Predoc Course 2013 Disease Mechanisms Module (16-18 December 2013)

Transcription

1 Predoc Course 2013 Disease Mechanisms Module () This module intends to cover topics at the interface of Biology and Medicine. Aspects from many common as well as several genetic diseases are covered. On the molecular level, there will be a particular focus on structural aspects of the proteins involved in disease, on signaling and drug design. Group leaders and instructors involved: Carsten Schultz (CBB, MMPU) Maja Koehn (GB) Rocio Sotillo (MR) Marcus Mall (MMPU), Magnus von Knebel-Doeberitz (MMPU) Christoph Metzendorf/Sandro Altamura (MMPU) Rohini Kuner (MMPU) John Overington (EBI) Miriam Reuschenbach/Matthias Kloor (MMPU) Martina Muckenthaler (MMPU) Sara Buonomo (MR) Andreas Kulozik (MMPU) Dmytro Yushchenko (CBB) Matthias Wilmanns (HH) Christoph Steinbeck (EBI) Scheduled for 2014: Martin Jechlinger (MR), Paul Heppenstall (MR), Stephen Cusack (GR), Christian Schuberth (MMPU) Schedule: Dec. 16 th Dec. 17 th Dec. 18 th 09:00-12:30 lectures and blackboard discussions 14:00-15:00 blackboard discussions 15:00-18:00 practical/virtual research program 09:10-12:30 lectures and blackboard discussions 14:00-15:00 blackboard discussions 15:00-18:00 practical/virtual research program 09:10 11:40 lectures and preparations 13:00 14:00 Pink seminar 14:00-15:00 preparation of presentations 15:00-18:00 practical presentations, discussions, social hour

2 Monday, 16 December 2013 Cancer Time Speaker Topic 09:00-9:05 Carsten Schultz Introduction to the module 09:05 9:45 Rocio Sotillo Molecular disease mechanisms in cancer 09:50 10:30 Magnus v. Knebel- Doeberitz Introduction of the main known cancer initiating events. Discussion of the progression and stem cell models of cancer. The molecular pathology of cancer 10:30-10:50 Break and blackboard subjects announced Malignant tumors arise as consequence of genetic changes in somatic cells that go along with major chromosomal abnormalities, extensive mutations in defined genes and substantial re-programming of major gene expression profiles. Basic principles that lead to these molecular changes in normal cells and their biological impact for clinical prevention, diagnosis and treatment will be discussed. 10:50 11:50 Blackboard discussions moderated by Magnus v. Knebel- Doeberitz, Rocio Sotillo, John Overington, Dmytro Yushchenko 11:50 12:30 John Overington Intro to chemoinformatics 12:30-14:00 Lunch break 14:00-15:00 Blackboard discussions moderated by Rocio Sotillo, Dmytro Yushchenko, Maja Köhn, John Overington 15:00-18:00 Database practical (John Overington) or Virtual research project (Rocio Sotillo, Maja Köhn, Carsten Schultz)

3 Tuesday, 17 December 2013 Genetic diseases Time Speaker Topic 09:10-9:50 Martina Muckenthaler Hemochromatosis Introduction to molecular mechanisms regulating iron homeostasis and their involvement in iron metabolism disorders 09:50-10:30 Andreas Kulozik 3' end mrna processing in thrombosis, inflammation and tumor invasion Introduction to the clinical relevance of RNA processing 10: Break and blackboard subjects announced 11:00-11:50 Blackboard discussions moderated by Andreas Kulozik, Martina Muckenthaler, Miriam Reuschenbach / Matthias Kloor, Marcus or Gregor, Christoph Steinbeck 11:50-12:30 Marcus Mall Cystic fibrosis The molecular basis of the disease and approaches for the discovery of a potential treatment. 13:00-14:00 Lunch break 14:00-15:00 Blackboard discussions moderated by Sara Buonomo, Christoph Metzendorf/Sandro Altamura, Miriam Reuschenbach/Matthias Kloor, Christoph Steinbeck 15:00-18:00 Database practical (Christoph) or Virtual research project (Maja, Carsten, Sara)

4 Wednesday, 18 December 2013 Infection and pain On Wednesday all student groups will present the result of the virtual research project within the afternoon session. In addition, students will present the results of their bioinformatics practical. Time Speaker Topic 09:10-09:50 Matthias Wilmanns M. Tuberculosis Tuberculosis is a re-emerging global thread, in the context of HIV, multiple-drug resistance and accelerated mobility of the world's population. However, most of presently available drugs have been discovered during the very early days of anti-tb treatment. The molecular understanding of the M. tuberculosis life cycle is pivotal for the development of new drugs, vaccines and diagnostics 09:50-10:30 Rohini Kuner Molecular mechanisms of pain sensation 10:30-11:00 Coffee break Understanding the mechanisms that underlie pain is of major clinical importance. I will describe some of the molecules involved in acute and chronic pain and discuss how targeting mechanisms rather than symptoms should lead to the development of better analgetics. 11:00-11:40 Sara Buonomo Cell cycle checkpoints: defense and dependence during cell transformation Implications for polymerase assembly, transcription and host adaptation will be discussed as well as a new impetus given to structure-based anti-influenza drug design targeting the polymerase 11:40-13:00 Preparation time for the following presentations, lunch 13:00-14:00 Pink Seminar

5 14:00-15:00 All group leaders Presentation of the practical and the virtual research project 17:00-18:00 Discussion / social hour Thursday, 19 December 2013 Time 13:00-15:00 Non-DMP (End of course meeting) 16:00-18:00 Non-DMP (Graduation ceremony) 20:00 Non-DMP (Party) Subjects for blackboard discussions in 4 or 5 groups: Heiko (2): Carsten Schultz (2) Magnus Knebel: Miriam Reuschenbach / Matthias Kloor (2): Maja Koehn (2): Dmytro Yushchenko: Rocio Sotillo (2) Statins to everyone? - How can we reduce the cardiovascular death toll? Peptides just biochemical tools or drug candidates. Abnormal growth factor signaling in cancer The fight against cancer cell evolution: how to overcome the flexibility of genomes in cancer cells? Theoretical concepts and practical implications. Cancer - defense mechanisms of the host Tumor evolution and heterogeneity - a challenge for therapy Antisense strategies for therapy advantages and challenges Phosphatases: no drug target? 3D tissue culture as a disease model How do late stage tumor cells evade? "Oncogene Addiction" How can we exploit this phenomenon for cancer treatment? Christoph Metzendorf /

6 Sandro Altamura Andreas Kulozik Animal models in molecular medicine what to do with incidental findings of next-generationsequencing based genetic diagnosis? Martina Muckenthaler John Overington (2) Christoph Steinbeck (2)