Part I Translational Stem Cell Research:What is Possible Today and What Still Remains to be Achieved?

Transcription

1 Part I Translational Stem Cell Research:What is Possible Today and What Still Remains to be Achieved? 1 Towards Clinical Application of Stem Cells in Neurodegenerative Disorders... Olle Lindvall and Zaal Kokaia 3 2 Treating Cardiac Disorders with Stem Cells... Christine Mummery 15 3 Treating Diabetes... Mattias Hansson and Ole Dragsbæk Madsen 23 4 Treating Oncologic Disease... Peter W. Andrews 35 5 Clinical Application of Autologous Epithelial Stem Cells in Disorders of Squamous Epithelia... Nicolas Grasset and Yann Barrandon 45 6 Towards a Cell Therapy for Muscular Dystrophy: Technical and Ethical Issues... Giulio Cossu 55 7 Towards Modeling and Therapy of Genetic Diseases Using Pluripotent Stem Cells... Petr Dvořák 65 8 Therapeutic Possibilities of Induced Pluripotent Stem Cells... Harold Ayetey 77 9 Industrial Applications of Stem Cells... Michael Roßbach, Manal Hadenfeld, and Oliver Brüstle 91 ix

2 x 10 The Obstacles on the Road to Clinical Applications of Stem Cell-Based Therapies: What Has Been Done to Overcome These Obstacles and What Remains to Be Done? Outi Hovatta Part II Translating Stem Cell Research Knowledge from Bench to Bedside: Ethical Issues 11 Translational Stem Cell Research and Animal Use: Examining Ethical Issues and Opportunities Kate M. Millar 12 Ethical Aspects of Stem Cell-Based Clinical Translation: Research, Innovation, and Delivering Unproven Interventions Jeremy Sugarman and Douglas Sipp 13 Translational Stem Cell Research in Pediatrics: Ethical Issues Michael Fuchs 14 Experimental Stem Cell-Based Therapy in Pediatrics: A Fictional Case Study Kristina Hug and Anders Castor Part III Creation of Human-Animal Entities for Translational Stem Cell Research: Scientific, Ethical and Regulatory Challenges 15 Creation of Human Animal Entities for Translational Stem Cell Research: Scientific Explanation of Issues That Are Often Confused Neville Cobbe and Valerie Wilson 16 Chimeras and Hybrids How to Approach Multifaceted Research? Gisela Badura-Lotter and Marcus Düwell 17 Chimeras + Hybrids = Chimbrids: Legal Aspects Jochen Taupitz Part IV Stem Cell Banking for Translational Stem Cell Research or Stem Cell-Based Therapies 18 Stem Cell Banks: Reality, Roles and Challenges Glyn Stacey

3 xi 19 Broad Consent Linus Broström and Mats Johansson 20 Banks, Repositories and Registries of Stem Cell Lines: The Challenges to Legal Regulation Mette Hartlev Part V 21 Translational Stem Cell Research and Commercial Funding Proprietary Interests and Collaboration in Stem Cell Science: Avoiding Anticommons, Countering Canalyzation Matthew Herder Part VI Patenting of Human Stem Cell-based Inventions: Scientific, Ethical and Regulatory Issues 22 Legal Problems Raised by Patents on Human Stem Cell-Based Inventions Paul L.C. Torremans 23 Patenting of Human Stem Cell-Based Inventions: Can There be Technological Solutions to a Moral Dilemma? Aliki Nichogiannopoulou 24 Patenting of Human Stem Cell-Based Inventions: Ethical Issues Including and Beyond the Morality Clause Göran Hermerén Part VII From General Public to Researchers, and Vice Versa: Communication Issues in Translational Stem Cell Research 25 Ethical, Legal and Social Implications of Translational Stem Cell Research: Effects of Commercialization on Public Opinion and Trust of Stem Cell Research Ubaka Ogbogu and Amy Zarzeczny 26 Patients Organizations and Their Opinions: How Much Have They Been Taken into Consideration When Regulating Stem Cell Research? Mary Baker and Philip Watson 27 Communicating Translational Stem Cell Research to the General Public: Challenges and Suggestions Sébastien Duprat

4 xii Part VIII Translational Stem Cell Research and Its Psychological Implications 28 Psychosocial and Cultural Factors Affecting Judgments and Decisions About Translational Stem-Cell Research Melissa L. Finucane and Andrew E. Williams Part IX Ethical Evaluation of Translational Stem Cell Research Projects in Research Ethics Committees 29 Ethics and Uncertainty: Considerations for the Design and Review of Translational Trials Involving Stem Cells James A. Anderson and Jonathan Kimmelman Part X Looking at the Future of Translational Stem Cell Research and Stem Cell-Based Therapeutic Applications: Risks, Long-Term Effects and Priority Setting 30 Unruhe und Ungewissheit: Stem Cells and Risks Nils-Eric Sahlin, Johannes Persson, and Niklas Vareman 31 Looking at the Future of Translational Stem Cell Research and Stem Cell-based Therapeutic Applications: Priority Setting and Social Justice Göran Hermerén Index

5