SCIENTIFIC PROGRAM ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS INTERNATIONAL SYMPOSIUM. 13th -14th DECEMBER 2018 VALENCIA CONFERENCE CENTRE

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1 26 VALENCIA. INTERNATIONAL 13th -14th DECEMBER 2018 VALENCIA CONFERENCE CENTRE SCIENTIFIC PROGRAM ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS Under the auspices of Organized by Acredited by Scientific and sanitary interest accredited by SPANISH COOPERATIVE GROUP FOR DIGESTIVE TUMOUR THERAPY Health Professions Continuous Formation Commission fo the Community of Valencia

2 26 INTERNATIONAL INTRODUCTION Dear friend, On behalf of the Digestive Tumour Treatment Group (TTD), we are pleased to invite you to the 26th International Symposium of our group, which this year is being held in Valencia on 13 and 14 December. Year after year, this event has continued to establish itself as a meeting point and reference for all those oncologists and other specialists involved in the research and treatment of digestive tumours. As in previous years, the event will welcome leading professionals from Spain and abroad to review and reach a consensus on the advances in patient care. The programme comprises two tables dedicated to localised colorectal cancer. On the first, we will analyse the possibility of minimising adjuvant treatment and its associated toxicity in colon cancer, while on the rectal cancer table, we will focus on evaluating the response and suitability of subsequent treatment. In addition, the latest advances in hepatobiliary, pancreatic and neuroendocrine tumours will be reviewed from a multidisciplinary perspective. There will also be a keynote speech on the clonal evolution of colon cancer. On the second day, we will address the comprehensive management of gastro-oesophageal tumours and will finish with a review of the treatment of metastatic colorectal cancer, with special emphasis on treatment selection, targeted therapies and the incipient role of immunotherapy. We hope that you find the programme interesting and enjoyable. It will be an honour for us to welcome you to Valencia and benefit from your active participation, which will undoubtedly contribute to increasing the educational value of the symposium. Mª José Safont Andrés Cervantes 2

3 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS ORGANIZATION ORGANIZING COMMITTEE: COORDINATOR Mª José Safont Hospital General Universitario Valencia, Spain Andrés Cervantes Hospital Clínico Universitario Valencia, Spain ORGANIZING COMMITTEE: VOCALS Enrique Aranda Hospital Universitario Reina Sofía Córdoba, Spain Manuel Benavides Hospital Regional Universitario y Virgen de la Victoria Málaga, Spain Alfredo Carrato Hospital Universitario Ramón y Cajal Eduardo Díaz-Rubio Hospital Universitario Clínico San Carlos Ana Fernández Montes Complejo Hospitalario Universitario Orense, Spain Pilar García Alfonso Hospital Universitario Gregorio Marañón Begoña Graña Complejo Hospitalario Universitario La Coruña, Spain Cristina Grávalos Hospital Universitario 12 de Octubre Jerónimo Jiménez Castro Hospital Virgen del Rocío Sevilla, Spain Paula Jiménez Fonseca Hospital Universitario Central de Asturias Oviedo, Spain Carles Pericay Corporación Sanitaria Parc Taulí Sabadell, Spain Fernando Rivera Hospital Universitario Marqués de Valdecilla Santander, Spain Ramón Salazar ICO. Hospital Duran i Reynals Barcelona, Spain Javier Sastre Hospital Universitario Clínico San Carlos Josep Tabernero Hospital Universitari Vall d Hebrón Barcelona, Spain 3

4 26 INTERNATIONAL FACULTY Antón, Antonio Hospital Universitario Miguel Servet Zaragoza, Spain Aranda, Enrique Hospital Universitario Reina Sofía Córdoba, Spain Arnold, Dirk Instituto CUF de Oncologia Lisbon, Portugal Bass, Adam Dana-Farber Cancer Institute Boston, United States Beets, Geerard Netherlands Cancer Institute Amsterdam, The Netherlands Benavides, Manuel Hospital Regional Universitario y Virgen de la Victoria Málaga, Spain Blomqvist, Lennart Karolinska Institutet Stockholm, Sweden Buyse, Marc International Drug Development Institute San Francisco, United States Carrato, Alfredo Hospital Universitario Ramón y Cajal Cervantes, Andrés Hospital Clínico Universitario Valencia, Spain Díaz-Rubio, Eduardo Hospital Universitario Clínico San Carlos Fernández Montes, Ana Complejo Hospitalario Universitario Orense, Spain García Alfonso, Pilar Hospital Universitario Gregorio Marañón García Carbonero, Rocío Hospital Universitario 12 de Octubre Glynne-Jones, Rob Mount Vernon Hospital Northwood, United Kingdom Gómez España, Auxiliadora Hospital Universitario Reina Sofía Córdoba, Spain González Flores, Encarnación Hospital Virgen de las Nieves Granada, Spain Graña, Begoña Complejo Hospitalario Universitario La Coruña, Spain Grávalos, Cristina Hospital Universitario 12 de Octubre Grothey, Axel West Cancer Center, University of Tennessee Germantown, United States 4

5 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS Jiménez Fonseca, Paula Hospital Central de Asturias Oviedo, Spain Lamarca, Ángela The Christie NHS Foundation Trust (ENETS Centre of Excellence) Manchester, United Kingdom Macarulla, Teresa Hospital Universitari Vall d Hebrón Barcelona, Spain Massutí, Bartomeu Hospital General Universitario Alicante, Spain Pericay, Carles Hospital de Sabadell. Corporación Sanitaria Parc Tauli Sabadell, Spain Rivera, Fernando Hospital Universitario Marqués de Valdecilla Santander, Spain Sabater, Luis Hospital Clínico Universitario Valencia, Spain Safont, Mª José Hospital General Universitario Valencia, Spain Salazar, Ramón ICO. Hospital Duran i Reynals Barcelona, Spain Sastre, Javier Hospital Universitario Clínico San Carlos Seymour, Matthew Leeds Institute of Cancer and Pathology, University of Leeds Leeds, United Kingdom Siravegna, Giulia Candiolo Cancer Institute-FPO, IRCCS Candiolo, Italy Smyth, Elizabeth Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom Valladares, Manuel Hospital Universitario Reina Sofía Córdoba, Spain Van Cutsem, Eric Gasthusberg University Hospital Leuven, Belgium Vera, Ruth Complejo Hospitalario de Navarra Pamplona, Spain Viéitez, José Mª MD Anderson Cancer Center 5

6 26 INTERNATIONAL SCIENTIFIC PROGRAM WEDNESDAY, 12 DECEMBER 19:00-21:00 SATELLITE. Sponsored by Amgen. THURSDAY, 13 DECEMBER 09:00-10:00 SATELLITE. Sponsored by Sanofi. 10:15-10:30 INAUGURATION 1ª TABLE. LOCALIZED COLON CANCER Moderators: A. Antón (Hospital Universitario Miguel Servet, Zaragoza. Spain). C. Pericay (Hospital de Sabadell. Corporación Sanitaria Parc Tauli, Sabadell. Spain). 10:30-10:45 Current value of adjuvant treatment in stage III colon cancer. A. Cervantes (Hospital Clínico Universitario de Valencia, Valencia. Spain). 10:45-11:05 Statistical evaluation of the IDEA study. M. Buyse (International Drug Development Institute, San Francisco. United States). 11:05-11:25 Clinical evaluation of the IDEA study. A. Grothey (West Cancer Center, University of Tennessee Germantown. United States). 11:25-11:45 Could neoadjuvant therapy become a standard treatment in colon cancer? M. Seymour (Leeds Institute of Cancer and Pathology, University of Leeds, Leeds. United Kingdom). 11:45-12:15 Discussion. 12:15-12:45 Coffee-break. 6

7 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS 2ª TABLE. CHALLENGES IN RECTAL CANCER Moderators: A. Gómez España (Hospital Universitario Reina Sofía, Córdoba. Spain) Mª J. Safont (Hospital General Universitario, Valencia. Spain) 12:45-13:05 Multiparametric imaging for assessment of response to neoadjuvant treatment in rectal cancer. L. Blomqvist (Karolinska Institutet, Stockholm. Sweden). 13:05-13:25 Patient selection for conservative treatment in rectal cancer. G. L. Beets (Netherlands Cancer Institute, Amsterdam. The Netherlands). 13:25-13:45 Should we use short-course radiotherapy more in rectal cancer? R. Glynne-Jones (Mount Vernon Hospital, Northwood. United Kingdom). 13:45-14:15 Discussion. 14:150-14:30 RESOLUTION OF CASE STUDY CONTEST 14:30-16:00 LUNCH 3ª TABLE. MULTIDISCIPLINARY APPROACH TO PANCREAS CANCER Moderators: A. Carrato (Hospital Universitario Ramón y Cajal, Madrid. Spain). R. Vera (Complejo Hospitalario de Navarra, Pamplona. Spain). 16:00-16:20 Pancreatic borderline cancer. Definition and treatment. L. Sabater (Hospital Clínico Universitario de Valencia, Valencia. Spain). 16:20-16:40 The role of neoadjuvant chemotherapy in locally advanced pancreatic cancer. A. Fernández Montes (Complejo Hospitalario Universitario de Ourense. Spain). 16:40-17:00 Towards an optimal treatment sequence in metastatic pancreatic cancer. B. Graña (Complejo Hospitalario Universitario, La Coruña. Spain). 7

8 26 INTERNATIONAL SCIENTIFIC PROGRAM 17:00-17:20 Experimental treatments in pancreatic cancer. T. Macarulla (Hospital Universitario Vall d Hebrón, Barcelona. Spain). 17:20-17:50 Discussion. 17:50-18:20 Coffee-break. KEYNOTE ADDRESS Moderator: E. Díaz-Rubio (Hospital Universitario Clínico San Carlos, Madrid. Spain). 18:20-18:50 Evaluating clonal evolution in colon cancer. G. Siravegna (Candiolo Cancer Institute-FPO, IRCCS; University of Torino, Candiolo. Italy). 4ª TABLE. UPDATES ON THE TREATMENT OF OTHER DIGESTIVE NEOPLASMS Moderators: J. Mª Viéitez (MD Anderson Cancer Center, Madrid. Spain). C. Grávalos (Hospital Universitario 12 de Octubre, Madrid. Spain). 18:50-19:10 Cholangiocarcinoma. Á. Lamarca (The Christie NHS Foundation Trust (ENETS Centre of Excellence), Manchester. United Kingdom). 19:10-19:30 Neuroendocrine tumors. R. García Carbonero (Hospital Universitario 12 de Octubre, Madrid. Spain). 19:30-19:50 Update on the treatment of hepatocarcinoma. J. Sastre (Hospital Universitario Clínico San Carlos, Madrid. Spain). 19:50-20:20 Discussion. 8

9 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS FRIDAY, 14 DECEMBER 09:00-10:00 SATELLITE. Sponsored by Merck. 5ª TABLE. OESOPHAGOGASTRIC CANCER. EVALUATION AND TREATMENT Moderators: B. Massutí (Hospital General Universitario de Alicante. Spain). F. Rivera (Hospital Universitario Marqués de Valdecilla, Santander. Spain). 10:15-10:35 Precision medicine in oesophagogastric cancer. Limitations and opportunities. A. Bass (Dana-Farber Cancer Institute, Boston. United States). 10:35-10:55 Updates on the neoadjuvant treatment of oesophagogastric cancer. E. Smyth (Cambridge University Hospitals NHS Foundation Trust, Cambridge. United Kingdom). 10:55-11:15 Continued treatment strategy in gastric cancer. P. Jiménez Fonseca (Hospital Universitario Central de Asturias, Oviedo. Spain). 11:15-11:35 Immunotherapy in gastric cancer. M. Valladares (Hospital Universitario Reina Sofía, Córdoba. Spain). 11:35-12:00 Discussion. 12:00-12:30 Coffee-break. 9

10 26 INTERNATIONAL SCIENTIFIC PROGRAM 6ª TABLE. METASTATIC COLON CANCER Moderators: R. Salazar (ICO. Hospital Duran i Reynals, Barcelona. Spain). E. Aranda (Hospital Universitario Reina Sofía, Córdoba. Spain). 12:30-12:50 How should first-line treatment for metastatic colorectal cancer be initiated? E. Van Cutsem (Gasthusberg University Hospital, Leuven. Belgium). 12:50-13:10 Treatment after best response. Maintenance vs. intermittent treatment. D. Arnold (Instituto CUF de Oncologia, Lisbon. Portugal). 13:10-13:30 Reintroduction of treatment to progression of the disease. P. García Alfonso (Hospital Universitario Gregorio Marañón, Madrid. Spain). 13:30-13:50 Immunotherapy. M. Benavides (Hospital Universitario Regional y Virgen de la Victoria, Málaga. Spain). 13:50-14:10 Therapeutic options in refractory disease. E. González Flores (Hospital Virgen de las Nieves, Granada. Spain). 14:10-14:30 Discussion 14:30-14:35 Final conclusions and Closure 14:35-15:30 Lunch 10

11 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS GENERAL INFORMATION VENUE VALENCIA CONFERENCE CENTRE Auditorium 2 Avenida de las Cortes Valencianas, Valencia. Spain Teléfono: ACCREDITATION All registered attendees will be able to download the certificate of attendance and the accreditation of continuing training from the web of TTD Group. All registered attendees will be able to download the certificate of attendance and the accreditation of continuing training from the web of TTD Group. The minimum attendance required to obtain the accreditation certificate is 80% of the total duration of the activity. Symposium accredited with 2,4 credits by the Health Professions Continuous Formation Commission fo the Community of Valencia. LANGUAGES The official languages of the Symposium will be English and Spanish, simultaneous translation will be available. LUNCH December 13 th Thursday, at 14:30 h December 14 th Friday, at 14:35 h Valencia Conference Centre Valencia Conference Centre 11

12 26 INTERNATIONAL GENERAL INFORMATION CONFERENCE SECRETARIAT SPANISH COOPERATIVE GROUP FOR DIGESTIVE TUMOUR THERAPY Susana Rodríguez Fernández C/ Téllez, 30 posterior. Piso 1º, Oficina Madrid. Spain Tel.: Fax: Mobile Phone: Website: REGISTRATION FEES General Registration fee: 795,00 E Residents fee*: 597,00 E *A document attesting fulfilment of resident physician condition must be provided. Included in the registration fee are: attendance to scientific sessions, conference materials, certificate of attendance, refreshment breaks and lunch breaks. ACCOMMODATION Hotel Meliá Valencia **** Av. de las Cortes Valencianas Valencia. Spain Teléfono.: Hotel Sorolla Palace**** Av. de las Cortes Valencianas Valencia. Spain TEL.: DUI Doble 107,80 e 118,80 e 93,50 e 104,50 e Prices are per room and night. Breakfast and taxes included. Hotel room assigned on a first-come, first-served basis. Please, check with the Conference Secretariat for availability at the hotel before the payment. 12

13 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS OFFICIAL TRANSPORT AGENTS RENFE offers attendees at the 26 International Symposium TTD discounts of up to 30% on train journeys. In order to obtain the reduction authorization form, please contact the Conference Secretariat. REGISTRATION FEE FORM OF PAYMENT Registration fees can be paid by: Checks payable to: Grupo de Tratamiento de los Tumores Digestivos. Bank Transfer to: Grupo de Tratamiento de los Tumores Digestivos. Bankia. Sucursal Plaza de Castilla, 3. Account : ES BIC: CAHMESMMXXX A photocopy of payment must be sent to the conference secretariat together with the registration form. Please, include the assistant name in thebank transfer. * Cancellations: Cancellations and refund request must be submitted in writing to the Conference Secretariat. There will be a refund of 50% of the total amount for cancellations received before 09 November After this date no refunds will be made. All refunds will be processed after the conference. ACCOMMODATION FORM OF PAYMENT The accommodation placement fee must be paid directly at the Grupo Viajabien Travel Agency Bank Transfer to: Grupo Viajabien. Calle Zurbano 45, Planta 6ª Account Nº: ES BIC: BSABESBBXXX A photocopy of payment must be sent to the conference secretariat together with the registration form. Please, include the assistant name in the bank transfer. 13

14 26 INTERNATIONAL MAP VALENCIA CONFERENCE CENTRE Avda. de las Cortes Valencianas Valencia. SPAIN Tel.:

15 ADVANCES IN THE TREATMENT OF DIGESTIVE TUMOURS 2 3 Hotel Sorolla Palace**** Av. de las Cortes Valencianas Valencia. SPAIN Tel.: Hotel Meliá Valencia **** Avda. de las Cortes Valencianas Valencia. SPAIN Tel.: