Commercialization of New Proteins: Feedkind Protein. BIO World Congress Montreal July 2017

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1 Commercialization of New Proteins: Feedkind Protein BIO World Congress Montreal July 2017

2 Food Security Is the Issue of the Future By 2050, 9.6B people will demand 75% more protein than currently available 2006 Protein Demand 2050 Protein Demand 63.9 million tonnes million tonnes Our research shows people will spend one-third of any increase in incomes on a more varied high-protein diet Greg Page Former Chairman of Cargill Source: UN World Population Prospects: The 2012 Revision. World agriculture: towards 2030/2050. Food and Agriculture Organization of the United Nations, Creating a Sustainable Food Future, World Resources Institute Report : Interim Findings 2

3 Feedkind Protein is a Premium, non-gmo Ingredient Bacteria (methanotrophs) metabolize methane as their sole source of carbon and energy, producing a nutritious, highprotein biomass Approved for use in the EU, Australia, Ecuador >10 years of safety data in salmon farming Safety studies completed in pigs, chickens, calves, rats, mink, and fox Analogous to yeast extract Supplied dry as powder or pellets; shelflife >12 months at ambient temperature 3

4 Calysta Production Process Methane Fermentation Product Separation Drying 4

5 Commercialization Under Way: European Fermentation Center Opens in the UK Operational since Feb, 2017 Over 5 tonnes produced, up to per year Demonstrated achievement of yield and productivity metrics in first campaign Samples currently available for customers and regulatory agencies Partnered with Center for Process Innovation ( CPI ) to facilitate quick build 9 months from start to finish Critical fermentation and analytical staff in place Received grant for up to ~ 3 million from the UK ergf Access to contract staffing provided by CPI and anaerobic digestion facilities for biogas work European Fermentation Center in Teesside, England. 5

6 Memphis, TN Corn Sweetener Terminal & Corn Oil Refinery OVERVIEW Original construction in 1974 as corn sweetener operation. Corn sweetener production operations idled in 2014 Corn sweetener terminal and corn oil refinery operations continue 24/7/365 Days a year 6

7 Memphis Site View

8 Planned Memphis Atlantis Build Layout

9 Superior High Protein Ingredient 100% Major Sources of Aquaculture Protein and New Alternatives 80% 60% 72% 70% 67% 66% 66% 62% 56% 40% Herring Fishmeal FeedKind Anchovy Fishmeal Soy PC Activated Brewery Waste Spirulina Corn Gluten Meal Crude Protein Lipid Crude Fiber Ash 47% 42% Chlorella Soldier Fly Larva High protein, low ash/fiber are major price drivers However! Composition is not the whole story Source: FAO Feed Ingredients and Fertilizers for Farmed Aquatic Animals, ADM Arcon SPC composition. 9

10 Feed Conversion Ratio Rainbow Trout * * * * * * Digestability and nutritional value of Feedkind Protein is higher than super prime fishmeal in this study Feed Conversion Ratio is the primary driver of profit on the farm; same output of fish for less feed eaten.

11 Improved performance Vannamei 10 PL shrimp per tank, 5-6 tanks per group, 8 weeks growth, fixed feeding schedule Control diet: 15% fishmeal compared to 100% replacement by Feedkind protein Significant increase in survival relative to fishmeal diet No significant difference in total biomass even completely eliminating fishmeal

12 Calysta Feedkind protein compared to alternatives Protein Digestability (multiple species) Shrimp Survival inclusion) Shrimp Growth inclusion relative to fishmeal) Bacterial meal Insect meal Fishmeal Feedkind 69% 82% 75%-85% 97% 85% 91% 85-91% 97% 85% 51% 100% 100%+ Feedkind represents a premium ingredient that performs better than competitors, including fishmeal! Source: Tlusty et al., Peer J. Cummins et al., 2017 Aquaculture 12

13 Superior performance on multiple metrics Aquaculture Growth Product Quality Survival / Disease Atlantic Salmon + = + Yellowtail = + ND Shrimp (Vannamei) + ND + Livestock Growth Product Quality Survival / Disease Weaning piglets + ND + Adult Pigs = + = Cattle = + = Chicken - + = Feedkind protein has been tested extensively across a wide range of species and markets. Performance is generally significantly improved on key price metrics Pets Growth Palatability Health Cats = = + Dogs = = + Human Nutrition (PDCAAS) Palatability Health + + ND Comparison to performance of equivalent ingredient in a control diet 13

14 Barriers to Entry - SCP IP: How to protect a natural strain? GMO strains can be protected, but how to overcome consumer acceptance? Production technology: How to scale up feedstocks? Mass transfer, surface area, toxicity, safety? Proprietary reactor vs off-the-shelf? Product performance: All SCPs are not equivalent! Target species, product profile, inclusion level, digestability, nutritional value, palatability. Regulatory approval: Approvals are not generic. Approval bodies will assess potential pathogenicity (species name). New products require extensive safety testing. Commercial scale-up: How to cross the valley of death? 14

15 Sustainable source of protein with superior impacts on both health and product quality THANK YOU! 15

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