University of Groningen. Post-transcriptional control of C/EBPα and C/EBPβ proteins Zaini, Mohamad

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1 University of Groningen Post-transcriptional control of C/EBPα and C/EBPβ proteins Zaini, Mohamad IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Zaini, M. A. (2017). Post-transcriptional control of C/EBPα and C/EBPβ proteins: Insights into their role in energy homeostasis and diseases [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Post-transcriptional Control of C/EBPα and C/EBPβ Proteins Insights into their role in energy homeostasis and diseases PhD thesis by Mohamad Amr Zaini

3 Post-transcriptional Control of C/EBPα and C/EBPβ Proteins. Insights into their role in energy homeostasis and diseases M.A. Zaini The research described in this thesis was mostly conducted at the European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, The Netherlands. And also at Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Jena, Germany. The printing of this thesis was financially supported by the University of Groningen and the Graduate School for Drug Exploration (GUIDE). Cover design and layout: Mohamad Amr Zaini Printing: ISBN (print): ISBN (electronic): Copyright 2017 by Mohamad Amr Zaini. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without permission of the author.

4 Post-transcriptional Control of C/EBPα and C/EBPβ Proteins Insights into their role in energy homeostasis and diseases PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 11 December 2017 at 12:45 hours by Mohamad Amr Zaini born on 20 June 1986 in Homs, Syria

5 Supervisor Prof. C.F. Calkhoven Co-supervisor Dr. C. Müller Assessment Committee Prof. G. de Haan Prof. T. Heinzel Prof. J.P. Tuckermann

6 Paranymphs: Tobias Ackermann Gertrud Kortman

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8 سورة طه الا ية ١١٤ My LORD increase me in knowledge. The Holy Quran (20:114) Dedication: This work is dedicated to the souls of all the Syrian martyrs in the last seven years.

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10 Chapter I Aim and outlines of the thesis 11 Chapter II C/EBPα and C/EBPβ transcription factors: Their post- 17 transcriptional control and roles in various tissues Chapter III A p300 and SIRT1 regulated acetylation switch of C/EBPα 47 controls mitochondrial function Chapter IV A screening strategy for the discovery of drugs that reduce 97 C/EBPβ-LIP translation with potential calorie restriction mimetic properties Chapter V Shwachman Bodian Diamond syndrome (SBDS) protein 127 deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mrnas Chapter VI Discussion and Perspectives 159 Appendices Nederlands Samenvatting 181 Acknowledgments 187 Curriculum Vitae 197