Engineering Materials

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1 Engineering Materials

2 More information about this series at

3 Emilio I. Alarcon May Griffith Klas I. Udekwu Editors Silver Nanoparticle Applications In the Fabrication and Design of Medical and Biosensing Devices 1 3

4 Editors Emilio I. Alarcon Bio-nanomaterials Chemistry and Engineering Laboratory, Cardiac Surgery Research University of Ottawa Heart Institute Ottawa Canada Klas I. Udekwu Swedish Medical Nanoscience Center Karolinska Institutet Stockholm Sweden May Griffith Integrative Regenerative Medicine Centre Linköping University Linköping Sweden ISSN ISSN (electronic) Engineering Materials ISBN ISBN (ebook) DOI / Library of Congress Control Number: Springer Cham Heidelberg New York Dordrecht London Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (

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6 Preface Nanomaterials bear the promise of revolutionizing the development of biomaterials for the medical sciences and biosensing. However, prior to safe and efficacious translational applications of such materials in the clinic, comprehension of the nature of nanoparticles and the properties they impart to the materials that they are incorporated into them, is necessary. Hence, multidisciplinary collaboration amongst biologists, chemists, engineers, physicists, and clinicians is critical for designing the next generation of nanomaterials with improved biological activity and regenerative properties, and for moving these along the translational pipeline from bench to bedside. Silver nanoparticles, in particular, have a special, almost unique, place among nano-sized materials. This is due to their unique and multi-functional properties that include their archetypical antimicrobial activity, excellent thermoplasmonic capabilities, and superior surface Raman properties. This book, authored by active researchers, reviews the latest research on silver nanoparticles and nanomaterials around the globe. We provide an overview of the current knowledge on the synthesis, uses, and applications of nanoparticulate silver. In short, students and researchers in the field will gain an up-to-date understanding of what silver nanoparticles are, their current uses, and future challenges and horizons of these nanomaterials in the development of new materials with improved properties. Emilio I. Alarcon May Griffith Klas I. Udekwu vii

7 Acknowledgments The editors would like to express their gratitude to the authors of this book; without their valuable contribution this endeavor would not have been possible. Also, the editors would like to express their thankfulness to Dr. Rashmi Tiwari- Pandey at the Division of Cardiac Surgery Biomaterials and Regeneration Program, University of Ottawa Heart Institute, for her help during the final stages of formatting and proofreading of the book. Emilio I. Alarcon May Griffith Klas I. Udekwu ix

8 Contents Silver Nanoparticles: From Bulk Material to Colloidal Nanoparticles... 1 Kevin Stamplecoskie Synthetic Routes for the Preparation of Silver Nanoparticles Natalia L. Pacioni, Claudio D. Borsarelli, Valentina Rey and Alicia V. Veglia Surface Enhanced Raman Scattering (SERS) Using Nanoparticles Altaf Khetani, Ali Momenpour, Vidhu S. Tiwari and Hanan Anis Silver Nanoparticles in Heterogeneous Plasmon Mediated Catalysis María González-Béjar Biomedical Uses of Silver Nanoparticles: From Roman Wine Cups to Biomedical Devices Hasitha de Alwis Weerasekera, May Griffith and Emilio I. Alarcon Anti-microbiological and Anti-infective Activities of Silver May Griffith, Klas I. Udekwu, Spyridon Gkotzis, Thien-Fah Mah and Emilio I. Alarcon Erratum to: Biomedical Uses of Silver Nanoparticles: From Roman Wine Cups to Biomedical Devices... Hasitha de Alwis Weerasekera, May Griffith and Emilio I. Alarcon E1 xi

9 Contributors Emilio I. Alarcon Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada; Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Canada Hasitha de Alwis Weerasekera Department of Chemistry and Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Canada Hanan Anis School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, Canada Claudio D. Borsarelli Laboratorio de Cinética y Fotoquímica (LACIFO), Centro de Investigaciones y Transferencia de Santiago del Estero (CITSE-CONICET), Universidad Nacional de Santiago del Estero (UNSE), Santiago del Estero, Argentina Spyridon Gkotzis Swedish Medical Nanoscience Centre, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden María González-Béjar Instituto de Ciencia Molecular (ICMol)/Departamento de Química Orgánica, Universidad de Valencia, Valencia, Paterna, Spain May Griffith Integrative Regenerative Medicine Centre, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Swedish Medical Nanoscience Centre, Department of Neuroscience, Karolinksa Institutet, Stockholm, Sweden Altaf Khetani School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, Canada Thien-Fah Mah Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada Ali Momenpour School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, Canada xiii

10 xiv Contributors Natalia L. Pacioni INFIQC, CONICET and Departamento de Química Orgánica- Facultad de Ciencias Químicas-Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina Valentina Rey Laboratorio de Cinética y Fotoquímica (LACIFO), Centro de Investigaciones y Transferencia de Santiago del Estero (CITSE-CONICET), Universidad Nacional de Santiago del Estero (UNSE), Santiago del Estero, Argentina Kevin Stamplecoskie Radiation Laboratory, University of Notre Dame, South Bend, IN, USA Vidhu S. Tiwari SRM University, Sonepat Kundli Urban Complex Sonepat, Haryana, India Klas I. Udekwu Swedish Medical Nanoscience Centre, Department of Neuroscience, Karolinksa Institutet, Stockholm, Sweden Alicia V. Veglia INFIQC, CONICET and Departamento de Química Orgánica- Facultad de Ciencias Químicas-Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, Argentina