RADIATION PROTECTION IN AN ANIMAL RESERCH UNIT WITH PET: OCCUPATIONAL DOSES AND ANIMAL DOSE RATES

Transcription

1 RADIATION PROTECTION IN AN ANIMAL RESERCH UNIT WITH PET: OCCUPATIONAL DOSES AND ANIMAL DOSE RATES J.M. Martí-Climent 1, M. Ecay 2, I. Bilbao 2, E. Prieto 1, M. Collantes 2, I. Peñuelas 1,2 1. Servicio de Medicina Nuclear. Clínica Universidad de Navarra. Pamplona, Spain 2. Unidad de Investigación micropet. CIMA-Clínica Universidad de Navarra. Pamplona, Spain

2 Introduction Parkinson desease Preclinical research with PET radiopharmaceuticals is done at the Animal Research Unit (ARU) located at the hospital. Objetives To correlate the dose received by the technicians managing the PET animal unit with the workload. To assess the dose rates produced by the animals. F 18 -FDOPA affected control

3 Material and methods 5 m to the GMP laboratory PET scanner Mosaic (Philips) Facility and premises Anesthesia system Autoradiography system and PET control Animal facility Rack PET room Biological security hood Cryostat Laboratory and control room

4 Material and methods Personal 2 technicians Tech#1 1 year exp Tech#2 3 year exp Period 12 months 29 Dosemeters Whole body dosemeter UD-82 AR (Panasonic) 2 chips Li 2 B 4 O 7 :Cu Hp(.7) 2 chips CaSO 4 :Tm Hp(1) Extremity ring dosemeters UD-87AT7N (Panasonic) Hp(.7) chip Li 2 B 4 O 7 :Cu worn on the base of the middle finger on each hand Official dose Dose evaluation

5 Material and methods Dose rate evaluation Measures GM minitrace S1 (Genitron Instruments) H*(1) in contact at 2 cm from the animal At the end of the PET study Period Prospectively studies

6 Workflow Activity manipulation and dose rate measurements GMP Laboratory Dispensing laboratory ARU Injection Positioning Removal Injection Massage Dose rate measure and decay correction Removal

7 Workload 29 Studies Activity GBq Activity/study % % (MBq/study) Mouse Rat Monkey Other mean 27 median 18

8 Workload 29 Radiopharmaceuticals % 4 35 Studies Mouse Rat Monkey Other FDG F-DOPA FHBG FLT FMISO 18F- Ammonia C-DTBZ MET Acetate Choline Tc-99m RF Studies (%) Activity FDG F-DOPA FHBG FLT FMISO F-.2.4 Ammonia C-DTBZ Mehionine Acetate.6.6 Choline.6.4 Tc-99m.8.7

9 Workload 29 4 % Studies % 35 Mouse 53. Rat Monkey Other Radiopharmaceuticals Activity Mouse Rat Monkey Other FDG F-DOPA FHBG FLT FMISO Ammonia C-DTBZ MET Acetate Choline Tc-99m RF Studies (%) Activity (%) FDG F-DOPA FHBG FLT FMISO F-.2.4 Ammonia C-DTBZ Mehionine Acetate.6.6 Choline.6.4 Tc-99m.8.7 FDG F-DOPA FHBG FLT FMISO 18F- 18F- Ammonia C-DTBZ MET Acetate Choline Tc-99m

10 Results Finger dose Finger dose Hp(.7) (msv/month) msv/month p<,1 (Wilcoxon) Rigth (msv/month) Tech#1 Tech#2 r=.94 p=.1 r =.86 p= Left (msv/month) Tech_1_L_ring 9 Tech_1_R_ring Left Right Tech#1 Tech_2_L_ring NS (T-test) Tech_2_R_ring Left Right Tech#2

11 Results (Dose vs Activity) / month Tech #1 Extremity ring dosemeter Tech #2 Dose (msv) Dose (msv) Left 12 1 R 2 =,48 Rigth R 2 =, ,5 1 1,5 2 2,5 Activity (GBq) Dose (msv) Left Whole body dosemeter 6 5 Rigth R 2 =,43 R 2 =, ,5 1 1,5 2 Activity (GBq) 1,2 Hp(.7) R 2 =,61,6 Hp(.7) R 2 =,39 1 R 2,5 Hp(1) =,57,8 Hp(1) R 2 =,35,4,6,3,4,2,2,1,5 1 1,5 2 2,5,5 1 1,5 2 Activity (GBq) Activity (GBq) p <.5 Dose (msv)

12 Results Technician doses 1 year Tech#1 Tech#2 Activity (GBq) Studies Whole body dosemeter Hp(.7) (msv) Hp(1) (msv) Ring dosemeter Left Hp(.7) (msv) Right Hp(.7) (msv)

13 Results Radiation rates Mean dose rate H*(1) (μsv/h) Before After PET scan Animal Monkey Rat Mouse Mouse RP DTBZ FDG FDG FLT Number Weight (g) Activity (MBq) RP Incorporation : 1: 1: :4 Scan duration :4 1: :15 :2 H*(1) at cm H*(1) at 2cm H*(1) at cm H*(1) at 2cm

14 Results Radiation rates Mean dose rate H*(1) (μsv/h) Before After PET scan Animal Monkey Rat Mouse Mouse RP DTBZ FDG FDG FLT Number Weight (g) Activity (MBq) RP Incorporation : 1: 1: :4 Scan duration :4 1: :15 :2 H*(1) at cm H*(1) at 2cm H*(1) at cm H*(1) at 2cm

15 Discussion MBq/study micropet 27 PET-CUN Hp(1) μsv/gbq μsv/study micropet PET-CUN Finger Hp(.7) micropet PET-CUN Martí 6 th European Alara Network Workshop Madrid,22

16 Conclusions The results have shown that extremities are the limiting organs as far as regulatory dose limits for workers are concerned. The procedures followed by the technicians at the animal research unit for the administration of PET radiopharmaceuticals and managing the animals are satisfactory and involve an acceptable radiation exposure risk.

17 RADIATION PROTECTION IN AN ANIMAL RESERCH UNIT WITH PET: OCCUPATIONAL DOSES AND ANIMAL DOSE RATES J.M. Martí-Climent 1, M. Ecay 2, I. Bilbao 2, E. Prieto 1, M. Collantes 2, I. Peñuelas 1,2 1. Servicio de Medicina Nuclear. Clínica Universidad de Navarra. Pamplona, Spain 2. Unidad de Investigación micropet. CIMA-Clínica Universidad de Navarra. Pamplona, Spain