Revaclear. For best in class high flux performance. Smarter dialyzer technology
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1 Revaclear For best in class high flux performance Smarter dialyzer technology
2 At your clinic Using the new Revaclear 300 and 400 high-flux dialyzers in your clinic gives you clear operational advantages over other highflux dialyzers. You can save costs through the need for fewer dialyzer sizes and with every cost saving comes the opportunity to make improvements in other areas of your operation. Fewer sizes. More possibilities A majority of all adult patients at a dialysis unit can be treated using the two dialyzer sizes: Revaclear 300 and 400. This is a great advantage over other dialyzer families that require several more sizes to treat the same range of patients, providing benefits both from a handling and storage perspective. Smaller size. Environmentally sound By using the more effective Poracton membrane Gambro has been able to reduce the size of the dialyzer, meaning less material to produce, ship and gather for disposal after use. Revaclear dialyzers will allow your clinic to lower its environmental impact thanks to the smaller size of the dialyzer. An additional bonus is reduced costs for biohazardous waste. Conserving your budget. Better use of resources With the smaller Revaclear dialyzers, it is possible to minimize the use of saline solution during rinsing procedures. Reducing the amount of solution needed is cost-effective for your clinic, saving time and storage space.
3 Simplified efficiency for nephrologists As a nephrologist, you appreciate any dialyzer that can simplify care and improve patient outcomes. Revaclear dialyzers with their novel Poracton membrane provide high efficiency and selectivity in solute removal. Reduced complexity comes from being able to treat most adult patients using only two dialyzer sizes: Revaclear 300 and 400. This gives you high treatment efficiency and costeffectiveness along with an operational simplicity that benefits both staff and patients. Having fewer dialyzers to choose from helps simplify treatment regimens
4 On your ward A company like Gambro, instrumental for decades in the development of dialysis, also knows what is important to nursing staff. Thus all our know-how from the practical application of dialyzers is manifested in the design of Revaclear dialyzers. Modern dialyzer design. Reduced dialysate consumption The undulated membranes of Revaclear dialyzers enhance dialysate flow distribution. For Revaclear dialyzers, clinical studies 1,2 have shown limited influence of dialysate flow rates above 600 ml/min on dialysis dose delivery (Kt/Vurea). This can help substantially reduce the consumption of dialysate thus avoiding unnecessary costs. Advanced production process. High quality products Revaclear dialyzers are produced in one of the most advanced production facilities in the industry. Our manufacturing processes are known for being state-of-the-art and conforming to legal and regulatory requirements, and beyond. Our quest for the highest possible quality has one aim, to gain your trust for our products and make it as easy as possible to perform your daily tasks when handling a Revaclear dialyzer. Innovative packaging concept. Easy handling The improved packaging design simplifies storage and handling. The dialyzers are arranged in drawers and each drawer contains eight individually packed dialyzers. The sterile packaging has a Tyvek top film for better protection and easy removal. This allows for quicker preparation procedures and creates speedy, space-saving waste disposal in folding boxes. In addition to the above, each dialyzer has a removable label that displays the batch number, sterilization and expiration date. This makes patient file documentation easy and avoids transcription errors.
5 Simplified procedures for nurses As a dialysis nurse, you appreciate the time saved by using equipment that simplifies the dialysis procedure. From a functional perspective, Revaclear dialyzers can be primed easily and are packed in a way that makes them easy to handle. Combining these factors saves time. Using Revaclear dialyzers means fewer types of dialyzers and less dialysate
6 Innovation in form and function Gambro s commitment to innovation is evident in the new and smaller design of the dialyzer and the high efficiency of the membrane, both contributing to proven clinical performance. The membrane Optimizing Gambro s membrane technology gives the novel Poracton membrane distinct performance advantages over previous generations of high-flux dialyzers. Lower diameter. Increased efficiency The Poracton membrane uses a synthetic polymer material in a 3-layer structure. Reduced diameter and wall thickness minimize resistance to solute diffusion and allow a more efficient removal of uremic toxins. Optimized fiber characteristics. Excellent performance The optimized fiber geometry improves the distribution of blood and dialysis fluid resulting in better performance per unit of membrane area. The excellent flush and rinse-back process is due to the uniform fluid distribution in the blood and dialysate compartments, which has been revealed by magnetic resonance imaging. This results in a low amount of residual blood in the membrane and headers after rinse-back seconds Magnetic resonance imaging: Uniform blood flow distribution in the Revaclear dialyzer shown by phase contrast images. 4 Smooth membrane surface. Minimized coagulation risk A combination of hydrophobic and hydrophilic polymers creates an exceptionally smooth surface on the interior side of the hollow fibers. This minimizes the protein adsorption and deposit formation that may lead to coagulation. More endotoxin retention. Minimizing microinflammation The exterior side of the membrane prevents endotoxin fragments from the dialysis fluid passing over into the blood minimizing the risk of chronic micro-inflammation that can develop in dialysis patients.
7 The dialyzer Continuous improvement and innovative engineering is Gambro s trademark resulting in improved header and housing design. Optimized header design. Minimized clotting The header design ensures that every fiber is surrounded by dialysate, preventing channeling or dead spaces that can reduce performance. The proven clinical performance Due to significant improvements made in membrane technology and dialyzer design, it is possible to achieve excellent urea clearance when using the Revaclear dialyzer. Highly efficient urea clearance with small surface area Gambro Gambro Fresenius Nipro FX m 2 PureFlux 210-H 2.1 m 2 Revaclear m 2 FX m 2 Polyflux 170H 1.7 m 2 Pureflux 170-H 1.7 m 2 Revaclear m 2 The smooth surface of the sealing compound reduces friction along the blood flow path and thus reduces the clotting risk. Urea clearance (ml/min) at: Q B =400ml/min, Q D =500ml/min, UF=0ml/min Clearance data in accordance with manufacturers IFU and technical specifications Low priming volume. Improved patient safety The low priming and rinse-back volume of Revaclear dialyzers can help avoid the risk of uncontrolled sodium loading during priming and rinsing of the extracorporeal circuit. References 1 Ward RA, Idoux JW, Hamdan H, Ouseph R, Depner TA, Golper TA. Dilayate Flow Rate and Delivered Kt/V urea for Dialyzers with Enhanced Dialysate Flow Distribution. Clin J Am Soc Nephrol (2011) 6: Bhimani JP, Ouseph R, Ward RA. Effect of increasing dialysate flow rate on diffusive mass transfer of urea, phosphate and β2-microglobulin during clinical haemodialysis. Nephrol Dial Transplant (2010) 25: Bosch J, Beck W, Buck R, Shideman J. Polyflux Revaclear: The Next Generation in High-Flux Dialyzers. White Paper, Gambro Lundia AB, 2010; retrieved from: 4 Huang Z, Attaluri AC, Gao D, Beck W, Buck R, Shideman J. Comparison of clearance and fluid distributions of newly designed high flux hemodialysers. Asaio J (2010) 56:139
8 HCEN15669_ Gambro Lundia AB Every patient is different, every session is different Individualized Quality-assured Dialysis (IQD) from Gambro helps healthcare professionals deliver the best care to every single patient, in every single session. Based on leading dialysis technology and fundamental insights into chronic dialysis care, our IQD offering provides a comprehensive range of treatment modalities and dialysis products for each patient and their individual needs. IQD gives you the confidence that the hemodialysis session is easily and effectively delivered and the target dose is consistently reached while making better use of the clinic s resources. Gambro, Revaclear, Poracton and IQD are trademarks belonging to the Gambro Group. Material not for use in Americas. The IQD approach is all about making a difference in the daily lives of patients and healthcare professionals Gambro Lundia AB PO Box SE Lund Sweden Phone partner@gambro.com
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