Course ADVANCED DRUG DELIVERY July 03-07, 2017 Faculty of Pharmacy Amphitheatre B Universidade de Lisboa, Portugal

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1 PhD Programme in Medicines and Pharmaceutical Innovation Course ADVANCED DRUG DELIVERY July 03-07, 2017 Faculty of Pharmacy Amphitheatre B Universidade de Lisboa, Portugal Organizing committee at imed.ulisboa/ffulisboa António Almeida (Coordinator) Helena Florindo The FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3du; trains students in target discovery, drug design, preclinical development, and drug safety, bridging the translational gap from discoveries on disease targets and mechanisms into novel diagnostic and therapeutic agents. The Course on Advanced Drug Delivery is part of the PhD Programme in Medicines and Pharmaceutical Innovation (i3du), trains students in the development of advanced medicinal products, covering crucial aspects that determine the fate of drugs in the human or animal body, from their fundamentals to the advanced strategies to overcome the physiological barriers, including innovative technological and therapeutic applications. The course will be held at the Research Institute for Medicines (imed.ulisboa), Faculdade de Farmácia, Universidade de Lisboa, in Lisbon, 3-7 July The training program is aimed at PhD students, but welcomes the participation of external academic and scientific community members. Registration ( is free but mandatory. Programme Drug delivery technology is becoming increasingly sophisticated involving several approaches and issues such as pharmacokinetics, drug biodistribution, drug targeting to its site of action (site-specific drug delivery), nanomedicines, nanotoxicology, etc. Therefore, advanced drug delivery is a crucial component of any PhD programme involving the discovery, design, development and usage of medicines. It is an area in which students from many different scientific backgrounds must have proper training and understanding. The course is intended to improve the understanding of advanced medicinal products, covering relevant aspects that determine the fate of drugs in the human or 1

2 animal body, from their fundamentals to the advanced strategies to overcome the physiological barriers, including innovative technological and therapeutic applications. It aims at explaining the principles underlying the development of advanced drug delivery systems as well as pointing future trends in this field. 3 July Drug Delivery Fundamentals 09:30h Drug Delivery: Quo Vadis? José Morais, Research Institute for Medicines (imed.ulisboa), Faculty 10:20h Discussion 11:00h Pharmacokinetics in advanced drug delivery Rosário Lobato, 12:10h Lunch Break 2. Overcoming Biological Barriers 14:00h Oral delivery of biopharmaceuticals Francisca Araújo, Instituto de Investigação e Inovação em Saúde (i3s), Universidade do Porto 15:10h Overcoming the skin barrier Sandra Simões, Research Institute for Medicines (imed.ulisboa), 4 July Nanoparticulate Delivery Systems 10:00h Nanotoxicology: implications for advanced drug delivery systems development Ana Francisca Bettencourt, Research Institute for Medicines (imed.ulisboa), 10:50h Discussion 11:10h Liposomes: Present and future of the first nanopharmaceutical dosage form Eugénia Cruz, Research Institute for Medicines (imed.ulisboa), 2

3 12:00h Discussion 12:20h Lunch Break 14:00h Lipid nanoparticles: formulation development and safety aspects Eliana Souto, Faculty of Pharmacy, Universidade de Coimbra 15:10h Taking the most from nanotechnology-based drug delivery in anticancer therapy João Nuno Moreira, Faculty of Pharmacy and Center for Neurosciences and Cell Biology (CNC), Universidade de Coimbra 5 July Delivery Systems in Theranostics 09:30h Biodistribution of nanoparticulate drug delivery systems António Rocha Paulo, Instituto Superior Técnico, Campus Tecnológico e Nuclear, Universidade de Lisboa 10:10 h Discussion 10:25h Coffee break 10h45h 11h25h 11h35h 12h15h In-vivo molecular imaging using PET-MRI Pedro Almeida, Instituto de Biofísica e Engenharia Biomédica (IBEB), Faculty of Sciences, Universidade de Lisboa Discussion Molecular interactions probed by AFM-based force spectroscopy Nuno Santos, Instituto de Medicina Molecular (IMM), Faculty of Medicine, Universidade de Lisboa Discussion 12:30h Lunch Break 14:30h Targeting Drug Conjugates: An emerging strategy for drug delivery Pedro Góis, Research Institute for Medicines (imed.ulisboa), Faculty 15:10h Discussion 15:25h Funtional nanoparticles for MRI: diagnostic and therapy applications Bárbara Martins, Research Institute for Medicines (imed.ulisboa), 3

4 16:15h Discussion 6 July Innovative Technological Applications 09:30h Biotherapeutics below the freezing temperature, unveiling thermo-stability and accelerating formulation by cold Miguel Angelo Rodrigues, Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa 12:20h Discussion 11:00h From in silico identification of proteasome inhibitors to in vivo application Rita Guedes, Research Institute for Medicines (imed.ulisboa), 12:10h Lunch Break 14:00h Spray-drying technology for targeted pulmonary delivery Ana Grenha, Centre for Biomedical Research, Universidade do Algarve 15:10h PAT tools towards translational advanced drug delivery João Lopes, Research Institute for Medicines (imed.ulisboa), Faculty 7 July Drug Delivery Strategies 09:30h Industrial perspectives on the use of predictive biopharmaceutics tools Mark McAllister, Drug Delivery Group Leader, Research Formulation, Pfizer Group R&D, UK 10:20h Discussion 4

5 11:00h Viral and non-viral gene therapy approaches for neurodegenerative disease treatment Luís Almeida, Center for Neurosciences and Cell Biology (CNC) and Faculty of Pharmacy, Universidade de Coimbra Assessment (i3du 1 st Year PhD students ONLY) Assessment of the course consists in the preparation and submission of a research project, characters long (including spaces). Students are grouped to build multidisciplinary teams. Each group works throughout the week on a research project that should reflect the topic of the course, including methodologies and strategies to solve an innovative research question. The project is expected to adhere to the following general structure: a) Title; b) Conceptual hurdle and innovative idea to be tested; c) Plan and methods: d) Relevance of the project (scientific and social impact). The students will select a broad topic of research and are expected to propose a specific project. This project will be evaluated according to the following criteria and weight: a) Novelty and relevance (30%); b) approach to the problem (30%); c) multidisciplinarity of the research plan (40%). Students will attend a workshop on How to write a research project. Specific slots are allocated in the course programme for group discussions, which will take place in prebooked rooms. 5

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