Special Report CSSX history in China ( )

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1 Asian Journal of Pharmacodynamics and Pharmacokinetics ISSN CSSX-CPS Special Report CSSX history in China ( ) Drug Metabolism Committee (CSSX), Chinese Pharmacological Society Abstract Chinese Society for Study of Xenobiotgics (CSSX), one of branches of Chinese Pharmacological Society, was established in The promotion. Nine national conferences and four international conferences have been organized by CSSX and over 4000 articles and reviews have been published by Chinese researchers in the areas of pharmacokinetics and drug metabolism (PKDM). This report summarized 24 year history of CSSX. Key words CSSX, Drug metabolism, Pharmacokinetics Article history Received March 10, 2010 ; Accepted March 28, 2010 Publication data Pages: 9; Tables:2; Figures:5; References: 2 Paper ID AJPP *Corresponding author CSSX Office. chinacssx@163.com Introduction Chinese committee of drug metabolism and pharmacokinetics (DMPK), Chinese Society for the Study of Xenobiotics (CSSX), is a secondary society affiliated to Chinese Pharmacological Society established in dedicated themselves in domestic and international academic exchanges and comminucations, training and education, and team working for supporting therapeutic innovation in China. In the passed 24 years, China Drug Metabolism and Pharmacokinetic Studies have rapidly developed; research teams, research levels, and research conditions have greatly improved, with the international gap has significantly narrowed. Since 1986, Chinese researchers published about 4000 papers on xenobiotics including pharmacokinetics and metabolism Hangzhou International Conference on Drug Metabolism, 2006, Dalian on behalf of the Eighth National Conference on Medicine as well as the 2008 Shanghai 2nd Asia-Pacific International Conference on pharmacokinetics have shown that the characteristics of development of the discipline, but also the International Society for Study of Xenobiotics (ISSX) attention, three meetings in ISSX communications publications reported. To make the professional committee to become a key member of the international organization and participate in an important force in international academic exchanges. In recent 10 years, Chinese researchers made contribution to drug metabolism and pharmacokinetics fields. Drug metabolic pathways, enzymes and enzyme complexes are responsible for the metabolism of drug and xenobiotics. New analytical methods and new instrumentation have 83

2 been developed for the separation and identification of drugs and their metabolites. New analytical methods and new instrumentation have been developed for the separation and identification of drugs and their metabolites. The theories and technologies have applied to drug metabolism and pharmacokinetics of traditional Chinese medicine, including quantitatively describing the kinetic changes of absorption, distribution, metabolism and elimination/excretion of complex system of the traditional Chinese medicine (TCM) products. Academic organization There have been Professor Song Zhenyu, Yu Yu-Wen, Chen Gang, Su Chengye, Ruan Jinxiu, Zhou Hao and Liu Changxiao as director of professional committee from the first to the ninth committee, respectively. The members of 9 sessions of Drug metabolism Committee (CSSX) are as follows: (1) The first Committee Advisor: Song Zhun-Yu Director: Yu Wei-Wen Vice-director: Zeng Yan-Lin Secretary-general: Lou Ya-Qin Vice-secretary-general: Yue Tian-Li Members: Chen Gang*, Chen Jiang-Liu, Huang Jiao-Cheng, Huang Xing-Kai, Li Duan, Li Rui*, Liu Chang-Xiao, Lou Ya-Ching*, Quan Yu-Zhun, Song Zhen-Yu, Su Cheng-Ye, Sun Rui-Yuan, Wang Zheng-Yu, Xia Wen-Jiang, Yu Yu-Wen*, Yue Tian-Li*, Zeng Yan-Lin*, Zhao Xiang-Lan, Zhu Xiu-Yuan. (* standing committee member) (2) The 2nd Committee Advisor: Song Zhun-Yu (post director) Director: Zeng Yan-Lin Vice-director: Chen Gang Secretary-general: Huang Xing-Kai Vice-secretary-general: Su Cheng-Ye Members: Chen Gang*, Chen Jiang-Liu, He Mei-Sheng, He Shao-Xiong, Huang Jiao-Cheng, Huang Xing-Kai*, Li Duan, Li Jing-Hen, Li Rui, Liu Chang-Xiao, Liu Zhi-Qiang, Lou Ya-Ching*, Peng Ren-Xiu, Quan Yu-Zhun, Su Cheng-Ye, Sun Rui-Yuan, Wang Zheng-Yu, Xia Wen-Jiang, Xu Qing-Yuan, Zeng Yan-Lin, Zhao Xiang-Lan, Zhu Xiu-Yuan*. (3) The 3rd Committee Advisor: Zeng Yan-Lin (post director) Director: Chen Gang Vice-director: Su Cheng-Ye Secretary-general: Huang Xing-Kai Vice-secretary-general: Yuan Jing-Xiu Members: Chen Gang*, Chen Hong, Chen Jiang-Liu, Feng Ren-Jun, He Mei-Sheng, He Shao-Xiong, Huang Jiao-Cheng, Huang Xing-Kai*, Li Duan, Li Jing-Hen, Li Rui, Liu Chang-Xiao, Liu Gen-Tao, Liu Zhi-Qiang, Peng Ren-Xiu, Quan Yu-Zhun, Su Cheng-Ye*, Sun Rui-Yuan, Wang Zheng-Yu, Xia Wen-Jiang, Xu Qing-Yuan, Zeng Yan-Lin*, Zhao Xiang-Lan, Zhu Xii-Yuan*. (4 ) The 4th Committee Advisor: Chen Gang (Post director) Director: Su Cheng-Ye Vice-director: Yuan Jing-Xiu Secretary-general: Liu Chang-Xiao Vice-secretary-general: Li Jing-Hen Members: Chen Gang*, Chen Jiang-Liu, He Mei-Sheng, He Shao-Xiong, Huang Xing-Kai*, Li Duan*, Li Hua, Li Jing-Hen*, Li Rui, Li Yan, Liu Chang-Xiao*, Liu Zhi-Qiang*, Lou Ya-Ching*, Peng Ren-Xiu, Quan Yu-Zhun, Su Cheng-Ye*, Sun Rui-Yuan, Zhou Hong-Hao, Zhou Zhong-Ming, Xia Wen-Jiang, Xu Qing-Yuan, Yuan Jing-Xiu*, Zeng Yan-Lin*, Zhao Xiang-Lan, Zhu Xii-Yuan*. (5) The 5th Committee Advisor: Su Cheng-Ye (Honor director) Director: Ruan Jin-Xiu Vice-director: Liu Chang-Xiao, Zhou Hong-Hao Secretary-general: Li Jing-Hen Vice-secretary-general: Yuan Shu-Lan Members: Chen Jiang-Liu, Han Guo-Zhu, Kong Ying-Mei, Li Duan*, Li Jing-Hen*, Li Rui, Li Yan, Liu Chang-Xiao*, Liu Xiu-Wen, Lou Ya-Ching*, Peng Ren-Xiu, Quan Yu-Zhun, Su Cheng-Ye*, Sun Rui-Yuan*, Wang Guang-Ji, Wei Xiu-Hua, Zhou Hong-Hao*, Zhou Zhong-Ming, Xia Wen-Jiang, Xu Qing-Yuan, Ruan Jin-Xiu*, Zhan Li-Fen, Zeng Fan-Dian*, Zhang Yuan, Zhang Ying-Di, Zhao Xiang-Lan, Zhong Da-Fang, Zhu Xing-Chu, Zhu Xiu-Yuan. 84

3 (6) The 6th Committee Advisor: Ruan Jin-Xiu (Honor director) Director: Zhou Hong-Hao Vice-director: Liu Chang-Xiao, Li Jing-Hen Secretary-general: Wang Guang-Ji Vice-secretary-general: Li Huan-De Members: Chen Jiang-Liu, Gu Zheng-Kai, Han Guo-Zhu*, Jiang Ji, Li Duan, Li Huan-De, Li Jing-Hen*, Li Rui, Liu Chang-Xiao*, Liu Xiu-Wen, Lou Jian-Shi,, Peng Ren-Xiu*, Quan Yu-Zhun, Su Cheng-Ye, Wang Guang-Ji*, Wang Wen-Jie, Wei Xiu-Hua, Xia Wen-Jiang, Xu Qing-Yuan, Yuan Jing-Xiu, Zeng Fan-Dian*,. Zeng Su, Zhan Li-Fen, Zhang Yuan*, Zhang Ying-Di, Zhao Xiang-Lan, Zhong Da-Fang*, Zhou Hong-Hao*, Zhou Zhong-Ming*, Zhu Xing-Chu*. (7) The 7th Committee: Advisor: Zhou Hong-Hao (Honor director) Director: Liu Chang-Xiao Vice-director: Wang Guang-Ji, Zhong Da-fang Secretary-general: Liu Xiao-Dong Vice-secretary-general: Wei Guang-Li Members: Wang Guang-ji*, Wang Zhengli, Wang Wenji, Liu Xiuwen, Liu Chang-xiao*, Liu Xiaodong*, Jiang Ji, Xu Qingyuan, Zhang Ke-jian, Zhang Zheng-qing*, Li Yishi, Li Duan, Li Yan, Li Huan-De, Nei Jian-zhong, Zhou Zhong-Ming*, Zhou Xiang-Jun, Chow MSM*, Zhang Guo-liang, Yuan Zong-hui, Gu Jing-kai, Zeng Fan-Dian*, Zeng Zheng-Lin, Jiang Xue-Hua, Han Guan-Zhu*, Li Jin-Heng*, Zhong Da-Fang*, Zeng Su*, Huang Ming, Zan Li-Fen, Wei Guang-Li, Wei Xiu-Hua. (8) The 8th Committee Advisor: Zhou Hong-Hao (Honor director) Director: Liu Chang-Xiao Vice-director: Wang Guang-Ji, Zhong Da-fang, Zhang Zheng-Qing, Liu Ke-Xin Hu Zhuo-Han Secretary-general: Liu Xiao-Dong Vice-secretary-general: Si Duan-Yun, Li Yan Members: Chen Hui, Cheng Neng-Neng, Jiang Ji, Dou Gui-Fang, Han Guo-zhu*, Hu Zhou-Han, Huang Ming, Jiang Xue-hua, Li Yan, Li Chuan, Li Huan-de, Li Jin-Heng*, Lin Ge, Liu Xiu-wen, Liu Chang-xiao*, Liu Ke-Xin, Liu Xiao-dong*, Ma Yue-Ming, Nei Jian-zhong, Ouyang Dong-Sheng, Si Duan-Yun,,, Wang Hui, Wang Guang-ji*, Wei Guang-li, Wei Jie-Min, Xie Hai-Tang, Xue Min Yang Ling, Yuan Zong-hui Zeng Su*,Zhang Shu-Qiu, Zhang Zheng-qing*, Zhang Guo-liang, Zheng Yi, Zhong Da-fang* (9) The 9th Committee Advisor: Zhou Hong-Hao (Honor director) Director: Liu Chang-Xiao Vice-director: Wang Guang-Ji, Zhong Da-fang, Zhang Zheng-Qing, Liu Ke-Xin Hu Zhuo-Han Secretary-general: Liu Xiao-Dong Vice-secretary-general: Si Duan-Yun, Li Yan Members: Chen Chun-Lin, Chen Hui, Cheng Neng-Neng, Jiang Ji, Dou Gui-Fang, Gao Chen-Yan, Han Guo-zhu*, He Zong-Gui, Hu Zhou-Han Huang Ming, Jiang Xue-hua, Li Yan, Li Chuan, Li Huan-de, Li Jin-Heng*, Lin Ge, Liu Xiu-wen, Liu Chang-xiao*, Liu Ke-Xin, Liu Xiao-dong*, Ma Yue-Ming, Nei Jian-zhong, Ouyang Dong-Sheng, Si Duan-Yun,, Wang Rui, Wang Yan, Wang Hui, Wang Guang-ji*, Wei Guang-li, Wei Jie-Min, Xie Hai-Tang, Xue Min Yang Ling, Yuan Zong-hui Zeng Su*, Zhang Shu-Qiu, Zhang Hong-Jian, Zhang Zheng-qing*, Zhang Guo-liang, Zheng Yi, Zhong Da-Fang* Academic activities National academic activities Drug Metabolism Committee, Chinese Pharmacological Association which is called China Society for study of Xenobiotics (CSSX), a young Society established in 1986, has at present about 200 members who come from academies, universities, industrial institutes, hospitals and related professions. Since CSSX establishment in 1986, has organized the 13 national and international academic meetings. The first CSSX national meetings were held in Guangzhou in 1986, the second in Nanjing in 1988, the 3rd in Dalian in 1991, the 4th in Tianjin in 1994, the 5th in Beijing in 1997, the 6th in Zhangjiajie in 2000, the 7th in Nanjing in 2003, the 8th in Dalian in 2006 and the 9th in Wuhan in The number of registered representatives was from the first meeting of the dozens of people, developed to the ninth meeting of more than 300 people (Fig 1). 85

4 Fig 1. The number of registered representatives in The national DMPK Conference The main theme of the past six meetings included: (a) pharmacokinetic studies of chemical drugs and some active compounds isolated from Chinese traditional medicines and herbs; (b) studies metabolism of new drugs; (c) the effects of drugs on hepatic P-450 enzyme activities; (d) pharmacodynamics in metabolism and pharmacokinetics and computer program for clinical and experimental pharmacokinetics for problems to approval of new drugs. The main theme of the coming meeting will add new projects, metabolism and pharmacokinetics of stereo-isomers and food additives, pharmacodynamicpharmacokinetici combined analysis, etc. In national meetings of drug metabolism and pharmacokinetics, the committee organized some specific subject discussion for new drug research and development, provided serve for government to prepare technique guidances of drug metabolism and pharmcokinetics for new drug approvals. The first scientific workshop on early ADME/T studies The first scientific workshop on early ADME/T studies in China has been held in Dalian during Sept , The workshop was hosted by Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS) and sponsored by CAS. The Chinese Society for the Study of Xenobiotics (CSSX) was also a co-organizer of this workshop. Prof. LING YANG from DICP was the executive chair. The workshop introduced the differences in the basic concepts, strategies and techniques between early ADME/T and whole-body PK studies. A lot of recent progress and novel techniques with the humanized tissues or human-derived preparations combined by the high throughput techniques were presented in application on screening and evaluation of drug-like properties, lead optimization, drug suitable ADME properties and drug safety. Nearly thirty keynote speakers are the distinguished professors and experts from CSSX and CAS, as well as famous universities in Asia. One notable feature of this workshop was that many teachers were younger researchers and experts with specific techniques and experimental skills for the practical training. More than hundred researchers and graduate students participated the workshop and expressed their appreciation in the high quality and top level in both lecture and practical training. The Ninth National Conference of Drug and xenobiotic metabolism The Ninth National Conference of Drug and xenobiotic metabolism was held in October 23-26, 2009 in Wuhan, Hubei, China. More than 400 persons attended the academic conference. The Conference hosted by the Division of Drug Metabolism, Chinese Pharmacological Society (CSSX, CPS), co-hosted by the International Society of Study for Xenobiotics (ISSX) and Chinese Journal of Clinical Pharmacology and Therapeutics magazine. On the morning, October 24, 2009, the opening ceremony was held. Professor Wang Guang-Ji, vice chairman CSSX, presided over the opening ceremony, Academician Liu Chang-Xiao opening address, a brief review of three years, the major work and purpose of the field in China. Professor Russell Prough, chairman of ISSX, and Dr. Theresa Smolarek, co-chairman of the Academic Council this conference, respectively speeches on China's field of drug metabolism and pharmacokinetics of achievements in recent years expressed his appreciation. 86

5 Fig 2. The Ninth National Conference of Drug and xenobiotic metabolism International academic activities In 1988, our scientists had taken ISSX activities, and 13 scientists (Chen Gang, Huang Cheng-Yi, Huang Sheng-Kai, Liu Chang-Xiao, Liu Geng-Tao, Liu Zhi-Qiang, Lou Ya-Qing, Peng Ren-Xiu, Song Zhen-Yu, Ni Yichang, Yue Tiasn-Li, Zeng Yan-Ling, and Zhu Xiu-Yuan) were as members of ISSX. [1] In 1992, ISSX Newsletter published Liu s paper to introduce to Drug metabolism and pharmacokinetics studies in China (Fig 3). The paper described from history, Society activities, computer application, and publications and so on. [2] countries attended this symposium. The objects of this symposium can contuenties were to review and discuss latest pharmacokinetics- formulation development relevant to modernization of TCM, and to establish consensus guidelines pertaining to pharmacokinetics and formulation studies for TCM products. The 5th APPC meeting The 5th APPC meeting hold in Beijing in 1986, CSSX members, Huang Sheng-Kai, Tang Zhong-Ming, and Liu Chang-Xiao, attended and orally reported at the Symposium on Drug Metabolism of this meeting. Liu was one of chairmen of this symposium Symposium on Modernization of Chinese medicine; Application of Pharmacokinetics principles and formulation science in the development of traditional Chinese medicine Symposium on Modernization of Chinese medicine; Application of Pharmacokinetics principles and formulation science in the development of traditional Chinese medicine (TCM) products was hold in Chinese University of Hong Kong on March 17-19, About 150 persons from Asian, European and American Fig 3. Paper on DMPK in China published in ISSX Newsletter in Hangzhou International Conference on Drug Metabolism, 2005 Hangzhou International Conference on Drug Metabolism, the first international meeting on this subject in China,was hold at Zhejiang University in 18-20, October College of Pharmaceutical Sciences, Zhejiang University; Committee of Drug 87

6 Metabolism (CSSX), Chinese Pharmacological Society; Zhejiang Association of Pharmaceutical Sciences; and Zhejiang Association of Biochemistry and Molecular Biology organized this conference. About 150 persons attended this conference. The conference provided an excellent opportunity for establishing international collaborations, especially, between the scientists in China and other countries. The three-day s meeting allowed us to exchange views and experience, and learn from each other on studying the metabolism, disposition and pharmacokinetics of drugs and Chinese traditional medicine, polymorphisms of drug metabolism and individualized medicine, pharmacogenomics and pharmacoproteomics, drug metabolism-related regulatory policy on new drug development and pharmaco-informatics. Thirteen scientists presented oral presentations at plenary session. Here, the 15 reports are introduced with abstracts. College of Pharmaceutical Sciences, Zhejiang University published Conference Program and Abstracts including plenary reports and more than 110 abstracts. At this meeting, Professor Liu introduced to Drug metabolism and Pharmacokinetics studies in China. Liu Said in China, drug metabolism is a young subject. 1960s, Chinese researchers began DM and PK study, that time, there are only less than 30 persons, Today researchers are more than years ago, Liu CX founded the first PK Lab, and in 1980 the first PK book was published by Liu CX in Hunan. In 1986, Drug metabolism Committee (also called CSSX) was founded, now its history is only 20 years. National Conference on Drug and Xenobiotic Metabolism is hold each 2-3 years. Chinese scholars also attend ISSX and IUPHA Congress and relative symposium and workshop, as well as topic symposium, such as PK of traditional Chinese medicines, bio-analytical methods, metabolomics/motabonomics. The Meeting of Drug Metabolism Committee of China was hold to discuss something for committee activity. In 2005, ISSX published news about 2005 Hangzhou International Conference on Drug Metabolism (Fig 4). The 2nd Asian Pacific Regional ISSX Meeting CSSX successfully organized 2 nd Asia and Pacific Regional Conference of International Society for Study of Xenebiotics (ISSX) at the School of Pharmacy, Fudan University in Shanghai, China, May 11 13, 2008, which co-chaired by Prof. Honghao Zhou (CSSX), Prof. Yuichi Sugiyama (ISSX), and Prof. Zhuohan Hu, (CSSX). Total 517 professionals and graduates in DMPK attended the meeting from 18 countries and areas in Asia / Pacific and Europe. The Pre Short Courses enrolled 398 young investigators including graduates and postdoctoral (Table 1). Fig 4. News on 2005 Hangzhou International Conference on Drug Metabolism published in ISSX Newsletter, 2005 Total 340 presentations including 297 poster presentations were contributed to this meeting and published in a special supplemental issue of Drug Metabolism Reviews. The Awards for Young Investigators were sponsored by Shanghai Government and issued to over 100 graduates and postdoctoral fellows who presented their posters in the meeting. The contributions by the Organizing Committee led by Prof. Honghao Zhou, Yuichi Sugiyama, and Zhuohan Hu were highly recognized and appreciated by ISSX. News of this meeting was published in ISSX Newsletters 2008;28(2):6 (Fig 5). 340 abstracts were published in a special issue of Drug Metabolism Reviews, official ISSX Journal with IF=5.59 (Fig 6). Table 2 listed the major contributors of the abstracts by Chinese scholars. 88

7 Table 1 Asian-Pacific Regional ISSX Meeting attendees by countries Country/ Regional Attendees China 239 USA 93 Japan 83 South 42 Taiwan, China 20 UK 8 Australia 7 including 98 oral presentations, in the Conference. Table 2 Chinese Leading Institutions contributed over 100 presentations to 2 nd APISSX Meeting No. Institution Paper number 1 Shanghai Research Center of Drug 33 Metabolism 2 Shanghai Institute of liver Disease 20 3 Tianjin Institute of Pharmaceutical 15 Research 4 Center South University 12 5 China Pharmaceutical University 11 6 Second Military Medical University 11 Fig 5. News of this meeting th Chinese Conference of Drug Metabolism and Pharmacokintics by CSSX This conference had fully demonstrated achievements of studies for xenobiotics by Chinese Scholars, Professionals and Graduates since 2006, which greatly supported therapeutic innovation and establishment and optimization of National DMPK laboratories in China. 210 DMPK research articles were presented, Fig 6. Abstracts publication of this Meeting Not only the Conference got Six s financial support but also, more importantly, it s academic/professional support. Prof. Russel Prough, the President of ISSX, attended the Conference for presenting his research, and brought the suggestion for strategy partnership between ISSX and CSSX. On October 24, 2009, Academician Chang-Xiao Liu, President of CSSX, and Professor Prough, agreed with partnership between the two professional societies principally, which included CSSX preparation of Joint Workshop in China, CSSX s application for 2012, and attracting more ISSX many Chinese scholars to become members and co-run Asian Journal of Pharmacodynamics and Pharmacokinetics reached a consensus on issues. Affiliation of CSSX with ISSX Based on consideration of mutual benefits and promotion of scientific communication and international cooperation in the studies of xenobiotics, The Chinese Society for the Study of Xenobiotics (CSSX) and ISSX officially agreed the affiliation between the two professional societies in February of We are excited about the affiliation with ISSX and strongly believe it will promote the scientific outcomes greatly. With support from ISSX, CSSX will prepare a Joint 89

8 DMPK Workshop in China 2010, apply for hosting 5 th Asia-Pacific ISSX Conference in 2012 and 10 th International ISSX Conference in 2016, and organize more Chinese DMPK professionals and graduates to attend 9 th International ISSX Conference this year and 4 th Asia-Pacific ISSX Conference CSSX will contribute itself to science exchange, communication with its colleagues the rest of the Asia Pacific region and the world commented by Prof. Changxiao Liu, Presidengt of CSSX. Affiliate organizations of ISSX maintain their autonomy but agree to work in a cooperative nature with ISSX to promote the study of xenobiotics and the interaction of established as well as new investigators via scientific meetings and social networking. Affiliation helps ensure that scientific meetings are scheduled so as to not compete and that ISSX and its affiliate organizations collaboratively work to develop meetings, engage undergraduates and graduate students to consider the field, and advance the science worldwide. CSSX has agreed to promote ISSX and help us recruit members from within China. CSSX will plan to send delegations to ISSX meetings and will develop a regional ISSX meeting or specialized workshop in China within the next five years. This arrangement has many benefits to both organizations but most importantly helps ISSX advance its mission of facilitating the interaction between scientists worldwide to help researchers expand their networks, possibly form rewarding collaborations, and to advance the latest research in our area of science. Affiliate organizations will have a variety of benefits available to them as well including promotion of their meetings, discounts to ISSX meetings, information sharing, and exposure through the ISSX Newsletter and Web site. Asian Journal of Pharmacodynamics and Pharmacokinetics (AJPP) Asian Journal of Drug Metabolism and Pharmacokinetics, which was renamed to Asian Journal of Pharmacodynamics and Pharmacokinetics (AJPP) (Fig 7). AJPP, an official international publication, is edited by Editorial Committee of CSSX, published by Hong Kong Medical Publisher, and sponsored by CSSX and Hong Kong International Traditional Medical Association. The Journal s purposes are to provide a forum for the studies on metabolism and pharmacokinetic of drugs and xenobiotics (specifically, nature products, herbal medicines and biotech- pharmaceuticals), including metabolism, bio-transformation, metabolite analysis, experimental and clinical pharmacokinetics, bioavailability, bioequivalence, toxicokinetics, pharmacokinetic- pharmacodynamic research, pharmacokinetic models and statistical programs, application of new methods and techniques in metabolism and pharnmacokinetics, as well as experimental and clinical pharmacology, and drug safety evaluation, and to provide a foster communication between educational, research, industrial, medical, and governmental personnel engaged in drug metabolism and pharmacokinetics, pharmacological, toxicological and clinical studies. Manuscripts are accepted for consideration with the understanding that they have not been published elsewhere and are not concurrently under review elsewhere. Papers that have been given at scientific meetings are accepted for consideration. Fig 7. AJPP Relative Journals Papers on xenobiotics studies are published in the 90

9 following national journals: (1) Acta Pharmaceutica Sinica (in Chinese and in English). (2) Acta Pharmacologa Sinica (in English). (3) Chinese Pharmaceutical Journal (in Chinese). (4) Chinese Journal of Pharmacology and Toxicology (in Chinese and in English). (5) Chinese Journal of Clinical Pharmacology (in Chinese and in English). (6) Chinese Traditional Drugs and Herbs (in Chinese). (7) Chinese Pharmaceutical Industry Journal (in Chinese). (8) China Medical Journal (in Chinese and in English). (9) Chinese Journal of Antibiotics (in Chinese). (10) Chinese Journal of Clinical Pharmacology and Therapeutics (in Chinese and in English). (11) Chinese Clinical Pharmacology Journal (in Chinese and in English). (12) Chinese Journal of New Drugs (in Chinese). (13) Chinese Journal of Hospital Pharmacy (in Chinese). (14) Journal of China Pharmaceutical University (in Chinese and in English). (15) Journal of Shengyang Pharmaceutical University (in Chinese and in English). (16) Journal of Chinese Pharmaceutical Sciences (in English). Books on Xenobiotics Some books on pharmacokinetics and drug metabolism were published in China. There are three books which produced wide influence in China. Liu Chang-Xiao Pharmacokinetics, Hunan Sci & Techn. Press in This is the first book on pharmacokinetics in China. It is an important reference book for medical students. Liu Chang-Xiao and Liu Ding-Yuan Introduction to Pharmacokinetics. China Academic Press in This book is classic specific style in mathematics and applications of classic pharmacokinetic models. Zhu Jia-Bi Phramcokinetics (the first and second editions, edited by M. Gibaldi and D. Perrir) were translated into Chinese by in 1981 and Song Zheng-Yu Research on Drug Metabolism: Significance, methods and application. People's Health Press in It is an interesting reference book on theory and methodology for investigation of new drugs. Liu Chang-Xiao Database of Pharmacokinetics. China Pharmaceutical Press in This book is database of pharmacokinetic parameters of the commonly used drugs in clinical therapy. Wei Shu-Li Bioavailability of Drug Preparations. Peking Union Medical College & Beijing Medical University Presss in It discussed theory and method in research for bioavailability of drug preparations. Zhong Da-Fang Drug Metabolism. China Pharmaceutical Press in This book summarized and analyzed reactions of drug metabolism and biotransformation. Deng Shu-Hai and Liu Zhao-Ping Pharmacokinetics: Theory and Practice published by People's Health Press in It is an interesting reference book for medical students. It introduced the basic theory and methodology of pharmacokinetics. Recent years, many books were published: Zhao Lan-Xiang, Clinical Pharmacokinetics published by Zhengzhou Uiversity Press in Wang Guangji, Liu Xiao-Dong, Liu Xiao-Quan. Pharmacokinetics published by Chinese Pharmaceutical Press in Zhong Dafang Drug Metabolism published by Chinese Pharmaceutical Press in Zeng Su Drug Metabolism Course published by Zhejiang Uiversity Press in Liu Changxiao, Zhong Da-Fang, Han Guo-Zhu et al. Applied Pharmacokinetics published by Chinese Pharmaceutical Press in Tang Chong-Ming, Pharmacokinetics of Bio-tech Products published by Chinese Pharmaceutical Press in Han Guo-Zhu Pharmacokinetics of Herb Medicnes 91

10 published by Chinese Pharmaceutical Press in Liu Ke-Xin and Han Guo-Zhu Clinical Pharmacokinetics published by Science Press in References 1. ISSX. Directory pp Liu CX. Drug metabolism and Pharmacokinetics studies in China ISSX Newsletter 1990; 9(2):1-2. Edited by Liu CX, Hu ZH Training Course: AAPS Workshop on Strategies to Address Therapeutic Protein Drug Interactions during Clinical Development Co-sponsored by ISSX Hilton San Francisco Union Square San Francisco, CA, USA May 15 16, 2010 GOALS AND OBJECTIVES To provide participants with a clear understanding on how to develop strategies for assessment of TP-drug interactions. Workshop objectives are to: review preclinical tools and in vitro test systems for assessing drug interaction potential of therapeutic proteins such as cytokines and cytokine modulators. provide an in-depth review of reported and documented clinically relevant TP-drug interactions. discuss case studies, study designs and acceptance criteria for assessing PK and PD based TP-drug interactions in clinical studies., provide participants with the skills to develop a science-driven, risk-based approach for assessing the potential of TP-drug interactions. BACKGROUND Therapeutic proteins, such as monoclonal antibodies, cytokines, and cytokine modulators, are increasingly being combined with small molecule drugs and/or other therapeutic proteins. Limited scientific and development experience is available in assessing the potential for PK and PD interactions of these TP-drug or TP-TP combination therapies. In this workshop, industry, academic and regulatory speakers will highlight important main themes that have started to emerge for considerations in drug interaction assessment for therapeutic proteins such as: molecule type, target, indication, and disease biology. Speakers will also discuss recent reports regarding the regulation of CYP450 enzymes and transporters in inflammatory states. The use of cytokine, cytokine modulators, and immunosuppressant-containing combinations in inflammatory indications may have potential for drug interactions, in particular when therapeutic proteins are combined with narrow therapeutic range drugs. This workshop will provide the opportunity for participants to interact with industry, academic and regulatory representatives and to participate in roundtable discussions on how to arrive at a science-driven, risk-based approach for assessing the potential for TP-drug interactions. For additional information, including Program-at-a-Glance, or to register please visit: 92