GLOBAL PHARMA INDUSTRY

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1 www. Advancing Development & Manufacturing CONNECTING THE GLOBAL PHARMA INDUSTRY SINCE M E D I A PLANNER

2 BRANDING Advancing Development & Manufacturing Pharmaceutical Technology Expert Insight. Targeted Audience. Global Coverage. Bio/pharmaceutical companies must navigate a complex global network in their efforts to develop and manufacture safe, effective, and successful therapies. Materials sourcing, drug formulation, and manufacturing operations cross borders and markets, with different regulatory processes and market demands. At the same time, drug companies are investigating and developing vital new therapies to meet the needs of a changing patient base amid payer resistance. The need for independent technical and scientific insight and analysis is great. Pharmaceutical Technology covers the world of bio/pharmaceuticals with expert analysis on solid dosage, semi-solid, and parenteral formulation and manufacturing; chemical and biologic APIs; pharmaceutical analysis; packaging; and standards, regulations, and quality issues. In addition, the brand s global coverage extends to established and emerging markets through its North American and European editions. A network of correspondents and contributors report on emerging scientific, technical, business, and regulatory trends for drug formulation, development, and manufacturing around the world. The readers of Pharmaceutical Technology seek innovative materials, equipment, instruments, products, and services to aid them in their drug development efforts. With the greatest reach into the bio/pharmaceutical market, Pharmaceutical Technology will convey your message directly to your customers. Loyal readers turn to Pharmaceutical Technology s print and electronic products for the most comprehensive and authoritative coverage in drug development and manufacturing. Our readers your customers will hear your message when you advertise in Pharmaceutical Technology, the Pharma industry leader. Pharmaceutical Technology: Leading the Global Pharma Industry since 1977.

3 Advancing Development & Manufacturing COMPETITIVE ANALYSIS POWERFUL AUDIENCE WHICH OF THE FOLLOWING PUBLICATIONS DO YOU SUBSCRIBE TO? Pharmaceutical Technology % Pharmaceutical Manufacturing % American Pharmaceutical Review... 35% Drug Development & Delivery % Contract Pharma % Pharmaceutical Processing % Pharmaceutical Outsourcing % Chemical and Engineering News % Pharmaceutical Engineering % Tablets and Capsules % BioProcess International % Life Science Leader % (multiple responses allowed) POWERFUL AUDIENCE IF YOU COULD READ JUST ONE PUBLICATION, WHICH WOULD YOU CHOOSE AS THE SINGLE SOURCE FOR INFORMATION? Pharmaceutical Technology % American Pharmaceutical Review % Chemical and Engineering News % Life Science Leader % Pharmaceutical Manufacturing % Contract Pharma % Drug Development & Delivery % Pharmaceutical Engineering % BioProcess International % Pharmaceutical Outsourcing % Pharmaceutical Processing % Tablets and Capsules % SOURCE: July 2014 Readership Survey Conducted by Advanstar Research Services PHARMACEUTICAL TECHNOLOGY S CIRCULATION IS UNPARALLELED IN THE INDUSTRY The largest average qualified audience with the highest number of direct request subscribers + Total Qualified Circulation Average Qualified Circulation Total Qualified Digital # Pharma/ Biopharm Manufacturing % Pharma/ Biopharm Manufacturing # R&D/ % R&D/ # of One Year % of One Year # of Two Year % of Two Year # of Three Year % of # of Total Three Direct Year Request Pharmaceutical Technology* 35,233 34,421 7,261 25, , , , , Pharmaceutical Outsourcing ++ 15,020 15,014 n/a 6, , , , , American Pharmaceutical Review ++ 30,031 30,020 n/a 16, , , , , Contract Pharma* 20,015 20,190 7,081 8, , , , , Drug Development & Delivery** 16,114 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Pharmaceutical Processing* 28,012 28,017 12,011 21,809^^ , , , , Pharmaceutical Manufacturing ++ 25,020 25,020 6,806 18,131^ , , , , Tablets & Capsules ++ 10,053 10,048 2,174 4,072^ , , , , *Source: BPA June 2014 statements + Source: Pharmaceutical Technology BPA June 2014 Statement compared to other named titles most recent BPA statement June 2014 or December Source: BPA December 2013 statements **Formerly Drug Development Technology; Source of Data: SRDS Sworn June 2013 ^Pharmaceutical Manufacturing only ^^Includes Nutritional/Nutraceutical Products Manufacturing % of Total Direct Request

4 CIRCULATION Advancing Development & Manufacturing The Industry s Most Highly Desired Audience Pharmaceutical Technology has cornered the market on R&D/Formulators,, Production/Manufacturing/Engineering. OUR AUDIENCE AND THEIR ORGANIZATIONS Pharmaceutical, Biopharmaceutical Manufacturing University, Research Institute, Foundation Contract Research, Analytical, Manufacturing Services Specialty Chemicals, Bulk Products and Raw Materials Producers Drug Delivery Devices & Instrumentation Manufacturing Government Consultant to the Pharmaceutical Industry Other Paid Circulation - Subscriptions 72.1% 7.5% 7.4% 4.9% 4.0% 3.2% 0.2% 0.7% SOURCE: June 2014 BPA Statement Total Qualified = 35,233 POWERFUL AUDIENCE PHARMACEUTICAL TECHNOLOGY REACHES FORMULATION, DEVELOPMENT, AND MANUFACTURING PROFESSIONALS AT LEADING MULTI-NATIONAL ORGANIZATIONS AND EMERGING BIO/PHARMA COMPANIES INCLUDING: Abbott AbbVie Actavis Alkermes Allergan Amgen Apotex Astellas Pharma AstraZeneca Baxter Bayer Biogen Idec Biomarin Boehringer Ingelheim SOURCE: Publisher s Own Data Bristol-Myers Squibb Celgene Coviden Daiichi Sankyo Dr. Reddy s Eisai Eli Lilly Forest Labs Genentech/Roche Gilead GlaxoSmithKline Hospira Johnson & Johnson Mallinckrodt Pharmaceuticals Medimmune Merck Mylan Novartis Novo Nordisk Perrigo Pfizer Procter & Gamble Sanofi Shire Takeda Teva Pharmaceuticals UCB Valeant Pharmaceuticals POWERFUL AUDIENCE PHARMACEUTICAL TECHNOLOGY SUBSCRIBERS FUNCTIONS Research, Development, Formulation % Quality Control, Assurance, Validation... 17% Production, Manufacturing % Corporate Management... 10% Engineering % Marketing, Sales Management % Project, Procurement, Contract Management, Purchasing % Lab Management % Technical, Analytical Service, Support % Regulatory Affairs % Information Technology % Other Paid Circulation % SOURCE: July 2014 BPA Statement

5 Advancing Development & Manufacturing PURCHASING INFLUENCE Count on Reaching Professionals with Purchasing Influence and Budgets to Spend POWERFUL AUDIENCE PHARMACEUTICAL TECHNOLOGY READERS RECOMMEND AND/OR APPROVE PURCHASES FOR PRODUCTS RELATED TO THE FOLLOWING AREAS: Analytical Instruments... 59% Laboratory Equipment % Chemicals, Excipients, APIs... 57% Contract Services % Manufacturing and Processing Equipment % Compliance and Validation/IT % Drug Delivery Technology % Packaging Equipment % Aseptic/Sterile Processing % PHARMACEUTICAL TECHNOLOGY READERS RECOMMEND AND/OR APPROVE PURCHASES FOR ANALYTICAL SERVICES RELATED TO THE FOLLOWING AREAS: HPLC % Process Instrumentation % Particle Size Analyzers % Spectrometers % UHPLC % Particle Counters % Pharmaceutical Technology readers recommend and/or approve purchases for contract services related to the following areas: SOURCE: July 2014 Readership Survey Conducted by Advanstar Research Services CONTRACT ANALYTICAL SERVICES 57.1% 55.4% CONTRACT MANUFACTURING 46.4% CONSULTING 42.9% CONTRACT PACKAGING 32.1% 28.6% CONTRACT PROCESS DEVELOPMENT CONTRACT FORMULATION DEVELOPMENT CLINICAL TRIAL MATERIALS MANUFACTURING 23.3%

6 PURCHASING INFLUENCE Advancing Development & Manufacturing Count on Reaching Professionals with Purchasing Influence and Budgets to Spend What Percent of Your Buyers Read Pharmaceutical Technology? 79.1% PURCHASING INFLUENCE SNAPSHOT: LABORATORY EQUIPMENT PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY 50.8% 44.8% 43.3% BALANCES/SCALES CENTRIFUGES/STIRRERS TEMPERATURE INSTRUMENTATION/ THERMOMETERS SAMPLE PREPARATION 38.8% DISSOLUTION TESTING 37.3% 37.3% 37.3% INSPECTION INSTRUMENTS TUBING/PIPING/ GLASSWARE VISCOMETERS 26.9% TABLET TESTERS PURCHASING INFLUENCE SNAPSHOT: MANUFACTURING & PROCESS EQUIPMENT PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY Mixing/Blending/Drying % Pumps % Filtration Purification Equipment % Filtration/Separation % Tablet Presses and Equipment % % Material Handling % Tubing % Coating % Fluid Bed Dryers % Disposables % Roller Compaction/Granulation % Lyophilizers/Freeze Dryers % Separation Columns and/or Membranes % Check Weighers % Inspection Systems % Bioreactors % Softgel Manufacturing % Cell Culture Medium % SOURCE: July 2014 Readership Survey Conducted by Advanstar Research Services

7 Advancing Development & Manufacturing PURCHASING INFLUENCE Count on Reaching Professionals with Purchasing Influence and Budgets to Spend PURCHASING INFLUENCE SNAPSHOT: DRUG DELIVERY & TECHNOLOGY PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY PURCHASING INFLUENCE SNAPSHOT: COMPLIANCE & VALIDATION, AND IT PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY Solid Dosage % Hard Capsules % 66% 66% Soft Capsules % Parenterals % 57.5% Injectables % Transdermal Patches/ Components % 48.9% Aerosols % Inhalation % Nasal % 38.3% 38.3% 34% 21 CFR PART 11 COMPLIANCE VALIDATION/GMP COMPLIANCE DOCUMENT MANAGEMENT CONSULTING CALIBRATION SOFTWARE/ MANAGEMENT SERVICES PROCESS ANALYTICAL TECHNOLOGIES (PAT)/ PROCESS CONTROL/MES LABORATORY INFORMATION MANAGEMENT SOFTWARE (LIMS) 29.8% ERP SOURCE: July 2014 Readership Survey Conducted by Advanstar Research Services

8 PURCHASING INFLUENCE Advancing Development & Manufacturing PURCHASING INFLUENCE SNAPSHOT: CHEMICALS, EXCIPIENTS, AND APIs 74.2% 63.6% 59.1% PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY 48.5% PURCHASING INFLUENCE SNAPSHOT: PACKAGING PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY Labeling Systems % Filling Equipment, Dry % Weighing Systems... 50% Bag Filling Equipment % Filling Equipment, Liquid % Serialization/Track and Trace... 30% Vial Packaging Equipment... 30% Accumulating Tables % Sterile Packaging Systems... 20% Syringe Filling and Assembly Equipment... 20% SOURCE: June 2014 Readership Survey Conducted by Advanstar Research Services RAW MATERIALS EXCIPIENTS APIs BULK INTERMEDIATES & FINE CHEMICALS PURCHASING INFLUENCE SNAPSHOT: ASEPTIC PROCESSING CLEAN ROOM PERCENTAGES OF ALL THE PROFESSIONALS LOOKING TO PURCHASE THESE PRODUCTS OR SERVICES THAT READ PHARMACEUTICAL TECHNOLOGY Disposables % Sanitizing/Cleaning Agents % Cleanrooms/Cleanroom Equipment % Cleanroom Garments/Gloves/Supplies % Barrier/Isolation Systems... 50% Gloveboxes % Particle/Microbe Counters % Terminal Sterilization Equipment % Vial Filing % Entry Systems %

9 EDITORIAL COVERAGE Advancing Development & Manufacturing EDITORIAL COVERAGE: EXPERT INSIGHT AND ANALYSIS Pharmaceutical Technology continues its tradition of providing industry-leading information on the technologies, strategies, and regulations crucial to professionals developing and manufacturing pharmaceuticals and biopharmaceuticals. The editorial mix of peer-reviewed papers, technical articles, technology reports, regulatory and business columns, and expert commentary provide comprehensive coverage of process and formulation development, manufacturing operations, drug delivery, packaging, labeling, and distribution. Contributors from bio/pharmaceutical companies and industry supplier companies, columnists, and the editorial staff are experts with specialized knowledge and experience in their fields. EDITORIAL FOCUS Each issue of Pharmaceutical Technology addresses a key trend in drug development, including solid dosage and parenteral manufacturing, analytical testing, biopharmaceutical manufacturing, equipment and manufacturing trends, quality by design, bioavailability, API manufacturing, drug formulation, and drug delivery. Through expert interviews, roundtable discussions, literature reviews, and survey analysis, the editors report on emerging trends, strategies, and best practices in these key areas. PEER-REVIEWED RESEARCH Pharmaceutical Technology publishes peer-reviewed papers in the form of data-driven research papers, literature and patent reviews, application and technical notes, and position papers on a broad range of drug development topics. All papers undergo a double-blind peer-review process by Pharmaceutical Technology s Editorial Advisory Board, which represents leading scientists, managers, directors, and consultants. KEY TOPICS Solubility, particle engineering, traditional and emerging dosage forms, and more. High potency, chiral chemistry, supply chain issues, smalland large-molecule APIs. Problems and solutions in equipment design and operation, and solid dosage, sterile, and biopharmaceutical manufacturing. Expert insight on analytical testing, data management, manufacturing, supply chain, and more. Quality metrics, product quality, investigations, process validation, and statistical practices. Packaging Forum Packaging equipment, containers, systems, and materials. Facilities Design/Management Key considerations for the design, operation, and maintenance of GMP facilities. Supply Chain/Logistics Equipment, software, and services to maintain a secure, compliant serialization program and supply chain. Product Spotlight New analytical instruments, automation and process control systems, information technology tools, laboratory equipment, and manufacturing equipment. REGULATION AND COMPLIANCE Regulatory Watch Legislation, court decisions, and regulatory changes in the United States and Europe. Inside Standards Industry associations and standard-setting bodies address compendial standards and guidances. BUSINESS/MARKET FOCUS Trends, partnerships, and business activities in the contract services market, as described by Jim Miller of PharmSource Information Services and Eric Langer, president and managing partner of BioPlan Associates. s Reports from established and emerging pharmaceutical markets tackle both regulatory initiatives and market trends. OTHER EDITORIAL FEATURES Business developments, new facilities, and other industry supplier activities are reported in. Executive interviews with industry supplier and pharmaceutical developers are featured in Industry/Pharma Q&A. Reader questions are addressed in.

10 PHARMACEUTICAL TECHNOLOGY 2015 EDITORIAL CALENDAR january Ad Close: December 9, 2014 february Ad Close: January 9, 2015 march Ad Close: February 9, 2015 Excipients for Emerging Dosage Forms Formulation Challenges for Biologics Custom Manufacturing Outlook Aseptic Processing/Sterile Manufacturing Extractables and Leachables Testing Statistical Solutions Packaging Forum Solid Dosage Packaging Inside Standards Informex USA, Feb. 3-5, New Orleans FREE 3-Minute Podcast, Posted on FREE Direct eresponse Ad Leads (Ask your rep for details.) Analytical Testing and Instruments Particle Engineering/Nanomedicine Chiral Chemistry Solid Dosage Visual Inspection Techniques Product Quality: Biologics Supply Chain/Logistics Cold Chain FDA Report Special Themed Issue Partnership Strategies in Outsourcing Best practices and metrics for choosing suppliers, ensuring quality control in vendor relationships, technology transfer, and intellectual property issues. Pittcon, March 8-12, New Orleans FREE 1/3-Page Products/Services Profile Lyophilization Process Design Semi-solid Dosage Forms High-Potency Manufacturing Biopharmaceutical Manufacturing Special Report Elemental Impurities Investigations/Root Causes Facilities Design/Operations GMP Considerations in Room Design Inside Standards Special Themed Issue Solid Dosage and Excipients ebook Trends in the development of soliddosage drug forms, including excipients, API compatibility, formulation development, solubilization, and manufacturing processes. PDA Annual Meeting, March 16-18, Las Vegas DCAT Week, March 16-19, New York INTERPHEX Planning Guide (Print) INTERPHEX Planning Guide (Online and epr Newsletter)

11 PHARMACEUTICAL TECHNOLOGY 2015 EDITORIAL CALENDAR april Ad Close: March 9, 2015 may Ad Close: April 9, 2015 june Ad Close: May 11, 2015 Manufacturing Scale Up Strategies Controlled Release Global API Supply Chain Equipment Design and Operation Analytical Testing for Biologics Process Validation Packaging Forum Parenterals Packaging FDA Report INTERPHEX, April 21-23, New York ExcipientFest Americas, April 28-29, San Juan, PR INTERPHEX Exhibitor Guide (Print) INTERPHEX Exhibitor Guide (Online and epr Newsletter) API Development and Manufacturing Transdermal Drug Delivery Polymorphism and Crystallization plus DCAT Roundup Solid Dosage Data Management in Manufacturing Biologics Raw Materials Supply Chain/Logistics Serialization Inside Standards Special Themed Issue Bioprocessing & Sterile Manufacturing ebook Novel technologies for the formulation, manufacture, purification, and delivery of sterile small- and large-molecule drugs and biologics, including single-use systems and process analytics. AAPS National Biotech Conference, June 8-10, San Francisco FREE Direct eresponse Ad Leads (Ask your rep for details.) Trends in Biopharmaceutical Manufacturing Orally Inhaled and Nasal Drug Products Hazardous Reagent Chemistry Aseptic Processing/Sterile Manufacturing Process Analytical Technology Statistical Solutions Facilities Design/Operations Clean Zone Definitions FDA Report Special Themed Issue Industry Guide and Outlook The global resource for suppliers of chemicals, raw materials, intermediates and excipients; equipment and supplies for manufacturing, packaging, and cleanrooms; laboratory equipment; and contract services. BIO International Convention, June 15-18, Philadelphia FREE 3-Minute Podcast, Posted on

12 PHARMACEUTICAL TECHNOLOGY 2015 EDITORIAL CALENDAR july Ad Close: June 9, 2015 august Ad Close: July 9, 2015 september Ad Close: August 10, 2015 Bioavailability/Solubilization Challenges GI Targeting Process Intensification/ Continuous Flow Manufacturing Biopharmaceutical Manufacturing Equipment Cleaning Operational Excellence Packaging Forum Solid Dosage Packaging Inside Standards Controlled Release Society, July 26-29, Edinburgh, Scotland Double up Program: Ask Your Sales Rep Equipment and Manufacturing Trends High Potency Drug Formulation Biopharmaceutical Manufacturing Equipment Design and Operation Lean Manufacturing Risk Assessment and Mitigation Supply Chain/Logistics Shipping Services FDA Report Special Themed Issue Outsourcing Resources An annual review of the market for outsourced resources, based on a survey and analysis by Jim Miller, president of PharmSource Information Services. Analysis of contract services and business, regulatory, and supply chain issues complement a directory of suppliers and the FastLocator guide to contract services. Pharma/Chem Outsourcing, TDB FREE Full-Page Cutting Edge Technologies Profile (Full-Page Advertisers Only) Quality by Design for Solid Dosage Manufacturing Taste-masking Low Temperature Chemistry Aseptic Processing/Sterile Manufacturing Modular/Flexible Manufacturing Quality Metrics Facilities Design/Operations Room declassification in biopharma facility Inside Standards Special Themed Issue CPHI/ICSE: APIs, Excipients, and Manufacturing Developments in the synthesis of APIs and pharmaceutical intermediates, plus advances in small-molecule synthesis, biologics manufacturing, formulation development and finished-product manufacturing. PDA/FDA Regulatory Conference, Sept , Washington, DC CPhI Worldwide, Oct. TBD, Madrid PharmExpo/Pack Expo, Sept , Las Vegas AAPS Planning Guide (Print) AAPS Planning Guide (Online and ept Newsletter) FREE CPhI Online Guide

13 PHARMACEUTICAL TECHNOLOGY 2015 EDITORIAL CALENDAR october Ad Close: September 9, 2015 november Ad Close: October 9, 2015 december Ad Close: November 9, 2015 Drug Reformulation Strategies Antibody Drug Conjugates Fluorination Chemistry in API Manufacturing Solid Dosage Process Controls Critical Quality Attributes Packaging Forum Parenterals Packaging FDA Report INTERPHEX Puerto Rico, TBD AAPS, Oct , Orlando ISPE Annual Meeting, Nov. 8-11, Philadelphia AAPS Exhibitor Guide (Print) AAPS Exhibitor Guide (Online and ept Newsletter) Large vs. Small Volume Parenteral Manufacturing Specialty Dosage Forms Heterocyclic Chemistry in API Manufacturing Equipment Design and Operation Continuous Solid Dosage Manufacturing Implementing Corrective and Preventive Action (CAPA) Supply Chain/Logistics Track and Trace Inside Standards Special Sponsored Content Issue Drug Development Application Handbook A compilation of whitepapers, application notes, case studies, and other technical reports from industry suppliers and contract service providers on drug development topics. FREE Direct eresponse Ad Leads (Ask your rep for details.) Emerging Therapeutics Salary and Employment Survey Combination Products API Review and Outlook Biopharmaecutical Manufacturing Biosimilars Product Quality: Solid/Semi-solid Dosage Facilities Design/Operations Room Pressurization FDA Report Special Sponsored Content Issue Corporate Capabilities Full-page descriptions of products and services from the industry s leading suppliers. FREE Corporate Capabilities Profile (To Qualified Advertisers) FREE Online Corporate Capabilities Profile (6 months)

14 Advancing Development & Manufacturing RATES 2015 Advertising Rates BLACK & WHITE RATES - US DOLLARS 1x 3x 6x 12x 18x 24x Full Page ,805 9,390 8,985 8,770 8,475 8,170 2/3 Page ,195 7,935 7,680 7,410 7,150 6,890 1/2 Page ,080 6,850 6,615 6,375 6,145 5,920 1/3 Page ,085 4,905 4,715 4,525 4,275 4,170 1/4 Page ,970 3,810 3,655 3,505 3,265 3,200 FOUR COLOR RATES - US DOLLARS 1x 3x 6x 12x 18x 24x Full Page ,945 11,530 11,125 10,910 10,615 10,310 2/3 Page ,335 10,075 9,820 9,550 9,290 9,030 1/2 Page ,220 8,990 8,755 8,515 8,285 8,060 1/3 Page ,225 7,045 6,855 6,665 6,415 6,310 1/4 Page ,110 5,950 5,795 5,645 5,405 5,340 Color Charges Special Positions Standard 1,010 Cover Matched 1,220 Cover Metalic 1,735 Cover 4 1,260 Four-Color 2,140 Preferred Position 655 Digital Ad Requirements 1. Digital data are required for all ad submissions. Preferred format is PDF/X-1a. Note that a standard PDF is not a preferred format, files should be a PDF/X-1a which is a PDF subset specific to printing. The file should be a high res pdf with all fonts embedded in CMYK. Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) if an ad is supplied to Publisher by Advertiser in any format other than our preferred formats. Non-preferred or non-acceptable formats will be charged a $150 processing fee. All files should be built to exact ad space dimensions purchased. For detailed instructions on preparing PDF/X-1a files and submitting ad files to the correct size, go to com or contact the production manager. 2. Publisher will not supply a faxed or soft proof for Advertiser-supplied files. Advertiser is solely responsible for preflighting and proofing all advertisements prior to submission to Publisher. If Publisher detects an error before going to press, Publisher will make a reasonable effort to contact Advertiser to give Advertiser an opportunity to correct and resubmit Advertiser s file before publication. 3. Accepted Method of Delivery: The preferred method of delivering ad files to Advanstar is via a web based ad uploader, Files can also be submitted on CD-R or DVD-R disc format. Ad Dimensions Width Depth 2/3 Page 4 1/2 9 1/2 1/2 Page Island 4 1/2 7 1/2 Page 6 3/4 4 5/8 Horizontal 1/2 Page Vertical 3 3/8 9 1/2 1/3 Page Square 4 1/2 4 5/8 1/3 Page Vertical 2 1/8 9 1/2 1/4 Page 3 3/8 4 5/8 Full Page Dimensions Width Depth Trim Size 7 3/4 10 1/2 Bleed /4 Live Matter 7 1/4 10 Spread Size 14 1/2 9 1/2 Bleed (Spread) 15 3/4 10 3/4 4. Ad Proofs: To ensure that Advertiser s ad is reproduced correctly, a SWOP-certified color proof that has been made from the same file that Advertiser supplies to Publisher must be provided. Publisher cannot provide Advertiser any assurances regarding the accuracy of reproduction of any ad submitted without a SWOP proof. Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) for any ad supplied to Publisher by Advertiser without a SWOP proof.