Call for tender for the "Acquisition and maintenance of an Inducted Coupled Plasma Mass Spectrometer (ICP-MS)"

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1 EUROPEAN COMMISSION JOINT RESEARCH CENTRE Institute for Health and Consumer Protection Nanobiosciences Unit ANNEX I TO CONTRACT N. CCR. IHCP.C. TECHNICAL SPECIFICATIONS Call for tender for the "Acquisition and maintenance of an Inducted Coupled Plasma Mass Spectrometer (ICP-MS)" Open call for tender ref. OJ 2010/S of 22/05/2010 Internal ref. IHCP/2010/I/05/17/OC I. INTRODUCTION The Nanotechnology action of the Institute for Health and Consumer Protection (IHCP), European Commission, DG-Joint Research Centre, sited in Ispra (VA), Italy, focuses on the potential risks coming from the use of nanomaterials. Part of our program studies the interaction of metal nanoparticles with in-vitro cell cultures. Within this frame, the quantification of elements is essential for the understanding of toxicology mechanisms. ICP-MS is a high sensitive type of instrument, based on the coupling of ionization plasma source with a mass spectrometer. It is able to determine a range of metal and non-metal elements, at concentrations below one part per For that purpose, the IHCP intends to buy an Inducted Coupled Plasma-Mass Spectrometer (ICP-MS) that will be placed in a NanoBiotechnology Clean Room. II. PURPOSE OF THE CONTRACT AND DURATION The equipment shall be completely installed by the Contractor and must be delivered ready to use after proper installation and calibration. The contract is divided into two stages: Stage 1: Supply, delivery, installation, testing, on site training and provision of documentation of the equipment within 2 months from the signature of the contract + 24 months of warranty. The warranty period starts from the date of the signature of a Certificate of conformity (Annex III to the Contract) by the Commission. The certificate of conformity will be signed at the successful completion of installation, testing, on-site training and provision of the documentation. The two years warranty of the equipment includes 1 preventive maintenance visit per year, the replacement of consumables and any defective part of the equipment, with related labour and travel costs. OJ 2010/S 99/ of 22/05/2010 1

2 Stage 2: Stage 1 may be followed by a maintenance service of an initial duration of 12 months, renewable up to 2 times, each time of period of 12 months. This maintenance service has to include 1 preventive maintenance visit per year, consumables and spare parts. Corrective maintenance shall start within 2 working days from the arrival of the request (see explanations at point 5.2). The coming into force of Stage 2 depends on the conditions specified in article I.2.2 of the contract. III.TECHNICAL REQUIREMENTS The minimum requirements are mandatory and form the basis for analysing the conformity of the offer. If the supply does not fulfil these minimum technical requirements the tender will not be considered for further evaluation. The description of the minimum requirements must be reported in the offer. The ICP-MS must be composed of, at least, the following basic parts: Sample introduction system Inductively coupled plasma ion source ICP-MS interface Interference removal system Quadrupole mass analyser Detector Vacuum production system and fulfil the following minimum requirements. Table 1 MINIMUM REQUIREMENTS 1. General technical features 1.1) The system mainframe must be benchtop, width 100 cm and depth 85 cm 1.2) The instrument should operate from one 32 A single phase electrical supply. All other components, including the heat exchanger must run from standard 200/240 V power outlet 1.3) The ICP-MS must employ a single exhaust vent with flow < 7.0 m 3 /min 1.4) 3-ways peristaltic pump 1.5) High frequency quadrupole mass spectrometer 1.6) For safety reasons, use a not-reactive carrier gas for all analytes and for all kind of matrices (i.e. more than 40 elements) 1.7) High vacuum system controlled by software, with 1 turbo molecular pump and 1 external rotary pump to be placed outside the Clean Room at ± 1 meter distance 1.8) Possibility to interface the instruments with other techniques such as: High Pressure Liquid Chromatography (HPLC), Gas Chromatography (GC), Flow Field Fractionation (FFF): provide evidence with application notes, published papers, poster presentations or any other published data OJ 2010/S 99/ of 22/05/2010 2

3 1.9) Possibility to routinely analyse, without any problem, in a reliable way, samples containing hydrofluoric acid (HF) at least 20% 1.10) Suitable for applications that require a mixed carrier gas or LC mobile phases, and capable to run samples in volatile organic solvents 2. ICP-MS performance: for all these points provide evidence with application notes, published papers, poster presentations or any other published data 2.1) Detector linear dynamic range of 9 orders of magnitude, over a concentration range of 0.5 ppt to 500 ppm under the same operating conditions and without any change in mass analyser resolution 2.2) Simultaneously elimination of all polyatomic interferences, in any sample matrices, by using a collision cell with a notreactive gas for safety reasons 2.3) Able to measure all analytes (i.e. more than 50 elements) in cell mode 2.4) Able to run a semi-quantitative measurement for all analytes (i.e. more than 50 elements) in cell mode 2.5) Oxides ratio (as CeO/Ce) and double charges ratio (as Ce ++ /Ce + ) < 3.0 % 2.6) Mass resolution =< 0.3 amu 2.7) Background at mass 9 =< 2 counts/sec 2.8) Mass range = amu 3. ICP-MS other components 3.1) Autosampler with rack configuration providing up to 300 vial positions, able to operate with either 14 ml than 50 ml tubes, and possibility to be covered 3.2) Adequate, low noise and low heat emission chiller/heat exchanger, to be placed outside the Clean Room at 1 meter distance 4. Hardware and software systems 4.1) Hardware compatibility with Microsoft Windows operating system and future upgrading with networking 4.2) Operating system Windows XP or equivalent: no operating system Vista or Windows7 will be accepted 4.3) The whole ICP-MS system must be completely computer controlled 4.4) Computer with a LAN card free for connection to JRC s Intranet 4.5) The computer must have the following characteristics: 4.5.1) colour monitor at least 22 inches 4.5.2) CD/DVD writer 4.5.3) Colour laser printer with LAN connection OJ 2010/S 99/ of 22/05/2010 3

4 4.5.4) At least dual core processor 4.5.5) Hard disk: at least 500 GB 4.5.6) Ram: at least 4 GB 4.6) Software for data analysis in a single, clear, window indicating: 4.6.1) the current batch, counts, concentrations, RSD 4.6.2) real-time results upgrade during sequence acquisition 4.6.3) able to generate a clear, tailored analytical report 4.6.4) display and flags analytical results out of specification and QC failures 4.6.5) graphical display of the calibration curves and mass spectrum 4.6.6) export the raw data and processed results for single samples, defined selections or an entire batch to Microsoft Excel 5. Maintenance Service 5.1) Preventive maintenance (see below) 5.2) Corrective maintenance (see below) 6. Other requirements 6.1) Twenty-four (24) months warranty (see point II, Stage 1) Additional features are listed in Table 2 in the Administrative Annex and will be taken into consideration for the award of technical merit points (see detailed information in the Administrative Annex, point 2 Award Procedure). 5. Maintenance service Description of the maintenance service The following minimum services are requested: 5.1) Preventive Maintenance Preventive Maintenance is understood as a periodic intervention on the equipment to ensure its proper function and calibration, in the absence of damage. This preventive maintenance shall take place once a year, in agreed dates between the Parties, at the JRC-IHCP-Ispra site, during its working hours (between and from Monday to Thursday and between and on Fridays, and includes: - control of the instrument s performance - Replacement of the necessary consumables (the cost of which is intended to be included in the price of the contract) updating of the software data processing 5.2) Corrective Maintenance A Corrective Maintenance intervention has to be provided upon request (phone call confirmed by fax or ) within 2 working days from the request. OJ 2010/S 99/ of 22/05/2010 4

5 As Corrective Maintenance intervention is understood any intervention made in case of improper performance or breakdown of the equipment. These interventions are made upon request to the company and shall take place at the JRC-IHCP-Ispra site during working hours. 5.3) Spare parts All costs for the spare parts shall be included in the Maintenance contract. The substitution of any parts will be performed after agreement with the JRC technician in charge of the equipment who will be present during the preventive and corrective intervention. The replacement parts used during the maintenance operations must be exclusively original manufacturer parts. 5.4) Maintenance Report At the end of each intervention, both for the preventive and corrective maintenance, a report on the work performed, shall be produced and counter-signed by the JRC responsible (filling in the "Maintenance Report" Annex IV to the contract). This will also include a detailed account of the defects found and of the eventual parts substituted. OJ 2010/S 99/ of 22/05/2010 5