St. Jude Children s Hospital cgmp Facility Memphis, TN

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1 St. Jude Children s Hospital cgmp Facility Memphis, TN CM Option Consultant TBD September 12, 2002 Overall Existing Conditions Summary Executive Summary This Overall Conditions Summary is a fairly comprehensive collection of general information about the St. Jude Facility. I ve been successful in obtaining the majority of the needed information thus far. The main findings of this report show that the facility is a typical laboratory/manufacturing building. The mechanical package of the project makes up 1/3 of the cost and is obviously a driving factor for construction. Another chief concern on this project is the integration of this new facility into both the existing Hospital Campus facilities and the ideas for future expansion. Other than these and a few other special features, this project is typical for one of its type, size and scope. Page 1 of 5

2 Primary Project Team? The Austin Company is the design-build firm for this project. They are the Architects, Engineers and Constructors for the St. Jude Facility. The Project Manager is Pinto Patel.? The Owner is St. Jude Children s Research Hospital. John Coleman, VP of Therapeutic Production and Rick Bolton, the Project Manager of Facility Planning for St. Jude Children s Research Hospital are the main representatives for the Owner. Dates of Construction & Design? St. Jude approved the design and budget on 8/17/01 and work on the Construction Documents began on 8/20/01.? Construction began on 10/26/01 and is scheduled for completion on 3/17/03. o Site and building shell began on 11/1/01 o Building is to be watertight by 9/17/02 o 2 nd Floor work scheduled from 4/8/02 to 1/17/03 o 1 st Floor work scheduled from 5/24/02 to 1/31/03 o Mechanical Penthouse scheduled from 4/22/02 to 1/2/03 o Punchlist scheduled from 2/3/03 to 3/14/03 o Occupancy scheduled for 3/17/03 Cost Information? The following is a table of costs and overhead/profit by CSI division: Div. Description OH & P Cost 02 Sitework 10% $1,429, Concrete 10% $1,792, Masonry 20% $255, Metals 10% $1,771, Wood & Plastics 20% $360, Thermal/Moisture Protection 20% $238, Doors & Windows 20% $849, Finishes 10% $2,198, Specialties 20% $95, Equipment 0 $321, Furnishings 0 $48, Conveying Systems 0 $90, Mechanical 20% $10,964, Electrical 20% $3,853,743 TOTAL $24,270,052 Building Function and Primary Uses? This building will be a pharmaceutical manufacturing production facility that will be used to manufacture and test pediatric vaccines, therapeutic proteins and antibodies. The building is mainly laboratory space, clean rooms, testing rooms, filling rooms, Page 2 of 5

3 etc. and there are some support office spaces on each of the two main floors. The third floor is the mechanical penthouse.? Specifically, the facility will be used for multiple processes including peptide synthesis/chemistry, production of plasmid DNA products, viral vector products, cell therapy products, monoclonal antibodies and live viral and bacterial vaccines. Location and Site? The facility is being constructed on the St. Jude Children s Hospital campus and is part of a 10 year expansion endeavor.? It is located on a corner (North Parkway and Third Street) in Memphis, TN.? The site is relatively small which has already caused problems during construction. Codes? The design of the building complies with the following codes and requirements: o Standard Building Code by Southern Building Code Congress International, 1994 edition (SBCCI-1994) o Life Safety Code (NFPA-101) o Americans with Disabilities Act o 1991 North Carolina Accessibility Code o Shelby County Fire Marshall o 1994 Standard Fire Protection Code o 1994 Standard Plumbing Code o 1994 Standard Mechanical Code o 1996 National Electric Code Zoning & Historical Information? The site is within a designated earthquake zone, which led to specialized structural designs, additional detailing time in design, and strengthened systems (such as additional rebar in foundation, special ceiling grid, etc.) Project Delivery Method? This is a fast-tracked, design build, GMP project.? It was awarded to The Austin Company due to its track record for successfully implementing complex projects on time and within budget. Austin also has experience in building facilities that comply with stringent federal cgmp standards, which will allow for a smooth building process, said John S. Coleman, VP of Therapeutics Production at St. Jude. Civil Work? Storm, sanitary, process waste sewage, city water piping, natural gas piping? Asphalt and concrete paving, demolition and grading to be done? Site security and decorative fencing Building Envelope? Precast concrete exterior wall panels? Aluminum and glass curtain wall, strip windows and slot windows. Page 3 of 5

4 Electrical System? Electrical system is typical for moderate to complex laboratory facility.? Besides typical electrical features, there are also the following special requirements: o AHU lighting and convenience outlets o Roof mounted GFI convenience outlets o Smoke control power o Heat tracing temperature control o Preaction system in communications room o Powered door operators o Dock levelers (truck locks, warning lights) o Elevator remote monitor panel o Cold rooms, freezers, refrigerators o Projection screen outlets o Air-lock interlocking wiring o Automatic gate to street on NW side of site Lighting System? Besides the typical lighting features, there are also the following special requirements: o Local switching, dimming for conference rooms and FACS room o Solid state ballasts on fluorescent sources (T8 typ. indoor). o Occupancy sensors in toilets and conference rooms o Site photo-control: photocell, astronomical timer o St. Jude standards for emergency system o Specialty lighting at washdown areas o 30 fc typical throughout building except laboratories and processing which are fc o Building perimeter lighting (wall packs on N and W sides) Mechanical? Piping and venting for restrooms, showers, floor drains in laboratories? Piping for safety showers? Lab service piping and/or tanks for cgmp (laboratory) areas including purified water, compressed air, liquid nitrogen, nitrogen gas, carbon dioxide gas and steam.? Conditioned air to cgmp, office and controls areas? Controls for room pressure and pressure differentials between rooms? Air supply and make-up must maintain cgmp area classifications? Exhaust systems required for biosafety cabinets and other laboratory equipment? Typical heating and cooling to follow St. Jude facility requirements. Structural? 3-story, structural steel facility? Auger cast piles? Typical composite floor system? Moment frame design required due to earthquake zoning restrictions Page 4 of 5

5 Fire Protection? Wet pipe sprinkler system? Preaction system for communication room? The fire alarm system will be integrated with the existing St. Jude. Campus system.? Intelligent detectors (smoke, heat, manual pull stations)? Monitor-Zone control (smoke control interlock, dampers, elevator controls)? Exterior visual/audible alarms (strobes, horns, bells, fire fighter phones, voice communications through speakers) Conveying Systems? Passenger hydraulic elevators rated for 3000 lbs (6-8 x 5-5 )? Freight hydraulic elevators rated for 4500 lbs (8-0 x 7-6 ) Telecommunications? Fiber, copper and underground services provided by Access Technologies.? cgmp and office areas typical 4-port, category 2, 3 and 5e outlets? Outdoor security telephone located near building Page 5 of 5