CURRICULUM VITAE (August 2015)

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1 CURRICULUM VITAE (August 2015) A. BUTIR-BUTIR PERIBADI (Personal Details) Nama Penuh (Full Name) LESLIE THAN THIAN LUNG Gelaran (Title): Dr Warganegara (Citizenship) Jantina (Gender) : Male Jawatan (Designation) Senior Lecturer Jabatan/Fakulti (Department/Faculty) Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences,, UPM Serdang Selangor. E-mel dan URL ( Address and URL) leslie@upm.edu.my Tel : Fax: B. KELAYAKAN AKADEMIK (Academic Qualification) Nama Sijil / Kelayakan Nama Sekolah Institusi (Certificate / Qualification obtained) (Name of School / Institution) PhD BSc. (Hons.) Tahun (Year obtained) Bidang pengkhusususan (Area of Specialization) 2010 Molecular Biology (Mycology) 2004 Biomedical Sciences C. PENGALAMAN SAINTIFIK DAN PENGKHUSUSAN (Scientific experience and Specialisation) Organization Position Start Date End Date Expertise UPM Research Assistant 1 Aug Nov 2004 Cloning, PCR, recombinant protein, culture and identification, monoclonal antibodies. D. PEKERJAAN (Employment) Majikan / Employer Jawatan / Designation Senior Lecturer Tutor Jabatan / Department Tarikh lantikan / Start Date Department of Medical Microbiology and Parasitology, UPM Department of Medical Microbiology and Parasitology, UPM Tarikh tamat / Date Ended 14 Jan 2010 Till to date 10 Dis Jun / 7

2 E. ANUGERAH DAN HADIAH (Honours and Awards) Name of awards Title Award Authority Award Type Year Bioinnovation Award Combined chemistry anticoagulant to prevent rapid blood clotting in warm water fish (Bronze medal) Biotechnology Asia National 2014 n Design, Research and Innovation Exhibition (PRPI 2014) n Design, Research and Innovation Exhibition (PRPI 2012) Combined chemistry anticoagulant to prevent rapid blood clotting in warm water fish (Gold medal, Best of all special award) Detection of 10 medically important Candida species by seminested polymerase chain reaction (Gold medal) UPM National 2014 UPM National 2012 HHMI Grants International Program Advanced Laboratory Training Course Molecular Medical Mycology Howard Hughes Medical Institute (HHMI) Course sponsorship 2009 Academic Awards Incentive Award for Patent Filing Innovation and Commercialisation Centre (ICC), UPM Cash Incentive 2008 UPM University 2008 F. SENARAI PENERBITAN (List of publications author (s), title, journal, volume, page and year published) Journal 1. Ng Tzu Shan, Mohd Nasir Mohd Desa, Doblin Sandai, Chong Pei Pei & Leslie Than Thian Lung (2015) Phylogenetic and transcripts profiling of glucose sensing related genes in Candida glabrata. Jundishapur Journal of Microbiology. Impact factor: (Accepted 22 July 2015) 2. Shu Yih Chew, Yoke Kqueen Cheah, Heng Fong Seow, Doblin Sandai, Leslie Thian Lung Than (2015) In vitro modulation of probiotic bacteria on the biofilm of Candida glabrata. Anaerobe, 34: Impact factor: S.Y. Chew, Y.K. Cheah, H.F. Seow, D. Sandai and L.T.L. Than (2015) Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. Journal of Applied Microbiology, Volume 118, Issue 5, pages , May Impact factor: Salman Sahab Atshan, Mariana Nor Shamsudin, Zamberi Sekawi, LT Thian Lung, FB Talab, YK Liew, AM Ali, SA Abduljaleel, RA Hamat (2015) Comparative proteomic analysis of extracellular proteins expressed by various clonal types of Staphylococcus aureus and during planktonic growth and biofilm development. Frontiers in Microbiology, doi: 2 / 7

3 /fmicb Impact factor: Leslie Than Thian Lung, Chong Pei Pei, Ng Kee Peng, Seow Heng Fong (2015) Detection of medically important Candida species by absolute quantitation real-time polymerase chain reaction (qpcr) method. Jundishapur Journal of Microbiology January; 8(1): e14940, DOI: /jjm Impact factor: Fang Lee Lim, Zailina Hashim, Leslie Thian Lung Than, Salmiah Md Said, Jamal Hisham Hashim, Dan Norbäck (2015) Asthma, Airway Symptoms and Rhinitis in Office Workers in : Associations with House Dust Mite (HDM) Allergy, Cat Allergy and Levels of House Dust Mite Allergens in Office Dust. PLOS One. DOI: /journal.pone Impact factor: Salman Sahab Atshan, Mariana Nor Shamsudin, Arunkumar Karunanidhi, Alex van Belkum, Leslie Than Thian Lung, Zamberi Sekawi, Jayakayatri Jeevajothi Nathan, King Hwa Ling, Johnson Shueh Chong Seng, Alreshidi Mateg Ali, Salwa A. Abduljaleel, Rukman Awang Hamat (2013) Quantitative PCR analysis of genes expressed during biofilm development of methicillin resistant Staphylococcus aureus (MRSA) Infection, Genetics and Evolution Vol. 18, August 2013, Pages Impact factor: S.Vinoshini, O. Malina, T.L. Leslie Than, Jamal H.H., Norback D., Zailina H. (2013) Characterization, identification and comparison of indoor microbial fungi and bacteria between urban and suburban schools in Penang,. Scientific Journal of Microbiology Vol 2(7): Salman Sahab Atshan, Mariana Nor Shamsudin, Leslie Thian Lung Than, King Hwa Ling, Zamberi Sekawi, Pei Pei Chong (2012) Improved method for the isolation of RNA from bacteria refractory to disruption, including S. aureus producing biofilm Gene 494 (2012) Impact factor: Nurhayatie Sajali, Mohd Nasir Mohd Desa, Leslie Than Thian Lung, Chong Pei Pei (2013) Anti-hyphal formation property of allicin in suppression of Aspergillus fumigatus growth n Journal of Microbiology Vol 9(3) 2013, pp (Scopus cited). 11. Leslie Thian Lung Than, Pei Pei Chong, Kee Peng Ng, Heng Fong Seow (2012) Detection of 10 medically important Candida species by seminested polymerase chain reaction. Diagnostic Microbiology and Infectious Disease 72 (2012) Impact factor: Salman Atshan, Mariana Nor Shamsuddin, Leslie Thian Lung Than, Zamberi Sekawi, Ehsanollah Ghaznavi-Rad, and Pei Pei Chong (2011) Comparative characterisation of genotypically different clones of MRSA in the production of biofilms Journal of Biomedicine and Biotechnology In press. doi: /2012/ Epub 2012 Mar 14. Impact factor: Salman Sahab Atshan, Mariana Nor Shamsudin, Leslie Than Thian Lung, Zamberi Sekawi, Chong Pei Pei (2011) A simple and rapid differentiation method for combating therapeutically challenging planktonic and biofilmproducing Staphylococcus aureus. African Journal of Microbiology Research Vol. 5 (12) Pg Impact factor: / 7

4 14. M. Jafarlou, L.T.L. Than, R. Ramasamy, H.F. Seow (2008) Production and Characterization of Monoclonal Antibodies to Aspergillus fumigatus International Journal of Infectious Diseases December 2008 (Vol. 12 Supplement 1, Page e283) Impact factor: L.T.L. Than, K.P. Ng, P.P. Chong, H.F. Seow (2008) Application of An Innovative Seminested PCR Test for Identification and Detection of Ten Medically Important Candida Species International Journal of Infectious Diseases December 2008 (Vol. 12 Supplement 1, Page e464). Impact factor: Than Leslie, TL, Chong PP, Ng, KP, Seow, HF. Detection of different medically important Aspergillus species involved in invasive aspergillosis through DNA microarray with tyramide signal amplification (2007). n Journal of Medicine and Health Sciences. 2007; Vol 3 (1), p.27 (Scopus cited). Manuscript under review 1. Tzu Shan Ng, Mohd Nasir Mohd Desa, Doblin Sandai, Pei Pei Chong, Leslie Thian Lung Than (2015) Growth, biofilm formation, oxidative stress resistance and antifungal susceptibility of Candida glabrata are affected by different glucose concentrations. Infection, Genetics and Evolution. Infection, Genetics and Evolution. (Accept but needed further revision) Impact factor: Shu Yih Chew and Leslie Thian Lung Than (2015) Vulvovaginal candidiasis: Contemporary challenges and the future of prophylactic and therapeutic approaches. Medical Mycology. Impact factor: Chapter in book 1. Medical Microbiology - A Laboratory Practical Book, Second Edition (2014), Chapter 5: Fungi ( ). 2. Nature s Yield and Wonders of Art (NYAWA 14: Microbe) (2014), Fruity microbes. (ISBN ) 3. Medical Microbiology - A Laboratory Practical Book, Second Edition (2014), Chapter 4: Miscellaneous Bacteria ( ). 4. Updates in Medical Microbiology (2012), Chapter 7, Candida glabrata: niche adaptation and mechanisms of survival. (ISBN: ) 5. Medical Microbiology: A laboratory practical book (2012), Chapter 4: Fungi. (ISBN: ) 4 / 7

5 Proceedings/ Presentations Oral presentations 1. Tzu Shan Ng, Mohd Nasir Mohd Desa, Doblin Sandai, Chong Pei Pei, and Leslie Than Thian Lung (2015) SNF3 as high affinity glucose sensor and its role in supporting Candida glabrata viability within the macrophage. 19 th ISHAM Congress, Melbourne, Australia. pg Tzu Shan Ng, Mohd Nasir Mohd Desa, Doblin Sandai, Chong Pei Pei, and Leslie Than Thian Lung (2015) Impact of glucose concentrations in directing the biofilm formation, oxidative stress resistance and antifungal susceptibility of Candida glabrata. Infections 2015 Conference, Putrajaya,, pg. 19. Poster presentations 1. Cheng Yee Low, Tzu Shan Ng, Leslie Thian Lung Than (2015) Fungicidal monoclonal antibody F4(2) exerts biofilm disruption and direct candidacidal activities against selected pathogenic Candida species. Infections 2015 Conference, Putrajaya,, pg. 25. (Top Five Best Poster Award) 2. Premmala Rangasamy, Vasanthakumari Neela, Peter Convey, Chun Wie Chong, Leslie Thian Lung Than (2015) Application of functional metagenomics for the isolation and screening of antimicrobial activity from Antarctic microorganisms found in soil. Infections 2015 Conference, Putrajaya,, pg. 37. (Top Five Best Poster Award) 3. Doblin Sandai, Aman Shah Abdul Majid, Leslie Than Thian Lung, Ishola Oluwaseun Ayodeji (2015) The roles of isocitrate lyase (ICL1) on metabolic adaptation of Candida albicans biofilms. Infections 2015 Conference, Putrajaya,, pg Shu Yih Chew, Cheng Yee Low, Jap Meng Jee, Heng Fong Seow, and Leslie Thian Lung Than (2015) Development and characterisation of hybridomaproducing monoclonal antibody directed against human pathogen Candida glabrata. Infections 2015 Conference, Putrajaya,, pg Tzu Shan Ng, Mohd Nasir Mohd Desa, Doblin Sandai, Chong Pei Pei, and Leslie Than Thian Lung (2014) Effects of glucose concentration in regulating biofilm formation, antioxidant capability and antifungal resistance of Candida glabrata. 12th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (MEEGID 2014), Bangkok, Thailand. 6. Shu Yih Chew, Leslie Thian Lung Than, Yoke Kqueen Cheah, Heng Fong Seow, and Doblin Sandai (2014) Cross-kingdom interactions of probiotic bacteria with planktonic and biofilms forms of vaginal fungal pathogen Candida glabrata. 10th International Mycological Congress, Bangkok, Thailand. 7. Nurhayatie Sajali, Mohd Nasir Mohd Desa, Suhaili Abu Jamaludin, Leslie Than Thian Lung,Chong Pei Pei (2013) Expression pattern of cell wall related genes in Aspergillus fumigatus post-treated with allicin using real time PCR. International Congress of the n Society for Microbiology 2013, p / 7

6 8. Chew Shu Yih, Seow Heng Fong, Cheah Yoke Kqueen, Doblin Sandai, Leslie Than Thian Lung (2013) Antagonistic activities of probiotic Lactobacillus spp. against vaginal fungal pathogen Candida glabrata. 8th National Infectious Diseases Seminar and Workshop 2013, p Ng Tzu Shan, Chong Pei Pei, Mohd Nasir Mohd Desa, Doblin Sandai, Leslie Than Thian Lung (2013) Sugar receptor-repressor pathway in Candida glabrata. 8th National Infectious Diseases Seminar and Workshop 2013, p Nurhayatie Sajali, Mohd. Nasir Mohd. Desa, Leslie Than Thian Lung, Chong Pei Pei (2012) Fungicidal effect of allicin, pure compound of garlic on Aspergillus fumigates. 7th National Infectious Diseases Seminar and Workshop 2012, pg Salman Atshan, Mariana Nor Shamsuddin, Leslie Thian Lung Than, Zamberi Sekawi, Chong Pei Pei (2011) Molecular Determination Of Adhesion And Biofilm Genes In Different Clones Of Staphylococcus aureus Clinical Isolates. International Congress of the n Society of Microbiology 2011, Vol. 1 pg Nurhayatie Sajali, Leslie Than Thian Lung, Chong Pei Pei (2011). In vitro study of antifungal effects of fresh garlic (Allium sativum) extract on Aspergillus Species. 5th National Infectious Diseases Seminar and Workshop Chew B.H., Than L.T.L., Nor Kasmawati J., Haslinda H. (2011) Prevalence and treatment outcomes of medical emergency at two public health clinics in. n Family Physician 2011, Vol. 6 Suppl L.T.L. Than, K.P. Ng, P.P. Chong, H.F. Seow (2006) Detection of different medically important Aspergillus spp. involved in invasive aspergillosis through DNA microarray with tyramide signal amplification. 2nd Advances Against Aspergillosis, February 2006, Hilton Athens, Athens, Greece. Other publications Patent 1. Seow Heng Fong, Leslie Than Thian Lung, Chong Pei Pei (2008) Method for Detection Identifying Candida Species, PCT Application no. : PCT/MY2009/ (Accepted) WIPO Pub. No. : WO/2010/ (Published, 2010) Registration no. (Japan Patent Office) : (Granted, 2014) 2. Maha, Abdullah; Chong, Chou Min; Mariana, Nor Shamsudin; Yusoff, Fatimah Md; Than, Leslie Thian Lung.(2013) An anticoagulant. Patent Application PI , filed 30 December Patent Pending. 6 / 7

7 G. PROJEK PENYELIDIKAN TERDAHULU (Past Research Project) Project Title Role Year Source of fund Status Characterisation of monoclonal antibodies against Candida glabrata RUGS Probiotic interference of lactobacilli strains against vaginal fungal pathogen Candida glabrata RUGS Characterisation of glucose sensing in Candida glabrata: Key that leads to microenvironment adaptation and virulence RUGS Further characterisation of monoclonal antibodies directed towards human pathogen Candida glabrata towards development of immunoassay Science Fund Metabolic flexibility and pathogenicity of Candida glabrata; role of glucose sensing and alternative carbon sources FRGS Ongoing Identification of early diagnostic and prognostic biomarkers for human leptospirosis through systems biology approaches encompassing clinical, biochemical, proteomics, transcriptomics, metabolomics and immunological aspects LRGS Ongoing 7 / 7