CellaVision DM96. Automated Digital Cell Morphology

Transcription

1 CellaVision DM96 Automated Digital Cell Morphology

2 Advanced Technology Automated Digital Cell Morphology is the process by which cells are automatically located on a stained peripheral blood smear, pre-classified, stored and transmitted for confirmation by a technologist. This technology dramatically improves the efficiency and proficiency of the historically subjective differential review. Additionally, the advances in image analysis and network integration allow the cell image to finally become an integral part of the patient's record. The CellaVision DM96 is an Automated Digital Cell Morphology and Informatics System for the location, pre-classification, display, storage and transmission of red and white blood cell images. Using an Artificial Neural Network (ANN), WBCs are pre-classified and RBC morphology is pre-characterized, grouped, and stored to await technologist confirmation. ANNs are exceptionally good in pattern recognition and classification due to their ability to generalize and make decisions about imprecise data. The CellaVision DM96 analyzes over 250 specific characteristics for each cell during the classification process. Quality assurance. CellaVision DM96 allows different technologists to perform differentials at the same high level of consistency. The system provides traceability of results at the individual cell level. Connectivity. Multiple Remote Review Stations enable supervisory review, inter/intra-lab comparison and the opportunity for real-time collaboration with Pathology. Efficiency. Automatic cell location and pre-classification, along with unique cell views, reduce the time spent performing differentials, training new techs and monitoring proficiency. Value to clinicians. As a result of network integration, the CellaVision DM96 will provide new value to clinicians, saving them time with remote, real-time access to a patient's image history.

3 Quality, Consistency and Efficiency Utilizing CLSI guidelines in conjunction with a neural network trained on thousands of cells identified by a group of global experts, the CellaVision DM96 offers an opportunity to improve efficiency and consistency. With continued cost constraints and the shortage of skilled technologists, especially in differential analysis, the CellaVision DM96 permits technologists to use their skills to the best benefit of the laboratory. Laboratory Benefits: Maintain High Quality Use of CLSI guidelines standardizes performance across all techs, shifts and location Viewing cell classes side by side Access to on-board, customized, reference cell library Access to a patient's image history, months or years back in time Complete traceability of results at the individual cell level Standardizes training and proficiency testing Improve Resource Utilization Automatic cell location and pre-classification performed at slides per hour, including leukopenic samples "Diff at a Glance" allows confirmation of cell counter results in seconds Networking allows centralized review and/or remote operation of multiple locations Improved ergonomics increases employee satisfaction Extensive Database Quick access to results and images for consults, collaboration and education Trend and compare patient progress over time Permanently store images without degradation over long time periods Unlimited results and images can be stored on the LAN Find results quickly and easily using multiple criteria Ability to search the database by 15 criteria including: doctor, technologist and comments Remotely Share Images via Tele-hematology Review images with experts regardless of location Users anywhere on the network can open the same slide simultaneously for collaboration Multiple Remote Review Stations enables supervisory review, inter/intra-lab comparison and the opportunity for real-time collaboration with pathology Flexible Result Outputs Bi-directional LIS interface Print reports

4 Diff at a Glance It is now possible to quickly screen for abnormalities, allowing fast confirmation of the CBC analyzer's results. When classifications need to be changed, cells can be dragged and dropped into the appropriate cell class. The system analyzes between slides per hour depending on the tests requested Slides are placed into a 12-position magazine; up to 8 magazines, or 96 slides can be loaded at once. Slides are transported into the system and: 10X dry objective finds monolayer and coordinates of nucleated events Oil is automatically added 50X obj takes 35 HPF images in order to pre-characterize RBC morphology 100X obj returns to each WBC, and captures a high quality image An Artificial Neural Network evaluates 250 cellular characteristics and pre-classifies each cell Results with images are stored and displayed for the technologist s verification Proficiency. The CellaVision DM96 provides th with the ability to perform a side-by-side comp different cell classes, by viewing similar cells t Additionally, there is an on-board reference ce the technologist. This library is customized fro hospital's own patient population. This proces streamlines training but it also ensures consis technologists and shifts.

5 WBC Cells: Cells are grouped with like cells to facilitate verification Cells are pre-classified into 18 classes: - Leukocytes: Segmented Neutrophils, Band Neutrophils, Eosinophils, Basophils, Lymphocytes, Monocytes, Blasts, Promyelocytes, Myelocytes, Metamyelocytes, Variant Lymphocytes, Plasma Cells, Unidentified - Non-Leukocytes: Smudge Cell, Artifact, Giant Platelet, NRBC, Platelet Clumps Handling leukopenic samples is more efficient due to the ability to merge cells from multiple slides on a single patient. RBC Cells: RBC Morphology is automatically precharacterized for hypo, hyper, micro, macro, aniso and poik as set by the lab, providing you with percentages of each type Multiple fields can be scanned as if on a virtual microscope A dynamic micrometer facilitates additional cell measurements e technologist arison between ogether. ll library for use by m the individual s not only tency across Easy Access to Powerful Features: Add pre-coded or free text comments to any slide, cell class or specific cell Attach any number of cells and send them via Customize the coloration and brightness of the cell images in your personal profile

6 Networking The CellaVision DM96 integrates into your existing LAN, WAN and VPN infrastructure, enabling the hematology laboratory with the tools to serve the needs of multiple facilities, while providing New Value to the various departments within the organization. Technologists save time searching for requested smears Multiple systems can be run from a central location eliminating transportation problems, and reducing TAT Clinicians and pathologists save time by accessing their patients images remotely in real time Multiple cell images can be easily ed to colleagues anywhere in the world without interrupting your workflow Pediatrics Oncology CellaVision DM96 - The heart of your network sending information where and when it is needed Pathology Adding New Value to the Clinician Time required for consultations are eliminated, resulting in faster, better diagnosis for the patient Morphology expertise can be centralized, resulting in staffing flexibility at remote locations Send images to yourself for use in other applications

7 Power of Integration MOLIS WAM (Work Area Manager). Designed for the high volume hematology laboratory, MOLIS WAM uses the power of MOLIS, a next generation LIS to deliver an advanced specimen process management system. Specimen centric software architecture empowers MOLIS WAM to deliver rich functionality and seamless integration with the Sysmex HST line. MOLIS WAM s rules-based, expert technology gives you unprecedented efficiency and control over workflow for advanced process control. MOLIS WAM connects your remote labs using one central repository for hematology results, giving you both control of the information as well as distributed processing capability. Operating on a high speed Ethernet network, MOLIS WAM easily interfaces to your LIS for demographics, orders results, including MOLIS WAM - initiated orders for repeats or add-on tests. Even if the LIS is down, MOLIS WAM keeps your hematology department up and running.

8 Performance Specifications: Slide Method Staining Method Slide Type Number of Cells Counted RBC Morphology Throughput Loading Capacity Slide Handling Oiling Storage Communications Printer Support Wedge Slides automated or manually prepared Romanowsky Stains (May Grünwald/Wright/Giemsa) Clipped/rounded corners; bar coded I.D. User definable 35, 50X High power fields composed into one Overview RBC Screen Up to 35 slides per hour for completedifferential (WBC + RBC + PLT) Up to 60 slides per hour (RBC and/or platelet only) 96 Slides (8 magazines; 12 slides per magazine) Continuous feed, walk away; up to 96 slides Automatic Locally, ~25,000 patient samples with 100cells/slide. Archival Storage, CD-R or CD-RW, ~200 slides with 100 cells /slide. Data may be easily transferred to additional external storage media via LAN resulting in a unlimited storage capacity Bi-directional LIS support Ethernet 10/100 Mps All Windows XP supported Laser and Inkjet Result Parameters Segmented and Band Neutrophils, Eosinophils, - WBC Basophils, Lymphocytes, Monocytes, Blast cells Pre-classification Promyelocytes, Myelocytes, Metamyelocytes, Variant Lymphocytes, Plasma Cells and Unidentified - Non-WBC Smudge Cells, Artifacts, Giant Platelets, Platelet Pre-classification Clumps, Erythroblasts (NRBC) - RBC Automated pre-characterization of: Anisocytosis, Pre-characterization Microcytosis, Macrocytosis; Polychromasia; Hypochromasia; Poikilocytosis Platelet Estimate Graphical user interface allows manual estimation of PLT concentration System Specifications System Components Accessories System Options PC with Windows XP Operating System 19 TFT Monitor Slide Scanning Unit CellaVision Blood Differential Software (U.S. Patent No and ) Barcode Labeled Slide Magazines CellaVision Remote Review Software Label Printer Kit (optional) SYSMEX CORPORATION Wakinohama-Kaigandori, Chuo-ku, Kobe , Japan Phone Fax SYSMEX AMERICA, INC. One Nelson C. White Pkwy, Mundelein, IL 60060, U.S.A. Phone Fax SYSMEX DO BRASIL INDÚSTRIA E COMÉRCIO LTDA Rua Professor Algacyr Munhoz Mader Bloco C - CIC Curitiba - Parana - Brasil - CEP Phone Fax SYSMEX EUROPE GMBH Bornbarch 1, Norderstedt, Germany Phone Fax SYSMEX DEUTSCHLAND GMBH Bornbarch 1, Norderstedt, Germany Phone Fax SYSMEX UK LTD. Sysmex House, Garamond Drive, Wymbush Milton Keynes, Buckinghamshire, Mk8 8DF, U.K. Phone Fax SYSMEX SINGAPORE PTE LTD. 2 Woodlands Sector 1, #01-06 Woodlands Spectrum Singapore , Singapore Phone Fax SYSMEX SHANGHAI LTD. 5th Floor, New Shanghai International Tower 360 Pudong South Road Shanghai, China Phone Fax Sysmex America Inc. Document Number /2006 2M