IK4 BIOTECHNOLOGY & BIOMATERIALS. Research Alliance.

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1 IK4 Research Alliance BIOTECHNOLOGY & BIOMATERIALS

2 BIOTECHNOLOGY AND BIOMATERIALS, CROSS-CUTTING TECHNOLOGIES The biotechnology and biomaterials fields are characterised by the fact that they encompass and serve a wide range of different scientific disciplines, giving rise to a plural and remarkably complex technological convergence. The technology centres which make up the IK4 Research Alliance combine their capacities in order to make the most of this complexity and to develop a set of tools within the life science field which provide first-rate technological solutions that can be applied to a diverse range of different industrial sectors. OUR SERVICES R&D Projects Evaluation of the effectiveness, metabolism, toxicity and safety of xenobiotics Improvement of products and processes by means of industrial microbiology technology Disease diagnosis and drug evaluation by means of bioinformatics, in-silico predictive modelling, genomics, proteomics, and applied molecular biology techniques Development of sensors, biosensors and biomems Manufacture of functionalizable polymer nanoparticles Manufacture of bioactive nanocoatings Development of new hydrogels as cellular scaffolding Processing of polymer materials for implant manufacture Tissue engineering _ Manufacture of bioactive coatings _ Characterization of biomaterials and biocompatible coatings

3 OUR SCOPE OF PERFORMANCE IN-VITRO TESTS* Cell Cultures Primary cultures and line cell cultures Physiological models in vitro Hematoencephalic barrier Pulmonary barrier Skin Intestinal barrier ADME/Tox in vitro* Cytotoxicity Flow cytometry Confocal microscopy Genotoxicity Nanotoxicity ADME Studies: strategy and development Analytical Identification and Quantification _ UPLC MS/MS chromatography _ HPLC/DAD/MS chromatography _ HPLC/FL chromatography _ Gas chromatography * Certification of Good Laboratory Practices (GLP), Spanish Bureau for Drugs and Health Products

4 MOLECULAR BIOLOGY AND X-OMICS Molecular biology PCR technologies Genetic engineering (prokaryotes and eukaryiotes) Genomics Genetic expression profiles in tissues as well as in cell lines Toxicogenomics and search for genes involved in toxity or detoxification routes Identification of genome mutations for detecting diseases In Silico Genomics by means of specialized software Design of DNA arrays Production of Genomic gene banks or libraries Epigenetics Proteomics Identification of Biomarkers for diagnosis and toxicity Toxicoproteomics: search for proteins involved in toxicity or detoxification routes Detection of post-translational modifications as biomarkers of metabolic states In Silico Proteomics by means of specialized software

5 BIODETECTION SYSTEMS AND BIOSENSORS Processes for immobilising biorecognition molecules on surfaces destined for the development of biochips Identification of target molecules or analytes Development of molecules of biorecognition Antibodies development DNA probes design Development of aptamers Development of peptides (phage display) Development of biodetection and biosensor systems Advances in detectable signals from molecular recognition events Modifying/functionalizing biorecognition molecules Enzymatic biosensors for detecting toxic products and analytes in solutions Molecular recognition sensors for the early detection of diseases Sensor systems to detect food and environmental pathogens MONITORING, ANALYSIS AND VISUALIZATION Cell cultures monitoring Visualization and analysis of metabolic pathways

6 BIOMATERIALS Biomaterial synthesis Synthesis and processing of materials for applications in Biomedicine Polymer nanoparticle synthesis for molecular image and drug delivery Hydrogels for regenerative medicine and tissue engineering (injectable and non-injectable hydrogels) Scaffold fabrication technology Bioactive coatings Improvement of metal implant biocompatibility through ceramic, anodized and polymer coatings obtained by means of electrochemical growth and deposit techniques Production of bioactive surfaces with applications in biotechnology, biomedicine and sensorics by means of biomolecule and polymer coating anchoring Development of biocompatibles coatings that enhance the wear produced in joints by PVD (Physical Vapour Deposition) tehcnique Generation of biocompatible surfaces with antibacterial capacity Improvement of osteointegration of metallic implants by the manufacturing of ceramic coatings through electrochemical techniques Characterization of biomaterials and biocompatible coatings Basic characterization _ Basic characterization _ Hardness _ Adhesion _ Thickness _ Roughness Mechanical tests (Tensile-compression) Tribological tests Corrosion and tribocorrosion tests CELL-MATERIAL INTERACTION Characterization techniques of mechanical cellular properties and of biological tissues

7 IK4 CENTERS CAPABILITIES IN BIO SECTOR The research activity of CEIT-IK4 is focused on these topics: biomems and lab-on-a-chip devices, microfluidics, biomaterials, biomedical instrumentation and haptics and biorobotics. GAIKER-IK4 research activity is focused in 4 main areas: In vitro ADME-Tox studies (GLP) Efficacy and safety assessment of pharmaceutical, nutraceutical and dermo-cosmetic products (GLP) Molecular diagnostic Point-of-Care systems Isolation, identification and characterization of microorganisms (antimicrobial and antibiofilms properties) IK4-TEKNIKER expertise is devoted to: Medical devices for the identification and quantification of biomarkers Scaffolds for tissue engineering Health products manufactured by microinjection Equipment for the bio

8 IK4 Research Alliance IK4 is a private and independent alliance of R&D centres, a benchmark in the European R&D context. It comprises 9 organisations in the Basque Country: AZTERLAN, CEIT, GAIKER, IDEKO, IKERLAN, LORTEK and TEKNIKER. Our aim is to generate technological and scientific knowledge, promote its uptake and transfer it to the business framework. This enables us to complement the technological capabilities of companies and to contribute towards improving their competitiveness MAIN DATA ,4 M TECHNOLOGY CENTRES PROFESSIONALS DOCTORS INCOME AZTERLAN CEIT GAIKER IDEKO IKERLAN LORTEK TEKNIKER Polígono Azitain, 3K 2ºG EIBAR (Gipuzkoa). España