mdi Filters for Sample Preparation

Transcription

1 mdi Filters for Sample Preparation Sample filtration is a very important part of any analytical procedure as it is required to safegaurd certified microfilters for filtration of organic solvents, chemicals, buffers, drug and other solutions for various applications involving instrumentation analysis. highly sensitive analytical equipment and also to These filters offer: ensure reliable results. mdi offers a very wide Minimum extractables range of high quality, Very low hold-up volume Large filtration area Absolute retention Very low back pressure The table below will help you select the most suitable filter device for your application. Product Key Features Product Code Dia / Size Application Nylon-66 Membrane Disc Filters Low extractables HNN 13mm/ 47mm Filtration of samples for HPLC (<10ml) Solvent filtration: HPLC mobile phase Nylon-66 Membrane Low extractables Low hold-up volume SY4NN 4mm Sample filtration for HPLC (<2ml) SY13NN 13mm Filtration of samples for HPLC (<10ml) SY25NN Sample filtration (<100ml) Nylon-66 Membrane with pre-filter With prefilter: highly retentive of colloidal particles SY25GN For difficult to filter turbid solutions (<100ml) Automated Nylon-66 Membrane Syringe Filters Specially designed for workstations for automated sample preparation SZ25NN Automated sample filtration (<100ml) Cellulose Acetate Membrane Low protein binding SYCA 4mm, 13mm, For protein samples PTFE Membrane Very wide chemical compatibility SYTF 4mm, 13mm, For highly aggressive solvents PTFE Membrane with pre-filter Very wide chemical compatibility High throughputs SY25TG For difficult to filter samples Nylon-66 membrane Capsule Filters Low extractables DNL 1" Particulate removal from solvents to be used in highly sensitive analytical instruments (500ml to 5 liter) Capsule filtration system for solvents as no elastomers are used CFS - S 5 liter capacity Particulate removal from chemicals, solvents, drug solutions, and especially hazardous chemicals as it does away with flexible tubings and peristaltic pumps in analytical and process development labs 2

2 mdi Nylon-66 Membrane Disc Filters Type HNN HNN membrane disc filters are, hydrophilic, non-media migrating, biologically inert, plain white absolute membrane filters useful for aqueous as well as organic solvent filtration. Special Features Very low extractables HPLC certified: assures that the filter will not add artifacts to the sample Specifications Diameter 0.2µm 0.45µm 13mm,, 47mm Water Flow Rate (ml/min/cm²) at DP=10psi, 20 C Sterilization: Autoclavable at 121 C for 5 cycles Maximum Operating Temperature: 80 C continuous Maximum Operating Pressure: 5Kg/cm² Biosafety: Passes the Biological tests for Class VI plastics as described in USP Extractables with Water: Within limits specified in USP Oxidizable Matter: Passes as per USP Type HNN (µm) 0.2, Diameter (mm) Pack Size (nos) Why do you need to filter your samples and solvents? Filtration of samples and solvents not only increases the accuracy and reliability of the results but also prevents instrument downtime and extends the time between maintenance or repairs. Accuracy and reliability 1. Eliminates background peaks 2. Assures correct and reproducible volumes are injected into the system 3. Eliminates dissolved gases in the mobile phase which cause noise in the detector Instrument downtime 1. Prevents plugging of critical valves and small ID tubing in the analytical instrument 2. Extends the life of the analytical column Type Dia Qty Example: HNN, 0.45µm, 47mm, 500nos Polypropylene Disc Filter Holder Polypropylene filter holder with PTFE gasket to house membrane filter discs. 3

3 mdi Disposable Membrane mdi Nylon-66 syringe filters type SYNN house Nylon-66 membrane disc filter in a polypropylene outer shell, offering absolute retention, wide chemical compatibility, and extremely low extractables. No adhesives are used in manufacture of these filters ensuring no leaching. Special Features Extremely low extractables HPLC certified: assures that the filter will not add artifacts to the sample Types Available Nylon-66 Membrane SY4NN, SY13NN, and SY25NN incorporate hydrophilic Nylon-66 Membrane compatible with a wide range of organic solvents. SY25GN This special syringe filter houses a microglassfiber prefilter along with the Nylon-66 membrane filter and is ideal for filtering difficult to filter turbid solutions. SZ25NN Specifically designed for use in Workstation for automated sample preparation. Offers all the special features of mdi Nylon-66 syringe filters. Cellulose Acetate PTFE Membrane SY4TF, SY13TF, and SY25TF Syringe filters with PTFE membrane which is inert and is specially used for highly aggressive solvents. SY25TG PTFE syringe filters with multilayer micorglassfiber prefilter offer chemical inertness with very high throughputs for difficult to filter solutions. Mobile Phase : Acetonitrile + Water Compound : 10mg/ml Napthalene Figure 1: Typical HPLC chromatogram for 0.45µm Nylon-66 SY4CA, SY13CA, and SY25CA Syringe filters with low protein binding Cellulose Acetate membrane are specially designed for protein samples. Specifications 0.2µm, 0.45µm Diameter 4mm 13mm Effective Filtration Area 0.07cm² 0.8cm² 4.15cm² Hold-Up Volume <5µl <20µl <50µl 4

4 Color Coding For easy identification mdi Syringe filter are available in different colors depending on the type of filter media and pore size. The pictures below show the color coding for different type of filters. 0.2µm SY25NN 0.45µm SY25NN 0.2µm SY25GN 0.45µm SY25GN 0.2µm or 0.45µm SZ25NN 0.2µm SY25TF 0.45µm SY25TF 0.45µm SY25TG 13mm Syringe filters are also available with color coding Type SY4XX Diameter 4mm Pore Size End Connections Inlet Outlet Pack Size 100, 500 XX: NN TF CA =Nylon-66 membrane =PTFE =Cellulose Acetate SY13XX SY25XX SY25GN 13mm 0.2µm, 0.45µm Female luer lock Male luer slip 100 Type Qty SZ25NN SY25TG Example: SY25TF, 0.2µm,1000 5

5 mdi Nylon-66 Membrane Capsule Filters mdi 1 capsule filters type DNL employ Nylon-66 membranes for wide chemical compatibility. These large area filtration devices are ideal for large volume (5-20 liter) filtrations such as mobile phase filtration for preparative HPLC and for large labs with many HPLC systems. Features Compact design Large filter area Long service life 100% Integrity tested No elastomers or adhesives used in sealing Preflushed to minimize particulate release at installation Non-toxic materials of construction End connections to suit different needs Specifications Length Diameter Effective Filtration Area Hold-Up Volume Retention Efficiency Maximum Operating Pressure: 30 C Maximum Operating Temperature: 80 C continuous Biosafety: 0.2µm, 0.45µm 38mm without adapters 42mm 260cm² <5ml 0.2µm: LRV>7 for Br. diminuta 0.45µm: LRV>7 for Sr.marcescens Passes the Biological tests for Class VI plastics as described in USP Extractables with Water: Within limits specified in USP Oxidizable Matter: Passes as per USP Water Flow Rates Pressure Drop (psi) Water Flow Rate (lpm) DNL 0.2µm DNL 0.45µm Figure 2: Water flow rates of DNL capsule filters Pressure Drop (Kg/cm ÿ² ) Type End Connections 1 0.2µm A 1/4" stepped hose barb DNL µm B 1/4" MNPT Type Example: DNL1AA Inlet Connection Outlet Connection For capsule filters with larger filtration area please refer our Process Filtration Product Guide. 6

6 mdi Capsule Filtration System for Solvents Advantages Very high flow rates (1-5lpm) resulting in much reduced filtration time even with 0.2µm capsule filters Very low hold-up volume helps minimize loss of expensive drug solutions Occupies very less laboratory space due to its compact design Components mdi Capsule Filtration System for solvents is ideal for pharmaceutical process development labs and for analytical labs requiring relatively larger volumes of particle free high purity solvents. Features Compact design Available in 5 liter capacity to filter volumes ranging from 500ml to 5 liters All components are of 316 stainless steel No polymeric tubing is used Filters offered are Nylon-66 membrane capsule filters type DNL SS316, 5 liter Pressure Vessel with vent - One valve and a special extended outlet connection to fit capsules with 1/4 MNTP Inlet mdi Nylon-66 membrane capsule filter - 5nos Type : DNL : 0.2µm or 0.45µm Size : 1 End Connections : 1/4 MNTP Inlet 1/4 Stepped hose barb outlet Type Capacity Qty Example: Type : CFSP - S Capacity : 5 liters : 0.2µm Quantity : 1 7