Curriculum Vitae Saonli Basu

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1 Curriculum Vitae Saonli Basu Contact Information Mailing Address Division of Biostatistics, University of Minnesota, A 460 Mayo Building, MMC 303 Phone 420 Delaware St. SE, (612) (O) Minneapolis, MN Homepage saonli Education Degree Institution Duration Ph.D.in Statistics University of Washington, Seattle, WA M.Stat. in Applied Statistics and Data Analysis Indian Statistical Institute, Calcutta, India B.Sc. in Statistics Presidency College, Calcutta, India Employment Associate Professor, School of Public Health 2012-present University of Minnesota, Twin Cities Assistant Professor, School of Public Health 2005-present University of Minnesota, Twin Cities Research Assistant, Department of Statistics, University of Washington, Seattle Teaching Assistant, Department of Statistics, University of Washington, Seattle Research Associate, Department of Statistics, Indian Statistical Institute, Calcutta, India Research Associate, Market Research, ORG MARG, Gujarat, India Current Membership in Professional Organizations American Statistical Association 1

2 International Biometric Society International Genetic Epidemiology Society Honors and Awards: Member of the Delta Omega Honorary Society in Public Health, Travel Award for Rockefeller Advanced Linkage Course, ENAR Distinguished Student Paper Award Winner, Program in Mathematics and Molecular Biology Fellow, University of Washington Best Student among Statistics Majors Award, Presidency College, Professional Activities Review Editor, Frontiers in Genetics, Associate Editor, JASA/TAS Reviews, 2010-present Reviewer for journals: Journal of American Statistical Association, Biometrics, Journal of Agricultural, Biological and Environmental Statistics, Statistics in Medicine, BMC Bioinformatics, Journal of American Medical Association, Journal of Dental Research, Genetics, BMC Genomics, Biometrics, Journal of Genetics, Human Heredity, Nucleic Acids Research, Pharmacogenomics, PLoS One, Genetic Analysis Workshop papers, Annals of Human Genetics. Reviewer of NIH RC4 grants, External Reviewer of ARC grant proposals, University de Liége, Liége, Belgium, Reviewer of 5 NIH Challenge grants, Reviewer of AHC seed grants, Reviewer of a NIH/NIDDK K24 grant,

3 Publication Refereed Journal Articles 1. Tang W, Teichert M, Chasman DI, Heit JA, MD, Morange P-E, Li G, MS, Pankratz N, Leebeek F, Parè G, de Andrade M, Tsourio C, Psaty BM, Basu S,..., Stricker BHC, Ridker PM, Folsom AR, Smith NL (2013). A genome-wide association study for venous thromboembolism: the extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic Epidemiology (to appear). 2. Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S et al. (2013), A multi-ethnic meta-analysis of genome-wide association studies in over 100,000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation (to appear). 3. McGue M, Zhang Y, Miller MB, Basu S, Vrieze S et al. (2013). A genome-wide association study of behavioral disinhibition. Behavioral Genetics (to appear). 4. Li X, Kirkpatrick R, Basu S (2013), RFGLS: a family GWAS data-analysis tool that uses a generalized least squares method to perform single-marker association analysis. ( an R package) 5. Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin S-Y, Ding J, Baumert J, Oudot- Mellkah T, Folkersen L, Johnson AD, Smith NL, Williams SM, Ikram, MA, Becker DM, Truong, V, Mychaleckyj JC, Tang W, Yang Q, Sennblad B, Moore JH, Williams FMK, Dehghan A, Schrijvers EMC, Smith S, Karakas M, Tofler GH, Silveira A, Navis GJ, Lohman K, Chen M-H, Peters A, Goel A, Hopewell JC, Chambers JC, Saleheen D, Lundmark P, Psaty BM, Strawbridge RJ, Carter AM, Meisinger C, Peden JF, Bis JC, McKnight B, Öhrvik J, Taylor K, Franzosi MG, Seedorf U, Collins R, Franco-Cereceda A, Syvänen A-C, Goodall AH, Yanek LR, Cushman, M, Müller-Nurasyid M, Folsom AR, Basu S, Matijevic N, van Gilst WH, Kooner JS, Hofman A, Danesh J, Clarke R, Meigs JB, DIAGRAM Consortium, Kathiresan S, Reilly MP, MBBCH, MSCE, CARDIoGRAM Consortium, Klopp N, Harris TB, Grant PJ, Hillege HL, Watkins H, C4D Consortium, Spector TD, Becker LC, Tracy RP, Uitterlinden AG, Eriksson P, Cambien F, CARDIOGENICS Consortium, Morange P-E, Koenig W, Soranzo N, van der Harst P, Liu Y, O Donnell CJ; Hamsten A (2012), A genomewide association study for circulating levels of plasminogen activator inhibitor type 1 (PAI-1) identifies four associated loci and provides novel insights into the regulation of PAI-1 and its role in coronary artery disease and type 2 diabetes. Blood, Vol 120(24): Thyagarajan B, Jackson S, Basu S, Jacobson P, Gross MD, Weisdorf D, Arora M (2013), Association between genetic variants in Immune Response genes and outcomes after Hematopoietic Cell Transplants. International Journal of Immunogenetics, Vol 40(2):

4 7. Miller MB, Basu S, Cunningham J, Eskin E, Malone SM, Oetting WS, Schork N, Sul JH, Iacono WG, McGue M (2012), The minnesota center for twin and family research genomewide association study, Twin Research and Human Genetics, Vol 15(6): Gieger C, Radhakrishnan A,..., Basu S,..., Soranzo N (2011), New gene functions in megakaryopoiesis and platelet formation. Nature Vol 480(7376): Basu S, Pan W, Shen X, Oetting WS (2011), Multilocus association testing with penalized regression. Genetic Epidemiology Vol 35(8): Pan W, Basu S, Shen X (2011), Adaptive Tests for Detecting Gene-Gene and Gene-Environment Interactions. Human Heredity. Vol 72(2): Seong WJ, Jung J, Barczak M, Basu S, Conrad HJ (2011), Prevalence of sinus augmentation associated with maxillary posterior implants. Journal of Oral Implantology (to appear). 12. Basu S, Pan W (2011), Comparison of Statistical Tests for Association with Rare Variants. Genetic Epidemiology Vol 35(7): Basu S, Pan W, Oetting WS (2011), A dimension reduction approach for modeling multilocus interaction in case-control studies. Human Heredity Vol 71(4): Li, X., Basu S, Miller MB, Iacono WG, McGue M (2011) A Rapid Generalized Least Squares Model for a Genome-Wide Quantitative Trait Association Analysis in Families. Human Heredity, Vol 71(1): Basu S, Pankow JS (2011). An Alternative Model for Quantitative Trait Loci (QTL) Analysis in General Pedigrees. Annals of Human Genetics Vol 75(2): Tang W, Basu S, Kong X, Pankow JS, Aleksic N, Boerwinkle E, Folsom AR (2010), Genomewide association study of activated partial thromboplastin time (aptt) and protein C- the ARIC Study. Blood Vol 116(23): (PMID: ). 17. Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B (2010), Polymorphisms in the Base Excision Repair Pathway and Graft-versus-Host Disease. Leukemia Vol 24(8): (PMID ) 18. Conrad HJ, Jung J, Barczak M, Basu S, Seong WJ (2010), Retrospective cohort study of the predictors of implant failure in the posterior maxilla. The International Journal of Oral & Maxillofacial Implants (to appear). 19. Thyagarajan B, Lindgren, B, Basu S, Nagaraj S, Weisdorf D, Gross M, Arora M (2010), Base Excision Repair: a predictor of treatment outcome after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation Vol 16(8): (PMID: ) 4

5 20. Smith, NL, Chen M-H, Dehghan A, Strachan DP, Basu S, Bis JC, de Maat M, Rumley A, Kong X, Yang Q, Wiggins KL, Van Duijn C, McArdle WL, Pankow JS, Johnson AD, McKnight B, Uitterlinden A, Wellcome Trust Case Control Consortium, Aleksic N, Meigs JB, Peters A, Koenig W, Cushman M, Kathiresan S, Rotter JI, Bovill EG, Hofman A, Boerwinkle E, Tofler GH, Psaty BM, Leebeek F, Folsom AR, Larson MG, Lumley T, Witteman JC, Tang W, ODonnell CJ (2010), Association of multiple novel genetic loci with plasma levels of factor VII, factor VIII, and von willebrand factor: The CHARGE Consortium, Circulation Vol 121(12): (PMCID: PMC ) He H, Oetting WS, Brott MJ, Basu S (2009), Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. BMC Med Genet Dec 4; 10(1): 127 (PMCID ) He H, Oetting WS, Brott MJ, Basu S (2009), Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case-control study. Human Heredity 2010; 69(1): (PMID ) 23. Thumbigere-Math V, Sabino MC, Gopalakrishnana R, Basu S, Huckabay S, Arkadiusz Z, Michalowicz BS, Hughes PJ, Leach JW, Swenson, KK, Swift JW, Basi DL (2009). Bisphosphonate-associated Osteonecrosis of the jaw: clinical features, risk factors, staging management system and treatment outcomes. Journal of Oral and Maxillofacial Surgery, Vol 67(9): Basu S, Stephens M, Pankow JS, Thompson EA (2009), A likelihood-based trait-model-free approach for linkage detection of binary trait. Biometrics Vol 66(1): (PMID ) 25. Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavous M, Chen M-H, Baumert J, Lowe GDO, McKnight B, Tang W, de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow, JS., Hofman, A., Massaro, JM., Rivadeneira, F., Kolz, M., Taylor, KD., van Duijn, CM., Kathiresan, S., Illig T, Aulchenko YS, Volcik KA, Uitterlinden A, Tofler GH, Gieger C, Welcome Trust Case Control Consortium, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, ODonnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR (2009), Association of novel genetic loci with circulating fibrinogen levels: A genome-wide association study in six population-based cohorts. Circulation: Cardiovascular Genetics Vol 2: (PMCID ) 26. Johnson LA, Oetting, WS, Basu S, Prausa S, Matas A, Jacobson PA (2008), Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors. Eur J Clin Pharmacology, Vol 64(11): (PMID ) 27. Vallee MC, Conrad HJ, Basu S, Seong WJ (2008). Accuracy of friction style and spring style mechanical torque-limiting devices for dental implants. Journal of Prosthodontic Dentistry, Vol 100(2):

6 28. Basu S, Di Y and Thompson EA (2008), Exact Trait-Model-Free Tests for Linkage Detection in Pedigrees, Annals of Human Genetics, Vol 72(5): (PMCID ) 29. Basu S (2007), Allele-sharing methods on extended pedigrees, Sankhya, Vol 69 (3): Yang Q, Biernacka JM, Chen M, Houwing-Duistermaat JJ, Bergemann TL, Basu S, Fan R, Liu L, Bourgey M, Clerget-Darpoux F, Lin W, Dupuis J, Elston RC, Cupples LA (2007), Group 4: Using Linkage and Association to Identify and Model Genetic Effects. Genetic Epidemiology, Vol 31(Suppl 1): S34-42 (PMID: ) 31. Liebeler CL, Basu S, Jackola DR (2006), Allergen-Specific IgG1 Provides Parsimonious Heritability Estimates For Atopy-Associated Immune Responses To Allergens, Hum Immunology, Vol 68(2): (PMCID ) 32. Jackola DR, Basu S, Liebeler CL, Willaert R, Luah S-S, Oetting W, King RA, Blumenthal MN (2006), CD14 Promoter Polymorphisms in Atopic Families: Implications for Modulated Allergen-Specific Immunoglobulin E and G1 Responses, Int Arch Allergy Immunol, Vol 139: (PMID ) 33. Sieh W, Basu S, Fu QA, Rothstein JH, Scheet PA, Stewart W, Sung JS, Thompson EA, Wijsman EA (2005), Comparison of marker types and map assumptions using Markov chain Monte Carlo-based linkage analysis of COGA data, BMC Genetics, Vol 6(Suppl 1): S11 (PMCID ) 34. Thompson EA, Basu S (2003), Genome Sharing in large pedigrees: multiple imputation of ibd for linkage detection, Human Heredity, Vol 56, (PMID ) 35. George AW, Basu S, Li N, Rothstein JH, Sieberts, SK, Stewart W, Wijsman, EM, and Thompson EA (2003), Approaches to Mapping Genetically Correlated Complex Traits, BMC Genetics, Vol 4:S71(PMCID ) + The first author was a graduate student of Dr. Basu and the paper is a part of the Doctoral/Master s thesis dissertation. Co first-author stated in the manuscript. Non-refereed Journal Articles or Book Chapters: 1. Basu S, Bergemann TL, Dvorkin D, Seth M (2006). The analysis of quantitative traits correlated with rheumatoid arthritis. Proceedings of Genetic Analysis Workshop 15, Florida. 6

7 Research and Grants Currently Funded Grants 1. Title: Statistical Methods for detection of genome-wide GxE interactions in longitudinal studies. Source: NIH/NIDA- R01 Purpose: This proposal aims to model interaction between multiple SNPs and environmental factors in longitudinal studies. We propose to develop a computationally efficient dimension-reduction approach to study the interplay of a group of SNPs and multiple environmental factors for both quantitative and binary traits over a time period. We have also proposed some powerful and flexible tests motivated by high-dimensional data to detect the joint effects of a SNP-set and multiple time-dependent environmental factors for both quantitative and binary traits in longitudinal studies. Period: May April Role: Principal Investigator. Award: $ 1,107, Title: A gene-set approach for pathway analysis of genome-wide SNP data with application to type 2 diabetes and related quantitative traits. Source: NIH/NIDDK- R21 Purpose: This proposal uses a dimension-reduction approach to model the effect of a group of SNPs incorporating the possibility of interaction among them. The approach proposes a likelihood-ratio test to compare between different groups of SNPs. It provides a powerful alternative to perform a pathway -based genome-wide association studies (GWAS) and could be useful to identify new genes associated with complex diseases that cannot be found using the traditional approach of single polymorphism analysis in a GWAS. Period: July 2010-June Role: Principal Investigator. Award: $ 395, Title: Serum Vitamin D and Cardiovascular Disease Risk in Bioethic ARIC cohort Source: NIH/NHLBI- R01 Period: June March Role: Co-Investigator. (PI: Pamala Lutsey, Division of Epidemiology) Award: $1,586, Title: Epidemiology of Venous Thrombosis and Pulmonary Embolism Source: NIH/NHLBI - R01 7

8 Purpose: This prospective epidemiologic study seeks to identify factors that contribute to increased risk of venous thromboembolism, i.e., blood clots in veins that may travel and block blood supply to organs. This renewal proposal seeks to identify novel genes that contribute to venous thromboembolism. Period: March January 2012 Role: Co-Investigator. (PI: Aaron Folsom, Division of Epidemiology) Award: $ 2,554, Title: Substance Abuse & Behavioral Disinhibition: Integrating Genes & Environment Source: NIH/NIDA - R01 Purpose: Under NIDA s Genes, Environment, and Development Initiative (GEDI), this project will conduct a genome-wide association study to find genetic variants which together with environmental factors affect the risk of alcohol addition, drug abuse, behavioral disinhibition, especially the development of these outcomes at the adolescent stage. The study samples come from 15 years of research on twins and their families from Minnesota Center for Twin and Family Research (MCTFR). Period: January December 2011 Role: Co-Investigator. (PI: William Lacono, Department of Psychology) Award: $8,703, Title: Genetic Epidemiologcal Study of Venous Thromboembolism (VTE) and Hemostatic Factors Source: NIH/NHLBI - R01 Purpose: This proposal seeks to perform genetic association studies of VTE and intermediate phenotypes and investigations of gene-gene and gene-environment interactions in the etiology of VTE. An anticipated 3447 SNPs in 116 selected candidate genes from CARe, measured on two or more cohorts, are the main focus of the proposal. Period: July 2009-June 2012 Role: Co-Investigator. (PI: Weihong Tang, Division of Epidemiology) Award: $ 1,155, Previously Funded Grants 1. Title: Association of genetic polymorphism with graft-versus-host disease post hematopoetic stem cell transplant Source: NIH/NIAID - R21 Purpose: Graft-versus-host disease is a devastating disease that affects 20-70% of blood and marrow transplant (BMT) recipients. The disease is caused by an immune attack by donor cells on patient tissue. Some genetic factors, including polymorphisms (changes in amino acids in genes that alter their function) may predict patients at high risk of these com- 8

9 plications. The proposal aims to identify patients at high risk of complications and death, and subsequently modify their treatment, using the information we learn from our genetic studies, to alter their course. The long term goal is to improve survival in these patients by determining groups at high risk towards whom intensive therapy should be targeted. Period: July June 2010 Role: Co-Investigator. (PI: Mukta Arora, Department of Medicine ) Award: $ 352, Title: A Likelihood-based Approach for Detecting Gene-Gene Interaction in a Case-Control Study Source: Minnesota Medical Foundation Purpose: The proposal aims to develop a statistical model to detect gene-gene interaction in a case control study. Period: July June 2009 Role: Principal Investigator. Award: $24, Title: Genomics of Kidney Transplantation Source: NIH/NIAID - R01 Purpose: This grant proposes to study whether genetic variants are, in part, responsible for the differing outcomes of transplant recipients treat with similar immunosuppressive protocols. Period: July June Role: Co-Investigator for the time period July 2006 to June (PI: Arthur Matas, Department of Surgery) Award: $ 8,833, Title: A trait-model-free approach for linkage detection of continuous trait in pedigrees Source: Grant-in-Aid of Research, Artistry, and Scholarship grant Purpose: The proposal aims to develop a statistical model for linkage detection in extended pedigrees for quantitative traits. Period: July June 2007 Role: Principal Investigator. Award: $22, Title: Factors Affecting Outcomes for Single-Tooth Implant and Endodontics Source: Am Association of Endodontics Foundation Purpose: This proposal investigates different factor affecting the outcome of single tooth implant and endodontics in a multi-center study. Period: July June

10 Role: Co-Investigator. (PI: Walter Bowles, School of Dentistry) Award: $292, Invited Presentations Presented at Professional Meetings, Conferences: 1. RFGLS findings on MCTFR dataset, GEDI Advisory Board Meeting, Washington DC, April A dimension reduction approach for modeling multilocus interaction in case-control studies. Division of Biostatistics, University of Minnesota, March RFGLS findings on MCTFR dataset, GEDI Workshop, San Diego, February Development and Use of a Database, School of Dentistry, University of Minnesota, January Modeling multilocus interaction in case-control studies, Indian Statistical Institute, Kolkata, January Geneset approaches for joint modeling multi-snp interactions in case-control studies, GEDI analysis group meeting, Minnesota, August Analytic approaches to the Minnesota Center of Twin and Family Research (MCTFR) GWAS data, National Institute of Drug Abuse (NIDA) s Genes, Environment and Development Initiative (GEDI) Advisory Board Meeting, Washington DC, April Evaluating bias and variance distortion in case-control association studies and an alternative to achieving greater power, Indian Statistical Institute, Kolkata, India, January A bayesian approach for detecting multi-snp interaction in large scale association studies, Indian Statistical Association Joint Meeting, Visakhapatnam, Andhra Pradesh, India, January A likelihood-based trait-model-free approach for linkage detection for quantitative trait in pedigrees, Indian Statistical Institute Platinum Jubilee Conference, ICSPRAR-08, Allele-sharing methods for linkage detection using pedigrees, Department of Statistics, University of Minnesota, Allele-sharing methods for linkage detection, Indian Statistical Institute, Kolkata, India, A Likelihood-based Trait-model-free Approach for Linkage Detection, Division of Statistical Genetics, University of Alabama, Birmingham,

11 14. A Likelihood-based Trait-model-free Approach for Linkage Detection, Division of Biostatistics, University of Minnesota, Allele-sharing methods in large pedigrees, Department of Statistical Genetics & Bioinformatics, North Carolina State University, Contributed Papers Presented at Professional Meetings, Conferences: 1. Kirkpatrick R, McGue M, Iacono WG, Miller MB, Basu S. Genome-Wide Association Study of General Cognitive Ability. Behavior Genetics Association meeting, Newport, RI, McGue M, Miller MB, Basu S, Eskin E, Hicks BM, Irons DE, Keyes MA, Legrand LS, Malone SM, Oetting WS, Samek D, Schork NJ, Sul J-H, Vrieze S, Iacono WG. A Genome-Wide Association Study (GWAS) of Behavioral Disinhibition. Behavior Genetics Association meeting, Newport, RI, Miller MB, McGue M, Basu S, Li X, Keyes MA, Hicks BM, Samek D, Malone SM, Iacono WG. GEDI GxE GWAS: Methods for Detecting Genotype-by-Environment Effects in Full Genome Scans. Behavior Genetics Association meeting, Newport, RI, Smith NL, Germain M, Tang W, Teichert M, Pare G, Cushman M, Morange P, Folsom A, Rose L, Bovill E, Tregouet D-A, Basu S, Stricker B, Ridker P. Genetic associations of pulmonary embolism among those with a deep vein thrombosis. XXIII Congress of the International Society on Thrombosis and Haemostatsis. 57th Annual SSC Meeting, Koyoto, Thyagarajan B, Jacobson P, Jackson B, Basu S, Weisdorf DJ, Gross M, Arora M. Pharmacogenetic variants and outcomes after hematopoietic cell transplantation. American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, Li X, Basu S. A Bayesian partitioning model for detection of multilocus interaction in case-control studies. International Genetic Epidemiology Society (IGES) meeting, Boston, Tang W, Cushman M, Basu S, Green D, Reiner AP, Delaney JA, Lange LA, Smith NL, Tracy RP, Wilson JG, Tofler G, Yang Q, Keating BJ, Taylor H, Jacobs D, O Donnell CJ, Folsom AR. Gene-centric Approach Identifies New and Known Loci for Factor VIII Activity and von Willebrand Factor Antigen in the Candidate Gene association Resource (CARe) Consortium. The American Society of Hematology (ASH) annual meeting, Florida Basu S. A Bayesian approach for detection of multilocus interaction in case control studies, Joint Statistical Meeting (JSM), Vancouver BC,

12 9. Basu S. A dimension reduction approach to detect multilocus interaction in a case control study, International Biometric Society- Eastern North American Region (ENAR) meeting, New Orleans, Thyagarajan B, Lindgren B, Basu S, Nagaraj S, Weisdorf D, Gross M, Arora M, DNA repair polymorphisms as predictors of Graft-versus-Host Disease after allogeneic hematopoietic cell transplants. American Association for Cancer Research (AACR) annual meeting, Washington, DC, Tan A and Basu S. Effects of Population Stratification in Logistic Regression and an Alternative to Achieving Greater Power. ENAR meeting, New Orleans, Seong WJ, Barczak M, Jung J, Basu S, Conrad H, Prevalence of Sinus Grafting among Posterior Maxillary Implants, American Society of Dental Research (AADR) annual meeting, Washington DC, Jacobson P, Israni A, Brearley A, Basu S, Bergemann TL, Leduc R, Julian B, Matas A, Oetting WS. Tacrolimus Pharmacogenomics in Kidney Transplant: Preliminary results from a 7 center consortium. Americal Society of Human Genetics (ASHG) annual meeting, Hawaii, Tang W, Basu S, Folsom A, Kong X, Pankow JS, Aleksic N, Boerwinkle E. Genome-wide association scan identifies multiple loci for plasma levels of protein C in the ARIC cohort. ASHG annual meeting, Hawaii, Israni A, Basu S, Schlad D, Kim S, Leduc R, Oetting,WS, Jacobson P, Julian B, Matas A. Single Nucleotide Polymorphism and Acute Rejection in Renal Transplants. American Transplant Congress (ATC) meeting, Boston, Basu S. A gene-set approach to detect gene-gene interaction in case-control studies, ENAR meeting, Pittsburgh, Smith NL, Tang W, Maat MD, McArdle WL, Chen M, Peters A, Koenig W, Bovill EG, Basu S, Witteman JCM, Strachan D, O Donnell CJ. Genome-wide Association Study Reveals Multiple Novel Genetic Loci With Plasma Levels of coagulation factor VII, factor VIII, and von willebrand factor: the cohorts for heart and aging research in genome epidemiology (CHARGE) consortium. XXII Congress of the International Society on Thrombosis and Haemostasis, Boston, Saldarriaga R, Schulte JK, Conrad H, Basu S, Drago K. Volumetric measurement of misfit in CAD/CAM and cast implant frameworks. American College of Prosthodontists (ACP) annual meeting, Thumbigere-Math V, Sabino MC, Gopalakrishnana R, Basu S, Huckabay S, Arkadiusz Z, Michalowicz BS, Hughes PJ, Leach JW, Swenson KK, Swift JW, Basi DL. Potential Risk 12

13 Factors of Bisphosphonate Related Osteonecrosis of the Jaws. AADR meeting, Dallas, Texas, Vallee MC, Conrad HJ, Basu S, Seong W-J. Accuracy of friction style and spring style mechanical torque limiting devices for dental implants. American Academy of Fixed Prosthodontics 57th Annual Scientific Session, Chicago, Illinois, Oetting WS, Basu S, Brott MJ, Matas AJ. Identification of an X-linked locus associated with acute rejection. ATC meeting, San Francisco, CA, Oetting WS, Basu S, Brott, MJ, Matas,AJ. Identification of SNPs associated with acute rejection in kidney allografts using a custom SNP chip. ATC meeting, San Francisco, CA, Johnson L, Oetting WS, Basu S, Prausa S, Jacobson PA. Pharmacogenetics of Mycophenolate in Kidney Transplantation. American Society of Clinical Pharmacology and Therapeutics, Anaheim, CA, Jacobson PA, Kennedy M, Oetting WS, Basu S, Sager J, Kasiske B, Matas G. Low Activity UGT1A8 Genetic Variant is Associated with Higher Mycophenolate Exposure. ATC meeting, San Francisco, CA, Oetting WS, Basu S, Brott MJ, Matas AJ. Identification of a SNP haplotype of the PON1 gene associated with acute rejection in kidney allografts using a custom SNP chip. ASHG annual meeting, New Orleans, Basu S. A likelihood-based trait-model-free approach for linkage detection. International Biometric Society- Western North American Region (WNAR) meeting. Fairbanks, Alaska, Basu S. Efficient algorithms for allele-sharing methods to detect linkage using extended pedigrees. ENAR meeting, Pittsburgh, Basu S. Allele-sharing methods in large pedigrees, IGES meeting, New Orleans, Teaching/Advising/ Service Courses taught 09/10-12/10, 09/09-12/09,09/08-12/08 Biostatistics Ph.D. level Course: Probability models. 01/08-05/08, 01/07-05/07 Biostatistics course for public health majors: Introduction to Biostatistics. 09/06-12/06, 09/05-12/05 Biostatistics Ph.D. level course: Modern Nonparametrics. Doctoral Dissertations Directed: Li, Xiang; PhD in Biostatistics (in process). 13

14 Doctoral Committees Served on Maki Inoue-Choi, Maki; PhD in Epidemiology (2011 expected) Choi, Jang; PhD in Statistics (2010) Li, Meijuan; PhD in Biostatistics (2008) Hang, Jiayin; PhD in Pharmacy (2008). Rasmussen-Torvik, Laura; PhD in Epidemiology (2007). Masters Theses Directed Saputera, Taufik (2011 expected) Feng, Wei (2010) Tan, Adrian (2010) Schladt, David (2009) He, Hua (2008) Seth, Milan (2007) Masters Student Advisees Gayle Johnson (2010) Matthew Rosseau (2009) Ann Brearley (2008) Wang, Dan (2007) Masters Committees Served on Kirkpatrick, Rob, MS in Psychology (2010) Hall, Kris; MS in Epidemiology (2010) Alves, Brunna; MS in Biostatistics (2010) Deyo-Svendsen, Matt MPH in Biostatistics (2009) Afshannia, Farsad, MS in Medicine (2009) 14

15 Vallee, Mark; MS in Dentistry (2008) Brearley, Ann; MS in Biostatistics (2008) Hall, Taryn; MS in Epidemiology (2007) Service to the University/College/Department Division of Biostatistics Committees: Curriculum Committee (2005- present) Faculty Search Committee (2007) Recruiting Committee ( ) School of Public Health Committees: Training faculty in the Training Grant in CVD Genetic Epidemiology (Principal Investigator Dr. James Pankow). Reviewer for AHC seed grants in