Cerenkov Imaging in Biomedicine

Transcription

1 Cerenkov Imaging in Biomedicine Nicole Ackerman Stanford Physics Department Department of Radiation Oncology Molecular Imaging Program at Stanford (MIPS) Bio-X 27 April 2011 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

2 Outline 1 The Cerenkov Effect 2 Imaging and Nuclear Medicine 3 Cerenkov Luminescence Imaging 4 Acknowledgements Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

3 Outline 1 The Cerenkov Effect 2 Imaging and Nuclear Medicine 3 Cerenkov Luminescence Imaging 4 Acknowledgements Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

4 Production: Polarization From: Jelley Čerenkov radiation and its applications 1958 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

5 Cerenkov Properties Cone of light cos θ C = 1 nβ Spectrum: 1/λ From: Jelley Čerenkov radiation and its applications 1958 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

6 Uses of Cerenkov Radiation Particle Detectors (DIRC of BaBar) Astrophysical Detectors (Ice Cube) From: "The DIRC Particle Identification System for the BaBar Experiment" From: Ice Cube (funded by NSF) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

7 Outline 1 The Cerenkov Effect 2 Imaging and Nuclear Medicine 3 Cerenkov Luminescence Imaging 4 Acknowledgements Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

8 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

9 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

10 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

11 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

12 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

13 Multi-Modality From: Massoud and Gambhir, Genes and Development, 2003 Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

14 Optical Imaging Bioluminescence Genetic (fireflies) Add substrate Fluorescence Genetic or exogenous External light From: Ted Graves Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

15 Optical Imaging From: Ted Graves Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

16 IVIS Imaging System From: IVIS-200 Hardware Manual Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

17 Nuclear Medicine Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

18 Radioisotopes Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

19 PET Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

20 Example: In Vitro Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

21 Example: In Vitro Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

22 Example: In Vitro Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

23 Example: In Vitro Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

24 Example: In Vitro Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

25 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

26 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

27 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

28 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

29 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

30 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

31 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

32 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

33 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

34 Example: In Vivo Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

35 Outline 1 The Cerenkov Effect 2 Imaging and Nuclear Medicine 3 Cerenkov Luminescence Imaging 4 Acknowledgements Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

36 Phantom Studies From: Ruggiero et al (J Nuc Med July 2010) From: Graves Group (unpublished) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

37 Isotopes From: Z. Cheng (Stanford University) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

38 Isotopes From: Ruggiero et al (J Nuc Med July 2010) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

39 Resolution From: Z. Cheng (Stanford University) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

40 Verification of Cerenkov From: Z. Cheng (Stanford University) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

41 Verification of Cerenkov From: Z. Cheng (Stanford University) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

42 Biodistribution Studies From: Ruggiero et al (J Nuc Med July 2010) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

43 Biodistribution Studies From: Ruggiero et al (J Nuc Med July 2010) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

44 Biodistribution Studies From: Ruggiero et al (J Nuc Med July 2010) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

45 Simulation of Cerenkov Simulation (Unpublished) Simulation (Unpublished) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

46 Phantom Comparison Data: Graves Group (Unpublished) Simulation (Unpublished) Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

47 Alpha-Emitters Submitted to J Nuc Med Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

48 Alpha-Emitters Submitted to J Nuc Med Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

49 Alpha-Emitters Submitted to J Nuc Med Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

50 Disadvantages Only 2-dimensional (surface) data -> Tomography Requires Radioactivity -> Treatment Scattering of light in tissue -> Preclinical, interoperative Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

51 Disadvantages Only 2-dimensional (surface) data -> Tomography Requires Radioactivity -> Treatment Scattering of light in tissue -> Preclinical, interoperative Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

52 Disadvantages Only 2-dimensional (surface) data -> Tomography Requires Radioactivity -> Treatment Scattering of light in tissue -> Preclinical, interoperative Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

53 Disadvantages Only 2-dimensional (surface) data -> Tomography Requires Radioactivity -> Treatment Scattering of light in tissue -> Preclinical, interoperative Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

54 Future Directions Technique Excitation of other probes Microscopy? Endoscopy/Surgery Simulation Complete modeling of IVIS Optics Volume Effects Resolution Studies Cerenkov from PET data Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

55 Outline 1 The Cerenkov Effect 2 Imaging and Nuclear Medicine 3 Cerenkov Luminescence Imaging 4 Acknowledgements Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

56 Graves Group Prof. Ted Graves Dr. Rehan (Bobby) Ali Matt Noll Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36

57 Funding & Resources Weiland Family Fellowship Bio-X Molecular Imaging Program at Stanford Small Animal Imaging Facility: Stanford Center for Innovation in In-Vivo Imaging Nicole Ackerman (Stanford) Cerenkov Imaging in Biomedicine 27 April / 36