Basic Information. I.1 If your company performs biotechnology research and development, uses a. The Categories of Biotechnology Applications.

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1 APPENDIX 2 SURVEY QUESTIONNAIRE Part I. Basic Information I.1 If your company performs biotechnology research and development, uses a biotechnology process in manufacturing, or produces research tools, please check the box(s) of at most six item(s) from the list below that can describe your company s application(s) of biotechnology. And then complete this survey please. Thank you very much for your cooperation! Medicine Category Medical Devices Industrial Biotechnology The Categories of Biotechnology Applications Examples Biopharmaceuticals Therapeutics Diagnostics Drug design and delivery Drug discovery Cell and tissue engineering Gene therapy Regenerative medicine Alternative medicine Traditional Chinese Medicine (TCM), botanical drugs, herbal medicine Vaccines Antibiotics Bio-chips (e.g. Protein-chips) Bio-sensors Gene probes Reagents, kits, assays Biologicals Medical devices Medical instrumentation Medical supplies Homecare (e.g. Diabetes monitoring) Specialty chemicals (e.g. Amino acids) Bio-processing (e.g. Bacteria culture) Bio-based lubricants and functional fluids Renewable alternative fiber papers and packaging Plant-based plastics, polymers and films Wood-based composite materials Fermentation Enzymes Catalysts Flavors or fragrances Cosmetics (e.g. Collagen) The National Innovation System of Taiwan s Biotechnology Industry (A.2) 133

2 Agricultural Biotechnology Environmental Biotechnology Enabling Technologies and R&D Services Phytochemicals Neutraceuticals Medical food Functional foods Supplements or vitamins Food processing Bio-fertilizers Bio-herbicides Tissue culture Seeds and plant breeding Genetically modified products Transgenic plants Livestock Transgenic animals Veterinary products Animal vaccines Aquaculture Bio-based energy (e.g. Microbiologically enhanced petroleum) Bio-based waste treatment Bio-based pollution prevention Natural resource recovery (e.g. Mineral recovery) Bio-processing Bioremediation Phytoremediation Bio-pulping Bio-bleaching Bio-filtration Biodesulphurization Biomaterials Biomass conversion Enzymes Marine microbial Terrestrial microbial DNA, peptides, or proteins sequencing DNA, peptides, or proteins synthesis DNA markers Polymerase Chain Reaction (PCR) amplification Bio-informatics Single-Nucleotide Polymorphisms (SNPs) Genomics Proteomics Cellomics / Cell receptors or signaling Pharmacogenomics High throughput screening Combinatorial chemistry 3-D molecular modeling Cloning / Culturing of cells, tissues, embryos Stem cells Extractions, purifications, separations Clinical tests Clinical trial management Contracted research (CRO) Contracted manufacturing (CMO) The National Innovation System of Taiwan s Biotechnology Industry (A.2) 134

3 I.2 Company Name: (in Chinese) (in English) I.3 Year Established: I.4 Capital: NT$ I.5 Revenues in 2002: NT$ I.6 R&D Expenditures in 2002: NT$ I.7 Operating Income in 2002: NT$ I.8 Number of Employees: Number of Employees with Master Degree: Number of Employees with PhD Degree: Number of Employees with Biotechnology-related Responsibilities: The National Innovation System of Taiwan s Biotechnology Industry (A.2) 135

4 Part II. Multiple-choice Questions II.1 Please indicate the founders of your company when established. (Check at most three items that apply.) Domestic Entrepreneurs Professors or Scientists from Domestic Universities Research Fellows from Domestic Research Institutes Students from Domestic Universities or Colleges Overseas Taiwanese Scientists or Professionals Foreigner II.2 Which of the following sources financed your company when established? (Check at most three items that apply.) Domestic Enterprises Foreign Enterprises Domestic Venture Capital Firms Foreign Venture Capital Firms Domestic Angel Investors Foreign Angel Investors Taiwan Government Funds II.3 Which of the following sources can describe the revenues of your company? (Check at most three items that apply.) Licensing-out Technologies Contracted Research Research Services Production Product Sales Capital Gains of Investment II.4 Which of the following sources accounts for the skilled workers and professionals of your company? (Check at most three items that apply.) Recruit Graduates from Universities or Colleges in Taiwan Recruit Talents from Other Companies in Taiwan Recruit Talents from Research Institutes in Taiwan Recruit Overseas Taiwanese Scientists Recruit Foreigners The National Innovation System of Taiwan s Biotechnology Industry (A.2) 136

5 II.5 What steps below is your company taking to ensure a sufficient number of adequately skilled workers and professionals? (Check at most three items that apply.) In-house Training Outsourcing Training Government Training Programs Academic Training Programs R&D Collaborations II.6 Which of the following expenditures accounts for the cost of R&D activities for your company? (Check at most three items that apply.) Licensing-in Fees Labor Cost Materials Equipments and Facilities R&D Collaborations Rents II.7 item.) Please provide the technology licensing-in fees as a percentage of sales. (Check one More than 30% 20%+~30% 10%+~20% 0%+~10% Zero II.8 Which of the following countries is the primary source licensing-out technology to your company? (Check one item.) U.S. European Nations Japan Taiwan Rest of World (specify please) II.9 Which of the following types describes the R&D activities of your company? (Check at most three items that apply.) In-house R&D The National Innovation System of Taiwan s Biotechnology Industry (A.2) 137

6 R&D Spin-out or Establishing Subsidiaries Establishing R&D Collaborations with Other Organizations R&D Outsourcing Technology Licensing or Trading II.10 Which of the following sources describes the key technologies of your company? (Check at most three items that apply.) Free or Expired Patents Non-patented Technologies Developed by the Company Patents of the Company s Own Licensing-in Technologies from the Other Companies in Taiwan Licensing-in Technologies from Research Institutes in Taiwan Using the Results from Research Collaborations with Other in Taiwan Crossing Licensing Technologies with Others Using the Results from Research Collaborations with Foreigners Licensing-in Technologies from Abroad II.11 Please identify the performances of R&D activities of your company. (Check at most three items that apply.) Reducing Labor Costs Expanding Production Capacity Extending Product Pipeline Upgrading Quality of Products Developing New Technologies Increasing Number of Patent Filings Increasing Revenues or Profits II.12 How many patent filings granted in Taiwan does your company have? (Check one item.) Three Patents or More Granted Each Year One or Two Patents Granted Each Year Having Patents Granted but Not for Each Year None of Patent Granted Yet No Patent Application Ever The National Innovation System of Taiwan s Biotechnology Industry (A.2) 138

7 II.13 How many patent filings granted abroad does your company have? (Check one item.) Three Patents and More Granted Each Year One or Two Patents Granted Each Year Having Patents Granted but Not for Each Year None of Patent Granted Yet No Patent Application Ever II.14 Which of the following selections best describes how the patents or new technologies developed by your company are used? (Check one item.) Both Applied to In-house Production and Licensed Out to Other Companies Licensed Out to Other Companies but Not Applied to In-house Production Applied to In-house Production but Not Licensed Out to Other Companies Neither Applied to In-house Production Nor Licensed Out to Other Companies Does your company currently have any R&D collaboration? Please proceed to the next question if Yes. II.15 Which of the following reasons accounts for the collaborative R&D of your company? (Check at most three items that apply.) Sharing of Risk for R&D Sharing of Cost for R&D Speeding up R&D Process Access to Complementary Capabilities or Specialized Skills Access to State-of-the-art Facilities Access to Market and Technology Information Building up Connections or Channels II.16 Please identify the collaborators for the R&D activities of your company. (Check at most three items that apply.) Competitors or Other Firms in Taiwan Customers or Suppliers in Taiwan Academia and Research Institutes in Taiwan Competitors or Other Firms Abroad Customers or Suppliers Abroad Academia and Research Institutes Abroad Research Projects Initiated by Taiwan Government Research Projects Subsidized by Taiwan Government The National Innovation System of Taiwan s Biotechnology Industry (A.2) 139

8 II.17 Please identify the barriers to the collaborative R&D of your company. (Check at most three items that apply.) Different Views on Intellectual Property Rights Different Views on Licensing Revenues or Loyalties Different Views on Expenditures or Shares Different Views on Human Resources or Inputs Different Views on Topics Different Views on Priorities or Processes Communications with Participants or Research Staffs Low Incentive of Participants or Research Staffs High Mobility of Participants or Research Staffs Forming R&D Collaboration Agreements Insufficient Government Funding for R&D Antiquated Rules and Regulations No Access to R&D Projects Subsidized by Government II.18 How many R&D projects funded by Taiwan government does your company have? (Check one item.) Three Projects or More Each Year One or Two Projects Each Year Having Projects Funded but Not for Each Year No Project Funded Ever II.19 Please provide the expenditures for the projects funded by Taiwan government in (Check one item.) More than NT$20,000,000 NT$10,000,000 - NT$20,000,000 NT$5,000,000 - NT$10,000,000 NT$1,000,000 - NT$5,000,000 Less than NT$1,000,000 Zero The National Innovation System of Taiwan s Biotechnology Industry (A.2) 140