A/Prof Bronwen Connor Neural Repair and Neurogenesis Lab Dept of Pharmacology & Clinical Pharmacology Centre for Brain Research University of
|
|
- Malcolm Shaw
- 5 years ago
- Views:
Transcription
1 A/Prof Bronwen Connor Neural Repair and Neurogenesis Lab Dept of Pharmacology & Clinical Pharmacology Centre for Brain Research University of Auckland
2 Overview What is a stem cell? Discovery - our research Adult stem cells Reprogramming Stem cells in the clinic the Myths the Reality
3 Unspecialised cells What Is A Stem Cell? Unique ability to grow into many different cell types in the body. Involved in development (embryonic stem cells) Also found in many adult tissues and serve as an internal repair system (adult stem cells)
4 What is Unique About Stem Cells? Capable of dividing and renewing themselves for long periods. Can be directed to turn into specialised cells.
5 What is So Exciting About Stem Cells? New potentials for treating many neurological diseases and injuries. Provide new replacement cells Provide supporting chemicals - enhance axon growth - prevent cell death - prevent inflammation. Information about how brain cells develop and are affected by disease process
6 What Are Embryonic Stem Cells?
7
8 What Are Adult Stem Cells? Uncommitted cells found in adult tissue or organs Can self-renew and generate the specialised cells found in mature tissue / organ Involved in maintenance and repair Exciting use in cell replacement therapy as provides potential to use patients own stem cells!
9 Sources of Adult Stem Cells Neural stem cells New brain cells Mesenchymal stem cells Bone, cartilage, fat, connective tissue Neural crest stem cells Bone, cartilage, fat, connective tissue, brain cells Hematopoietic stem cells Blood cells
10 Similarities and Differences Between Embryonic and Adult Stem Cells Embryonic stem cells can become any cell type (pluripotent) - but can form tumours Adult stem cells limited to become cells from tissue of origin - unlikely to form tumours Adult stem cells rare and more difficult to grow in lab Embryonic stem cells grow easily but ethical issues regarding source Adult stem cells can obtained from patient - Removes issues of rejection
11 Our Research... Focused on adult neural stem cells Understanding the role of resident stem cells in the adult brain Normal brain Diseased brain Enhancing Self-Repair Process Stem Cell Transplantation Therapy
12
13 Stem Cells in the Adult Human Brain: Death of a Dogma Eriksson et al 1998; Nature Medicine 4;
14
15 The RMS Pathway for New Brain Cells in the Human Brain Curtis et al, Science, 2007
16 Stem Cells Try to Repair the Diseased or Injured Brain Stem cell division Generation of new brain cells Curtis et al 2003 PNAS
17 Stem Cells Try to Repair the Diseased or Injured Brain Huntington s disease Stroke Brain injury Parkinson s disease
18 Stem Cell Migration Increases and Changes Direction Following Cell Death. Normal Huntington s disease Gordon et al Neuroscience
19
20 The Role of Inflammation Stem Cell Brain Inflammation Chemokine Migration Injury Release Towards Injury Site
21 Stem Cells Try to Repair the Diseased or Injured Brain
22 Stem Cells Generate New Brain Cells But less than 1% survive long-term!
23 Increasing the Generation and Survival of New Brain Cells Brain-derived Neurotrophic Factor (BDNF) injected into rodent model of Huntington s disease. BDNF Generation and survival of new brain cells Henry et al Eur J Neurosci 2007
24 BDNF Increases the Generation and Survival of New Neurons in the Huntington s Disease Brain
25 Stem Cell Transplantation Therapy Using stem cells to replace cells lost through disease or injury. Embryonic stem cells Adult neural stem cells Neural stem cells Neural stem cells Neural stem cells
26 Embryonic Stem Cells Rodent model of HD Long-term survival Generation of new GABAergic neurons BUT tumour formation in ~10% animals Vazey et al 2010 Cell Transplantation
27 Adult Neural Stem Cells BrdU/SOX2 ~1% BrdU/GFAP ~50% BrdU/NeuN / DARPP32 BrdU/NeuN / GAD67 ~35% / 15% Vazey et al 2006 Expt Neurol
28 A bit of Science Fiction... Skin cells can be turned into embryonic stem cells!! Skin Cells 2012 Nobel Prize Winner
29 We Can Turn Skin Cells Into Immature Brain Cells!!! SOX2/PAX6 Skin cells Maucksch et al 2012 JSRM
30 We Can Take Patients Cells and Turn Them Into Specific Brain Cells Dopamine neurons made from skin cells taken from Parkinson s disease patient.
31 The Myths and Reality It s nothing that a few stem cells and 75 years of research can t fix
32 The Truth - Current Clinical Trials Clinical trials are used to establish whether new treatments are safe and effective. Unwanted side effect? Risk level? Benefit level? Clinical trials are based on extensive preclinical research and rigorous peer review. Stem cell therapy MUST obtain US FDA (or equivalent) approval.
33 The Truth - Current Clinical Trials Bone marrow / umbilical cord stem cells Undergoing clinical trials for a range of disorders Heart disease; vascular repair; bone and cartilage repair etc Clinical trials in CNS: Multiple sclerosis; motorneuron disease; stroke; cerebral palsy etc. Autologus; easily accessed; currently approved for leukemias and rare blood disorders No evidence bone marrow / umbilical cord stem cells generate new brain cells Provide chemicals to protect cells, support re-growth of connections, stimulate resident stem cells, reduce inflammation
34 Approved Clinical Trials Neural Stem Cells Company Cell Type Development Progress Indication Indication ReNeuron ReN001 (adult neural stem cells 12 wk old fetus). Commited, not pluripotent. Phase 1. Ischemic stroke. Six months to two years after injury StemCells HuCNS-SC (adult stem cells derived from fetal tissue). Cultured but not altered. Same cells used for both Batten s and cord injury Phase 1. Chronic spinal cord injury Batten s disease Neuralstem NSI-566RSC, human spinal cord derived neural stem cell lines Phase 1 Amyotrophic lateral sclerosis IND filed Chronic spinal cord injury Geron GRNOPC1 (oligodendrocyte progenitor cells, derived and differentiated from hescs) Phase 1 HALTED! Spinal cord injury (acute 7 to 14 days after injury)
35 The Myths Stem Cell Clinics Multiple diseases treated with the same cells. Claims based on patient testimonials. Clinical trials are based on extensive preclinical research or Phase 1/2 clinical trial data. The source of the cells or how the treatment will be done is not clearly documented. Claims there is no risk.
36 The Myths Stem Cell Clinics High cost of treatment or hidden costs. It is not customary for someone to pay to be in a clinical trial. Consider whether you should pay for a treatment that is unproven. Ask about the costs of emergency medical care if something goes wrong, particularly if you are outside your own country. No follow-up after procedure. No assessment of improvement. No reporting of the outcomes of the procedure to the international community.
37 The Myths Stem Cell Pills Stimulating the release of adult stem cells from bone marrow into the circulation to slow aging process and repair areas of the body suffering from degeneration / injury. ColoStem Colostrum product Colostrum has no effect on bone marrow stem cell release.
38 The Myths Stem Cell Pills StemEnhance Blend of two compounds extracted from the aquatic botanical Aphanizomenon flos-aquae (AFA). No scientific evidence that AFA effects bone marrow stem cell release or migration Suggestions that chronic ingestion of AFA may cause liver toxicity. These are food supplements so do not require FDA approval be careful!
39
40 In Conclusion Stem cell therapy for neurological disease and injury is an exciting possibility. We still have much to learn about stem cells. We need to be sure of the long-term safety and effectiveness of stem cell therapies before clinical use Approved clinical trials are the only way to do this. Stem cell clinics do not assist with further development of stem cell therapy and many offer empty promises. There is no over-the-counter stem cell pill
41 Thanks To All Those Involved Palingu Aponso Kevin Chen Jane Evans Renee Gordon Erin Firmin Rebecca Henry Kathryn Jones Adrian Kells Monica Kam Joan Lim Andrew Tattersfield Elena Vazey Stephanie Hughes Alisa McGregor Christof Maucksch Richard Faull Mike Dragunow Maurice Curtis Martin Pera (USC) Mirella Dottori (Uni Melb) Malcolm Horne (HFI, Uni Melb)
42 Supporting Information Patient guideline to stem cell therapy Please feel free to contact the Centre for Brain Research for support and information.
Patient Handbook on Stem Cell Therapies
Patient Handbook on Stem Cell Therapies WWW.ISSCR.ORG WWW.CLOSERLOOKATSTEMCELLS.ORG Patient Handbook on Stem Cell Therapies Introduction We have all heard about the extraordinary promise that stem cell
More informationStem cells and motor neurone disease
Stem cells and motor neurone disease F Stem cell research has fuelled hope of a treatment for a variety of conditions. This information sheet explains what these cells are and includes details of the current
More informationStem Cells & Neurological Disorders. Said Ismail Faculty of Medicine University of Jordan
Stem Cells & Neurological Disorders Said Ismail Faculty of Medicine University of Jordan Outline: - Introduction - Types & Potency of Stem Cells - Embryonic Stem Cells - Adult Stem Cells - ipscs -Tissue
More informationPresenter: Teresa Holm
Slides are from Level 3 Biology Course Content Day, 7 th November 2012 Presenter: Teresa Holm Teachers are free to use these for teaching purposes with appropriate acknowledgement Human Stem cells Dr Teresa
More informationUnderstanding brain diseases from stem cells to clinical trials
Understanding brain diseases from stem cells to clinical trials Alan Mackay Sim Griffith Institute for Drug Discovery Griffith University Brisbane, QLD Making ES cells Fertilise an egg Put in a dish Embryonic
More informationResearch collaboration with Q Therapeutics and its founder Dr. Mahendra Rao. REPROCELL Inc., 2017
Research collaboration with Q Therapeutics and its founder Dr. Mahendra Rao 1 29 th November, 2017 Collaboration with Q therapeutics to develop new ipsc therapies for CNS diseases REPROCELL announced a
More informationFuture of Stem Cell Engineering. Jaeseung Jeong, Ph.D Department of Bio and Brain Engineering KAIST
Future of Stem Cell Engineering i Jaeseung Jeong, Ph.D Department of Bio and Brain Engineering KAIST Keywords of Stem Cell Engineering g Embryo and Fetus (Foetus) Adult stem cells and embryonic stem cells
More informationThe New News in Stem Cell Research Andrés Bratt-Leal, PhD 12/1/2017
The New News in Stem Cell Research Andrés Bratt-Leal, PhD 12/1/2017 Cell Therapy and Parkinson s Disease Very specific neural degeneration >50% of DA neurons are gone by diagnosis 1 million in the USA,
More informationCases of Academic Misconduct. Core Components
Cases of Academic Misconduct May 2015 Examination Session Core Components Extended Essay / Biology Infringement: Plagiarism Pages 1-6 show no evidence of plagiarism. Comments A significant portion of the
More informationBME 177. Engineering stem cells. Gayatri Pal Lecturer Biomolecular Engineering
BME 177 Engineering stem cells Gayatri Pal Lecturer Biomolecular Engineering Introduction Graduated from MCD Biology (Yeast Cell Cycle) -CIRM classes (Introduction to stem cell biology) Post-doc training
More informationStem Cells: Introduction and Prospects in Regenerative Medicine.
Stem Cells: Introduction and Prospects in Regenerative Medicine www.gothamgazette.com/.../stemcell/stem_cell.jpg Ode to a Stem Cell, Part II by VCW There once was stem cell stuck in the hood Dividing endlessly,
More informationBanking Human Neural Stem Cells for Clinical Applications. Lisa Fox Director, Cell Process Development & Operations
Banking Human Neural Stem Cells for Clinical Applications Lisa Fox Director, Cell Process Development & Operations 7 th Annual Somatic Cell Therapy Symposium September 27, 2007 Stem Cells Inc. Approach
More informationLets regenerate! The exci0ng life of a stem cell. Deepa Subramanyam, PhD Na0onal Centre for Cell Science, Pune. Slides adapted from CIRM
Lets regenerate! The exci0ng life of a stem cell Deepa Subramanyam, PhD Na0onal Centre for Cell Science, Pune Slides adapted from CIRM Our body is made up of different cells and organs. how are these made?
More informationRenew, Repair, Rejuvenate. Presented by: Clinton Howard at the 2012 Leadership Retreat Maui, Hawaii, September 29, 2012
Stem-Kine Renew, Repair, Rejuvenate Presented by: Clinton Howard at the 2012 Leadership Retreat Maui, Hawaii, September 29, 2012 I am pleased to have the opportunity to talk with you about one of the most
More informationFrom Stem Cell to Any Cell
sciencenewsforkids.org http://www.sciencenewsforkids.org/2005/10/from-stem-cell-to-any-cell-2/ From Stem Cell to Any Cell By Emily Sohn / October 11, 2005 For maybe a day, about 9 months before you were
More informationTherapeutic Cell Replacement. Steven McLoon Department of Neuroscience University of Minnesota
Therapeutic Cell Replacement Steven McLoon Department of Neuroscience University of Minnesota 1 Neuronal Death Neurons are lost due to four main causes: Trauma Toxin Hypoxia (typically loss of air or blood
More informationTowards a stem cell based therapy for Parkinson s Disease
Stem cell based therapies for Parkinson s Disease Towards a stem cell based therapy for Parkinson s Disease MALIN PARMAR NYSCF Robertson Investigator Lund University, Sweden INTR, Port Douglas, Sept 13-16,
More informationLesson 7A Specialized Cells, Stem Cells & Cellular Differentiation
Lesson 7A Specialized Cells, Stem Cells & Cellular Differentiation Learning Goals I can explain the concept of cell differentiation and cell specialization. I can explain how the cell structure relates
More informationStem cells and cell therapy
Stem cells and cell therapy lecture 7-15.05.2012 What is a stem cell? Stem cell can differentiate into two or more cell types Progenitor cells differentiates into single cell type 2 Sources of stem or
More informationThe Science of Stem Cell Therapy
The Science of Stem Cell Therapy AVM Biotechnology City Centre Building 1420 Fifth Avenue, Suite 2650 Seattle, WA 98101 206-906-9922 www.avmbiotech.com Copyright 2008 AVM Biotechnology, LLC speaker disclosure
More informationINUED DISCONTINUED DISCONTINUED DISCON MAKING THE IMPOSSIBLE POSSIBLE CENTER FOR REGENERATIVE MEDICINE
INUED DISCONTINUED DISCONTINUED DISCON MAKING THE IMPOSSIBLE POSSIBLE CENTER FOR > SOLUTIONS AND HOPE Millions of people worldwide suffer from deadly diseases, chronic conditions and congenital disorders
More informationAndrew Finnerty General Manager - CCMI
Andrew Finnerty General Manager - CCMI Manufacturing Human Mesenchymal Stem Cells for Clinical Trials Quality Considerations Biopharma and Pharma RQA Regional Forum Bioclin Laboratories, Athlone 13 May
More informationCURRENT STATUS OF STEM CELL TREATMENTS FOR CEREBRAL PALSY: A GUIDE FOR PATIENTS, FAMILIES AND CAREGIVERS
SPRING, 2011 CURRENT STATUS OF STEM CELL TREATMENTS FOR CEREBRAL PALSY: A GUIDE FOR PATIENTS, FAMILIES AND CAREGIVERS *Crystal Ruff, *Jared Wilcox, Michael G. Fehlings Krembil Neuroscience Centre, Toronto
More informationTherapeutic Cell Replacement. Steven McLoon Department of Neuroscience University of Minnesota
Therapeutic Cell Replacement Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Coffee Hour Wednesday (Dec 13) Thursday (Dec 14) Friday (Dec 15) 9:00-10:00am Surdyk s Café in
More informationStem Cell Research 101
Stem Cell Research : A promising type of bioscience research The Stem Cell debate and the impact of the induced pluripotent stem cell procedure Why Is Vocabulary Important? Key terms frame the debate Mature
More informationDes cellules-souches dans le poumon : pourquoi faire?
Des cellules-souches dans le poumon : pourquoi faire? Karl-Heinz Krause Dept. of Pathology and Immunology, Medical Faculty Dept. of Genetic and Laboratory Medicine, University Hospitals Geneva, Switzerland
More informationSTEM CELL RESEARCH PRIMER
STEM CELL RESEARCH PRIMER WHAT YOU NEED TO KNOW ABOUT STEM CELLS AND STEM CELL RESEARCH What Stem Cells Are And Why They Are Important Stem cells are the body s very own internal repair system. They are
More informationSTEM CELLS IN NEUROLOGY ISABELLE COCHRANE MERIT
STEM CELLS IN NEUROLOGY BY ISABELLE COCHRANE MERIT RESEARCH PAPER BASED ON PATHOLOGY LECTURES AT MEDLINK 2011 1 Abstract Ever since their discovery, stem cells have been heralded as the ultimate cure to
More informationCharacteristics. Capable of dividing and renewing themselves for long periods of time (proliferation and renewal)
STEM CELLS (p 2-8) Overview The body is made up of about 200 different kinds of specialised cells, such as muscle cells, nerve cells, fat cells and skin cells. Cells with the capacity to give rise to the
More informationWHAT IS EMBRYONIC STEM CELLS
31 March, 2018 WHAT IS EMBRYONIC STEM CELLS Document Filetype: PDF 436.17 KB 0 WHAT IS EMBRYONIC STEM CELLS Explore Current Stem Cell Treatments. Embryonic stem cells - Embryonic stem cells include those
More informationTHE GLOBAL MARKET FOR STEM CELLS
THE GLOBAL MARKET FOR STEM CELLS BIO035F May 2016 Paul Evers Project Analyst ISBN: 1-62296-292-3 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215 (toll-free within the USA),
More informationRegenerative Medicine and Stem Cell Therapies
Regenerative Medicine and Stem Cell Therapies Regenerative Medicine Major component of successful regenerated / tissue engineered organs Scaffolds A critical element is the binding of the repopulating
More informationSTEM CELLS: THE FUTURE OF REGENERATIVE MEDICINE
STEM CELLS: THE FUTURE OF REGENERATIVE MEDICINE BY SHIVAM KOLHE Grade awarded: Pass RESEARCH PAPER BASED ON PATHOLOGY LECTURES AT MEDLINK and VET-MEDLINK 2014 Abstract Within the UK, around 1000 people
More informationMolecular Medicine. Stem cell therapy Gene therapy. Immunotherapy Other therapies Vaccines. Medical genomics
Molecular Medicine Molecular Medicine Stem cell therapy Gene therapy Tumor therapy Immunotherapy Other therapies Vaccines Genetic diagnostics Medical genomics Medication Diagnostics medicine: old desire
More informationStem Cell Research From Bench to Bedside
Stem Cell Research From Bench to Bedside Stem Cell Dialogues Jan A. Nolta, Ph.D. Professor, Internal Medicine Director, UC Davis Institute for Regenerative Cures October 26, 2010 Stem Cells at UC Davis
More informationNPTEL Biotechnology Tissue Engineering. Stem cells
Stem cells S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Joint Initiative of IITs and IISc
More informationHypoxic Preconditioning Strategy for Stem Cell Transplantation Therapy after Ischemic Stroke
The 13 th International Conference on Dose-Response Preconditioning: Adaptive Responses in Biology and Medicine; UMass Amherst Hypoxic Preconditioning Strategy for Stem Cell Transplantation Therapy after
More informationAdult Stem Cells for Chronic Pain. Dr. John Hughes, DO January 24 th, 2018
Adult Stem Cells for Chronic Pain Dr. John Hughes, DO January 24 th, 2018 Dr. John Hughes, DO Doctor of Osteopathy From Georgia Arizona College of Osteopathic Medicine - 2007 Aspen Integrative Medicine
More informationThe NYSCF Research Institute
Regenerative Medicine Research Update Susan L. Solomon The NYSCF Research Institute New York Pharma Forum February 25, 2016 Regenerative Medicine Research Regenerative medicine uses laboratory grown human
More information2/12/2009. Virus enters here. Rakic, JCN, 1972
Stem Cell Update Feb. 12, 2009 Arnold R. Kriegstein, MD, PhD, Department of Neurology, Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF Virus enters here Rakic,
More informationMonitoring the Safety of Stem Cell Based Therapeutics in Clinical Trials. Jane Lebkowski Ph.D. ASGCT May 18, 2010
Monitoring the Safety of Stem Cell Based Therapeutics in Clinical Trials Jane Lebkowski Ph.D. ASGCT May 18, 2010 Disclosure Received salary & ownership interest from Geron Corporation as an employee. Multiple
More informationStem Cel s Key Words:
Stem Cells Key Words: Embryonic stem cells, Adult stem cells, ips cells, self-renewal, differentiation, pluripotent, multipotent, Inner cell mass, Nuclear transfer (Therapeutic cloning), Feeder cells,
More informationAre remyelination strategies realistic?
Presenter: Benjamin Greenberg, MD, MHS University of Texas Southwestern and Children s Medical Center Transcription from presentation available at https://youtu.be/npsgkpaqeyg 00:00 This afternoon even
More informationhpsc Growth Medium DXF Dr. Lorna Whyte
hpsc Growth Medium DXF Dr. Lorna Whyte 27.06.2014 Training from Heidelberg Overview Background: Stem Cells Introduction: Human Pluripotent Stem Cells (hpsc) vs. Adult Stem Cells Promise of PSC Research
More informationStem cells and cell therapy. lecture
Stem cells and cell therapy lecture 7-20.05.2012 What is a stem cell? Stem cell can differentiate into two or more cell types Progenitor cells differentiates into single cell type Classification of SCs
More informationAt the conclusion of this lesson you should be able to:
Learning Objectives At the conclusion of this lesson you should be able to: Understand the key terms and definitions regarding stem cells Differentiate between the adult and embryonic stem cells Differentiate
More informationWill Stem Cells Finally Deliver Without Controversy?
Will Stem Cells Finally Deliver Without Controversy? Keith Gary, Ph.D. Director of Program Development Kansas City Area Life Sciences Institute Olathe North Life Sciences 1 February 2012 What s the Buzz?
More informationInFocus In Ontario 9 HIGH-POTENTIAL MAKING AN IMPACT STEM CELL INNOVATION
InFocus 2018 In Ontario MAKING AN IMPACT STEM CELL INNOVATION As Canada s most populous province and host to globally respected research organizations, Ontario is a dynamic centre for stem cell exploration.
More informationFundamental properties of Stem Cells
Stem cells Learning Goals: Define what a stem cell is and describe its general properties, using hematopoietic stem cells as an example. Describe to a non-scientist the current progress of human stem cell
More informationEMBRYONIC STEM CELL RESEARCH: ALTERNATIVE METHODS & ALZHEIMER S DISEASE
EMBRYONIC STEM CELL RESEARCH: ALTERNATIVE METHODS & ALZHEIMER S DISEASE BY KHYATI PATEL Word count: Approx 2300 Grade awarded June 2006: PASS WITH DISTINCTION RESEARCH PAPER BASED ON PATHOLOGY LECTURES
More informationCELL THERAPY FOR NEUROLOGICAL DISEASE
CELL THERAPY FOR NEUROLOGICAL DISEASE Sally Temple PhD Neural Stem Cell Institute sallytemple@neuralsci.org 518 694 8188 UNMET MEDICAL NEED Brain Spinal Cord Disease Approx prevalance Alzheimer s 5.3MM
More informationChapter 8 Healthcare Biotechnology
Chapter 8 Healthcare Biotechnology Outline: 8.1 Introduction 8.2 Biopharming 8.3 Models of Human Disease 8.4 Detecting and Diagnosing Human Disease 8.5 Monoclonal Antibodies 8.6 Gene Therapy 8.7 Tissue
More informationOffice of Patents and Licensing STEM CELLS & TISSUE ENGINEERING
1 STEM CELLS & TISSUE ENGINEERING Technology : University of Medicine and Dentistry of New Jersey 335 George Street, New Brunswick, NJ 08901 Direct Phone: (732)-235-9355 Office Phone: (732)-235-9350 Fax:
More informationStem cells in Development
ANAT 2341 Embryology Lab 10 8 Oct 2009 Therapeutic Use of Stem Cells Practical Hurdles & Ethical Issues Stem cells in Development Blastocyst Cord blood Antonio Lee PhD Neuromuscular & Regenerative Medicine
More informationMyelin Repair Foundation Research Progress Report June 2006-July 2007
Myelin Repair Foundation Research Progress Report June 2006-July 2007 In July 2004, the Myelin Repair Foundation initiated a five-year research plan with the mission of discovering and validating new therapeutic
More informationMesenchymal Stromal Cells Large-scale Culture
Mesenchymal Stromal Cells Large-scale Culture Adrian Gee Center for Cell & Gene Therapy Baylor College of Medicine Houston, Texas Hanley et al: Efficient manufacturing of therapeutic mesenchymal stromal
More informationStem cells in Development
ANAT 2341 Embryology Lab 10 8 Oct 2009 Therapeutic Use of Stem Cells Practical Hurdles & Ethical Issues Stem cells in Development Blastocyst Cord blood Antonio Lee PhD Neuromuscular & Regenerative Medicine
More informationStem Cell Uses and FDA Regulation
Stem cells have been called everything from cure-alls to miracle treatments. But don t believe the hype. Some unscrupulous providers offer stem cell products that are both unapproved and unproven. So beware
More informationMaking Sense of Stem Cell Research and Cloning. Alan Shlemon Stand to Reason
Making Sense of Stem Cell Research and Cloning Alan Shlemon Stand to Reason www.str.org The body has over 200 different types of specialized cells. Stem Cells A stem cell is an unspecialized cell Unspecialized
More informationThe 3Rs: are Human Stem Cells and Organs on Chip alternatives?
The 3Rs: are Human Stem Cells and Organs on Chip alternatives? Towards precision medicine in future healthcare Christine Mummery Leiden University Medical Centre University Twente hdmt Three kinds of human
More informationDifferentiation = Making specialized cells. Self-renewal = copying. What is a stem cell?
Differentiation = Making specialized cells What is a stem cell? What the photo shows A lump of metal and lots of different kinds of screws that can be made from it. Things to think about What is a specialized
More informationANAT 2341 Embryology Lecture 18 Stem Cells
ANAT 2341 Embryology Lecture 18 Stem Cells 29 September 2010 Dr Antonio Lee Neuromuscular & Regenera
More informationFederal Funding for Brain Research. Congressional Support Accelerates Discovery
The American Brain Coalition (ABC) is a non-profit organization that brings together people with disabling brain disorders, the families of those that are affected, and the professionals who research and
More informationTOP ST. search articles. ' s. . Discovery brings with it possible implications for brain regeneration -
Like 1.1M Follow 0 Research News Clinical Updates Publications NeuroInsights Product News search articles Scientists discover neuron-producing stem cells in the membranes covering the brain November 23,
More informationStem Cells Canadian Perspective
Stem Cells Canadian Perspective John Laffey Critical Illness and Injury Research Centre, Keenan Research Centre, St Michael s Hospital. Departments of Anesthesia, Physiology and Interdepartmental Division
More informationStem Cell Therapy: Miracle Cure or Mirage?
Stem Cell Therapy: Miracle Cure or Mirage? Nipan Israsena M.D., Ph.D. Head, Stem Cell and Cell Therapy Research Unit Faculty of Medicine, Chulalongkorn University Bangkok Thailand BM transplantation 1950s
More informationFROM CONCEPT TO PATIENT TREATMENT: A CLINICAL TRIAL OF MESENCHYMAL STROMAL CELLS FOR AMYOTROPHIC LATERAL SCLEROSIS
FROM CONCEPT TO PATIENT TREATMENT: A CLINICAL TRIAL OF MESENCHYMAL STROMAL CELLS FOR AMYOTROPHIC LATERAL SCLEROSIS Allan B. Dietz, Ph.D. Human Cell Therapy Lab Mayo Clinic Acknowledgements Human Cell Therapy
More informationUnit 1: DNA and the Genome. Sub-Topic (1.4) Cellular Differentiation
Unit 1: DNA and the Genome Sub-Topic (1.4) Cellular Differentiation Duncanrig 2016 Unit 1: DNA and the Genome Sub-Topic (1.4) Cellular Differentiation On completion of this subtopic I will be able to Cellular
More informationDuncanrig Secondary School
National 4 Biology Unit 1Topic 3: Therapeutic Uses of Cells, Duncanrig Secondary School Duncanrig Secondary School National 4 Biology Unit 1 Topic 3: Therapeutic Uses of Cells Pupils Activity Booklet National
More informationFDA Regulatory, Compliance and Policy Developments: 361 HCT/Ps
FDA Regulatory, Compliance and Policy Developments: 361 HCT/Ps September 27, 2018 Presentation by: Elaine H. Tseng Partner FDA and Life Sciences Group King & Spalding Discussion with: Thomas Poché Vice
More informationfor SCI: Challenges for Entry and Execution of Phase 1 Clinical Trials Challenges and Opportunities of Cellular Therapeutic Development
Case Study: Human Embryonic Stem Cell Based Therapy for SCI: Challenges for Entry and Execution of Phase 1 Clinical Trials Jane S Lebkowski Ph.D NHLBI-PACT Workshop Sept 15, 2011 Challenges and Opportunities
More informationTeam Training. Jan Nolta, Ph.D., Director UC Davis Stem Cell Program and Institute for Regenerative Cures. Editor in Chief, Stem Cells
Team Training Jan Nolta, Ph.D., Director UC Davis Stem Cell Program and Institute for Regenerative Cures Editor in Chief, Stem Cells Goal: To improve therapies for our patients through translational research
More informationISSCR 2017 Abstract Submission Guide
ISSCR 2017 Abstract Submission Guide The International Society for Stem Cell Research (ISSCR) invites the submission of abstracts that report new research developments across the breadth of stem cell biology,
More informationT H E R A P Y REGENERATIVE MEDICINE NATURAL EFFECTIVE LIFE-CHANGING
S T E M C E L L T H E R A P Y REGENERATIVE MEDICINE NATURAL EFFECTIVE LIFE-CHANGING STEM CELL THERAPY Early stem cell research has traditionally been associated with the controversial use of embryonic
More informationThe Role of Adult Stem Cells in Personalized and Regenerative Medicine
The Role of Adult Stem Cells in Personalized and Regenerative Medicine Christopher J. Neill, Director of Corporate Operations American CryoStem Corporation Objective To illustrate the potential benefits
More informationAvailable through Online
ISSN: 0975-766X CODEN: IJPTFI Available through Online Review Article www.ijptonline.com STEM CELLS-MODERN APPROACH IN MEDICINE Kameshwar Sharma YVR* 1, Prasidhi Tyagi 2 and Samarth Kulshrestha 3 * 1 Department
More informationMAGNIFICATION? Human Embryonic Stem Cell
Stem Cells: The Silver Lining Behind the Dark Clouds by Fr. Robert Gahl Associate Professor of Ethics Pontifical University of the Holy Cross Human Embryonic Stem Cell MAGNIFICATION? Stem Cells: The Silver
More informationTHE THERAPEUTIC REALITIES OF STEM CELLS
Ferghana Partners Group is a Life Sciences investment banking house with offices in London and New York. We specialise in creating and executing effective strategic transactions for pharmaceutical, chemical,
More informationLisa Griffin (BSc Hons Biology), David Hughes August 2013
Title Authors Contact Target level Publication date Lisa Griffin (BSc Hons Biology), David Hughes Maggy.fostier@manchester.ac.uk KS4 science, GCSE August 2013 Activity Length Content related to the GCSE
More informationStem Cells. Part 1: What is a Stem Cell? STO Stem cells are unspecialized. What does this mean?
STO-120 Stem Cells Part 1: What is a Stem Cell? Stem cells differ from other kinds of cells in the body. When a stem cell divides by mitosis, each new cell has the potential to either remain a stem cell
More informationInduced Stem Cells in Research and Therapy of Neuropsychiatric Disorders
Berlin-Brandenburg Center for Regenerative Therapies Induced Stem Cells in Research and Therapy of Neuropsychiatric Disorders Josef Priller Department of Neuropsychiatry Laboratory of Molecular Psychiatry
More informationSNC2D BIOLOGY 3/31/2013. TISSUES, ORGANS & SYSTEMS OF L Stem Cells & Meristematic Cells (P.40-41) Specialized Cells. Stem Cells
SNC2D BIOLOGY TISSUES, ORGANS & SYSTEMS OF L & Meristematic Cells (P.40-41) Specialized Cells The cell theory states that all cells come from pre-existing cells. Every cell that makes up an animal s body
More informationSTEM CELLS BONE FRACTURE
BIOLOGY UNIT 2 MRS. CATHERINE JACKSON STEM CELLS BONE FRACTURE By AYESHA SYED 10C 2 Stem Cell (Introduction) Stem cells are undifferentiated cells that have not yet become a specialised cell, with a specific
More informationDeveloping Targeted Stem Cell Therapeutics for Cancer. Shawn Hingtgen, Ph.D. Assistant Professor UNC Eshelman School of Pharmacy May 22 nd, 2013
Developing Targeted Stem Cell Therapeutics for Cancer Shawn Hingtgen, Ph.D. Assistant Professor UNC Eshelman School of Pharmacy May 22 nd, 2013 The Challenge of Drug Delivery for Brain Cancer Stem Cells
More informationGenetics Lecture 19 Stem Cells. Stem Cells 4/10/2012
Genetics Lecture 19 Stem Cells Stem Cells Much of the excitement about stem cells in the scientific and medical communities comes from their largely untapped and unproven potential for treating human conditions)
More informationStem Cells: A Primer National Institutes of Health
Stem Cells: A Primer National Institutes of Health I. INTRODUCTION Research on stem cells is advancing knowledge about how an organism develops from a single cell and how healthy cells replace damaged
More informationEducation Critical to Stem Cell Therapy Pipeline
June 2016 Education Critical to Stem Cell Therapy Pipeline Don L. Gibbons Senior Science and Education Communication Officer ABOUT California Institute for Regenerative Medicine (CIRM) CIRM is California
More informationStem Cell Transplantation Combined with Niche Modification: A Novel Strategy for Treatment of Neurodegeneration
Stem Cell Transplantation Combined with Niche Modification: A Novel Strategy for Treatment of Neurodegeneration Keiko Nakanishi 1, *, Atsuhiko Oohira 2 1 Department of Perinatology, Institute for Developmental
More informationCells, Tissues and Organs
Cells, Tissues and Organs You have already learned the basic function of cells, but how do these cells work together to make you the truly amazing organism that you are? Some of the key words you will
More informationHow You Can Use Stem Cells
How You Can Use Stem Cells Dr. Ralph T Bright Macquarie Cosmetic Medicine 21B Bathurst Street Liverpool NSW 2170 www.cosmeticmedicine.com.au (02) 9824 3044 Stem Cell Transfer Many of the people in this
More informationSHOULD THE GOVERNMENT FUND STEM CELL RESEARCH?
Join the national conversation! SHOULD THE GOVERNMENT FUND STEM CELL RESEARCH? Focus Words embryo paralyzed theory investigate obtain! WEEKLY PASSAGE Word Generation - In summer 2003, toddler Kai Harriott
More informationWhat Are Stem Cells? Where Are These Stem Cells?
While stem cell therapies may seem to have appeared overnight, they have been practiced for some time prior to the recent burst in new applications and stem cell sources. The most recent developments in
More informationPhysicsAndMathsTutor.com. Question Number. Answer Additional guidance Mark. 1(a) 1. reference to stem cells being {totipotent / pluripotent} ;
1(a) 1. reference to stem cells being {totipotent / pluripotent} ; 2. can specialise or differentiate / can give rise to {differentiated / specialised} cells ; 3. idea that these can replace damaged cells
More informationSpecial Issue. Mesoblast Limited
Overview is an Australian biotechnology company committed to the commercialization of novel treatments for orthopedic conditions by using its unique adult stem cell technology for the regeneration and
More informationShould Embryonic Stem Cell Research be Permitted to Continue? Over the past few years a debate has been going on over the moral implications of
Courtesy of Christopher Waits. Used with permission. Waits 1 Should Embryonic Stem Cell Research be Permitted to Continue? Over the past few years a debate has been going on over the moral implications
More informationStem cells in regenerative medicine: introduction
Published Online May 11, 2011 Stem cells in regenerative medicine: introduction Dusko Ilic 1, and Julia M. Polak 2* 1 Kings College London School of Medicine, Division of Women s Health, Assisted Conception
More informationStem cells and tissue engineering
Stem cells and tissue engineering S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Joint Initiative
More informationIntroduction This is an exam style question on stem cells that might be useful towards the end of the topic.
Teacher Notes Introduction This is an exam style question on stem cells that might be useful towards the end of the topic. Suggested mark scheme (a) (i) a non-specialised cell any 1 for 1 a cell that can
More informationThe European Stroke Network
The European Stroke Network A Unique Alliance for Combating Stroke Prof. Dr. Stephen Meairs Department of Neurology University Medicine Mannheim University of Heidelberg, Germany European Stroke Network
More informationLeading the world in novel adult stem cell therapies Half-Year Financial Results
Leading the world in novel adult stem cell therapies 2013 Half-Year Financial Results CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS This presentation, including any comments made during or following
More information