicological properties of this substance have not been fully investigated. Section 12. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Section 13. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations.

5 Calcium Hydroxyapatite Page Number: 5 Section 14. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Not applicable. Special Provisions for Transport Not applicable. DOT Section 15. Other Regulatory Information and Pictograms Federal and State Regulations No products were found. California Proposition 65 Warnings Other Regulations Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) R36- Irritating to eyes. S2- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 2 1 E National Fire Protection Association (U.S.A.) Health 1 Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment

6 Calcium Hydroxyapatite Page Number: 6 Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. Section 16. Other Information MSDS Code References Other Special Considerations C3331 Validated by Sonia Owen on 8/11/26. Verified by Sonia Owen. Printed 9/11/26. CALL (31) Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.