Design Criteria for an IBT facility

Transcription

1 Design Criteria for an IBT facility Presented at the 2nd Workshop on Hadron Beam Therapy of Cancer, Erice, Italy Udo Weinrich 1

2 References and Credits My personal experience is based on the HIT facility (project leader accelerator) and RKA (part time beam commissioner within Siemens company) during the years 2003 to The presentations at this workshop of those persons in my IBT world are: - Today: M.Scholz (GSI), Open questions in heavy ion clinical radiobiology - Monday: M.Scholz (GSI), New developments in the local effect model K.Noda (NIRS), The rotating gantry for the HIMAC facility - Tuesday: K.Noda (NIRS), NIRS accelerator present and future activities M.Pullia (CNAO), The design and commissioning of CNAO P.Urschütz (Siemens), The Marburg particle therapy center - Wednesday: K.Parodi (HIT), Imaging techniques for in vivo treatment verification - Thursday: I.Hofmann (GSI), Prospects of laser accelerated ions for therapy U.Linz (FZJ), Summary Udo Weinrich 2

3 Main statement You should design an IBT facility in order to get the money to build it make it operational in the end bring the community a step forward Udo Weinrich 3

4 Criteria to get the money Basic concepts Operation Facility for high patient throughput (Based on health insurance compensation) Development Facility with improved performance (supported in addition by public or industrial funding) Research Facility with new acceleration technology (Based on research funding) Local Competence Centers (Based on funding from governments) Udo Weinrich 4

5 Criteria to get the money Operation Facility Idea: Large patient throughput based on known industrial systems with minimized risk for the clinic. Delivery of the whole system by one supplier Taking the financial risk until the facility works Sometimes even provides the investment money Takes often large responsibility for the operation phase Examples: SPITH (Shanghai), NRock (Kiel), RKA (Marburg) IONTRIS Siemens AG Healthcare Sector Particle Therapy Siemens AG All rights reserved. Siemens Particle Therapy products and solutions are worksin-progress and require country specific regulatory approval prior to clinical use Udo Weinrich 5

6 Criteria to get the money Development Facility Idea: Basis of standard patient treatment but special development systems. Attempt to get Unique criteria in some aspects and sharpen the profile of the clinic. Fractions of the system and time are used for development Strong link to industrial development units or research centers with strong technological competence Possibility to validate improvements in clinical studies Improvement often located around treatment technique Examples: HIMAC, HIT HIT accelerator Udo Weinrich 6

7 Criteria to get the money Research Facility Idea: Use of a new acceleration technology providing better or cheaper treatment. New principles of acceleration are tested Often pure public funding for research Sometimes sharing of cost with interested companies Examples: ARCHADE (CAEN) (cyclotron for carbon beam treatment) Udo Weinrich 7

8 Criteria to get the money Local Competence Centers Idea: Gaining experience in a strategic manner for countries or regions. Relying on research institutions Participation of industry only as subcontractor Often pure public funding for research

9 Criteria to make it operational in the end (I) Gather the required competence in all relevant fields building, accelerator, treatment technique, medical aspects Example: cabling for rotating gantry Organize correctly to identify and clarify the interfaces Example: building accelerator on media supply and connectors Use proven technology where possible RFQ quality assurance, power converters Udo Weinrich 9

10 Criteria to make it operational in the end (II) Keep close contact with the suppliers to identify major risks and define mitigating actions - personal for control system Think big, i.e. always ask yourself whether your concept really helps the patient and eases the job of the medical staff surrounding him. - short switching time from one patient treatment to the other in another room requires secure and fast solutions Correctly define the requirements for control system and beam from the treatment point of view and make sure that they are respected in detail and all along the project. - criteria and tools for quality assurance and readjustment Udo Weinrich 10

11 Criteria to bring the community a step forward We need many more facilities to help the patients better. Provide more treatment capacity! Ion Beam treatment should be extended to more cancer indications. Improve the results on moving targets! Further improve the results of the treatments. Fully explore the geometrical potential! Fully optimize the ion combinations and fractionation schemes! Udo Weinrich 11

12 Bring the community a step forward Treatment Capacity Flexible use of stored ions different intensities within one spill => faster irradiation isoenergetic slices different spot sizes within one spill intensity variation with one synchrotron cycle Dynamic Intensity Control (DIC) (courtesy Siemens, work in progress) courtesy M.Bräuer => faster irradiation isoenergetic slices different beam energies within one cycle => several slices per synchrotron filling Higher beam intensities for treatment with few fractions for experimental and QA purpose with better synchrotrons (RF harmonics and resonances) with better LINACS (ion sources and RFQ) Udo Weinrich 12

13 Bring the community a step forward Treatment Capacity Shorter cycle time with synchrotron dipole field regulation (HIT) The standard number of treatment rooms is three to four. The optimum number of treatment rooms depends on accelerator performance and patient workflow and is therefore subject to the improvements in both fields. courtesy A.Peters several energies with one synchrotron cycle (HIMAC) courtesy K.Noda Udo Weinrich 13

14 Bring the community a step forward Moving organs Gating irregular isoenergetic slices treatment at minimal organ motion 8e4 6e4 4e4 2e4 gating at HIT: (C, 250 MeV/u, ions, 3 interruptions) 0.5 ms 50 ms Energy variation with material moved in with beam bump on material active synchrotron energy variation t [s] energy variation with material moved in (HIMAC) courtesy K.Noda Udo Weinrich 14

15 Bring the community a step forward Best Ion combinations carbon beam dose profile courtesy K.Noda Intensity-Controlled Rasterscan Technique, Haberer et al., GSI, NIM A,1993 more ion types: He (HIT) 11 C, 13 O (HIMAC) Udo Weinrich 15

16 Bring the community a step forward Full geometrical flexibility 0 deg 0 d e g more ion sources (HIT, NROCK) semi-vertical beam lines (NROCK) 288 deg 72 deg gantry beams (HIT, HIMAC) IMIT (Intensity Modulated Ion Therapy ) courtesy K.Noda 216 deg 144 deg Udo Weinrich 16

17 Bring the community a step forward Full geometrical flexibility 45 dipoles scanner magnets 90 dipole HIT Gantry treatment room absorber Udo Weinrich 17

18 Conclusions There is a large potential for more treatment stations, further improvements and even new principles. Identify which of the many directions is adequate for your special situation. => Go on until you reach your added value to the community for the benefit of the society! Many thanks to the colleagues from HIMAC (K.Noda), HIT (A.Peters) and Siemens (M.Bräuer) for their support Udo Weinrich 18