Agilent Technologies. Jim Hollenhorst, Ph.D. Senior Director of Technology. FAPESP/Agilent Workshop August 30,

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1 Agilent Technologies Jim Hollenhorst, Ph.D. Senior Director of Technology 1

2 A Brief History of Agilent : 1999: 2005: : 2013: 2013: 2014: The Hewlett-Packard years 60-year heritage of leadership and innovation Agilent is born Biggest IPO in Silicon Valley: $2.1 billion Agilent refines scope Focus on measurement Transformation Acquisitions, divestitures and restructuring World s premier measurement company $6.8 billion revenue Agilent announces spinoff of Electronic Measurement Agilent to focus on Life Sciences, Diagnostics and Applied Chemical markets Agilent spins off Keysight Technologies The spinoff is final Nov. 1, 2014, through a tax-free distribution of Keysight common stock 2

3 The Century of Biology is Here Full mainstream adoption and impact may take decades Cellular Manufacturing Precision Medicine Communications / Internet Chemical Analysis Electronics / Computers Test / Measurement

4 A COMMITMENT TO TECHNOLOGY AND INNOVATION 4

5 Agilent at a Glance REVENUE IN FY16 $4.2 billion (more than 70% generated outside the U.S.) Revenue by Geography EMPLOYEES Approximately 12,500 Americas 37% 26% Europe PRESIDENT & CEO Mike McMullen 37% CUSTOMER LOCATIONS 100+ countries Asia Pacific Headcount by Geography MANUFACTURING AND R&D LOCATIONS U.S., Europe, Asia Pacific Americas 34% 29% Europe STOCK TRADING NYSE: A 37% Asia Pacific (1) Global Infrastructure Organization includes Finance, HR, Legal, IT, Workplace Services, Quality and Regulatory Assurance 5

6 Agilent is uniquely positioned to: Drive the science and economics of the lab Leverage analytical strengths to drive success in diagnostics Consumables & Reagents Instruments & Tools Software & Informatics Services & Consulting Analytical Lab Clinical Research Clinical Lab Analytical lab solutions and lab enterprise services Analytical tools to transition discovery into diagnostics Integrated workflows and reagents for routine diagnostics Chemical & Energy Environment Food Pharma Academia & Government Clinical & Diagnostics 6

7 Technology Platforms and Workflow Solutions Cell analysis FlSH Probes Gas chromatography Genome editing and control (CRISPR) Immunohistochemistry Liquid chromatography Mass spectrometry Microarrays Oligonucleotide Libraries Nucleic acid synthesis Spectroscopy Target enrichment for NGS Vacuum technologies Informatics and Software Chemistries and Supplies Automation Bioreagents Services 7

8 Agilent Research Laboratories Competitive advantage through technology Applied research Breakthrough technologies Innovation synergies across product lines World-class research teams across multidisciplinary, global organization Collaboration with leading academic, government & industrial researchers Bridge from academia to Agilent R&D commercialization 8

9 Agilent Laboratories Research Themes Cellular Imaging and Analysis Omics Cellular Reprogramming Intelligent Systems Nucleic Acid Synthesis and Function Life Science and Pathology Workflow Engineering 9

10 Academic and Government Research Program for University Research >750 Collaborations connect us to >250 universities in 30 countries Agilent technical staff and university professors collaborate to explore new technologies and methods, informing Agilent R&D and advancing science (since 2006). 10

11 A Global Academic Network >100 active university collaborations U of Calgary U of Washington UCSF U of Michigan MIT Yale UC Berkeley U of Illinois Harvard UC Davis U of Maryland Stanford CU Boulder Arizona State Johns Hopkins UC San Diego Princeton U of Texas U of Houston Baylor U U of Florida Technical U of Denmark Karolinska Inst., Sweden U of Twente, NL U of Kent, UK Maastricht U, NL Charles U, Czech Republic NIBRT, Ireland Karlsruhe U, Germany Peking U, China Tsinghua U, China U of Manchester, UK Tohoku U, Japan U of Alicante, Spain Seoul Nat l U, Korea Southeast U, China U of Oviedo, Spain Technion, Israel Chungnam Nat l U, Korea U Teknologi MARA, Malaysia U of São Paulo, Brazil UNICAMP, Brazil U of Pretoria, S. Africa NUS, Singapore NTU, Singapore U of Queensland U of W. Australia U of Sydney Macquarie U Curtin U. U Tech, Sydney Monash U U of Tasmania 11

12 Highlights of Our Solutions in Action PHARMA ACADEMIA & GOVERNMENT We help customers speed drug discovery, development and manufacturing. Our analytic products support every step of multi-omics integrated biology research. DIAGNOSTICS & CLINICAL FOOD Our products enable pathology labs to meet accreditation demands and reach accurate diagnoses faster. We help safeguard the global food chain with solutions for food safety, quality and authenticity. ENVIRONMENTAL & FORENSICS We provide environmental labs with the tools to test water, air and soil. Our solutions help law enforcement identify illicit drugs and analyze evidence. CHEMICAL & ENERGY From crude oil, natural gas and refining to specialty chemicals and alternative fuels, we help customers meet quality, safety, regulatory and environmental standards. 12

13 FAPESP/Agilent - Call for Research Proposals Focus Areas Biopharma Metabolomics In both focus areas, successful proposals could include refinement of instruments, development of new measurement protocols, new ways to analyze data, invention of new workflows, or applications of existing techniques to yield new biological understanding within the context of the specific focus. Proposals Due: 29 September 2017 For more information: 13

14 BioPharma We live in a time of rapid advances in the study of disease and the development of new therapies. New tools lead to new understanding that is revolutionizing the development of biotherapeutics. Companion diagnostics are leading us into the era of personalized medicine. New approaches based on a sound understanding of biology may lead to exciting new cures for some of our most intractable diseases. Within this focus area, the goal is to fund projects that can advance the state of the art of measurements for BioPharma, for human health, veterinary medicine and agricultural research. Specifically, we are interested in finding ways to make the discovery, development, and manufacture of biologics and biosimilars faster, easier, more robust and higher in quality. This includes characterization of monoclonal antibodies and addressing all phases of the manufacturing process: QC of inputs, process control, characterization of outputs, and authentication. Our interests span sample prep, LC, LC/MS, Columns, cellular analysis, informatics, database development and management, workflow development and standardization, and effective integration of services in support of robust and efficient analytical measurements. Research which combines leading academic work, a Biopharma partner with analytical challenges, and Agilent s unique measurement capabilities would be of added interest. 14

15 Metabolomics Small molecules have been measured in biological system for centuries; but new measurement tools have led to a renaissance in our understanding of metabolites and metabolism. Metabolomics is now one of the fastest growing areas in life science research. New tools enable identification, quantification, and structure determination of small molecules with unprecedented sensitivity, accuracy, and throughput. Increasingly, tools are being used to measure not just the presence of metabolites, but also their flux in a cell, tissue, or organism. Human health, veterinary medicine, and agricultural research are each areas of interest. The goal for this focus area is to fund projects that lead to improved tools for metabolomics or to use them to increase the understanding of biological systems to improve the quality of life. 15