23andMe Research: By the People, For the People. Carrie Northover, PhD Manager, Research Partnerships Health Datapalooza 2016

Transcription

1 23andMe Research: By the People, For the People Carrie Northover, PhD Manager, Research Partnerships Health Datapalooza 2016

2 What is 23andMe? Direct to consumer genetic testing company Customers receive raw genotype data and 60+ reports 1.2M+ genotyped customers 2

3 Our Mission: To help people access, understand and benefit from the human genome

4 Access: First and only DTC service with reports that meet FDA standards 35+ Carrier Status* 3 Ancestry 5+ Wellnes s 19+ Traits *Our tests can be used to determine carrier status in adults from saliva collected using an FDA-cleared collection device (Oragene DX model OGD ), but cannot determine if you have two copies of the genetic variant. Each test is most relevant for people of certain ethnicities. The tests are not intended to diagnose a disease, or tell you anything about your risk for developing a disease in the future. On their own, carrier status tests are not intended to tell you anything about the health of your fetus, or your newborn child s risk of developing a particular disease later in life. 4

5 Understand: User Comprehension 600+ people in 5 cities across the United States Demographically diverse: age, race/ethnicity, education level >90% comprehension 5

6 Our Mission: To help people access, understand and benefit from the human genome

7 Benefit: Personalized Medicine and More Efficient Drug Development Use genetics to personalize treatment Understand risk to maximize prevention Help industry develop better drugs and diagnostics using genomic data from everyday people Nine out of ten drugs deemed successful in animal tests fail in human clinical trials Drugs with human genetic support are 1.5-2x times more likely to succeed 7

8 23andMe Research Opt-in IRB approved protocol Participation is easy Geography not a barrier Aggregated and anonymized Everyone in multiple studies 8

9 Engaged Consumers Enable a New Model for Research Total of Pink (1,306 total) 80% consent 75% survey 345M+ questions answered Genotype data Phenotype data Biobanked samples Longitudinal data Ability to re-contact

10 discoveries maximize through collaborations

11 Apple ResearchKit Module Supports existing and new 23andMe customers Allows researchers to obtain permission to access customer data Two partner apps: Stanford MyHeartCounts Mt. Sinai Asthma Health 11

12 Academic Collaborations 30+ ongoing free collaborations 12

13 Academic Collaborations PRNP variants previously thought pathogenic are at least 30X more common than expected Some benign, others incomplete penetrance Changed prognoses, therapeutic clues 13

14 Industry Partnerships Research Platform (existing participants) Surveys Clinical Trial Recruitment 14

15 Industry Partnerships Disease Initiatives (new participants) 15

16 Richard Scheller, PhD CSO and Head of Therapeutics Former Genentech EVP of research and early development Lasker Award winner Member, American Academy of Arts & Sciences Member Member, National Academy of Sciences I have dedicated my life to research aimed at fulfilling unmet needs for very sick people.i am excited about the potential for what may be possible through 23andMe s database. It is unlike any other.

17 By the people, for the people Participants database 23andMe Research 23andMe Therapeutics therapies reports and papers biotech/ pharma 17

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