World s 1 st Clinical Trial with Allogeneic ipsc-derived Therapeutic Product (Cynata Therapeutics) Physician Led Study Using ipscs for

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2 Table of Contents SCOPE AND METHODOLOGY... 8 Market Definition... 8 Market Scope... 8 Market Stakeholders... 9 Research Methodology Secondary and Primary Research Methodology Market Size Estimation Methodology Market Forecast Methodology Assumptions Years Considered for the Study Currency EXECUTIVE SUMMARY Introduction BACKGROUND ipsc RESEARCH About ipscs Importance of ipscs in Modern Medical Science Evolution of ipsc Research and Application Scientific Discoveries and Progress Since Discovery of ipscs Potential Future Use of ipscs Hepatic Differentiation of Human ipscs Disease Modelling with Human ipscs Drug Toxicity and Drug Discovery using Human ipscs Therapeutic Potential of Human ipscs Present Day Utilizations Drug Development and Discoveries Cellular Therapy Toxicology Screening ipsc Cell Lines and ipsc Banks Cancer Research Recent Research & Clinical Updates Building the World s Largest ipsc Repository st Investigator Led Study with ipsc-derived Cell Sheets to Treat Macular Degeneration (RIKEN)... 36

3 World s 1 st Clinical Trial with Allogeneic ipsc-derived Therapeutic Product (Cynata Therapeutics) Physician Led Study Using ipscs for Parkinson s Disease (Kyoto University) Physician Led Study Using ipsc-derived Cell Sheets for Heart Disease (Osaka University)...39 Moving ipsc-derived Platelets Toward the Clinic (CiRA of Kyoto University) Advantages and Disadvantages of ipsc Advantages of ipscs Disadvantages of ipscs Recent Activity: ipsc Research Supply Companies Ncardia and Nanion Technologies FUJFILM Cellular Dynamics and University of California - Irvine Evotec and Celgene Ncardia (Formed by Merger of Pluriomics and Axiogenesis) ID Pharma and Axol Bioscience Evotec and Censo Biotechnologies ORIG3N Fujifilm Establishes CDI Japan Stemgent Company Fujifilm Holdings REPROCELL Recent Activity: ipsc Cell Therapy Companies / Organizations Fate Therapeutics and ONO Pharmaceutical Cynata Therapeutics (Positive Phase I Data) Center for ips Cell Research & Application (CiRA), Kyoto University Osaka University Fujifilm and Takeda Pharmaceutical BlueRock Therapeutics and Universal Cells RIKEN Fujifilm Takes Equity Stake in Cynata Therapeutics Cellular Dynamics International (CDI) RIKEN Centre for Developmental Biology (CDB)... 55

4 MARKET ANALYSIS BY PRODUCT CATEGORY Market Segments Key Findings Introduction Reprogramming Cell Culture Differentiation Cell Analysis Engineering Others MARKET ANALYSIS BY APPLICATION Key Findings Introduction Academic Research Drug Development & Discovery Cellular Therapy Toxicology Screening Stem Cell Banking MARKET ANALYSIS BY GEOGRAPHY Key Findings Introduction North America Europe APAC Rest of the World (ROW) SCIENTIFIC PUBLICATIONS Key Findings Overview of ipsc Research Activity PATENTS Key Findings Introduction Patent List Patents by Geography Commentary

5 Patents by Category Commentary ANALYSIS OF ipsc MARKET LEADERS FEATURED COMPANIES: Companies Specializing in ipsc Products Cellular Dynamics International (CDI), a Fujifilm Company Ncardia REPROCELL Axol Bioscience FEATURED COMPANIES: Broad Providers of Research Tools to Include ipsc Products Lonza Thermo Fisher Scientific Takara Bio FEATURED COMPANIES: Companies Developing ipsc-derived Cell Therapeutics Cynata Therapeutics Fate Therapeutics Megakaryon Corporation RIKEN ORIG3N CONCLUSIONS

6 List of Figures Figure 1: Research Methodology Steps Figure 2: Market Size Estimation Methodology: Bottom-Up Approach Figure 3: Market Size Estimation Methodology: Top-Down Approach Figure 4: Research Design Figure 5: Global Induced Pluripotent Stem Cell Market Estimates (USD billion) Figure 6: Process of ipsc Cell Formation Figure 7: From Somatic Cell to Treatment Figure 8: The Leading Applications for Pluripotent Stem Cell Derivatives Figure 9: ips Derived Models of Diabetic Cardiomyopathy Figure 10: Recent Technological Updates and Clinical Applications of Induced Pluripotent Stem Cells Figure 11: ipsc Technology Figure 12: Human Induced Pluripotent Stem Cell (hipsc)-based Platforms for Drug Development Figure 13: Construction of Carcinogenesis model Figure 14: ipscs in Dentistry Figure 15: Stem Cell Reprogramming Figure 16: Bad effects of ipscs Figure 17: ipsc market Share by Product Type Figure 18: Share of of ipsc Clinical Studies by Region (January 2015 to August 2017) Figure 19: Percentage Share of Patent Granted by Region ( ) Figure 20: Percentage Share of Patents by Categories ( ) List of Tables Table 1: From Innovation to Commercialization Table 2: Global ipsc Market, by Product Category, USD Million, Table 3: Global ipsc Reprogramming Market, by Geography, USD Million, Table 4: Global ipsc Cell Culture Market, by Geography, USD Million, Table 5: Global ipsc Differentiation Market, by Geography, USD Million, Table 6: Global ipsc Cell Analysis Market, by Geography, USD Million, Table 7: Global ipsc Engineering Market, by Geography, USD Million, Table 8: Global ipsc Other Product Category Market, by Geography, USD Million, Table 9: Global ipsc Market, by Application, USD Million, Table 10: Global ipsc Market for Academic Research Application, by Geography, USD Million, Table 11: Global ipsc Market for Drug Development & Discovery Application, by Geography, USD Million, Table 12: Global ipsc Market for Cellular Therapy Application, by Geography, USD Million,

7 Table 13: Global ipsc Market for Toxicology Screening Application, by Geography, USD Million, Table 14: Global ipsc Market for Stem Cell Biobanking, by Geography, USD Million, Table 15: ipsc Publication Output, Growth and Citation Impact, by Country (2008 to 2012) Table 16: Global ipsc Market, by Geography, USD Million, Table 17: North America ipsc Market for Academic Research Application, by Country, USD Million, Table 18: North America ipsc Market, by Product Category, USD Million, Table 19: North America ipsc Market, by Application, USD Million, Table 20: U.S. ipsc Market, by Product Category, USD Million, Table 21: U.S. ipsc Market, by Application, USD Million, Table 22: Europe ipsc Market, by Product Category, USD Million, Table 23: Europe ipsc Market, by Application, USD Million, Table 24: APAC ipsc Market for Academic Research Application, by Country, USD Million, Table 25: APAC ipsc Market, by Product Category, USD Million, Table 26: APAC ipsc Market, by Application, USD Million, Table 27: Japan ipsc Market, by Product Category, USD Million, Table 28: Japan ipsc Market, by Application, USD Million, Table 29: RoW ipsc Market, by Product Category, USD Million, Table 30: RoW ipsc Market, by Application, USD Million,