Human Heredity Biology 130 (CRN 30233) Fall 2018

Transcription

1 Human Heredity Biology 130 (CRN 30233) Fall 2018 Instructor: Buran Haidar, Ph.D. Phone: (619) Office: S6-112S Web Page: BA Class Meeting: Office Hours: uesday/hursday 8:35 10:00 AM, Room S5103 ues/ hurs: 8:00-8:30 AM & 10:00-11:00 AM Course Description: Human Heredity (BIOL 130) covers the concepts and applications of human heredity, which includes both classical Mendelian genetics and modern molecular genetics. opics include gamete formation, human karyotypes, genetic crosses, sex-linked inheritance, structure and function of DNA and RNA, gene expression, transcription and translation, genetic engineering, and population genetics. Pre-requisites: None. Advisory: ENGL 101 with a grade of "C" or better, or equivalent or Assessment Skill Level R6/W6 or ENGL 105 with a grade of "C" or better, or equivalent or Assessment Skill Level R6/W6 Course Objectives Upon successful completion, the student will be able to: 1. Understand DNA as the genetic material, its structure, cellular function and location, and its genetic code. 2. Explain the basic chemistry, structure, and cellular function of biomolecules including that of proteins. 3. Describe the process of gene expression and the cellular compartments of transcription and translation in both prokaryotic and eukaryotic cells. 4. Understand the patterns of inheritance of autosomal and sex-linked traits, the concepts of genotype and phenotype, and to apply their understanding of the principles of heredity to predict genotypes and phenotypes of members of different generations. 5. Understand the relationship between genetic systems and the evolutionary process. 6. Discuss modern applications of genetics and DNA technology and related bioethical issues. Student Learning Outcomes (SLOs) As a result of completing this class your will: 1. Communicate understanding of the distinct structures and roles of DNA and RNA as the genetic material and proteins as the functional molecules carrying out the diverse cellular functions, the genetic code, and the mechanism of the flow of genetic information within a cell: transcription and translation. 2. Apply understanding of gamete formation and Mendelian inheritance to pedigree analysis by designating the genotypes and phenotypes of family members of different generations inheriting dominant and recessive autosomal, X-linked, Y-linked, and mitochondrial traits, and by calculating the odds that offspring of a mating would be normal or affected, using Punnett square analysis. In addition, students will demonstrate competency in retrieving, understanding, and communicating the impact of modern genetic knowledge and technologies on personal, public, or ethical issues of modern relevance, using information technology. Required ext Human Genetics: Concepts and Applications. Ricki Lewis 12 th Ed. McGraw Hill Publishing Co. HUMAN GENEICS CONNEC 1 SEMESER ACCESS CARD FOR HUMAN GENEICS + EEX / LEWIs (ISBN: ) 1

2 Examinations and Grading 8 Short 10 points each (drop the lowest score) 70 points 3 Lecture 40 points each 120 points Additional Course Assignments adjusted for a total of 20 points 210 points here will be no extra credit assignments or points. Scantrons (No. 882-E) will be required for quizzes and exams. Your grade will be based upon a percentage of the total points that you accumulate during the session. Additional course assignments may be scheduled for points that are adjustable for a total of 20 points. No late assignment will be accepted. Grading will be as follows: A %; B 78-87%; C 67-77%; F below 67%. NOE: Should the total possible points change for any reason; your grade will still be based on the percentages listed above, rather than on the point values. here will be no make ups for quizzes or exams. If you do miss a quiz or an exam, your score for that will be zero. he missed quiz will be considered as your lowest score to be dropped. Lecture exams only are open note. You may use a single one-sided half sheet (8.5 X 11) of original hand-written notes. Special Needs: 1. Students with disabilities should notify the instructor and the Disability Support Programs and Services. (DSPS) department immediately. DSPS department is located in K-204, and can be reached by phone Students with hearing or vision problems should talk to me during the first week to arrange for suitable seating that meets their needs. 3. Students who may need evacuation assistance during campus emergencies should meet with me as soon as possible to assure the health and safety of all students. Important Administrative Dates: Last day to add or drop with refund and no W : Aug. 31 st, 2018 and the last day to withdraw with a W : Oct. 26 th, his is a Grade Only course and it is the student s responsibility to take care of any official administrative procedures of withdrawing from or dropping the course. Attendance: AENDANCE IS REQUIRED FOR YOUR BENEFI. You may be dropped from class if you miss more than one week s work consisting of 3 hours of lecture. An absence is defined as missing the class both for excused and unexcused reasons. ardiness and leaving class early may be treated in the same manner as an absence. I reserve the right to drop any student who exceeds the maximum number of tolerated absences, which include both excused and unexcused absences, even after the last day to withdraw with a W. At that point the student will receive zero points for all subsequent assignments and tests. he student s grade will be reported as the points accrued up to the time of drop as a percentage of the total possible points for the course. Academic Honesty: Honesty and integrity are integral components of the academic process. Students are expected to be honest and ethical at all times in their pursuit of academic goals in accordance with Student Code of Conduct, Policy Plagiarism and cheating constitute violations of academic honesty and will not be tolerated. All violations and suspected violation whether perpetrated actively or passively will result in action taken against the student involved. Sanctions will include a grade of zero on the assignment in question. Violations may result in referral for disciplinary action in accordance with Administrative Procedure , Student Disciplinary Procedures. 2

3 Other information: 1. Biology 130 is a general education biology transferrable course. A college education is a personal endeavor and students are expected to take charge of their learning. Learning biology requires students to learn many new scientific words, new scientific principles and concepts, and their connections. Learning happens as you engage in reflecting on experiences that shape and reshape your brain. herefore, it is important for students to commit to learning by spending the necessary time, working on developing effective study skills, keeping up with pre-and post-lecture assignments, coming to class on time, prepared and ready to learn. 2. During the semester, I reserve the right to modify the schedules, topics, assignments, tests etc. in order to optimize the progress of the class. Students will be notified of changes during a regularly scheduled class. It will be the student s responsibility to ensure that they possess the latest version of the relevant information. 3. he lecture is designed as face-to-face learning environments where open discussion of ideas takes place. Students may not record classroom or lab lectures, discussions, and/or activities without my advance written permission. Any such recording that is properly approved in advance can be used solely for the student s own personal learning purposes. Videotaping will not be allowed. 4. All students are expected to respect and obey standards of student conduct and to maintain the rights of others to a learning environment while in class or on campus. hese include respect of other students dignity, rights and property, and maintaining a learning environment free of unnecessary distractions in which all can participate in learning and can succeed through their personal efforts. Distractions include talking and side conversations while the instructor is speaking, unnecessary remarks, exhibiting disrespect to anyone in class, and use of PMDs for personal non-instructional purposes. Violating these standards of conduct may result is dismissal from the class for the day and point deductions. 5. Use of personal mobile devices (PMDs), including cell phones and all types of Personal Digital Assistants (PDAs) will be allowed only to support ongoing teaching and learning in the classroom. All cell phones are to be turned off during class. Cell phones and all other PMDs are to be placed on the desk tops during tests/exams and quizzes. During class time, no text messages are to be received or sent from any mobile or digital device, and use of PMDs for personal noninstructional purposes is prohibited (see item 3, above). Violations may result in course point deductions and other disciplinary action. Use of cell phones or PMDs as calculators will not be allowed. Only regular calculators are to be used when necessary. In emergency situations when you expect to receive a phone call, please notify me prior to the class. In that situation only, you may leave your cell phone on silent mode and sit next to the door to step out to receive that call without disrupting the class. Multiple violations may result in course point deductions and possible suspension from the class. Student Contacts: It is the student s responsibility to keep informed of all class activities, assignments, and changes. You are encouraged to form your own study or support group to communicate with throughout this course. Obtain contact information of at least three other students after the first week of the class. Please consider this privileged information and respect the privacy of others. Don t contact others uninvited, before 9:00 am and after 9:00 pm. Name Phone number Have a great semester! 3

4 Biology 130 entative Schedule, Fall 2018 CRN Week Date Lecture opics & Activities Human Genetics (11 th edition) Aug 21 Introduction PowerPoint & 1 Biological & Genetic hemes Ch. 1 Aug 23 Biological & Genetic hemes Ch. 1 h Aug 28 Quiz 1 2 PowerPoint & Ch. 2.1 &2.2 Cells & Biomolecules Aug 30 h 3 Sept 3 Holiday 4 Sept 4 Sept 6 h Sept 11 5 Sept 13 h Sept 18 6 Sept 20 h Sept 25 Activity assigned date Cells & Biomolecules PowerPoint & Ch. 2.1 & 2.2 Disorders of Biomolecules Cells & Bodies PowerPoint & Ch. 2.1 & 2.2 Disorders of cellular structures Report Quiz 2 Cell Death and Cell Division: Ch. 2.3 Mitosis Cell-Cell Interactions, Stem Cells, Ch. 2.4 and Cell Lineage Cell-Cell Interactions, Stem Cells, and Cell Lineage; the human Ch. 2.5 microbiome Quiz 3 he reproductive system, Ch. 3 Meiosis, Development he reproductive system, Meiosis, Development Ch. 3 Quiz 4 Chromosomes and Karyotyping Chromosomal abnormalities Ch. 13 eratogens, Critical Period, and Birth Defects Worksheet Chromosomal Abnormalities Worksheet Assignment due dates Disorders of Biomolecules presentations Disorders of cellular structures Report 4

5 7 Sept 27 h Exam Oct 2 Oct 4 h Oct 9 Oct 11 h Oct 16 Oct 18 h Oct Oct 25 h DNA Structure Ch DNA Replication Ch. 9.3 Quiz 5 From DNA to Protein: Genetic Code & ranscription and RNA processing From DNA to Protein: ranslation & protein Processing Mutation Quiz 6 Control of Gene Expression Ch Ch Ch Ch and Ch Epigenetics Ch. 6.5 & Ch Exam 2 - eratogens, Critical Period, and Birth Defects Worksheet due - Chromosomal Abnormalities worksheet due Oct 30 Nov 1 h Nov 6 Nov 8 h Nov 12 M Human Genome Complexity & Viruses Single Gene Patterns of Inheritance: Mendel s laws Sex-linked Genes Mitochondrial Genes & linkage PowerPoint & Ch Ch. 4 Ch. 5 & 6 Multi-Factorial raits Ch. 7 Holiday 5

6 14 Nov 13 Nov 15 h Nov 20 Nov 22 h 15 Nov Nov 29 h Dec 4 Dec 6 h Dec 11 Dec 13 h Quiz 7 Cell Communication & Genetics of Behavior Cell Communication & Genetics of Behavior hanksgiving hanksgiving Ch. 8 Ch. 8 Population Genetics & Evolution Ch. 14, Ch. 15 Genetic and Genomic echnologies/gene Editing Quiz 8 Human Ancestry Student Presentations Student Presentations Exam 3 Ch. 16 6