A New Standard for the Future

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1 technology history For over 130 years, Toshiba has been a world leader in developing technology to improve the quality of life. Our 50,000 global patents demonstrate a long, rich history of leading innovation. It might surprise you to learn about some of the things we ve invented First x-ray tube 1954 First digital computer 1978 First cardiac ultrasound scanner 1985 First slip-ring CT scanner 1986 First laptop computer 1989 First helical CT scanner 1993 First real-time CT fluoro 1995 First DVD 1998 First quiet MRI 1999 First 0.5 mm multidetector CT 2002 First 400 ms CT scanner 2004 First Quantum Denoising Software 2007 First dynamic volume CT scanner 2009 First 160 Helical 2010 First iterative recon technique for 320 detector Row CT 2011 First 80 detector row CT scanner AwArd-winning service And support Developed with customer input, Toshiba s innovative support programs have resulted in greater satisfaction when using Aquilion products as reflected in customer surveys time after time. InTouch Center A centralized service facility that provides applications and service support expertise for Aquilion customers 24 hours a day, seven days a week. InnerVision Plus Monitored around the clock, remote system diagnostics help identify problems and provide potential solutions before care is interrupted or an engineer can arrive. InTouch Agreements Tailored to meet specific customer requirements, these range from an a la carte approach that helps manage risk to full security agreements that provide complete system protection. Technical Assistance Customer support specialists are available 24/7 to identify and resolve technical issues in real time. Application specialists are also on hand to assist staff with protocol and image quality issues. Local Customer Teams A single call mobilizes a local team of Toshiba Customer Engineers. Averaging 10 years of experience with Toshiba and 105 hours of specialized training per year, they can quickly resolve almost any performance issue. Parts Support A complete inventory of Aquilion product parts is ready for shipment when and where they re needed, any time day or night Michelle Drive, Tustin CA / A New Standard for the Future Toshiba Medical Systems Corporation All rights reserved. Design and specifications are subject to change without notice. Made for Life, Aquilion, Aquilion ONE, SURE Subtraction, SURE Cardio, SURE Fluoro, SURE Exposure Boost 3D and conexact are trademarks of Toshiba Medical Systems Corporation. InTouch Center is a trademark of Toshiba America Information Systems. InnerVision is a registered trademark of Toshiba America Medical Systems, Inc. CTBR11712US

2 Setting a new standard for performance and productivity. To meet the needs of a growing and more diverse patient population while satisfying the demands of a new healthcare model for better care at a lower cost, providers are looking for a single CT system that can do it all. And That Single System is Toshiba s Aquilion Prime. Aquilion PRIME is the latest addition to the ONE family of scanners and is the industry s only 80-detector row CT scanner. With the technology of the Aquilion ONE built in, Aquilion PRIME is capable of reconstructing 160 unique slices with every rotation of the gantry and incorporates a host of ergonomic and automated features to streamline productivity and deliver the highest quality images while lowering radiation dose. ONE Family. Aquilion Premium Aquilion ONE Aquilion PRIME System shown with dual console option.

3 Ultra-high performance. Accelerating Workflow with Advanced Technologies Toshiba has optimized every aspect of performance with Aquilion PRIME in order to design a system that offers the ultimate clinical value for your facility. Aquilion PRIME incorporates a variety of advanced technologies into a new-generation platform, reducing the total time to diagnosis and improving productivity with highquality images and workflow efficiencies every step of the way. Optional Advanced Applications investment protection, secured by optional application enhancements, maintains the state-of-the-art CT capabilities. SUre Subtraction * SUre Cardio Prospective * FASTEST DATA-TO- DIAGNO SIS SURE Subtraction provides automated digital subtraction of the vessels from bone, specially developed for head and neck regions. It enhances diagnostic accuracy and improves workflow. SURE Cardio Prospective delivers high-quality diagnostic studies for coronary CTA procedures while speeding up exam times and reducing radiation dose. With industry-leading reconstruction speeds, images are available almost immediately after acquisition slices (vhp) Variable Helical Pitch * SUre Fluoro * Helical scanning, with 0.5 mm x 80 detector row for rapid acquisition and reconstruction, is ideal for trauma CT imaging 0.5 mm slice thickness with 350-micron isotropic spatial resolution displays anatomic details with uniform image quality 0.5 mm x 160 slices ECG GaTEd HEliCal PiTCH TablE SPEEd CHanGE 78 cm aperture for interventional access the largest available in a high-end CT makes scanning easier for hard-to-scan emergency or bariatric patients slices conexact with double-slice technology can reconstruct acquired volume data with double density technology, resulting in 160 slices per rotation on Aquilion PRIME. STandard HEliCal PiTCH Double-slice technology developed for Aquilion ONE gives users the ability to reconstruct 160 unique slices per gantry rotation with no dose penalty vhp has the ability to automatically change an ECG gated to a non ECG gated acquisition; reducing IV contrast and radiation dose. SURE Fluoro allows real-time monitoring by three contiguous CT slices for interventional procedures improving accuracy while shortening the procedure time. *Optional.

4 Dose reduction for every patient and every procedure. Aquilion PRIME CT systems feature advanced dose reduction and image processing software. Developed based on Toshiba s long-standing commitment to improving patient safety, these features ensure delivery of the best possible image quality at the lowest possible dose. These software enhancements reinforce Toshiba s guiding principle of ALARA for every patient. Adaptive and Integrated Dose Management In order to achieve the highest quality images at the lowest possible dose, Aquilion PRIME implements an array of adaptive and integrated dose reduction strategies. These strategies are implemented at every stage in the scanning process from patient registration through data acquisition, raw data and image reconstruction. 58 mas 82 mas 112 mas Active Collimation In Helical scanning, exposure is needed before the start and after the end of the planned scan range in order to reconstruct images at these positions. This over-ranging requires at least one extra rotation, although only a small portion of this data is utilized. Active collimation synchronizes the width of the X-ray beam at the ends of the scan range to the clinically useful area needed for image reconstruction. By eliminating exposure that is not used for diagnosis, patient dose can be reduced. Aidr (Adaptive Iterative Dose Reduction)* Reconstruction Volume AIDR is the next step in the evolution of noise reduction This iterative algorithm is superior in removing background technology. noise while preserving diagnostic information compared AIDR is an iterative algorithm, where noise is removed from to non-iterative approaches. AIDR can be applied to all the original data, the results are analyzed and the process is acquisition modes for routine clinical use and is able to repeated until the target level of noise reduction is achieved. remove image noise resulting in dose reduction. Patient Registration The system prompts the user to select the appropriate protocol based on patient age, weight and exam type Dose is displayed on the console prior to scanning for operator confirmation and validation Aquilion PRIME includes the National Electrical Manufacturers Association (NEMA) XR-25 Dose Check requiring dose notification and alert features Acquisition Integrated SURE Exposure 3D ma modulation is scanogram-based to automatically reduce patient dose Active Collimation limits helical overranging, reducing dose delivered to the patient on all helical scans Variable Helical Pitch (vhp) changes the helical pitch automatically from an ECG gated to a non-ecg gated exam, saving dose, IV contrast and time Raw Data and Reconstruction Adaptive Iterative Dose Reduction (AIDR) adaptively targets image noise; this iterative process can be used to lower patient dose while maintaining spatial resolution and image texture Quantum Denoising Software (QDS) reduces image noise to optimize image quality while lowering patient dose Boost 3D improves image quality and lowers dose by selectively reducing noise and streak artifacts from those areas where it is needed Raw Data NOISE REDUCTION UPDATE OBJECT UPDATE OBJECT AIDR Reconstruction Process Multiple iterations of noise reduction adaptively targeted to the clinical task. NOISE REDUCTION AIDR Image *In clinical practice, the use of AIDR feature may reduce CT patient dose depending on the clinical task, patient size, anatomical location and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task.

5 Brain Metastasis A solitary metastasis in the left parietal lobe of the brain is demonstrated in these contrast enhanced MPR and 3D images. The extent of the surrounding edema is clearly visualized in multiple planes. Lung Lesions Two lung lesions are seen in this helical scan of the chest. The larger lesion in the left upper lobe appears spiculated. The smaller lesion in the right middle lobe lies adjacent to a vessel. The scan time in this case was just 3.2 seconds. Scan Mode Collimation Pitch kvp mas Rotation Time CTDIvol DLP Effective Dose Scan Mode Collimation Pitch kvp mas Rotation Time CTDIvol DLP Effective Dose Helical 0.5 mm x s 54.3 mgy mgy.cm 1.8 msv (k=0.0021)* Helical 0.5 mm x s 4.0 mgy mgy.cm 2.3 msv (k=0.014)* *AAPM Report 96 *AAPM Report 96

6 LAD Stenosis A stenosis of the proximal LAD is seen in this prospectively gated cardiac scan of a male patient with a BMI of The lesion appears to be calcified, but with some non-calcified areas. A large calcification is also seen in the left main coronary artery. Another lesion is seen in the LCx distal to the first OM branch. Abdominal Aortic Aneurysm This abdominal CTA demonstrates an aneurysm of the aorta. The abdominal aorta and iliac arteries are also calcified. This scan can be used to obtain measurements for an endoluminal stent graft. Scan Mode Collimation Pitch kvp mas Rotation Time CTDIvol DLP Effective Dose Scan Mode Collimation Pitch kvp mas Rotation Time CTDIvol DLP Effective Dose Helical 0.5 mm x s 10.4 mgy 151 mgy.cm 2.1 msv (k=0.014)* Helical 0.5 mm x s 7.5 mgy mgy.cm 4.7 msv (k=0.015)* *AAPM Report 96 *AAPM Report 96

7 Continuous improvements in comfort and convenience. Increasing Efficiency with Enhanced Ergonomics 78 cm With the Aquilion PRIME CT System, ergonomics and patient access have evolved to an unprecedented degree with the evolution couch and gantry. Offering greater comfort and convenience, they increase operator efficiency for faster throughput while improving patient compliance to ensure higher quality exams. The evolution Couch Carbon fiber couch features exclusive XYZ table movement with a full 2000 mm scan range 8.4 cm lateral table movement* improves access for interventions and makes it possible to center a scan target without patient discomfort 660 lb. weight capacity with industry s widest couch of 47 cm increases comfort and the ability to accommodate larger patients Convenient front and optional rear table footswitches facilitate a more efficient workflow The ability to be lowered to 33 cm above the floor facilitates access for pediatric, elderly and emergency patients The evolution Gantry 72 kw generator coupled with rapid 350 ms rotation acquires data faster to reduce exam duration 78 cm gantry accommodates all of your patients and improves access for interventional procedures Tilts +/- 22 degrees to improve access for interventional cases and reduce exposure to sensitive organs Controls positioned on the left and right, front and rear, significantly enhance operator efficiency i Station display provides child-friendly exam instructions and gives operators feedback for breath hold, ECG waveforms and other inputs An electric regeneration function that converts energy generated during gantry deceleration into electricity used by the system reduces energy requirements *Optional.

8 Ultra-high investment protection. Maximizing Utilization with Toshiba Service and Support Protecting your investment as well as your ability to consistently enhance patient care Aquilion PRIME CT is backed by industry leading sales, service and support. Together with on-going training to optimize system performance, Aquilion PRIME represents today s best value in advanced imaging technology. Flexible financing options and consulting services from Toshiba help facilities make more efficient use of limited resources Faster throughput and greater capabilities provide the ability to increase clinical volume and perform a wider range of procedures Productivity improvements are assured over time with the availability of software enhancements from Toshiba In terms of service, we needed flexibility, and Toshiba was very accommodating to all of our staff. Karen Botts, Director of Imaging Pinnacle Health

9 Unequaled training and education. At Toshiba s Institute for Advanced Imaging, we believe the best medical imaging products should be operated by the most knowledgeable professionals and it s for that reason we offer our customers in-depth training and education at our state-of-the-art facility located in beautiful Southern California. Through our Performance Plus program, you can purchase education events with your system and customize education and training programs designed to achieve the highest levels of staff proficiency and system productivity starting with the moment your equipment goes live. A global network of facilities provide training that meet stringent guidelines for clinical competence to help ensure consistent results and more rapid diagnoses The Toshiba Institute of Advanced Imaging located in Irvine, CA, offers classroom instruction coupled with hands-on experience using the Aquilion PRIME On-site training and follow-up visits by Toshiba training professionals help facilities maintain and add new competencies over time Accessible 24/7, an extensive library of Continuing Education and CME-accredited courses relating to CT are conveniently available on-line Toshiba has put together a cohesive education program to support their products at the education center. With the instructors well-versed and knowledgeable, the subject matter was easy to master. Raul Santiago Cooper University Hospital

10 Unsurpassed customer satisfaction. Toshiba s over-riding goal in pursuing excellence in CT has been to develop stateof-the-art systems that clinicians can use to provide superior care for their patients. And year after year, customers have confirmed this achievement in industry-wide surveys like MD Buyline and KLAS where Toshiba CT has ranked highest among its competitors for service, education and productivity. MD Buyline has consistently ranked Toshiba #1 in customer satisfaction, more often than any other diagnostic imaging vendor. Toshiba has held the #1 ranking in CT for over 8 years, since Top 20 Best In KLAS Awards: Medical Equipment & Infrastructure, June, Ranked #1: CT 64 Slice+: Aquilion ONE, MR 1.5T: Vantage. Tied for #1: Ultrasound Cardiovascular: Aplio Cardiovascular. Category Leaders: Infinix-i Angio in CV/IR x-ray, Aquilion 32 in CT-Under 64 Slice KLAS Enterprises, LLC. All rights reserved. Toshiba offers a wide variety of things on top of the technology, so from a customer service standpoint, Toshiba has always been there for us when we have that case that is a little more complex than your typical everyday case, they are always there for us, at a moment s notice. From a research standpoint, Toshiba has been very helpful, very willing to work with us, which I think is a huge plus for an academic institution like us. Daniel J. Podberesky, MD Chief, Thoracoabdominal Imaging Cincinnati Children s Hospital Medical Center

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