FACULTY OF LIFE SCIENCES

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1 FACULTY OF LIFE SCIENCES SYLLABUS FOR Interdisciplinary Course Human Genetics (UG & PG) (Under Credit Based Continuous Evaluation Grading System) Examinations: GURU NANAK DEV UNIVERSITY AMRITSAR Note: (i) Copy rights are reserved. Nobody is allowed to print it in any form. Defaulters will be prosecuted. (ii) Subject to change in the syllabi at any time. Please visit the University website time to time.

2 1 HGL-ID-001 FUNDAMENTALS OF HUMAN BIOLOGY (Odd Semester-UG) Credit The cell, cell division, chromosome structure, DNA structure, sex determination, mutations, chromosomal disorders and overview of population genetics I Introduction to human biology, levels of organization of human body, overview of all the systems of human body II Overview of human growth, physique, body composition, growth abnormalities, evolution, demography, primatology, human ecology and pollution. Recommended Books: Cummings, M.R. (2009) Human Genetics, Cengage Learning India Pvt. Ltd., New Delhi. Chiras, D.D. (2012) Human Biology, Jones and Bartlett Publishers. Harrison, G.A., Tanner, J.M., Pilbeam, D.R. and Bahor, P.T. (1976), Human Biology, Oxford University Press, London

3 2 HGL-ID-002 BASIC HUMAN GENETICS (Even Semester-UG) Credit Unit I Introduction to Genetics, Mitosis and Meiosis, Mendelian Genetics, The Human Genomestructure and organization, mitochondrial genome, Patterns of Inheritance, Genetic variation, Multifactorial Inheritance. Unit II Human chromosomes-types and analysis, Gametogenesis, Sex Determination and Sex Chromosomes, Chromosome Mutations: Variation in Number and Arrangement, Gene Mutation and single gene disorders, DNA Repair, Genetic basis of cancer: Oncogenes and tumour suppressor genes. Unit III Overview of population genetics, biochemical genetics, prenatal diagnosis, genetic counselling, gene therapy, stem cell therapy, genetic testing, genetic basis of human diversity, The human genome project, eugenics. Recommended Books: 1. Cummings, M.R. (2009), Human Heredity: Principles and Issues, Pacific Grove, CA: Brooks/Cole. 2. Cummings, M.R. (2009), Human Genetics, Cengage Learning India Pvt. Ltd., New Delhi. 3. Gardner, A. and Davies, T. (2009). Human Genetics. 2 nd ed., Scion Publishing. 4. Lewis, R. (2011). Human Genetics: The Basics. Routledge, Oxon. 5. Sanders, M.F. and Bowman, J.L. (2012), Genetics- An Integrated Approach. Pearson, Boston.

4 3 HGL-051 HUMAN GENETICS IN HEALTH AND DISEASE (Odd Semester-PG) Credits: An Overview of Human Genetics, Fields of Human Genetics, The Human karyotype, Origin and consequences of point and chromosomal mutations, Gamete maturation and embryonic development, Sex ratios, Sexual development and dosage compensation, Human chromosomal abnormalities. I Genetic traits, diseases and disorders, Single gene disorders Autosomal, X-linked, Y-linked, The Human nuclear and mitochondrial genome, Structural and molecular organization, Mitochondrial, Multifactorial and polygenic (complex) disorders. The Human Genome Project, Human Genetic variation. II Applications DNA fingerprinting and profiling, Prenatal diagnosis, Genetic testing. Gene and cell therapy, Cloning, Personalized medicine, Human Genetics and ethical concerns. Books Recommended: 1. Cummings, M.R. (2009). Human Heredity: Principles and Issues. Pac ific Grove, CA: Brooks/Cole. 2. Gardner, A. and Davies, T. (2009). Human Genetics. Scion Publishing, 2 nd ed. 3. Korf, B.R. (2006).Human Genetics and Genomics: A Problem-Based Approach. Blackwell Publishing Co., Oxford. 3 rd Revised ed. 4. Lewis, R. (2008). Human Genetics: Concepts and Applications, McGraw-Hill Publishing, New York, 8 th ed. 5. Lewis, R. (2010). Human Genetics: The Basics. Routledge. 6. Mange, E.J. and Mange, A.P. (1999). Basic Human Genetics. Sinauer, Sunderland. 7. Skirton, H. and Patch, C. (2009). Genetics for the Health Sciences. Scion Publishing.

5 4 HGL-052: INTRODUCTORY HUMAN GENETICS (Even Semester-PG) Credits: Overview of genetics, Cell and cell components, Prokaryotic/Eukaryotic cells, Cell division Mitosis, Meiosis, Gametogenesis, Basic concepts of inheritance Mendelian inheritance, Sexlinked inheritance, Multifactorial traits. I Molecular basis of inheritance Chemical composition of DNA, DNA structure, DNA replication, Gene Action From DNA to protein, Gene mutations and chromosomes, Human sex determination. II Human genome Nuclear and mitochondrial, Genetic diseases and disorders, Human Genome Project. Manipulation of genetic material Genetic engineering, Genetic forensics, Genetic testing, Gene therapy, Cloning. Books Recommended: 1. Adkison, L. and Brown, M.D. (2007). Elsevier's Integrated Genetics (Elsevier's Integrated S.) Mosby (St. Louis). 2. Hartwell, L., Hood, L., Goldberg, M. and Reynolds, A. (2008). Genetics: From Genes to Genomes. McGraw-Hill Higher Education, 3 rd Ed. 3. Lewis, R. (2011). Human Genetics The Basics, Routledge, London. 4. Mange, E.J. and Mange, A.P. (1999), Basic Human Genetics. Sinauer, Sunderland. 5. Passarge, E. (2007). Color Atlas of Genetics, Thieme, 3 rd ed. 6. Tamarin, R.H. (2001). Principles of Genetics. WCB/McGraw-Hill, 7 th ed.