POLYMERASE CHAIN REACTION (PCR) TECHNOLOGIES AND GLOBAL MARKETS

Transcription

1 POLYMERASE CHAIN REACTION (PCR) TECHNOLOGIES AND GLOBAL MARKETS BIO087B March 2014 Jackson Highsmith Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THIS STUDY 2 INTENDED AUDIENCE 2 SCOPE AND FORMAT 2 METHODOLOGY AND INFORMATION SOURCES 3 ANALYST'S CREDENTIALS 3 RELATED BCC RESEARCH REPORTS 3 BCC RESEARCH ONLINE SERVICES 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 SUMMARY TABLE A GLOBAL PCR TECHNOLOGIES MARKET BY SEGMENT, THROUGH SUMMARY FIGURE GLOBAL PCR TECHNOLOGIES MARKET BY SEGMENT, DRIVERS 8 RAPID PROGRESS IN PROTEOMICS AND GENOMICS 8 AVAILABILITY OF FUNDING INCREASES TECHNOLOGY DEVELOPMENT AND ADOPTION RAPID GROWTH IN MOLECULAR DIAGNOSTIC INDUSTRY 9 PRODUCT INNOVATIONS INCREASE TECHNOLOGY ADOPTION AND APPLICATION AREAS WIDE RANGE OF APPLICATIONS 10 RESTRAINTS 11 LACK OF AWARENESS 11 REQUIREMENT FOR SKILLED LABOR 11 HIGH COST OF REAL-TIME PCR INSTRUMENTS 11 INSTRUMENT SELECTION CRITERIA 11 DEVELOPMENT OF ALTERNATIVE TECHNOLOGIES 12 OPPORTUNITIES AND CHALLENGES 12 SUMMARY TABLE B GLOBAL PCR TECHNOLOGIES MARKET BY GEOGRAPHIC REGION, THROUGH CHAPTER 3 MARKET OVERVIEW 16 EVOLUTION OF PCR TECHNOLOGY AND ITS IMPACT ON THE HEALTHCARE INDUSTRY FIGURE 1 IMPACT OF PCR TECHNOLOGY ON THE HEALTHCARE ENVIRONMENT 17 TRENDS IN DEVICE DESIGN 18 TRADITIONAL PCR VS. REAL-TIME PCR 18 USE OF 96- OR 384-WELL FORMAT 19 TABLE 1 TRADITIONAL PCR VS. REAL-TIME PCR 19 KEY APPLICATION AREAS 19 FIGURE 2 KEY APPLICATIONS OF PCR TECHNOLOGY 20 TABLE 2 ANALYSIS OF NUMBER OF REAL-TIME PCR RUNS/WEEK, BY SOURCE OF SAMPLE, 2013 PCR QUANTIFICATION METHODS

3 THE HUMAN GENOME PROJECT AND PCR 22 HUMAN MICROBIOME PROJECT AND PCR 22 TAQMAN PROBES AND MOLECULAR BEACONS: POTENTIAL ALTERNATIVES TO DYES USED IN REAL-TIME PCR ALTERNATIVES TO PCR-BASED ANALYTICAL METHODS 24 FIGURE 3 DISADVANTAGES OF PCR VS. THE ADVANTAGES OF ALTERNATIVES 24 LOOP MEDIATED ISOTHERMAL AMPLIFICATION 25 REACTION DISPLACEMENT CHIMERIC 26 NUCLEIC ACID SEQUENCE-BASED AMPLIFICATION 26 TRANSCRIPTION-MEDIATED AMPLIFICATION 26 KEY APPLICATION AREAS 27 FIGURE 4 KEY APPLICATIONS OF PCR 27 PCR AND PUBLIC HEALTH SURVEILLANCE 28 EMERGING ECONOMIES AND TECHNOLOGY ADOPTION 29 FUTURE OF PCR 30 MARKET TRENDS/KEY INSIGHTS 30 GROWTH DRIVERS 30 GROWTH CHALLENGES 31 MARKET RESTRAINTS 31 ROBUST INSTRUMENTATION 32 INNOVATION AT THE EDGE OF TECHNOLOGY VS. AT THE CORE 32 PCR AS A MATURE MARKET 32 PRICING TRENDS 33 KEY RECOMMENDATIONS/MARKET STRATEGIES 33 SWITCHING COSTS INHIBIT TECHNOLOGY CHANGES 34 PATENT ANALYSIS 34 FIGURE 5 PATENT ANALYSIS BY GEOGRAPHIC REGION, (%) 35 FIGURE 6 PATENT ANALYSIS BY TYPE OF PRODUCT, (%) CHAPTER 4 PCR MARKET SEGMENTS 38 INSTRUMENTS MARKET 38 TABLE 3 GLOBAL PCR INSTRUMENTS MARKET BY PRODUCT TYPE, THROUGH 2018 TABLE 4 REAL-TIME PCR INSTRUMENTS MARKET SHARE BY COMPANY THROUGH 2018 (%) TABLE 5 GLOBAL PCR INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH DRIVERS AND RESTRAINTS 39 MARKET FLOODED WITH CHOICE OF INSTRUMENTS WITH A WIDE RANGE OF PRICES GROWING POPULARITY OF REAL-TIME PCR INSTRUMENTS 40 REAL-TIME VS. ENDPOINT QUANTITATIVE PCR 41 SUMMARY 41 EXPERIMENTAL DESIGN 42 RAPIDLY CHANGING MARKET DEMAND 42 TRADITIONAL THERMAL CYCLERS/THERMAL CYCLERS 43 TABLE 6 GLOBAL THERMAL CYCLERS MARKET BY GEOGRAPHIC REGION, THROUGH REAL-TIME PCR INSTRUMENTS/REAL-TIME THERMAL CYCLERS

4 TABLE 7 GLOBAL REAL-TIME PCR INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH OTHERS 44 TABLE 8 GLOBAL OTHER INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH REAGENTS AND CONSUMABLES MARKET 45 TABLE 9 GLOBAL REAGENTS AND CONSUMABLES MARKET BY PRODUCT TYPE, THROUGH TABLE 10 GLOBAL REAGENTS AND CONSUMABLES MARKET BY GEOGRAPHIC REGION, THROUGH DRIVERS 46 Increased Use of PCR Technology 46 Master Mixes and Ready-to-Use Kits Boost the Market 47 RESTRAINTS 47 REAGENTS 48 TABLE 11 GLOBAL REAGENTS MARKET BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 12 GLOBAL REAGENTS MARKET BY GEOGRAPHIC REGION, THROUGH 2018 Individual Reagents 49 TABLE 13 GLOBAL INDIVIDUAL REAGENTS BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 14 GLOBAL INDIVIDUAL REAGENTS BY GEOGRAPHIC REGION, THROUGH Enzymes 50 TABLE 15 GLOBAL ENZYMES MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ Deoxynucleotide Triphosphates 51 TABLE 16 GLOBAL DNTP MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ Buffers/Reaction Buffers and Additives 52 TABLE 17 GLOBAL BUFFERS AND ADDITIVES MARKET BY GEOGRAPHIC REGION, THROUGH Primers and Probes 53 TABLE 18 GLOBAL PRIMERS AND PROBES MARKET BY GEOGRAPHIC REGION, THROUGH Controls/Templates 54 TABLE 19 GLOBAL TEMPLATES MARKET BY GEOGRAPHIC REGION, THROUGH 2018 Master Mixes/Reagents Kits 55 TABLE 20 GLOBAL MASTER MIXES MARKET BY GEOGRAPHIC REGION, THROUGH Other Reagents 55 TABLE 21 GLOBAL OTHER REAGENTS MARKET BY GEOGRAPHIC REGION, THROUGH CONSUMABLES 56 TABLE 22 GLOBAL CONSUMABLES MARKET BY GEOGRAPHIC REGION, THROUGH PCR SOFTWARE 57 TABLE 23 GLOBAL PCR SOFTWARE MARKET BY PRODUCT TYPE, THROUGH 2018 ($

5 TABLE 24 GLOBAL PCR SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH PRIMER DESIGN AND SEQUENCING SOFTWARE 58 TABLE 25 GLOBAL PRIMER DESIGN AND SEQUENCING SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH PCR ANALYZER SOFTWARE 59 TABLE 26 GLOBAL PCR ANALYZER SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH OTHER SOFTWARE MARKETS 59 TABLE 27 GLOBAL OTHER SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH SERVICES 60 TABLE 28 GLOBAL PCR SERVICE MARKET BY GEOGRAPHIC REGION, THROUGH CHAPTER 5 PCR APPLICATION MARKET 63 TABLE 29 GLOBAL APPLICATION MARKET BY SEGMENT, THROUGH 2018 ($ TABLE 30 GLOBAL APPLICATION MARKET BY GEOGRAPHIC REGION, THROUGH DRIVERS 64 PRESSING NEED FOR MANAGEMENT OF INFECTIOUS AND FATAL DISEASES 64 IMPROVEMENTS IN PCR PRODUCTS AND AVAILABILITY HAVE FACILITATED USE CAPABILITY TO ANALYZE OLD/ANCIENT SAMPLES 64 FOCUS ON PREVENTIVE HEALTHCARE 65 DEMAND FOR GENETIC, MOLECULAR DIAGNOSTIC TESTING 65 NEWER TECHNOLOGIES AND AN INCREASE IN END USERS 65 RESTRAINTS AND CHALLENGES 66 RESEARCH APPLICATIONS 66 TABLE 31 GLOBAL RESEARCH MARKET BY APPLICATION TYPE, THROUGH 2018 ($ TABLE 32 USE OF PCR IN LIFE SCIENCES: TECHNIQUE, TOOLS, AND DIAGNOSTIC OUTCOME TABLE 33 GLOBAL RESEARCH APPLICATION MARKET BY GEOGRAPHIC REGION, THROUGH DNA SEQUENCING 67 TABLE 34 GLOBAL DNA SEQUENCING MARKET BY GEOGRAPHIC REGION, THROUGH FORENSIC SCIENCE 69 TABLE 35 GLOBAL FORENSIC SCIENCE MARKET BY GEOGRAPHIC REGION, THROUGH 2015 GENOTYPING 70 TABLE 36 GLOBAL GENOTYPING MARKET BY GEOGRAPHIC REGION, THROUGH BIOINFORMATICS 71 TABLE 37 GLOBAL BIOINFORMATICS MARKET BY GEOGRAPHIC REGION, THROUGH GENE EXPRESSION AND GENETIC MAPPING

6 TABLE 38 GLOBAL GENE EXPRESSION AND GENETIC MAPPING MARKET BY GEOGRAPHIC REGION, THROUGH DNA CLONING 72 TABLE 39 GLOBAL DNA CLONING MARKET BY GEOGRAPHIC REGION, THROUGH OTHERS 73 TABLE 40 GLOBAL OTHER RESEARCH APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH CLINICAL APPLICATIONS 74 TABLE 41 GLOBAL PCR MARKET BY TYPE OF CLINICAL APPLICATION, THROUGH TABLE 42 GLOBAL CLINICAL APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH PRENATAL DIAGNOSIS 75 TABLE 43 GLOBAL MARKET FOR PCR IN PRENATAL DIAGNOSTICS BY GEOGRAPHIC REGION, THROUGH TISSUE TYPING/TRANSPLANT 76 TABLE 44 GLOBAL PCR TISSUE TYPING/TRANSPLANT INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH CANCER THERAPY AND DETERMINATION 76 TABLE 45 GLOBAL MARKET FOR PCR TESTING IN CANCER THERAPY BY GEOGRAPHIC REGION, THROUGH INFECTIOUS DISEASE DIAGNOSIS 77 TABLE 46 GLOBAL MARKET FOR PCR IN THE TESTING OF INFECTIOUS DISEASES BY APPLICATION TYPE, THROUGH TABLE 47 GLOBAL MARKET FOR PCR IN THE TESTING OF INFECTIOUS DISEASES BY GEOGRAPHIC REGION, THROUGH Hepatitis B and Hepatitis C Testing 79 TABLE 48 GLOBAL MARKET FOR PCR IN HEPATITIS B AND C TESTING BY GEOGRAPHIC REGION, THROUGH Tuberculosis Diagnosis 80 TABLE 49 GLOBAL MARKET FOR PCR IN TUBERCULOSIS TESTING BY GEOGRAPHIC REGION, THROUGH HIV/AIDS Diagnosis 80 TABLE 50 GLOBAL HIV TESTING MARKET BY GEOGRAPHIC REGION, THROUGH 2018 Other Infectious Diseases 81 TABLE 51 GLOBAL MARKET FOR PCR TESTING OF OTHER INFECTIOUS DISEASES BY GEOGRAPHIC REGION, THROUGH GENETIC TESTING 82 TABLE 52 GLOBAL GENETIC TESTING MARKET BY GEOGRAPHIC REGION, THROUGH BLOOD SCREENING 83 TABLE 53 GLOBAL MARKET FOR PCR BLOOD SCREENING TESTS BY GEOGRAPHIC REGION, THROUGH OTHER PCR APPLICATIONS 84 TABLE 54 GLOBAL OTHER PCR APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH CHAPTER 6 PCR TECHNOLOGY MARKET 87 TECHNOLOGY TYPES 87

7 TABLE 55 GLOBAL PCR TECHNOLOGY MARKET BY TYPE, THROUGH 2018 ($ TABLE 56 GLOBAL PCR TECHNOLOGY MARKET BY GEOGRAPHIC REGION, THROUGH MARKET DRIVERS 88 WIDE RANGE OF APPLICATIONS DRIVING TECHNOLOGY ACCEPTANCE 88 TECHNOLOGICAL VARIANTS OPEN NEW AVENUES FOR PCR TECHNOLOGY 88 PCR TECHNOLOGY PATENT EXPIRY HAS BOOSTED MARKET GROWTH 89 CHALLENGES 89 STANDARD/BASIC PCR 89 TABLE 57 GLOBAL STANDARD PCR MARKET BY GEOGRAPHIC REGION, THROUGH REAL-TIME PCR/QPCR 90 TABLE 58 GLOBAL REAL-TIME PCR/QPCR MARKET BY GEOGRAPHIC REGION, THROUGH REVERSE TRANSCRIPTASE PCR 91 TABLE 59 GLOBAL REVERSE TRANSCRIPTION PCR MARKET BY GEOGRAPHIC REGION, THROUGH ASSEMBLY PCR 92 TABLE 60 GLOBAL ASSEMBLY PCR MARKET BY GEOGRAPHIC REGION, THROUGH INVERSE PCR 93 TABLE 61 GLOBAL INVERSE MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ NESTED PCR 94 TABLE 62 GLOBAL NESTED PCR MARKET BY GEOGRAPHIC REGION, THROUGH 2018 MULTIPLEX PCR 94 TABLE 63 GLOBAL MULTIPLEX PCR MARKET BY GEOGRAPHIC REGION, THROUGH HOT START AND TOUCHDOWN PCR 95 TABLE 64 GLOBAL HOT START AND TOUCHDOWN PCR MARKET BY GEOGRAPHIC REGION, THROUGH OTHERS 96 TABLE 65 GLOBAL OTHER TECHNOLOGY TYPES BY GEOGRAPHIC REGION, THROUGH INVESTIGATIVE METHODS OF QUANTIFICATION 96 STANDARD CURVE 97 RELATIVE QUANTIFICATION 98 QPCR CHEMISTRY OPTIONS 99 DNA BINDING DYES 99 PROBE-BASED CHEMISTRIES 100 LINEAR PROBES 100 STRUCTURED PROBES 102 PRIMER AND PROBE DESIGN 103 CONTROLS FOR QUANTITATIVE PCR EXPERIMENTS 106 POSITIVE CONTROLS 107 NEGATIVE CONTROLS 108 PASSIVE REFERENCE DYE

8 CHAPTER 7 COMPETITIVE LANDSCAPE 111 FIGURE 7 PCR MARKET STRATEGIES BY TYPE, MARCH (%) 111 FIGURE 8 KEY PLAYERS IN STRATEGIC DEVELOPMENT (%) 112 TABLE 66 MERGERS AND ACQUISITIONS 113 TABLE 67 NEW PRODUCT LAUNCHES, SEPTEMBER 2008 NOVEMBER TABLE 68 AGREEMENTS AND COLLABORATIONS, JANUARY 2010 TO DECEMBER CHAPTER 8 GEOGRAPHIC ANALYSIS OF THE PCR APPLICATIONS MARKET 124 FIGURE 9 TOTAL PCR MARKET BY GEOGRAPHIC REGION, 2013 VS (%) 124 NORTH AMERICA 125 TABLE 69 NORTH AMERICAN PCR MARKET BY SEGMENT, THROUGH 2018 ($ EUROPE 126 TABLE 70 EUROPEAN PCR MARKET BY SEGMENT, THROUGH 126 ASIA 127 TABLE 71 ASIAN PCR MARKET BY SEGMENT, THROUGH 127 ROW 128 TABLE 72 ROW PCR MARKET BY SEGMENT, THROUGH CHAPTER 9 COMPANY PROFILES 130 ABBOTT LABORATORIES 130 TABLE 73 ABBOTT RECENT DEVELOPMENTS 130 AFFYMETRIX, INC. 132 TABLE 74 AFFYMETRIX RECENT DEVELOPMENTS 133 AGILENT TECHNOLOGIES 134 TABLE 75 AGILENT RECENT DEVELOPMENTS 135 BECKMAN COULTER, INC./DANAHER 136 TABLE 76 BECKMAN COULTER RECENT DEVELOPMENTS 137 BECTON, DICKINSON AND CO. 138 TABLE 77 BD RECENT DEVELOPMENTS 139 BIOLINE 141 TABLE 78 BIOLINE RECENT DEVELOPMENTS 141 BIONEER, INC. 142 TABLE 79 BIONEER RECENT DEVELOPMENTS 143 BIO-RAD 143 TABLE 80 BIO-RAD RECENT DEVELOPMENTS 144 COMPLETE GENOMICS/BGI 144 TABLE 81 COMPLETE GENOMICS RECENT DEVELOPMENTS 145 THE ELITECH GROUP (NANOGEN/EPOCH BIOSCIENCES) 146 TABLE 82 ELITECH RECENT DEVELOPMENTS 147 ENZO LIFE SCIENCES (ENZO BIOCHEM SUBSIDIARY) 147 TABLE 83 ENZO RECENT DEVELOPMENTS 148 EXIQON 148 TABLE 84 EXIQON RECENT DEVELOPMENTS 149 GE HEALTHCARE 150 TABLE 85 GE HEALTHCARE RECENT DEVELOPMENTS 151 GEN-PROBE, INC. 152

9 TABLE 86 GEN-PROBE RECENT DEVELOPMENTS 153 HY LABORATORIES LTD. 154 TABLE 87 HY RECENT DEVELOPMENTS 154 IDAHO TECHNOLOGY, INC. 154 TABLE 88 IDAHO TECHNOLOGY RECENT DEVELOPMENTS 155 ILLUMINA 156 TABLE 89 ILLUMINA RECENT DEVELOPMENTS 157 KAPA BIOSYSTEMS 158 TABLE 90 KAPA RECENT DEVELOPMENTS 159 LIFE TECHNOLOGIES CORP./APPLIED BIOSYSTEMS AND INVITROGEN 159 TABLE 91 LIFE TECHNOLOGIES RECENT DEVELOPMENTS 161 LUCIGEN 163 TABLE 92 LUCIGEN RECENT DEVELOPMENTS 163 MAXIM BIOTECH 164 TABLE 93 MAXIM RECENT DEVELOPMENTS 164 NEW ENGLAND BIOLABS (NEB) 165 TABLE 94 NEW ENGLAND RECENT DEVELOPMENTS 165 PROMEGA CORP. 166 TABLE 95 PROMEGA RECENT DEVELOPMENTS 166 QIAGEN N.V. 168 TABLE 96 QIAGEN RECENT DEVELOPMENTS 168 QUANTA BIOSCIENCES INC. 170 TABLE 97 QUANTA RECENT DEVELOPMENTS 170 ROCHE 171 TABLE 98 ROCHE RECENT DEVELOPMENTS 172 SIGMA-ALDRICH CORP. 174 TABLE 99 S-A RECENT DEVELOPMENTS 175 TAKARA BIO 176 TABLE 100 TAKARA BIO RECENT DEVELOPMENTS 176 THERMO FISHER SCIENTIFIC 177 TABLE 101 THERMO FISHER RECENT DEVELOPMENTS 178

10 LIST OF TABLES TABLE HEADING SUMMARY TABLE A GLOBAL PCR TECHNOLOGIES MARKET BY SEGMENT, THROUGH SUMMARY TABLE B GLOBAL PCR TECHNOLOGIES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 1 TRADITIONAL PCR VS. REAL-TIME PCR 19 TABLE 2 ANALYSIS OF NUMBER OF REAL-TIME PCR RUNS/WEEK, BY SOURCE OF SAMPLE, 2013 TABLE 3 GLOBAL PCR INSTRUMENTS MARKET BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 4 REAL-TIME PCR INSTRUMENTS MARKET SHARE BY COMPANY THROUGH 2018 (%) TABLE 5 GLOBAL PCR INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 6 GLOBAL THERMAL CYCLERS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 7 GLOBAL REAL-TIME PCR INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 8 GLOBAL OTHER INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 9 GLOBAL REAGENTS AND CONSUMABLES MARKET BY PRODUCT TYPE, THROUGH TABLE 10 GLOBAL REAGENTS AND CONSUMABLES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 11 GLOBAL REAGENTS MARKET BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 12 GLOBAL REAGENTS MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ TABLE 13 GLOBAL INDIVIDUAL REAGENTS BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 14 GLOBAL INDIVIDUAL REAGENTS BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 15 GLOBAL ENZYMES MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ TABLE 16 GLOBAL DNTP MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ TABLE 17 GLOBAL BUFFERS AND ADDITIVES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 18 GLOBAL PRIMERS AND PROBES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 19 GLOBAL TEMPLATES MARKET BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 20 GLOBAL MASTER MIXES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 21 GLOBAL OTHER REAGENTS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 22 GLOBAL CONSUMABLES MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 23 GLOBAL PCR SOFTWARE MARKET BY PRODUCT TYPE, THROUGH 2018 ($ TABLE 24 GLOBAL PCR SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH

11 TABLE HEADING TABLE 25 GLOBAL PRIMER DESIGN AND SEQUENCING SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 26 GLOBAL PCR ANALYZER SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 27 GLOBAL OTHER SOFTWARE MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 28 GLOBAL PCR SERVICE MARKET BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 29 GLOBAL APPLICATION MARKET BY SEGMENT, THROUGH 63 TABLE 30 GLOBAL APPLICATION MARKET BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 31 GLOBAL RESEARCH MARKET BY APPLICATION TYPE, THROUGH 2018 ($ TABLE 32 USE OF PCR IN LIFE SCIENCES: TECHNIQUE, TOOLS, AND DIAGNOSTIC OUTCOME TABLE 33 GLOBAL RESEARCH APPLICATION MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 34 GLOBAL DNA SEQUENCING MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 35 GLOBAL FORENSIC SCIENCE MARKET BY GEOGRAPHIC REGION, THROUGH 2015 TABLE 36 GLOBAL GENOTYPING MARKET BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 37 GLOBAL BIOINFORMATICS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 38 GLOBAL GENE EXPRESSION AND GENETIC MAPPING MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 39 GLOBAL DNA CLONING MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 40 GLOBAL OTHER RESEARCH APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 41 GLOBAL PCR MARKET BY TYPE OF CLINICAL APPLICATION, THROUGH 2018 TABLE 42 GLOBAL CLINICAL APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 43 GLOBAL MARKET FOR PCR IN PRENATAL DIAGNOSTICS BY GEOGRAPHIC REGION, THROUGH TABLE 44 GLOBAL PCR TISSUE TYPING/TRANSPLANT INSTRUMENTS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 45 GLOBAL MARKET FOR PCR TESTING IN CANCER THERAPY BY GEOGRAPHIC REGION, THROUGH TABLE 46 GLOBAL MARKET FOR PCR IN THE TESTING OF INFECTIOUS DISEASES BY APPLICATION TYPE, THROUGH TABLE 47 GLOBAL MARKET FOR PCR IN THE TESTING OF INFECTIOUS DISEASES BY GEOGRAPHIC REGION, THROUGH TABLE 48 GLOBAL MARKET FOR PCR IN HEPATITIS B AND C TESTING BY GEOGRAPHIC REGION, THROUGH TABLE 49 GLOBAL MARKET FOR PCR IN TUBERCULOSIS TESTING BY GEOGRAPHIC REGION, THROUGH TABLE 50 GLOBAL HIV TESTING MARKET BY GEOGRAPHIC REGION, THROUGH

12 TABLE HEADING TABLE 51 GLOBAL MARKET FOR PCR TESTING OF OTHER INFECTIOUS DISEASES BY GEOGRAPHIC REGION, THROUGH TABLE 52 GLOBAL GENETIC TESTING MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 53 GLOBAL MARKET FOR PCR BLOOD SCREENING TESTS BY GEOGRAPHIC REGION, THROUGH TABLE 54 GLOBAL OTHER PCR APPLICATIONS MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 55 GLOBAL PCR TECHNOLOGY MARKET BY TYPE, THROUGH 2018 ($ TABLE 56 GLOBAL PCR TECHNOLOGY MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 57 GLOBAL STANDARD PCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 58 GLOBAL REAL-TIME PCR/QPCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 59 GLOBAL REVERSE TRANSCRIPTION PCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 60 GLOBAL ASSEMBLY PCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 61 GLOBAL INVERSE MARKET BY GEOGRAPHIC REGION, THROUGH 2018 ($ TABLE 62 GLOBAL NESTED PCR MARKET BY GEOGRAPHIC REGION, THROUGH 2018 TABLE 63 GLOBAL MULTIPLEX PCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 64 GLOBAL HOT START AND TOUCHDOWN PCR MARKET BY GEOGRAPHIC REGION, THROUGH TABLE 65 GLOBAL OTHER TECHNOLOGY TYPES BY GEOGRAPHIC REGION, THROUGH TABLE 66 MERGERS AND ACQUISITIONS 113 TABLE 67 NEW PRODUCT LAUNCHES, SEPTEMBER 2008 NOVEMBER TABLE 68 AGREEMENTS AND COLLABORATIONS, JANUARY 2010 TO DECEMBER TABLE 69 NORTH AMERICAN PCR MARKET BY SEGMENT, THROUGH 2018 ($ TABLE 70 EUROPEAN PCR MARKET BY SEGMENT, THROUGH 126 TABLE 71 ASIAN PCR MARKET BY SEGMENT, THROUGH 127 TABLE 72 ROW PCR MARKET BY SEGMENT, THROUGH 128 TABLE 73 ABBOTT RECENT DEVELOPMENTS 130 TABLE 74 AFFYMETRIX RECENT DEVELOPMENTS 133 TABLE 75 AGILENT RECENT DEVELOPMENTS 135 TABLE 76 BECKMAN COULTER RECENT DEVELOPMENTS 137 TABLE 77 BD RECENT DEVELOPMENTS 139 TABLE 78 BIOLINE RECENT DEVELOPMENTS 141 TABLE 79 BIONEER RECENT DEVELOPMENTS 143 TABLE 80 BIO-RAD RECENT DEVELOPMENTS 144 TABLE 81 COMPLETE GENOMICS RECENT DEVELOPMENTS 145 TABLE 82 ELITECH RECENT DEVELOPMENTS 147 TABLE 83 ENZO RECENT DEVELOPMENTS 148 TABLE 84 EXIQON RECENT DEVELOPMENTS

13 TABLE HEADING TABLE 85 GE HEALTHCARE RECENT DEVELOPMENTS 151 TABLE 86 GEN-PROBE RECENT DEVELOPMENTS 153 TABLE 87 HY RECENT DEVELOPMENTS 154 TABLE 88 IDAHO TECHNOLOGY RECENT DEVELOPMENTS 155 TABLE 89 ILLUMINA RECENT DEVELOPMENTS 157 TABLE 90 KAPA RECENT DEVELOPMENTS 159 TABLE 91 LIFE TECHNOLOGIES RECENT DEVELOPMENTS 161 TABLE 92 LUCIGEN RECENT DEVELOPMENTS 163 TABLE 93 MAXIM RECENT DEVELOPMENTS 164 TABLE 94 NEW ENGLAND RECENT DEVELOPMENTS 165 TABLE 95 PROMEGA RECENT DEVELOPMENTS 166 TABLE 96 QIAGEN RECENT DEVELOPMENTS 168 TABLE 97 QUANTA RECENT DEVELOPMENTS 170 TABLE 98 ROCHE RECENT DEVELOPMENTS 172 TABLE 99 S-A RECENT DEVELOPMENTS 175 TABLE 100 TAKARA BIO RECENT DEVELOPMENTS 176 TABLE 101 THERMO FISHER RECENT DEVELOPMENTS 178

14 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL PCR TECHNOLOGIES MARKET BY SEGMENT, FIGURE 1 IMPACT OF PCR TECHNOLOGY ON THE HEALTHCARE ENVIRONMENT 17 FIGURE 2 KEY APPLICATIONS OF PCR TECHNOLOGY 20 FIGURE 3 DISADVANTAGES OF PCR VS. THE ADVANTAGES OF ALTERNATIVES 24 FIGURE 4 KEY APPLICATIONS OF PCR 27 FIGURE 5 PATENT ANALYSIS BY GEOGRAPHIC REGION, (%) 35 FIGURE 6 PATENT ANALYSIS BY TYPE OF PRODUCT, (%) 36 FIGURE 7 PCR MARKET STRATEGIES BY TYPE, MARCH (%) 111 FIGURE 8 KEY PLAYERS IN STRATEGIC DEVELOPMENT (%) 112 FIGURE 9 TOTAL PCR MARKET BY GEOGRAPHIC REGION, 2013 VS (%) 124 7