Beleggers bijeenkomst Quest Photonic Devices B.V Quest medical imaging B.V.

Transcription

1 Quest medical imaging Making the Invisible Visible Pn1 Beleggers bijeenkomst Quest Photonic Devices B.V Quest medical imaging B.V.

2 Disclaimer With the exception of historical information contained in this presentation, content herein may contain "forward looking statements" that are made pursuant to the Safe Harbor Provisions of the Private Securities Litigation Reform Act of These statements are based on management's current expectations and are subject to uncertainty and changes in circumstances. Investors are cautioned that forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from the statements made. These factors include general economic conditions, delays and risks associated with the performance of contracts, risks associated with international sales and currency fluctuations, uncertainties as a result of research and development, acceptable results from clinical studies, including publication of results and patient/procedure data with varying levels of statistical relevancy, risks involved in introducing and marketing new products, potential acquisitions, consumer and industry acceptance, litigation and/or court proceedings, including the timing and monetary requirements of such activities, the timing of finding strategic partners and implementing such relationships, regulatory risks including approval of pending and/or contemplated 510(k) filings, the ability to achieve and maintain profitability in the Company's business lines, and other factors. The Company disclaims any obligation to update its forward-looking relationships. It is understood that here is a risk that not all current or future risks are known Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 2

3 Introduction Richard Meester President/CEO Quest Group Started Company in 1998 Hendrik jan van Es VP Business development Quest Group Joined company in 2010 Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 3

4 Presentation Introduction Company & Structure Key personnel Treating cancer Performing surgery Battling cancer with photonics Market (value chain) Competitive landscape Technology & Advantages Strategy and business model Milestones Installed base Summary Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 4

5 Company Structure Quest Photonic Devices Research and Development of Spectral Imaging Systems Quest Innovations Imaging Heads and Light engines Production and manufacturing of Camera heads OEM Customers Quest Medical Imaging Medical end products Marketing & Sales Medical surgical application development Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 5

6 Main Personnel Richard Meester President/CEO Quest Group Started Company in years experience in Imaging Systems and business management Hendrik jan van Es VP Business development Quest Medical Imaging B.V. (Benelux) Joined company in years in business development and market strategy Rob NGungu COO Quest Medical Imaging Inc. (USA) Joined company in years experience in regulatory filings with FDA Frederic Wasielewski Sales Director Quest Medical Imaging SAS (France) 15+ years in medical device sales Joined company in 2018 Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 6

7 Milestones Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 7

8 Cancer Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 8

9 Cancer Key is removing the complete tumor during surgery Any residual cancer cells increase chance of recurrance Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 9

10 Treating cancer Lifestyle Detection Biopsy/ Analysis Localize Therapy Result Monitor & Recurrence Quest Innovations customers Quest Medical Product Focus Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 10

11 Company position in the chain Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 11

12 Everybody is different Treatment Treatment Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 12

13 Focus on surgical intervention Improve surgical performance Improve treatment process Localize (CT/MRI) Treatment (Surgical) Result (Pathology & Follow up) Provide real time tissue information to surgeon Improve patient care overall Localize Therapy Result Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 13

14 Surgical Challenges How to: Identify the Tumor during surgery CT/MRI done before, no real time imaging Identify complete tumor removal Identify remaining small tumor spread CT/MRI resolution may not detect small tumors Person is located differently, organs have shifted Detection of vital structures Detection of tissue types Navigation through human body (specifically minimal invasive) Patient information, everybody is different Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 14

15 What if: You can visualize information to the surgeon in real time instead of simulation? Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 15

16 Targeted tumor examples Color NIR Fluorescence Color - NIR Merge Cases at Leiden University Medical Center. A. Vahrmeyer. Targeted tumor agent ovarian Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 16

17 Targeted lymph node examples Cases at Leiden University Medical Center. A. Vahrmeyer. Targeted tumor agent in lymph node Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 17

18 Tissue tumor detection & segmentation Clasification Ex vivo study - Pathology - Spectral imaging - False color indication of spectral similarities Tumor detection Currently only superficial Aid for different applications like: - Cervical cancers - Melanoma tumor bed scan Use other body chromophores than just blood Requires OR environment control Healthy tissue Tissue with tumor Dept. of Surgery, Leiden University Medical Center, The Netherlands Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 18

19 Battling cancer with Photonics LUMC Presentation on moleculair imaging Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 19

20 Why invest in Quest? Prism Technology Company Technology Strategic partners Market development Socially Improving patient outcome Lowering costs for hospital and society The camera is actually several cameras behind one lens, making perfect overlays possible Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 20

21 Competition Storz Mini Flare Fluobeam PDE Hypereye Pinpoint/Spy Strong Add-on on tower Well developed distribution Large install base Large install base (Mostly Japan) Computer overlaid image Large install base (Luna via Life Cell) Relative Low price Computer overlaid image Low price Low price More market ready company + system Weak Switching image Only NIR vision Only NIR vision No data collection Single Chip solution Bad NIR image Technical inferior Cannot be CE/ FDA certified ICG or Methylene blue Can do only ICG Can do only ICG Can do only ICG Only open system Only open system Only open system Only open or MIS system Technical inferior Technical inferior Technical inferior Technical inferior Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 21

22 Partnerships contrast agents Smart tumor targeting contrast agent provides 4 contracted 4 in progress One agent works only with our camera Registering exclusively with us (FDA) Capability of seeing more than one agent at the time Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 22

23 Installed base Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 23

24 Top 10 Cancer centers US Currently at the following locations #2 Memorial Sloan Kettering Cancer Center, new York #7 Cleveland Clinic, Cleveland #7 Upenn, Philadelphia #10 UCSF, San Diego Goal focus on installing units at complete top 10. Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 24

25 Partners Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 25

26 Recent take overs / investments Camera systems Novadaq => Stryker $ 701 Mln Surgvision => Bracco $? Vision sense => Medtronic $ 75 Mln Targeted probes On Target => Johnson & Johnson $ 40 Mln Partners => Total investment last 3 yrs (> 150 Mln) Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 26

27 Milestones ICG open application phase ICG open & MIS applications phase 2020 Key priorities: - Recruitment of Sales manager France/ internal sales/ clinical assistant - Formalize agreements with 3 Probe developers Key priority: - Build out distributor network and via them install systems in key hospitals, building out install base. - Build out production hospitals (not only university hospitals - Expand product line Expected Start Targeted probe roll out phase. Gen 3 system The first targeted probes will have completed registration. Joint roll out based on install base already in place, distributor network of QMI and sales structure of probe developer Adding modules / integrate with OR setup Several additional modalities are under development that can be added to the towers in the field. Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 27

28 Sales cycle 3. Rent/ Sale 2. Budget allocation 1.Identify & Demo Step sales approach 1. Predefined target hospital list Demonstrate machine in real use (perform surgery with surgeon) 2. Find budget 3. Acquire machine or place through rental or pay per surgery Average sales cycle 9 15 months Rental with option to buy shortens cycle Pay per surgery easiest. Pay through kit (US only right now) Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 28

29 Short term action points Increase distribution network New distributors under negotiation to close this year Increase demo systems Increase device production Increase direct sales network US East coast (Sales reps + clinical assistants) US West coast (Sales reps + clinical assistants) US Central clinical assistants Germany office (Sales reps + clinical assistants) Strengthen office backbone Build out product portfolio and technology Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 29

30 Questions Fluorescent image guided surgery 2018 Quest medical imaging B.V. Pn1 30

31 Quest Medical Imaging B.V. Pn1 PO Box 22, 1770 AA, Wieringerwerf the Netherlands T:+31(0) F:+31(0) Quest medical imaging B.V.