Future Areas of Technology Convergence

Transcription

1 Future Areas of Technology Convergence Dr J Malcolm Wilkinson Managing Director Technology For Industry Ltd Cambridgeshire, UK Medilink Yorkshire & Humberside, 8 December

2 Technology For Industry Bridging the gap between industry and revolutionary technology from academia and research institutes 2

3 Convergence or Divergence? What does it mean to your organisation? Opportunities new ways to add value Threats your staff will need to learn new skills The supply chain will change new suppliers and customers before we get out the crystal ball to try to look in to the future let us see what we can learn from the past 3

4 Two routes to the Nanoscale Dimensional scale 1mm Bulk Materials 100µm 10µm 1µm Ultra Precision Machining Lithography Top down approach 100nm 10nm Microtechnology Nanotechnology Biochemistry Energy beams Self Organising Molecular System Unique Properties of Materials at the Nanoscale 1nm Chemistry Bottom-up approach 0.1nm Atomic Material Year 4

5 Technology Convergence in Microelectronics Physics Optics Device design Lithography Microelectronics Process models Mathematics Crystal growing Etching Chemistry Materials Science 5

6 Technology Convergence in Microelectronics Results: Valve manufacturers put out of business A $200 billion components business created The IT revolution enabled a whole new industry has been created by convergence creating a new platform technology 6

7 Technology Convergence in Medical Devices Microelectronics Micromachining Stealth drugs, Quantum dots Nanotechnology Computers,portable products, lasers Medical Devices Cell culturing Lab-on-chip Biocompatible materials Biomaterials Tissue Engineering 7

8 Technology Convergence in Medical Products Results: Lots of interesting product innovations but no platform technology The supply chain is complex and immature Medical product markets grow relatively slowly no major disruptive technology has emerged as yet, so we need to look on an application by application basis 8

9 Diagnostic Imaging Discipline Technology Impact Photography X-rays Non invasive imaging Computers Image processing CAT Scanning Nuclear Physics NMR Material differentiation Materials Science Piezoelectric effect Ultrasound images Semiconductors Infra-red detector Thermal images Photonics Quantum dot markers Contrast, organ and tissue selectivity 9

10 NanoParticles -Optical Contrast Agents Tunable Absorption Resonances Allows precise control of optical properties Biocompatible Optically triggered drug delivery Contrast Agent for NIRF Imaging Photoacoustic contrast agent Need to be biocompatible 10

11 Medical Application of Photonics Clinical Imaging Opthalmology OCT IV-OCT IVD OB/GYN Dermatology Microvascular Intraoperative Breast Tomography Brain Tomography iredex David Boas Pathogen detection Raman spectroscopy PACS Optical data transmission Light Labs Columbia Patient monitoring Pulse oximetry Genomics Micro array readers FISH Pre-Clinical Imaging Small Animal - Pharmacokinetics - Biodistribution - Drug Efficacy ART 11 Acknowledgement: Dr Leonard Fass, GE Healthcare

12 Diagnostic Imaging Technology convergence creates product innovations Most of the products are large and expensive The large incumbents control this market and are adept at technology acquisition from the smaller innovative companies No sign yet of the Star Trek hand held universal diagnostic device 12

13 Point of Care Diagnostics Discipline Technology Impact Biology + ELISA Microfluidics Lateral flow devices Pregnancy test kits Microelectronics + ISFET s Microfluidics + Microembossing Biology Glucose oxidase POC Blood Tests Photonics + Lasers Non-invasive blood Microelectronics + Low cost computing glucose monitoring Software Algorithms to unscramble data from noise 13

14 Point of Care Diagnostics Technology convergence is creating some potentially disruptive products Small companies are innovating Who owns the channels to market? Many of the small players do not have the marketing muscle or cash reserves to change the way diagnosis is done 14

15 Patient Monitoring 15

16 Patient Monitoring 16

17 Future Concepts in Patient Monitoring Advice, intervention Health system Memory, dossiers Wireless Communication R&D system Products for sensing, diagnosis, medication, etc With acknowledgements to Kees Eijkel MESA+ Product developers and IT companies 17

18 Example: Health Buddy 18

19 General Comment Even if the technology works, will the patient accept it? Consider the case of the Glucowatch Regulatory concerns One size doesn t fit all 19

20 Drug Delivery MICROPARTS Micronozzle in nebuliser, Microparts KTH Microneedles development, KTH ALZA CORP Stealth technology, lipid nanoparticle, Alza Corp. 20

21 Drug Delivery Roadmap for MNT Implantable Release Reservoirs Closed Loop Systems: External Internal Implantable Infusion Pumps External Infusion Pumps Needle-less Injectors Inhaler Delivery Devices: CFC free Ease of use Deep lung Variable dose Oral/Nasal Sprays Transdermal: chemical modifiers Transdermal Ultrasound Transdermal Microneedles Transdermal Iontophoresis Oral Nanotechnologies (hydrogels, dendrimers, liposomes etc.) Peptide drugs Proteins + Sustained release Nanotechnology Based Directed Delivery (e.g. dendrimers, microencapsulation) Inhaler Nanopowders Virus Vector Directed Delivery Tablet Coatings Years 21 Time to Market from 2005

22 Drug Delivery Roadmap for MNT Implantable Release Reservoirs Closed Loop Systems: External Internal Implantable Infusion Pumps External Infusion Pumps Needle-less Injectors Inhaler Delivery Devices: CFC free Ease of use Deep lung Variable dose Oral/Nasal Sprays Transdermal: chemical modifiers Transdermal Ultrasound Transdermal Microneedles Transdermal Iontophoresis Oral Nanotechnologies (hydrogels, dendrimers, liposomes etc.) Peptide drugs Proteins + Sustained release Nanotechnology Based Directed Delivery (e.g. dendrimers, microencapsulation) Inhaler Nanopowders Virus Vector Directed Delivery Tablet Coatings Years 22 Time to Market from 2005

23 Transdermal DD or sampling Diagnostic sensor or drug container Micro hollow injectors Epidermis Dermis NanoPass Inc.

24 Conclusions Technology convergence is creating product innovation Convergent technology is not necessarily disruptive Creation of multidisciplinary centres can facilitate technology convergence ( work in progress) 24

25 Technology For Industry Ltd Cambridgeshire, UK Tel: +44 (0)