HLA and other tales: The different perspectives of Celiac Disease Gutierrez Achury, Henry Javier

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1 University of Groningen HLA and other tales: The different perspectives of Celiac Disease Gutierrez Achury, Henry Javier IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2015 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Gutierrez Achury, H. J. (2015). HLA and other tales: The different perspectives of Celiac Disease [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 HLA and other tales: The different perspectives of Celiac Disease Henry Javier Gutierrez-Achury

3 Henry Javier Gutierrez-Achury HLA and other tales: The different perspectives of celiac disease Thesis, University of Groningen, with summary in English, Dutch and Spanish. The research presented in this thesis was mainly performed at the Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, and was financially supported by ERC Grant Agreement no and Groningen University Institute for Drug Exploration (GUIDE). Printing of this thesis was financially supported by: Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen University Institute for Drug Exploration (GUIDE). Cover design and layout by Claudia Marcela Gonzalez Arevalo ( Printed by Netzu Druk Javier Gutierrez-Achury. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without permission of the author. ISBN:

4 HLA and other tales: The different perspectives of Celiac Disease PhD Thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 2 December 2015 at hours by Henry Javier Gutierrez-Achury born on 27 December 1982 in Neiva, Colombia

5 Promotor Prof. T.N. Wijmenga Co-promotor Dr. A. Zhernakova Assessment committee Prof. J.D. Laman Prof. P. Heeringa Prof. P.I.W. de Bakker

6 Parany phs Maria Magdalena orro ndres Eduardo ui ones sis Rica o Ponce

7 Table of contents Chapter 1. Preface and outline 8 Part I Chapter 2 Chapter 3 Celiac disease: Past, present and future challenges Journal of Pediatric Gastroenterology and Nutrition, 2014 Jul;59 Suppl 1:S4-7 Shared genetics in coeliac disease and other immune-mediated diseases Journal of Internal Medicine, 2011 Jun;269(6): Chapter 3.1 Part II Chapter 4 Appendix. Update in the genetics findings of autoimmune diseases Best Practice & Research Clinical Gastroenterology, 2015 Jun; 29(3): Fine-mapping in the MHC region accounts for 18 additional genetic risk for celiac disease Nature Genetics, 2015 Jun;47(6): Corrigendum Chapter 4: Chapter 5 Fine-mapping in the MHC region accounts for 18 additional genetic risk for celiac disease. Nature Genetics, 2015 Jun;47(6): Evaluation of European coeliac disease risk variants in a north Indian population. European Journal of Human Genetics, 2015 Apr; 23(4): Part III Chapter 6 Contrasting the genetic background of type 1 diabetes and celiac disease autoimmunity Diabetes Care, 2015 Oct;38 Suppl 2:S

8 Chapter 7 variants in loci jointly associated to coeliac disease and rheumatoid arthritis. Human Molecular Genetics in press 137 Part IV Chapter 8 Discussion and future perspectives 161 Appendix Summary 190 Sammevating 196 Resumen 202 Acknowledgment 208 Publication list 215