the PLATFORM Pipeline in Lyon AREA

Transcription

1 the PLATFORM Pipeline in Lyon AREA Do you have development or partnership projects in Life Sciences? Are you interested in developing your business in France?

2 This overview is designed to give you an idea about the innovation to be found in Lyon area, providing a nonexhaustive list of products developed by local companies. This product pipeline is intended for the stakeholder community of the Life Sciences and is aimed at facilitating partnerships and boosting international collaborations. This information directly does not claim to be a complete description and is subject to change without notice. For more information regarding any of these companies, please contact ADERLY / Invest in Lyon. CONTENTS

3 Bio Elpida 04 Calixar 04 Cynbiose 05 Kallistem 05 Metabolys 05 Novadiscovery 06 Platine Pharma 06 The Cosmo Company 07 Vivalis 07 Voxcan 08

4 Advanced Therapeutics Medicinal Products; Cell therapy Biologicals CMO: feasibility, development, immunoassays, GMP manufacturing, fill and finish Immunomotherapy; Therapeutic cancer vaccine; Stem Cell Regenerative medecine Single use processes; pharmaceutical batch manufacturing for allogenic and autologous therapy Sequence identification Target discovery Mass spectroscopy / optimal membrane fractions preparation (enrichment process) All membrane proteins / antigens (GPCRs, Ion channels, Transporters, Cell-surface proteins, complexes ) Production Non-denaturing extraction from biological samples or recombinant cell lines Purification Quality control / Functional / Structural tests Crystallization tests Protein / Protein interaction Drug Screening Conformational Antibodies production (monoclonal / polyclonal) Antigen validation for vaccine discovery Oligomerization level determination 3D structure determination Co-crystallization All expression systems (eukaryotic / prokaryotic / cell-free) Optimized approach to avoid inclusion bodies Homemade non denaturing reagents Multi-step extraction process Rational design of detergent Chromatographic steps: ion exchange / gel filtration / affinity Coomassie Gel / WB / Clear Native Page / Circular Dichroïsm / DLS / ITC / FACS / Int or Ext Fluorescence / MS /... Crystallogenesis robot + visualization + diffraction tests Know How transfer Extraction process license with the supply of specific homemade reagents Know How transfer ADERLY The Platform Pipeline in Lyon Area 04

5 Biotechnology and pharmaceutical companies; Academic research in partnership assessment platform dedicated to Non Human Primate models Exploratory studies: Pharmacokinetic, Toxicokinetic, Biodistribution; Efficacy testing Relevant model for human diseases: CNS, Infectious diseases, Cardiovascular diseases, Metabolic diseases; Surgery Imaging Microdialysis Pharma, Biotech, Agrochemicals, Cosmetics Predictive & mechanistic Testicular Toxicity Reproductive toxicology Bio-AlteR:The Bio-Alter technology is a 3D cell culture process which allows achieving 80% of spermatogenesis in vitro in rats and humans over 4 weeks in a serum free culture medium. This culture process ensures the maintenance (or reformation) of the blood-testis barrier and allows to study the mitotic and meiotic phases of spermatogenesis and the beginning of spermiogenesis. This technology allows to measure with high accuracy and predictivity the testicular toxicity profile of chemicals Pharmaceutical, Agro-food, Chemical and Cosmetic Industries Prediction of Safety/ Efficacy of test compounds Pharmacology, Toxicology Metabolic Flux Analysis (Cellular Metabolomics) ADERLY The Platform Pipeline in Lyon Area 05

6 High value in-silico applications for the pharmaceutical industry Prediction of drug candidate efficiency over selected populations: - Accelerate PoC / Prioritise compounds in DISCOVERY - Identify responders & optimise treatment (regimen, duration, dose) to focus trials in CLINIC - Characterise target population & compare cost/ effectiveness to demonstrate value to payers during MARKET ACCESS Drive STOP-GO decisions from early discovery to market access & post-market All disease areas (existing project pipeline in cardiovascular, CNS, oncology, infectious diseases) - Novadiscovery proprietary technology platform is designed to ensure the optimal transfer of knowledge from bench to clinic geared towards applications in public health and personalised medicine. - Unique expertise in numerical modelling in biology (biomathematics, computing) and knowledge management applied to drug and biomarker R&D programs. Strategic Research Alliances on selected disease areas to help our partner drive their R&D Healthcare Industry, including biopharmaceutical, diagnostic & medical device companies Regulatory Immunomonitoring, including immunophenotyping, cytokine & chemokine screening, drugtarget interactions, immunogenicity, immunotoxicity and complex cell-based assays Assay development and validation - Monitoring the effect of given compound on the immune system - Biomarker monitoring in support of preclinical studies and clinical trials Multiparametric Flow Cytometry - ELISpot - ELISA - MesoScale Discovery - Luminex - Cell culture and biobanking ADERLY The Platform Pipeline in Lyon Area 06

7 Pharmaceutical, cosmetics and medical technology, R&D, production and marketing Modeling and simulation of complex multiscale dynamic systems. Numerical experiments Critical systems robustness assessment Vaccine and drug development QbD in Bioprocess Patient sorting Market evaluation Pandemic management The proprietary software platform provides a set of user friendly tools to design and integrate models, build and run in-silico simulations to understand molecules, cells, tissues, organs and organisms interactions in their evolutive environment. Software licensing of modeling and simulation plaftorm and model library. Research Partnership Pharmaceutical and vaccine Industries (Human and Veterinary) Integration of several platforms that link discovery through the manufacturing of clinical trial materials Infectious diseases Oncology Inflammatory CNS VIVA SCREEN TM platform is a new method for the discovery of biologically active and difficult-to-isolate monoclonal antibodies. This technology enables the discovery and isolation of naturally occuring and rare fully human monoclonal antibodies secreted by human B-cells. EB66 TM cell line (duck embryo stem cell) Research collaboration ADERLY The Platform Pipeline in Lyon Area 07

8 Efficacy study in Infectious diseases Antibacterial, antiviral (level 2) Molecular Imaging Efficacy study in Oncology Solid tumor, metastasis, néoangiogenesis Anatomical or molecular imaging Efficacy study in Inflammatory processes Inflammatory Diseases Molecular Imaging Pharmaceutical and biotech companies Efficacy study in Bone diseases Osteoporosis and Implants Anatomical imaging (µct - CT) Efficacy studies in Osteoarthritis Osteoarthristis Anatomical imaging (µct) Efficacy studies in Vascular diseases Genetic diseases and Implants Anatomical or molecular imaging Efficacy studies in Metabolic diseases Metabolic diseases and Nutrition Anatomical imaging (µct - CT) Biodistribution studies PK/PD in all murin models Molecular Imaging ADERLY The Platform Pipeline in Lyon Area 08

9 ADERLY The Platform Pipeline in Lyon Area 09

10 ADERLY The Platform Pipeline in Lyon Area 10

11 ADERLY The Platform Pipeline in Lyon Area 11

12 2013 photo credit Shutterstock ADERLY - Lyon Area Economic Development Agency Place de la Bourse Lyon Cedex 02 - FRANCE Tel. 33 (0) Fax 33 (0) aderly@investinlyon.com -